Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder

AIM To observe the effects of Qiwei Baizhu Powder ( QWBZP) on rotaviral gastroenteritis in children and in animal models.``METHODS Enrolled patients were divided into two groups, and one group was treated with oral rehydration solution(ORS) and the other treated with oral liquid of QWBZP. Neonate mice were orally infected with 50 μLrotavirus suspension (4 × l0s PFU/mL) and treated with ORS or oral liquid of QWBZP, respectively.``RESULTS Eighty-three cases of rotaviral gastroenteritis treated with QWBZP revealed a better efficacy than that treated with ORS (x2 - 10.8T, P<0.05). The contents of sodium and glucose as well as number of patients with positive human rotavirus antigen in stool in QWBZP group were all less than that in ORS group. In animal models,QWBZP was found effective in treating rotavirus gastroenteritis in neonate NIH mice, as compared with control groups. In QWBZP group, the mortality of infected mice was decreased by 73.3%, the body weight of infected mice was increased, the contents of sodium and glucose as well as number of mice with positive rotavirus antigen in feces were significantly reduced, and the pathological changes such as damage of small intestinal mucosa and villi were also obviously alleviated.``CONCLUSION QWBZP has effects on improving the absorptive function of small intestine, shortening the duration of diarrhea and rotavirus shedding from stool and alleviating the pathological changes of small intestine induced by rotavirus.

氯霉素粉局部施用治疗匐行性角膜溃疡

目的 观察氯霉素粉局部施用治疗匐行性角膜溃疡的疗效。方法 将 34例 4 8眼患者随机分为治疗组和对照组 ,前组在常规西医治疗的基础上加用氯霉素粉局部施用 ,后组采用西医常规治疗。结果 治疗组治愈率为 76 .0 %,总有效率为 96 .0 %;对照组治愈率为 5 6 .5 %,总有效率为 6 9.6 %。两组比较有显著性差异 (P <0 .0 5 )。结论 氯霉素粉局部施用治疗匐行性角膜溃疡 ,可使疗程较常规治疗明显短 ,治愈率高 ,治疗中未发现任何毒副作用。