We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement w...We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement with the experimental data. Our study not only reveals that the maximum efficiency depends on elasticity and is independent of transition rates but also indicates that the parameters fitted to fast muscle are different from those fitted to a slow one. The latter may imply that the structure of the fast muscle is different from that of the slow one. The main reason that our model succeeds is that velocity in this model is an independent variable.展开更多
目的:肌肉收缩是肌动蛋白与肌球蛋白发生相对滑动的结果,而滑动步长的大小被定义为动力冲程,对肌肉收缩动力冲程模型做进一步讨论。方法:通过文献综述的方法,分析了肌球蛋白和肌动蛋白的微观组织结构及分子作用机理,讨论了Huxley A F和H...目的:肌肉收缩是肌动蛋白与肌球蛋白发生相对滑动的结果,而滑动步长的大小被定义为动力冲程,对肌肉收缩动力冲程模型做进一步讨论。方法:通过文献综述的方法,分析了肌球蛋白和肌动蛋白的微观组织结构及分子作用机理,讨论了Huxley A F和Huxley H E提出的具有代表性的在ATP水解循环过程中肌丝滑行的动力冲程模型。结果:讨论了固体物理学、统计物理学、热力学、电磁学、化学等学科在动力冲程模型中的应用,发现动力冲程模型在解释相关实验结果及动力冲程大小等方面存在一些问题,这些存在的问题也表明肌动蛋白和肌球蛋白分子结构及其生物学背景的复杂性。结论:全面了解肌动蛋白和肌球蛋白的动力学行为及其生物学意义,将生命科学的研究与物理学、化学等多学科相结合。期望建立一个比较合理的符合肌肉运动基本生理过程的理论模型,为肌肉运动训练及药物设计提供理论参考。展开更多
基金Project supported by the Key Research Program of Frontier Sciences of Chinese Academy of Sciences(Grant No.Y7Y1472Y61)the National Natural Science Foundation of China(Grant Nos.11205123,11574329,11774358,11747601,and 11675017)+3 种基金the Joint NSFC–ISF Research Program(Grant No.51561145002)the CAS Biophysics Interdisciplinary Innovation Team Project(Grant No.2060299)the CAS Strategic Priority Research Program(Grant No.XDA17010504)the Fundamental Research Funds for the Central Universities(Grant No.2017EYT24)
文摘We proposed a modified ratchet model including power-stroke and elastic coupling to study the efficiency of collective non-processive motors such as myosin Ⅱ in muscle. Our theoretical results are in good agreement with the experimental data. Our study not only reveals that the maximum efficiency depends on elasticity and is independent of transition rates but also indicates that the parameters fitted to fast muscle are different from those fitted to a slow one. The latter may imply that the structure of the fast muscle is different from that of the slow one. The main reason that our model succeeds is that velocity in this model is an independent variable.
文摘目的:肌肉收缩是肌动蛋白与肌球蛋白发生相对滑动的结果,而滑动步长的大小被定义为动力冲程,对肌肉收缩动力冲程模型做进一步讨论。方法:通过文献综述的方法,分析了肌球蛋白和肌动蛋白的微观组织结构及分子作用机理,讨论了Huxley A F和Huxley H E提出的具有代表性的在ATP水解循环过程中肌丝滑行的动力冲程模型。结果:讨论了固体物理学、统计物理学、热力学、电磁学、化学等学科在动力冲程模型中的应用,发现动力冲程模型在解释相关实验结果及动力冲程大小等方面存在一些问题,这些存在的问题也表明肌动蛋白和肌球蛋白分子结构及其生物学背景的复杂性。结论:全面了解肌动蛋白和肌球蛋白的动力学行为及其生物学意义,将生命科学的研究与物理学、化学等多学科相结合。期望建立一个比较合理的符合肌肉运动基本生理过程的理论模型,为肌肉运动训练及药物设计提供理论参考。
