Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in ...Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in mammals.Studies on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between neurons.Astrocytes,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic function.Recent research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel signaling.This summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical states.These findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and responsiveness.Targeting astrocytic signaling pathways shows promise for treating sleep disorders and arousal dysregulation.More research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.展开更多
Although so many methods have been put forward about arousing students' English interest,college teachers still encounter various difficulties in practical teaching.Based on the practical professional-college Engl...Although so many methods have been put forward about arousing students' English interest,college teachers still encounter various difficulties in practical teaching.Based on the practical professional-college English teaching experiences,five more concrete and practical means will be puts forward from a professional-college English teacher's perspective,so as to get the conclusion that teachers should first get good acknowledgement of their students and then apply proper and effective ways to arouse students' English interest.展开更多
目的探究言语刺激强度对健听者听配能的影响。方法选取38例健听成人,采用语速x刺激强度的言语理解测试范式,将瞳孔扩张听配能测量和听觉任务完成准确度及反应速度相结合,观察阈上范围内20 dB SPL的强度变化对听配能和任务表现的影响。...目的探究言语刺激强度对健听者听配能的影响。方法选取38例健听成人,采用语速x刺激强度的言语理解测试范式,将瞳孔扩张听配能测量和听觉任务完成准确度及反应速度相结合,观察阈上范围内20 dB SPL的强度变化对听配能和任务表现的影响。结果语速对平均瞳孔扩张有显著影响(P<0.001,η_(p)^(2)=0.618),但刺激强度对平均瞳孔扩张无显著影响(P=0.213,η_(p)^(2)=0.040)。增加言语刺激强度能够显著提升任务反应速度(P=0.043,η_(p)^(2)=0.099),在正常语速下,还能够显著提升言语理解准确度(P<0.001,η_(p)^(2)=0.374)。结论健听人群听觉舒适阈范围内将言语声刺激强度增加20 dB SPL能够提高聆听效率,但该效应可能并不是通过改变可听度或唤醒度,从而影响听配能结果,可能是改变听觉处理速度。展开更多
Crises in the past have caused devastating,long-lasting impacts on the global economy.The after-effects always bring some dynamic and rigorous challenges for businesses and governments.Such challenges have always been...Crises in the past have caused devastating,long-lasting impacts on the global economy.The after-effects always bring some dynamic and rigorous challenges for businesses and governments.Such challenges have always been a point of discussion for scholars.The recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological impairments.One of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymakers and practitioners.To address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online surveys.It found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator role.Moreover,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk uncertainties and panic situations and thus contribute to consumers’wellbeing.展开更多
基金supported by the Corbett Estate Fund(62285-531021-41800,to EW)the Helen Vosburg McCrillus Plummer and Robert Edward Lee Plummer,Jr.Chair Fund(to JHH).
文摘Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in mammals.Studies on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between neurons.Astrocytes,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic function.Recent research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel signaling.This summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical states.These findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and responsiveness.Targeting astrocytic signaling pathways shows promise for treating sleep disorders and arousal dysregulation.More research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.
文摘Although so many methods have been put forward about arousing students' English interest,college teachers still encounter various difficulties in practical teaching.Based on the practical professional-college English teaching experiences,five more concrete and practical means will be puts forward from a professional-college English teacher's perspective,so as to get the conclusion that teachers should first get good acknowledgement of their students and then apply proper and effective ways to arouse students' English interest.
文摘目的探究言语刺激强度对健听者听配能的影响。方法选取38例健听成人,采用语速x刺激强度的言语理解测试范式,将瞳孔扩张听配能测量和听觉任务完成准确度及反应速度相结合,观察阈上范围内20 dB SPL的强度变化对听配能和任务表现的影响。结果语速对平均瞳孔扩张有显著影响(P<0.001,η_(p)^(2)=0.618),但刺激强度对平均瞳孔扩张无显著影响(P=0.213,η_(p)^(2)=0.040)。增加言语刺激强度能够显著提升任务反应速度(P=0.043,η_(p)^(2)=0.099),在正常语速下,还能够显著提升言语理解准确度(P<0.001,η_(p)^(2)=0.374)。结论健听人群听觉舒适阈范围内将言语声刺激强度增加20 dB SPL能够提高聆听效率,但该效应可能并不是通过改变可听度或唤醒度,从而影响听配能结果,可能是改变听觉处理速度。
基金supported by the National Natural Science Foundation of China(Grant Nos.72272136 and 72172024)Humanities and Social Science Project from the Ministry of Education of China(20YJA630061).
文摘Crises in the past have caused devastating,long-lasting impacts on the global economy.The after-effects always bring some dynamic and rigorous challenges for businesses and governments.Such challenges have always been a point of discussion for scholars.The recent COVID-19 pandemic emaciated the global economy,leaving everyone mired in uncertainty,fear,and psychological impairments.One of the headwind features utilized by consumers during pandemic was panic buying(PB),which must be explored in various contexts for policymakers and practitioners.To address this gap,this study deployed a moderated mediation mechanism,integrating the health belief model(HBM)and competitive arousal theory(CAT)to excavate the notions underlying PB with the intrusion of evolved real-time psychological disorders:intolerance of uncertainty(IU)and cyberchondria(CYC).The study was conducted as a natural experiment in a South Asian developing economy using online surveys.It found that health beliefs—perceived severity(PSV)and perceived susceptibility(PSC)—positively impact perceived arousal(PA),which causes PB,and that PA has a sturdy mediator role.Moreover,in the relationship between health beliefs and arousal,the different psychological disorders were found to have significant moderating roles The study findings can help mitigate risk uncertainties and panic situations and thus contribute to consumers’wellbeing.
