OBJECTIVE: To explain the present status of study on diffuse axonal injury, investigate its pathogenesis and pathophysiological changes, and suggest principles for the diagnosis and treatment. DATA SOURCES: Articles a...OBJECTIVE: To explain the present status of study on diffuse axonal injury, investigate its pathogenesis and pathophysiological changes, and suggest principles for the diagnosis and treatment. DATA SOURCES: Articles about diffuse axonal injury published in English from January 1994 to October 2006 were searched in Pubmed database using the of 'diffuse axonal injury, pathogenesis, therapy'. STUDY SELECTION: The collected articles were primarily screened to select those associated with diffuse axonal injury, the obviously irrelated articles were excluded, and the rest ones were retrieved manually, and the full-texts were searched. DATA EXTRACTION: Totally 98 articles were collected, 41 of them were involved, and the other 57 were excluded. DATA SYNTHESIS: Diffuse axonal injury is mainly caused by acceleratory or deceleratory injury, and its pathophysiological change is a progressive duration, local axonal injury finally develops to axonal breakage, mainly includes inactivation of natrium channel, intracellular Ca2+ overloading, activation of calcium protease, caspase, etc., and mitochondrial injury. At present, there is still lack of effective therapeutic methods for diffuse axonal injury, so we should actively explore more effective methods to relieve the pain of patients and improve their prognosis. CONCLUSION: At present, diffuse axonal injury has not attracted enough attentions in China, the mechanisms for its diagnosis and attack are still unclear, and the treatments are mainly aiming at the symptoms.展开更多
The South China Sea （SCS） is the largest marginal sea in West Pacific formed by a combined effect of the Eurasian plate, Pacific plate and India-Australian plate, and is thus considered to be a unique natural labora...The South China Sea （SCS） is the largest marginal sea in West Pacific formed by a combined effect of the Eurasian plate, Pacific plate and India-Australian plate, and is thus considered to be a unique natural laboratory to study oceanic dynamics and tectonic evolutions （Xie et al., 2006; Luan and Zhang, 2009）. Besides, the SCS contains enormous petroleum resources for its favorable conditions of oil-gas generation, accumulation and preservation. It is therefore imperative to intensively study the marine in-situ stress and its controlling factors of the SCS.展开更多
文摘OBJECTIVE: To explain the present status of study on diffuse axonal injury, investigate its pathogenesis and pathophysiological changes, and suggest principles for the diagnosis and treatment. DATA SOURCES: Articles about diffuse axonal injury published in English from January 1994 to October 2006 were searched in Pubmed database using the of 'diffuse axonal injury, pathogenesis, therapy'. STUDY SELECTION: The collected articles were primarily screened to select those associated with diffuse axonal injury, the obviously irrelated articles were excluded, and the rest ones were retrieved manually, and the full-texts were searched. DATA EXTRACTION: Totally 98 articles were collected, 41 of them were involved, and the other 57 were excluded. DATA SYNTHESIS: Diffuse axonal injury is mainly caused by acceleratory or deceleratory injury, and its pathophysiological change is a progressive duration, local axonal injury finally develops to axonal breakage, mainly includes inactivation of natrium channel, intracellular Ca2+ overloading, activation of calcium protease, caspase, etc., and mitochondrial injury. At present, there is still lack of effective therapeutic methods for diffuse axonal injury, so we should actively explore more effective methods to relieve the pain of patients and improve their prognosis. CONCLUSION: At present, diffuse axonal injury has not attracted enough attentions in China, the mechanisms for its diagnosis and attack are still unclear, and the treatments are mainly aiming at the symptoms.
基金supported by the project of the China Geological Survey(Grant No.1212011220122)
文摘The South China Sea （SCS） is the largest marginal sea in West Pacific formed by a combined effect of the Eurasian plate, Pacific plate and India-Australian plate, and is thus considered to be a unique natural laboratory to study oceanic dynamics and tectonic evolutions （Xie et al., 2006; Luan and Zhang, 2009）. Besides, the SCS contains enormous petroleum resources for its favorable conditions of oil-gas generation, accumulation and preservation. It is therefore imperative to intensively study the marine in-situ stress and its controlling factors of the SCS.
