Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and ga...Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas recovery.Identifying interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples.展开更多
Severe well interference through complex fracture networks(CFNs)can be observed among multi-well pads in low permeability reservoirs.The well interference analysis between multi-fractured horizontal wells(MFHWs)is vit...Severe well interference through complex fracture networks(CFNs)can be observed among multi-well pads in low permeability reservoirs.The well interference analysis between multi-fractured horizontal wells(MFHWs)is vitally important for reservoir effective development.Well interference has been historically investigated by pressure transient analysis,while it has shown that rate transient analysis has great potential in well interference diagnosis.However,the impact of complex fracture networks(CFNs)on rate transient behavior of parent well and child well in unconventional reservoirs is still not clear.To further investigate,this paper develops an integrated approach combining pressure and rate transient analysis for well interference diagnosis considering CFNs.To perform multi-well simulation considering CFNs,non-intrusive embedded discrete fracture model approach was applied for coupling fracture with reservoir models.The impact of CFN including natural fractures and frac-hits on pressure and rate transient behavior in multi-well system was investigated.On a logelog plot,interference flow and compound linear flow are two new flow regimes caused by nearby producers.When both NFs and frac-hits are present in the reservoir,frac-hits have a greater impact on well#1 which contains frac-hits,and NFs have greater impact on well#3 which does not have frac-hits.For all well producing circumstances,it might be challenging to see divergence during pseudosteady state flow brought on by frac-hits on the logelog plot.Besides,when NFs occur,reservoir depletion becomes noticeable in comparison to frac-hits in pressure distribution.Application of this integrated approach demonstrates that it works well to characterize the well interference among different multi-fractured horizontal wells in a well pad.Better reservoir evaluation can be acquired based on the new features observed in the novel model,demonstrating the practicability of the proposed approach.The findings of this study can help for better evaluating well interference degree in multi-well systems combing PTA and RTA,which can reduce the uncertainty and improve the accuracy of the well interference analysis based on both field pressure and rate data.展开更多
Polymer flooding in fractured wells has been extensively applied in oilfields to enhance oil recovery.In contrast to water,polymer solution exhibits non-Newtonian and nonlinear behavior such as effects of shear thinni...Polymer flooding in fractured wells has been extensively applied in oilfields to enhance oil recovery.In contrast to water,polymer solution exhibits non-Newtonian and nonlinear behavior such as effects of shear thinning and shear thickening,polymer convection,diffusion,adsorption retention,inaccessible pore volume and reduced effective permeability.Meanwhile,the flux density and fracture conductivity along the hydraulic fracture are generally non-uniform due to the effects of pressure distribution,formation damage,and proppant breakage.In this paper,we present an oil-water two-phase flow model that captures these complex non-Newtonian and nonlinear behavior,and non-uniform fracture characteristics in fractured polymer flooding.The hydraulic fracture is firstly divided into two parts:high-conductivity fracture near the wellbore and low-conductivity fracture in the far-wellbore section.A hybrid grid system,including perpendicular bisection(PEBI)and Cartesian grid,is applied to discrete the partial differential flow equations,and the local grid refinement method is applied in the near-wellbore region to accurately calculate the pressure distribution and shear rate of polymer solution.The combination of polymer behavior characterizations and numerical flow simulations are applied,resulting in the calculation for the distribution of water saturation,polymer concentration and reservoir pressure.Compared with the polymer flooding well with uniform fracture conductivity,this non-uniform fracture conductivity model exhibits the larger pressure difference,and the shorter bilinear flow period due to the decrease of fracture flow ability in the far-wellbore section.The field case of the fall-off test demonstrates that the proposed method characterizes fracture characteristics more accurately,and yields fracture half-lengths that better match engineering reality,enabling a quantitative segmented characterization of the near-wellbore section with high fracture conductivity and the far-wellbore section with low fracture conductivity.The novelty of this paper is the analysis of pressure performances caused by the fracture dynamics and polymer rheology,as well as an analysis method that derives formation and fracture parameters based on the pressure and its derivative curves.展开更多
A review of the pressure transient analysis of flow in reservoirs having natural fractures,vugs and/or caves is presented to provide an insight into how much knowledge has been acquired about this phenomenon and to hi...A review of the pressure transient analysis of flow in reservoirs having natural fractures,vugs and/or caves is presented to provide an insight into how much knowledge has been acquired about this phenomenon and to highlight the gaps still open for further research.A comparison-based approach is adopted which involved the review of works by several authors and identifying the limiting assumptions,model restrictions and applicability.Pressure transient analysis provides information to aid the identification of important features of reservoirs.It also provides an explanation to complex reservoir pressuredependent variations which have led to improved understanding and optimization of the reservoir dynamics.Pressure transient analysis techniques,however,have limitations as not all its models find application in naturally fractured and vuggy reservoirs as the flow dynamics differ considerably.Pollard’s model presented in 1953 provided the foundation for existing pressure transient analysis in these types of reservoirs,and since then,several authors have modified this basic model and come up with more accurate models to characterize the dynamic pressure behavior in reservoirs with natural fractures,vugs and/or caves,with most having inherent limitations.This paper summarizes what has been done,what knowledge is considered established and the gaps left to be researched on.展开更多
Sealing analysis of sealing system in reactor pressure vessels is relevant with multiple nonlinear coupled-field effects, so even large-scale commercial finite element software cannot finish the complicated analysis. ...Sealing analysis of sealing system in reactor pressure vessels is relevant with multiple nonlinear coupled-field effects, so even large-scale commercial finite element software cannot finish the complicated analysis. A finite element method of 3D transient coupled thermo-elastic-plastic contact sealing analysis for reactor pressure vessels is presented, in which the surface nonlinearity, material nonlinearity, transient heat transfer nonlinearity and multiple coupled effect are taken into account and the sealing equation is coupling solved in iterative procedure. At the same time, a computational analysis program is developed, which is applied in the sealing analysis of experimental reactor pressure vessel, and the numerical results are in good coincidence with the experimental resuits. This program is also successful in analyzing the practical problem in engineering.展开更多
Dear Sir,Triamcinolone acetonide(TA)is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenes...Dear Sir,Triamcinolone acetonide(TA)is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenesis inhibitors[1-2].展开更多
A numerical method is proposed for the elasto-plasticity and pore-pressure coupled analysis on the pull- out behaviors of a plate anchor. The bounding-surface plasticity (BSP) model combined with Blot's consol- ida...A numerical method is proposed for the elasto-plasticity and pore-pressure coupled analysis on the pull- out behaviors of a plate anchor. The bounding-surface plasticity (BSP) model combined with Blot's consol- idation theory is employed to simulate the cyclic loading induced elasto-plastic deformation of the soil skeleton and the accompanying generation/dissipation of the excess pore water pressure. The suction force generated around the anchor due to the cyclic variation of the pore water pressure has much effect on the pullout capacity of the plate anchor. The calculated pullout capacity with the proposed method (i.e., the coupled analysis) gets lower than that with the conventional total stress analysis for the case of long-term sustained loading, but slightly higher for the case of short-term monotonic loading. The cyclic loading induced accumulation of pore water pressure may result in an obvious decrease of the stiffness of the soil-Plate anchor svstem.展开更多
Black rockfish(Sebastes schlegelii)has evolved viviparous reproduction mode.Different from the oviparous fishes,the spermatozoa of black rockfish are stored on the surface of ovarian follicle for over four months unti...Black rockfish(Sebastes schlegelii)has evolved viviparous reproduction mode.Different from the oviparous fishes,the spermatozoa of black rockfish are stored on the surface of ovarian follicle for over four months until the egg mature in ovary,while the adaptive evolution of fertilization-related genes remains to be studied.In the present study,based on the genome and transcriptome information of black rockfish,a total of 10 hyaluronidase genes were identified by phylogenetic and sequence analyses,including hyal1,hyal2,hyal3,hyal4,hyal6 and spam1a,spam1b,spam1c and spam1d.The spam1 subfamilies,including spam1a,spam1b,spam1c and spam1d,were significantly expanded compared to other species.The adaptive evolution of hyaluronidase was further investigated by selection pressure analysis of branch model and branch site model.The results showed that only spam1 subfamily was positively selected with a large number of positive selection sites,and the evolution rate was significantly higher thanthose of other teleosts.Two positively selected sites,LYS-171 and GLY-164,were located in the neutral hyaluronidase activity domain,which was pivotal for SPAM1 to participate in enzymatic hydrolysis of the extracellular hyaluronic acid matrix and mediate acrosome reaction in mammals.Furthermore,spam1 was mainly expressed in spermatocytes,secondary spermatocytes,and spermatids of testis,whereas it was not found in metamorphic sperm and mature sperm based on the spatiotemporal expression analysis.All results indicated that spam1 might originate from the testis and might be an adaptation of viviparous trait in black rockfish.展开更多
Feline calicivirus(FCV)is an important feline pathogen mainly causing upper respiratory tract disease,conjunctivitis,and stomatitis,and it is classifed into genotype I and genotype II.To investigate the prevalence and...Feline calicivirus(FCV)is an important feline pathogen mainly causing upper respiratory tract disease,conjunctivitis,and stomatitis,and it is classifed into genotype I and genotype II.To investigate the prevalence and molecular characteristics of FCV,this study collected 337 cat swab samples from animal hospitals in diferent regions of China from 2019 to 2021.The positive detection rate of FCV was 29.9%(101/337)by RT-PCR.Statistical analysis showed that FCV prevalence was signifcantly associated with living environment(p=0.0004),age(p=0.031)and clinical symptoms(p=0.00),but not with sex(p=0.092)and breed(p=0.171).The 26 strains of FCV were isolated using F81 cells.Phylogenetic analysis showed that 10 isolates belonged to genotype I,and 16 isolates belonged to genotype II.These 26 isolates were highly genetically diverse,of which HB7 isolate had three same virulence-related amino acid loci with VSD strains.Potential loci distinguishing diferent genotypes were identifed from 26 isolates,suggesting the genetic relationship between diferent genotypes.In addition,selection pressure analysis based on capsid protein of 26 isolates revealed that the protein is under diversifying selection.This study reveals the genetic diversity of FCV and provides a reference for the screening of vaccine candidate strains and the development of vaccines with better cross-protection efects.展开更多
Fixed offshore wind turbines usually have large underwater supporting structures. The fluid influences the dynamic characteristics of the structure system. The dynamic model of a 5-MW tripod offshore wind turbine cons...Fixed offshore wind turbines usually have large underwater supporting structures. The fluid influences the dynamic characteristics of the structure system. The dynamic model of a 5-MW tripod offshore wind turbine considering the pile-soil system and fluid structure interaction (FSI) is established, and the structural modes in air and in water are obtained by use of ANSYS. By comparing low-order natural frequencies and mode shapes, the influence of sea water on the free vibration characteristics of offshore wind turbine is analyzed. On basis of the above work, seismic responses under excitation by E1-Centro waves are calculated by the time-history analysis method. The results reveal that the dynamic responses such as the lateral displacement of the foundation and the section bending moment of the tubular piles increase substantially under the influence of the added-mass and hydrodynamic pressure of sea water. The method and conclusions presented in this paper can provide a theoretical reference for structure design and analysis of offshore wind turbines fixed in deep seawater.展开更多
Back-to-back mechanically stabilized earth walls (BBMSEWs) are encountered in bridge approaches, ramp ways, rockfall protection systems, earth dams, levees and noise barriers. However, available design guidelines fo...Back-to-back mechanically stabilized earth walls (BBMSEWs) are encountered in bridge approaches, ramp ways, rockfall protection systems, earth dams, levees and noise barriers. However, available design guidelines for BBMSEWs are limited and not applicable to numerical modeling when back-to-back walls interact with each other. The objective of this paper is to investigate, using PLAXIS code, the effects of the reduction in the distance between BBMSEW, the reinforcement length, the quality of backfill material and the connection of reinforcements in the middle, when the back-to-back walls are close. The results indicate that each of the BBMSEWs behaves independently if the width of the embankment between mechanically stabilized earth walls is greater than that of the active zone. This is in good agreement with the result of FHWA design guideline. However, the results show that the FHWA design guideline underestimates the lateral earth pressure when back-to-back walls interact with each other. Moreover, for closer BBMSEWs, FHWA design guideline strongly overestimates the maximum tensile force in the reinforcement. The investigation of the quality of backfill material shows that the minor increase in embankment cohesion can lead to significant reductions in both the lateral earth pressure and the maximum tensile force in geosynthetic. When the distance between the two earth walls is close to zero, the connection of reinforcement between back-to-back walls significantly improves the factor of safety.展开更多
In this study, free and forced vibration analysis of nano-composite rotating pressurized microbeam reinforced by carbon nanotubes (CNTs) under magnetic field based on modify couple stress theory (MCST) with temper...In this study, free and forced vibration analysis of nano-composite rotating pressurized microbeam reinforced by carbon nanotubes (CNTs) under magnetic field based on modify couple stress theory (MCST) with temperature-variable material propertiesis presented. Also, the boundary conditions at two ends of nano-composite rotating pressurized microbeam reinforced by CNTs are considered as simply supported. The governing equations are obtained based on the Hamilton's principle and then computed these equations by using Navier's solution. The magnetic field is inserted in the thickness direction of the nano-composite microbeam. The effects of various parameters such as angular velocity, temperature changes, and pressure between of the inside and outside, the magnetic field, material length scale parameter, and volume fraction of nanocomposite microbeam on the natural frequency and response systemare studied. The results show that with increasing volume fraction of nano-composite microbeam, thickness, material length scale parameter, and magnetic fields, the natural frequency increases. The results of this research can be used for optimization of micro-structures and manufacturing sensors, displacement fluid, and drug delivery.展开更多
Purpose: Assessment of contractile function is a major challenge in patients with left ventricular dysfunction, especially during cardiac surgery. The initial tangent of the femoral arterial pressure increase (tanin) ...Purpose: Assessment of contractile function is a major challenge in patients with left ventricular dysfunction, especially during cardiac surgery. The initial tangent of the femoral arterial pressure increase (tanin) has recently been described to be an estimate of left ventricular (LV) contractility. To confirm these findings tanin was compared to various indices of LV performance in patients undergoing cardiac surgery. Methods: Data from 17 patients were evaluated retrospectively. Myocardial performance was estimated by the echocardiographic indices ejection fraction (EF), shortening fraction (FS), circumferential fiber shortening velocity (Vcf), the parameters of pulse contour analysis area under the curve (AUC) and tanin. Measurements were taken before and after cardiopulmonary bypass (CPB). Results: Tanin increased significantly (813 ± 216 mmHg/s vs. 1490 ± 450 mmHg/s, p < 0.05) after CPB, as well as Vcf (0.89 ± 0.14 circ/s vs. 1.47 ± 0.27 circ/s, p < 0.05) and EF (65% ± 7% vs. 74% ± 6%, p < 0.05). FS did not change (40.7% ± 7% vs. 46.5% ± 5%, p = 0.30). AUC significantly dropped after CPB (435 ± 54 mmHg*s vs. 263 ± 27 mmHg*s). Tanin and Vcf correlated strongly (r = 0.70, p < 0.001), while tanin showed only weak correlation with EF (r = 0.36, p = 0.037). There was no significant correlation with FS (r = 0.31, p = 0.079). Tanin and AUC correlated inversely (r = -0.62, p < 0.001). Conclusions: While showing little or no correlation with EF and FS respectively, tanin correlated well with the less preload-dependent parameter Vcf, thus suggesting that tanin may be used as an easily accessible estimate of LV contractility during cardiac surgery.展开更多
One of the design methods for closing the end of a pressure cylinder is to screw down a screw plug on the threaded end of the cylinder. In this case, there is the problem of stress concentration in the threaded end of...One of the design methods for closing the end of a pressure cylinder is to screw down a screw plug on the threaded end of the cylinder. In this case, there is the problem of stress concentration in the threaded end of the pressure cylinder. To solve the problem, it is necessary to know accurately the load distribution on the threaded end of the cylinder. To find the load distribution on the threaded end of the pressure cylinder engaged with the screw plug, the following experiments are carried out. Applying the tensile load between the screw plug and the pressure cylinder and regarding the situation above as equivalent to the situation in which the internal pressure is applied, the load distribution is measured with the strain gauge. The influence of thread pitch on the load distribution on the threaded end of the cylinder is presented and an optimum pitch for design is discussed.展开更多
The assumption of constant rock properties in pressure-transient analysis of stress-sensitive reservoirs can cause significant errors in the estimation of temporal and spatial variation of pressure. In this article, t...The assumption of constant rock properties in pressure-transient analysis of stress-sensitive reservoirs can cause significant errors in the estimation of temporal and spatial variation of pressure. In this article, the pressure transient response of the fractal medium in stress-sensitive reservoirs was studied by using the self-similarity solution method and the regular perturbation method. The dependence of permeability on pore pressure makes the flow equation strongly nonlinear. The nonlinearities associated with the governing equation become weaker by using the logarithm transformation. The perturbation solutions for a constant pressure production and a constant rate production of a linear-source well were obtained by using the self-similarity solution method and the regular perturbation method in an infinitely large system, and inquire into the changing rule of pressure when the fractal and deformation parameters change. The plots of typical pressure curves were given in a few cases, and the results can be applied to well test analysis.展开更多
The transient flow mathematical model of arbitrary shaped heterogeneous reservoirs with impermeability barrier is proposed in this paper. In order to establish this model, the perturbation method is employed and the s...The transient flow mathematical model of arbitrary shaped heterogeneous reservoirs with impermeability barrier is proposed in this paper. In order to establish this model, the perturbation method is employed and the solution of model is expanded into a series in powers of perturbation parameter. By using the Boundary Element Method (BEM) and Duhamel principle, wellbore pressure with effects of skins and wellbore storage is obtained. The type curves are plotted and analyzed considering effects of heterogeneity, arbitrary shape and impermeable barriers. Finally, the results obtained by perturbation boundary element method is compared with the analytical solution and is available for the transient pressure analysis of arbitrary shaped reservoirs.展开更多
Based on the numerical simulation analysis, structure parameters of the high pressure fuel pump and common rail as well as flow limiter are designed and the GD-1 high pressure common rail fuel injection system is self...Based on the numerical simulation analysis, structure parameters of the high pressure fuel pump and common rail as well as flow limiter are designed and the GD-1 high pressure common rail fuel injection system is self-developed. Fuel injection characteristics experiment is performed on the GD-1 system. And double-factor variance analysis is applied to investigate the influence of the rail pressure and injection pulse width on the consistency of fuel injection quantity, thus to test whether the design of structure parameters is sound accordingly. The results of experiment and test show that rail pressure and injection pulse width as well as their mutual-effect have no influence on the injection quantity consistency, which proves that the structure parameters design is successful and performance of GD-1 system is sound.展开更多
With mean yield(MY)criterion,an analytical solution of the collapse load for a defect-free pipe elbow under internal pressure is first obtained.It is a function of ratio of thickness to radius t0/r0,strain hardening...With mean yield(MY)criterion,an analytical solution of the collapse load for a defect-free pipe elbow under internal pressure is first obtained.It is a function of ratio of thickness to radius t0/r0,strain hardening exponent n,curvature influence factor mand ultimate tensile strength.The collapse load increases with the increase of m,and it is the same as the burst pressure of straight pipe if m=1is assumed.The MY-based solution is compared with those based on Tresca,Mises and twin shear stress(TSS)yield criteria,and the comparison indicates that Tresca and twin shear stress yield criteria predict a lower bound and an upper bound to the collapse load respectively.However,the MY-based solution lies just between the TSS and Tresca solutions,and almost has the same precision with the Mises solution.展开更多
Long piles of the ocean oil platform are usually manufactured as the integration of several segments, which have to be assembled one by one during installation. During pile driving, excessive pore pressure will build ...Long piles of the ocean oil platform are usually manufactured as the integration of several segments, which have to be assembled one by one during installation. During pile driving, excessive pore pressure will build up in such a high level that hydraulic fracturing in the soil round the pile may take place, which will cause the soil to consolidate much faster during pile extension period. Consequently, after pile extension, the soil strength will recover to some extent and the driving resistance will increase considerably, which makes restarting driving the pile very difficult and even causes refusal. A finite element (FE) analysis procedure is presented for judging the risk of refusal by estimating the blow counts after pile extension, in which the regain of soil strength is considered. A case analysis in Bohai Gulf is performed using the proposed orocedure to exolain the nile refusal phenomenon.展开更多
Although the Chinese government has published a seriesof favorable policies for textile industry,the outcome of thesefiscal policies in Chinese cotton machinery industry tends to besmall at this stage,since the effect...Although the Chinese government has published a seriesof favorable policies for textile industry,the outcome of thesefiscal policies in Chinese cotton machinery industry tends to besmall at this stage,since the effects of policies is hysteresial,and the industry had extended 2009 spring holiday amid thefinancial crisis.展开更多
文摘Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas recovery.Identifying interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples.
基金The authors are grateful to the financial support from China Postdoctoral Science Foundation(2022M712645)Opening Fund of Key Laboratory of Enhanced Oil Recovery(Northeast Petroleum University),Ministry of Education(NEPU-EOR-2021-03).
文摘Severe well interference through complex fracture networks(CFNs)can be observed among multi-well pads in low permeability reservoirs.The well interference analysis between multi-fractured horizontal wells(MFHWs)is vitally important for reservoir effective development.Well interference has been historically investigated by pressure transient analysis,while it has shown that rate transient analysis has great potential in well interference diagnosis.However,the impact of complex fracture networks(CFNs)on rate transient behavior of parent well and child well in unconventional reservoirs is still not clear.To further investigate,this paper develops an integrated approach combining pressure and rate transient analysis for well interference diagnosis considering CFNs.To perform multi-well simulation considering CFNs,non-intrusive embedded discrete fracture model approach was applied for coupling fracture with reservoir models.The impact of CFN including natural fractures and frac-hits on pressure and rate transient behavior in multi-well system was investigated.On a logelog plot,interference flow and compound linear flow are two new flow regimes caused by nearby producers.When both NFs and frac-hits are present in the reservoir,frac-hits have a greater impact on well#1 which contains frac-hits,and NFs have greater impact on well#3 which does not have frac-hits.For all well producing circumstances,it might be challenging to see divergence during pseudosteady state flow brought on by frac-hits on the logelog plot.Besides,when NFs occur,reservoir depletion becomes noticeable in comparison to frac-hits in pressure distribution.Application of this integrated approach demonstrates that it works well to characterize the well interference among different multi-fractured horizontal wells in a well pad.Better reservoir evaluation can be acquired based on the new features observed in the novel model,demonstrating the practicability of the proposed approach.The findings of this study can help for better evaluating well interference degree in multi-well systems combing PTA and RTA,which can reduce the uncertainty and improve the accuracy of the well interference analysis based on both field pressure and rate data.
基金This work is supported by the National Natural Science Foundation of China(No.52104049)the Young Elite Scientist Sponsorship Program by Beijing Association for Science and Technology(No.BYESS2023262)Science Foundation of China University of Petroleum,Beijing(No.2462022BJRC004).
文摘Polymer flooding in fractured wells has been extensively applied in oilfields to enhance oil recovery.In contrast to water,polymer solution exhibits non-Newtonian and nonlinear behavior such as effects of shear thinning and shear thickening,polymer convection,diffusion,adsorption retention,inaccessible pore volume and reduced effective permeability.Meanwhile,the flux density and fracture conductivity along the hydraulic fracture are generally non-uniform due to the effects of pressure distribution,formation damage,and proppant breakage.In this paper,we present an oil-water two-phase flow model that captures these complex non-Newtonian and nonlinear behavior,and non-uniform fracture characteristics in fractured polymer flooding.The hydraulic fracture is firstly divided into two parts:high-conductivity fracture near the wellbore and low-conductivity fracture in the far-wellbore section.A hybrid grid system,including perpendicular bisection(PEBI)and Cartesian grid,is applied to discrete the partial differential flow equations,and the local grid refinement method is applied in the near-wellbore region to accurately calculate the pressure distribution and shear rate of polymer solution.The combination of polymer behavior characterizations and numerical flow simulations are applied,resulting in the calculation for the distribution of water saturation,polymer concentration and reservoir pressure.Compared with the polymer flooding well with uniform fracture conductivity,this non-uniform fracture conductivity model exhibits the larger pressure difference,and the shorter bilinear flow period due to the decrease of fracture flow ability in the far-wellbore section.The field case of the fall-off test demonstrates that the proposed method characterizes fracture characteristics more accurately,and yields fracture half-lengths that better match engineering reality,enabling a quantitative segmented characterization of the near-wellbore section with high fracture conductivity and the far-wellbore section with low fracture conductivity.The novelty of this paper is the analysis of pressure performances caused by the fracture dynamics and polymer rheology,as well as an analysis method that derives formation and fracture parameters based on the pressure and its derivative curves.
基金the financial support received from the College of Petroleum Engineering and Geosciences at KFUPM through the project SF20006 toward the completion of this work。
文摘A review of the pressure transient analysis of flow in reservoirs having natural fractures,vugs and/or caves is presented to provide an insight into how much knowledge has been acquired about this phenomenon and to highlight the gaps still open for further research.A comparison-based approach is adopted which involved the review of works by several authors and identifying the limiting assumptions,model restrictions and applicability.Pressure transient analysis provides information to aid the identification of important features of reservoirs.It also provides an explanation to complex reservoir pressuredependent variations which have led to improved understanding and optimization of the reservoir dynamics.Pressure transient analysis techniques,however,have limitations as not all its models find application in naturally fractured and vuggy reservoirs as the flow dynamics differ considerably.Pollard’s model presented in 1953 provided the foundation for existing pressure transient analysis in these types of reservoirs,and since then,several authors have modified this basic model and come up with more accurate models to characterize the dynamic pressure behavior in reservoirs with natural fractures,vugs and/or caves,with most having inherent limitations.This paper summarizes what has been done,what knowledge is considered established and the gaps left to be researched on.
文摘Sealing analysis of sealing system in reactor pressure vessels is relevant with multiple nonlinear coupled-field effects, so even large-scale commercial finite element software cannot finish the complicated analysis. A finite element method of 3D transient coupled thermo-elastic-plastic contact sealing analysis for reactor pressure vessels is presented, in which the surface nonlinearity, material nonlinearity, transient heat transfer nonlinearity and multiple coupled effect are taken into account and the sealing equation is coupling solved in iterative procedure. At the same time, a computational analysis program is developed, which is applied in the sealing analysis of experimental reactor pressure vessel, and the numerical results are in good coincidence with the experimental resuits. This program is also successful in analyzing the practical problem in engineering.
文摘Dear Sir,Triamcinolone acetonide(TA)is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenesis inhibitors[1-2].
基金supported by the National Natural Science Foundation of China(51309213)the 973 program of China (2014CB046200)
文摘A numerical method is proposed for the elasto-plasticity and pore-pressure coupled analysis on the pull- out behaviors of a plate anchor. The bounding-surface plasticity (BSP) model combined with Blot's consol- idation theory is employed to simulate the cyclic loading induced elasto-plastic deformation of the soil skeleton and the accompanying generation/dissipation of the excess pore water pressure. The suction force generated around the anchor due to the cyclic variation of the pore water pressure has much effect on the pullout capacity of the plate anchor. The calculated pullout capacity with the proposed method (i.e., the coupled analysis) gets lower than that with the conventional total stress analysis for the case of long-term sustained loading, but slightly higher for the case of short-term monotonic loading. The cyclic loading induced accumulation of pore water pressure may result in an obvious decrease of the stiffness of the soil-Plate anchor svstem.
基金supported by the National Natural Science Foundation of China(Nos.32273133,31970492).
文摘Black rockfish(Sebastes schlegelii)has evolved viviparous reproduction mode.Different from the oviparous fishes,the spermatozoa of black rockfish are stored on the surface of ovarian follicle for over four months until the egg mature in ovary,while the adaptive evolution of fertilization-related genes remains to be studied.In the present study,based on the genome and transcriptome information of black rockfish,a total of 10 hyaluronidase genes were identified by phylogenetic and sequence analyses,including hyal1,hyal2,hyal3,hyal4,hyal6 and spam1a,spam1b,spam1c and spam1d.The spam1 subfamilies,including spam1a,spam1b,spam1c and spam1d,were significantly expanded compared to other species.The adaptive evolution of hyaluronidase was further investigated by selection pressure analysis of branch model and branch site model.The results showed that only spam1 subfamily was positively selected with a large number of positive selection sites,and the evolution rate was significantly higher thanthose of other teleosts.Two positively selected sites,LYS-171 and GLY-164,were located in the neutral hyaluronidase activity domain,which was pivotal for SPAM1 to participate in enzymatic hydrolysis of the extracellular hyaluronic acid matrix and mediate acrosome reaction in mammals.Furthermore,spam1 was mainly expressed in spermatocytes,secondary spermatocytes,and spermatids of testis,whereas it was not found in metamorphic sperm and mature sperm based on the spatiotemporal expression analysis.All results indicated that spam1 might originate from the testis and might be an adaptation of viviparous trait in black rockfish.
基金supported by the National Natural Science Foundation of China(NSFC):(Grant No.32002268)the China Postdoctoral Science Foundation(Grant No.2019M662677)the Wuhan 3551 Optics Valley Talent Program and the Wuhan Talent Program.
文摘Feline calicivirus(FCV)is an important feline pathogen mainly causing upper respiratory tract disease,conjunctivitis,and stomatitis,and it is classifed into genotype I and genotype II.To investigate the prevalence and molecular characteristics of FCV,this study collected 337 cat swab samples from animal hospitals in diferent regions of China from 2019 to 2021.The positive detection rate of FCV was 29.9%(101/337)by RT-PCR.Statistical analysis showed that FCV prevalence was signifcantly associated with living environment(p=0.0004),age(p=0.031)and clinical symptoms(p=0.00),but not with sex(p=0.092)and breed(p=0.171).The 26 strains of FCV were isolated using F81 cells.Phylogenetic analysis showed that 10 isolates belonged to genotype I,and 16 isolates belonged to genotype II.These 26 isolates were highly genetically diverse,of which HB7 isolate had three same virulence-related amino acid loci with VSD strains.Potential loci distinguishing diferent genotypes were identifed from 26 isolates,suggesting the genetic relationship between diferent genotypes.In addition,selection pressure analysis based on capsid protein of 26 isolates revealed that the protein is under diversifying selection.This study reveals the genetic diversity of FCV and provides a reference for the screening of vaccine candidate strains and the development of vaccines with better cross-protection efects.
基金financially supported by the Fund for Creative Research Groups of China(Grant No.51421064)
文摘Fixed offshore wind turbines usually have large underwater supporting structures. The fluid influences the dynamic characteristics of the structure system. The dynamic model of a 5-MW tripod offshore wind turbine considering the pile-soil system and fluid structure interaction (FSI) is established, and the structural modes in air and in water are obtained by use of ANSYS. By comparing low-order natural frequencies and mode shapes, the influence of sea water on the free vibration characteristics of offshore wind turbine is analyzed. On basis of the above work, seismic responses under excitation by E1-Centro waves are calculated by the time-history analysis method. The results reveal that the dynamic responses such as the lateral displacement of the foundation and the section bending moment of the tubular piles increase substantially under the influence of the added-mass and hydrodynamic pressure of sea water. The method and conclusions presented in this paper can provide a theoretical reference for structure design and analysis of offshore wind turbines fixed in deep seawater.
文摘Back-to-back mechanically stabilized earth walls (BBMSEWs) are encountered in bridge approaches, ramp ways, rockfall protection systems, earth dams, levees and noise barriers. However, available design guidelines for BBMSEWs are limited and not applicable to numerical modeling when back-to-back walls interact with each other. The objective of this paper is to investigate, using PLAXIS code, the effects of the reduction in the distance between BBMSEW, the reinforcement length, the quality of backfill material and the connection of reinforcements in the middle, when the back-to-back walls are close. The results indicate that each of the BBMSEWs behaves independently if the width of the embankment between mechanically stabilized earth walls is greater than that of the active zone. This is in good agreement with the result of FHWA design guideline. However, the results show that the FHWA design guideline underestimates the lateral earth pressure when back-to-back walls interact with each other. Moreover, for closer BBMSEWs, FHWA design guideline strongly overestimates the maximum tensile force in the reinforcement. The investigation of the quality of backfill material shows that the minor increase in embankment cohesion can lead to significant reductions in both the lateral earth pressure and the maximum tensile force in geosynthetic. When the distance between the two earth walls is close to zero, the connection of reinforcement between back-to-back walls significantly improves the factor of safety.
基金the Iranian Nanotechnology Development Committee for their financial supportthe University of Kashan (463855/7)
文摘In this study, free and forced vibration analysis of nano-composite rotating pressurized microbeam reinforced by carbon nanotubes (CNTs) under magnetic field based on modify couple stress theory (MCST) with temperature-variable material propertiesis presented. Also, the boundary conditions at two ends of nano-composite rotating pressurized microbeam reinforced by CNTs are considered as simply supported. The governing equations are obtained based on the Hamilton's principle and then computed these equations by using Navier's solution. The magnetic field is inserted in the thickness direction of the nano-composite microbeam. The effects of various parameters such as angular velocity, temperature changes, and pressure between of the inside and outside, the magnetic field, material length scale parameter, and volume fraction of nanocomposite microbeam on the natural frequency and response systemare studied. The results show that with increasing volume fraction of nano-composite microbeam, thickness, material length scale parameter, and magnetic fields, the natural frequency increases. The results of this research can be used for optimization of micro-structures and manufacturing sensors, displacement fluid, and drug delivery.
文摘Purpose: Assessment of contractile function is a major challenge in patients with left ventricular dysfunction, especially during cardiac surgery. The initial tangent of the femoral arterial pressure increase (tanin) has recently been described to be an estimate of left ventricular (LV) contractility. To confirm these findings tanin was compared to various indices of LV performance in patients undergoing cardiac surgery. Methods: Data from 17 patients were evaluated retrospectively. Myocardial performance was estimated by the echocardiographic indices ejection fraction (EF), shortening fraction (FS), circumferential fiber shortening velocity (Vcf), the parameters of pulse contour analysis area under the curve (AUC) and tanin. Measurements were taken before and after cardiopulmonary bypass (CPB). Results: Tanin increased significantly (813 ± 216 mmHg/s vs. 1490 ± 450 mmHg/s, p < 0.05) after CPB, as well as Vcf (0.89 ± 0.14 circ/s vs. 1.47 ± 0.27 circ/s, p < 0.05) and EF (65% ± 7% vs. 74% ± 6%, p < 0.05). FS did not change (40.7% ± 7% vs. 46.5% ± 5%, p = 0.30). AUC significantly dropped after CPB (435 ± 54 mmHg*s vs. 263 ± 27 mmHg*s). Tanin and Vcf correlated strongly (r = 0.70, p < 0.001), while tanin showed only weak correlation with EF (r = 0.36, p = 0.037). There was no significant correlation with FS (r = 0.31, p = 0.079). Tanin and AUC correlated inversely (r = -0.62, p < 0.001). Conclusions: While showing little or no correlation with EF and FS respectively, tanin correlated well with the less preload-dependent parameter Vcf, thus suggesting that tanin may be used as an easily accessible estimate of LV contractility during cardiac surgery.
文摘One of the design methods for closing the end of a pressure cylinder is to screw down a screw plug on the threaded end of the cylinder. In this case, there is the problem of stress concentration in the threaded end of the pressure cylinder. To solve the problem, it is necessary to know accurately the load distribution on the threaded end of the cylinder. To find the load distribution on the threaded end of the pressure cylinder engaged with the screw plug, the following experiments are carried out. Applying the tensile load between the screw plug and the pressure cylinder and regarding the situation above as equivalent to the situation in which the internal pressure is applied, the load distribution is measured with the strain gauge. The influence of thread pitch on the load distribution on the threaded end of the cylinder is presented and an optimum pitch for design is discussed.
基金the National High Technology Research and Development Program of China (863 Program,Grant No. 2006AA06Z236)the Natural Science Foundation of Shandong Province (Grant No. Y2007F13)
文摘The assumption of constant rock properties in pressure-transient analysis of stress-sensitive reservoirs can cause significant errors in the estimation of temporal and spatial variation of pressure. In this article, the pressure transient response of the fractal medium in stress-sensitive reservoirs was studied by using the self-similarity solution method and the regular perturbation method. The dependence of permeability on pore pressure makes the flow equation strongly nonlinear. The nonlinearities associated with the governing equation become weaker by using the logarithm transformation. The perturbation solutions for a constant pressure production and a constant rate production of a linear-source well were obtained by using the self-similarity solution method and the regular perturbation method in an infinitely large system, and inquire into the changing rule of pressure when the fractal and deformation parameters change. The plots of typical pressure curves were given in a few cases, and the results can be applied to well test analysis.
基金Project supported by the National Natural Science Foundation of China (Grant Nos: 50174011 10172028) the Science Tech. Research Program of Heilongjiang Provincial Education Department (Grant No: 10531032).
文摘The transient flow mathematical model of arbitrary shaped heterogeneous reservoirs with impermeability barrier is proposed in this paper. In order to establish this model, the perturbation method is employed and the solution of model is expanded into a series in powers of perturbation parameter. By using the Boundary Element Method (BEM) and Duhamel principle, wellbore pressure with effects of skins and wellbore storage is obtained. The type curves are plotted and analyzed considering effects of heterogeneity, arbitrary shape and impermeable barriers. Finally, the results obtained by perturbation boundary element method is compared with the analytical solution and is available for the transient pressure analysis of arbitrary shaped reservoirs.
文摘Based on the numerical simulation analysis, structure parameters of the high pressure fuel pump and common rail as well as flow limiter are designed and the GD-1 high pressure common rail fuel injection system is self-developed. Fuel injection characteristics experiment is performed on the GD-1 system. And double-factor variance analysis is applied to investigate the influence of the rail pressure and injection pulse width on the consistency of fuel injection quantity, thus to test whether the design of structure parameters is sound accordingly. The results of experiment and test show that rail pressure and injection pulse width as well as their mutual-effect have no influence on the injection quantity consistency, which proves that the structure parameters design is successful and performance of GD-1 system is sound.
基金Sponsored by National Natural Science Foundation of China(51074052,50734002)
文摘With mean yield(MY)criterion,an analytical solution of the collapse load for a defect-free pipe elbow under internal pressure is first obtained.It is a function of ratio of thickness to radius t0/r0,strain hardening exponent n,curvature influence factor mand ultimate tensile strength.The collapse load increases with the increase of m,and it is the same as the burst pressure of straight pipe if m=1is assumed.The MY-based solution is compared with those based on Tresca,Mises and twin shear stress(TSS)yield criteria,and the comparison indicates that Tresca and twin shear stress yield criteria predict a lower bound and an upper bound to the collapse load respectively.However,the MY-based solution lies just between the TSS and Tresca solutions,and almost has the same precision with the Mises solution.
基金supported by the National Natural Science Foundation of China(51322904 and 51279127)the Program for New Century Excellent Talents in University(HCET-11-0370)
文摘Long piles of the ocean oil platform are usually manufactured as the integration of several segments, which have to be assembled one by one during installation. During pile driving, excessive pore pressure will build up in such a high level that hydraulic fracturing in the soil round the pile may take place, which will cause the soil to consolidate much faster during pile extension period. Consequently, after pile extension, the soil strength will recover to some extent and the driving resistance will increase considerably, which makes restarting driving the pile very difficult and even causes refusal. A finite element (FE) analysis procedure is presented for judging the risk of refusal by estimating the blow counts after pile extension, in which the regain of soil strength is considered. A case analysis in Bohai Gulf is performed using the proposed orocedure to exolain the nile refusal phenomenon.
文摘Although the Chinese government has published a seriesof favorable policies for textile industry,the outcome of thesefiscal policies in Chinese cotton machinery industry tends to besmall at this stage,since the effects of policies is hysteresial,and the industry had extended 2009 spring holiday amid thefinancial crisis.