Cytogenetic indicators,especially dicentric chromosomes,have been globally considered the gold standard of biological dose estimation for more than 60 years.The application of these indicators to biological dose estim...Cytogenetic indicators,especially dicentric chromosomes,have been globally considered the gold standard of biological dose estimation for more than 60 years.The application of these indicators to biological dose estimation in victims of radiation accidents in China has undergone approximately 40 years of development and thus provides more accurate information for the clinical diagnosis and patients’treatment.This paper reviews the application and future development of cytogenetic indicators,including chromosomal aberrations(dicentric chromosomes and chromosomal translocations),cytokinesis-block micronuclei,nucleoplasmic bridges,and premature condensation chromosome ring,as biodosimeters in China.展开更多
基金This work was supported by Key Science and Technology Project of Henan Province,China,IDs:142102310086Medical Science and Technology Reseach of Henan Province,China,IDs:LHGJ20190815。
文摘Cytogenetic indicators,especially dicentric chromosomes,have been globally considered the gold standard of biological dose estimation for more than 60 years.The application of these indicators to biological dose estimation in victims of radiation accidents in China has undergone approximately 40 years of development and thus provides more accurate information for the clinical diagnosis and patients’treatment.This paper reviews the application and future development of cytogenetic indicators,including chromosomal aberrations(dicentric chromosomes and chromosomal translocations),cytokinesis-block micronuclei,nucleoplasmic bridges,and premature condensation chromosome ring,as biodosimeters in China.
