In the recent years,error recovery circuits in optimized data path units are adopted with approximate computing methodology.In this paper the novel multipliers have effective utilization in the newly proposed two diff...In the recent years,error recovery circuits in optimized data path units are adopted with approximate computing methodology.In this paper the novel multipliers have effective utilization in the newly proposed two different 4:2 approximate compressors that generate Error free Sum(ES)and Error free Carry(EC).Proposed ES and Proposed EC in 4:2 compressors are used for performing Partial Product(PP)compression.The structural arrangement utilizes Dadda structure based PP.Due to the regularity of PP arrangement Dadda multiplier is chosen for compressor implementation that favors easy standard cell ASIC design.In this,the proposed compression idealogy are more effective in the smallest n columns,and the accurate compressor in the remaining most significant columns.This limits the error in the multiplier output to be not more than 2n for an n X n multiplication.The choice among the proposed compressors is decided based on the significance of the sum and carry signals on the multiplier result.As an enhancement to the proposed multiplier,we introduce two Area Efficient(AE)variants viz.,Proposed-AE(P-AE),and P-AE with Error Recovery(P-AEER).The proposed basic P-AE,and P-AEER designs exhibit 46.7%,52.9%,and 52.7%PDP reduction respectively when compared to an approximate multiplier of minimal error type and are designed with 90nm ASIC technology.The proposed design and their performance validation are done by using Cadence Encounter.The performance evaluations are carried out using cadence encounter with 90nm ASIC technology.The proposed-basic P-AEA and P-AEER designs demonstrate 46.7%,52.9%and 52.7%PDP reduction compared to the minimal error approximate multiplier.The proposed multiplier is implemented in digital image processing which revealed 0.9810 Structural SIMilarity Index(SSIM),to the least,and less than 3%deviation in ECG signal processing application.展开更多
A paper titled"The CRISPR-Cas13 a gene-editing system induces collateral cleavage of RNA in glioma cells",recently published in Advanced Science by the Kang group,reports the promising application of the CRI...A paper titled"The CRISPR-Cas13 a gene-editing system induces collateral cleavage of RNA in glioma cells",recently published in Advanced Science by the Kang group,reports the promising application of the CRISPR-Cas13 a system in cancer cells1.展开更多
The field experiment designs with single replication were frequently used for factorial experiments in which the numbers of field plots were limited, but the experimental error was difficult to be estimated. To study ...The field experiment designs with single replication were frequently used for factorial experiments in which the numbers of field plots were limited, but the experimental error was difficult to be estimated. To study a new statistical method for improving precision of regression analysis of such experiments in rice, 84 fertilizer experiments were conducted in 15 provinces of China, including Zhejiang, Jiangsu, Anhui, Hunan, Sichuan, Heilongjiang, etc. Three factors with 14 treatments (N: 0—225kg/ha, P: 0 —112. 5kg/ha, K: 0—150kg/ha) and two replications were employed using approaching optimun design. There were 2352 (84×14×2=2352) Yield deviations (d) between the individual treatment yields and its arithmetic mean. The results indicated that:展开更多
The stellarator has inherent advantages over the tokamak in achieving steady-state operation,especially due to its absence of disruptions and lack of need for current drive and the associated recirculating power.In re...The stellarator has inherent advantages over the tokamak in achieving steady-state operation,especially due to its absence of disruptions and lack of need for current drive and the associated recirculating power.In recent years,there have been remarkable advances in the field of stellarator optimization,where precisely quasi-symmetric and precisely quasi-isodynamic magnetic configurations have been achieved with coils,allowing the neoclassical transport and energetic particle losses of stellarators to be reduced to levels comparable to those of tokamaks.At the same time,the development of high-temperature superconducting magnet technology will potentially double the magnetic field strength of stellarators.While these strong fields are expected to introduce new challenges,and while turbulent transport remains a common challenge for both stellarators and tokamaks,the combination of these physical and technological advances results in the expectation that stellarators will become a competitive approach to tokamaks for realizing steady-state fusion.展开更多
Liver metastasis is the commonest form of distant metastasis in colorectal cancer.Selection criteria for surgery and liver-directed therapies have recently been extended.However,resectability remains poorly defined.Tu...Liver metastasis is the commonest form of distant metastasis in colorectal cancer.Selection criteria for surgery and liver-directed therapies have recently been extended.However,resectability remains poorly defined.Tumour biology is increasingly recognized as an important prognostic factor;hence molecular profiling has a growing role in risk stratification and management planning.Surgical resection is the only treatment modality for curative intent.The most appropriate surgical approach is yet to be established.The primary cancer and the hepatic metastasis can be removed simultaneously or in a two-step approach;these two strategies have comparable long-term outcomes.For patients with a limited future liver remnant,portal vein embolization,combined ablation and resection,and associating liver partition and portal vein ligation for staged hepatectomy have been advocated,and each has their pros and cons.The role of neoadjuvant and adjuvant chemotherapy is still debated.Targeted biological agents and loco-regional therapies(thermal ablation,intra-arterial chemo-or radio-embolization,and stereotactic radiotherapy) further improve the already favourable results.The recent debate about offering liver transplantation to highly selected patients needs validation from large clinical trials.Evidencebased protocols are missing,and therefore optimal management of hepatic metastasis should be personalized and determined by a multi-disciplinary team.展开更多
卫星导航地基增强系统(Ground Based Augmentation System,GBAS),可以提高卫星导航的精度、完好性、连续性和可用性,使飞机在复杂天气和恶劣环境下依然能够实现安全、高效的进近和着陆,满足民航精密进近和着陆引导等高精度导航需求.目前...卫星导航地基增强系统(Ground Based Augmentation System,GBAS),可以提高卫星导航的精度、完好性、连续性和可用性,使飞机在复杂天气和恶劣环境下依然能够实现安全、高效的进近和着陆,满足民航精密进近和着陆引导等高精度导航需求.目前GBAS一类精密进近(CATⅠ)服务水平已经完成验证和应用,但是其定位精度等服务水平仍不能完全满足民航需求.GBAS二类/三类精密进近(CATⅡ/Ⅲ)具有更好的服务水平,其技术和应用仍在开发验证中.为了提高民航运行效率和安全,急需开展基于CATⅡ/Ⅲ与CATⅢ的飞行校验活动.当前GBAS主要采用基于单频GPS的工作模式,在系统可用性、安全性和自主性方面非常受限,因此需要开发自主可控的兼容北斗的GBAS系统.本文设计了飞行校验方案,使用自主研制的国产GBAS设备,设计了飞行校验方案,在西安咸阳机场完成了CATⅡ/Ⅲ盲降精密进近着陆引导的GBAS飞行校验.试验结果表明:兼容北斗的国产GBAS具备支持CATⅡ/Ⅲ精密进近的能力,并且其性能远超传统仪表着陆系统(instrument landing system,ILS).这一成果的取得为我国航空运输的安全性提供了有力保障.展开更多
文摘In the recent years,error recovery circuits in optimized data path units are adopted with approximate computing methodology.In this paper the novel multipliers have effective utilization in the newly proposed two different 4:2 approximate compressors that generate Error free Sum(ES)and Error free Carry(EC).Proposed ES and Proposed EC in 4:2 compressors are used for performing Partial Product(PP)compression.The structural arrangement utilizes Dadda structure based PP.Due to the regularity of PP arrangement Dadda multiplier is chosen for compressor implementation that favors easy standard cell ASIC design.In this,the proposed compression idealogy are more effective in the smallest n columns,and the accurate compressor in the remaining most significant columns.This limits the error in the multiplier output to be not more than 2n for an n X n multiplication.The choice among the proposed compressors is decided based on the significance of the sum and carry signals on the multiplier result.As an enhancement to the proposed multiplier,we introduce two Area Efficient(AE)variants viz.,Proposed-AE(P-AE),and P-AE with Error Recovery(P-AEER).The proposed basic P-AE,and P-AEER designs exhibit 46.7%,52.9%,and 52.7%PDP reduction respectively when compared to an approximate multiplier of minimal error type and are designed with 90nm ASIC technology.The proposed design and their performance validation are done by using Cadence Encounter.The performance evaluations are carried out using cadence encounter with 90nm ASIC technology.The proposed-basic P-AEA and P-AEER designs demonstrate 46.7%,52.9%and 52.7%PDP reduction compared to the minimal error approximate multiplier.The proposed multiplier is implemented in digital image processing which revealed 0.9810 Structural SIMilarity Index(SSIM),to the least,and less than 3%deviation in ECG signal processing application.
基金supported by grants from the National Natural Science Foundation of China(Grant No.81772682,81974389)Jiangsu Province’s Key Discipline of Medicine(Grant No.ZDXKA2016001)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘A paper titled"The CRISPR-Cas13 a gene-editing system induces collateral cleavage of RNA in glioma cells",recently published in Advanced Science by the Kang group,reports the promising application of the CRISPR-Cas13 a system in cancer cells1.
文摘The field experiment designs with single replication were frequently used for factorial experiments in which the numbers of field plots were limited, but the experimental error was difficult to be estimated. To study a new statistical method for improving precision of regression analysis of such experiments in rice, 84 fertilizer experiments were conducted in 15 provinces of China, including Zhejiang, Jiangsu, Anhui, Hunan, Sichuan, Heilongjiang, etc. Three factors with 14 treatments (N: 0—225kg/ha, P: 0 —112. 5kg/ha, K: 0—150kg/ha) and two replications were employed using approaching optimun design. There were 2352 (84×14×2=2352) Yield deviations (d) between the individual treatment yields and its arithmetic mean. The results indicated that:
基金This work was supported by the National Magnetic Confinement Fusion Energy Program of China(grant no.2019YFE03030000).
文摘The stellarator has inherent advantages over the tokamak in achieving steady-state operation,especially due to its absence of disruptions and lack of need for current drive and the associated recirculating power.In recent years,there have been remarkable advances in the field of stellarator optimization,where precisely quasi-symmetric and precisely quasi-isodynamic magnetic configurations have been achieved with coils,allowing the neoclassical transport and energetic particle losses of stellarators to be reduced to levels comparable to those of tokamaks.At the same time,the development of high-temperature superconducting magnet technology will potentially double the magnetic field strength of stellarators.While these strong fields are expected to introduce new challenges,and while turbulent transport remains a common challenge for both stellarators and tokamaks,the combination of these physical and technological advances results in the expectation that stellarators will become a competitive approach to tokamaks for realizing steady-state fusion.
文摘Liver metastasis is the commonest form of distant metastasis in colorectal cancer.Selection criteria for surgery and liver-directed therapies have recently been extended.However,resectability remains poorly defined.Tumour biology is increasingly recognized as an important prognostic factor;hence molecular profiling has a growing role in risk stratification and management planning.Surgical resection is the only treatment modality for curative intent.The most appropriate surgical approach is yet to be established.The primary cancer and the hepatic metastasis can be removed simultaneously or in a two-step approach;these two strategies have comparable long-term outcomes.For patients with a limited future liver remnant,portal vein embolization,combined ablation and resection,and associating liver partition and portal vein ligation for staged hepatectomy have been advocated,and each has their pros and cons.The role of neoadjuvant and adjuvant chemotherapy is still debated.Targeted biological agents and loco-regional therapies(thermal ablation,intra-arterial chemo-or radio-embolization,and stereotactic radiotherapy) further improve the already favourable results.The recent debate about offering liver transplantation to highly selected patients needs validation from large clinical trials.Evidencebased protocols are missing,and therefore optimal management of hepatic metastasis should be personalized and determined by a multi-disciplinary team.
