With the mine exploitation depth getting deeper and deeper, the mine heat-harm turns into another natural disaster after the five disasters, which are the roof, the gas, the fire, the dust and the flood disaster. Comp...With the mine exploitation depth getting deeper and deeper, the mine heat-harm turns into another natural disaster after the five disasters, which are the roof, the gas, the fire, the dust and the flood disaster. Compared with other researches on prevention and cure against the heat-harm, the research on prevention and cure against the heat-harm in constructing mine are less. Referring to the experience of prevention and cure against the heat-harm home and 'abroad, analyzing the characteristic of cooling in the constructing mine, and based on the ground former freezing equipments and the modified mine temporary cooling equipments, the paper proposed four technical projects. By comparing with the four technical projects, the second project is preponderant both in technology and economy and can solve the heat-harm of the constructing mine, which is proved by the forecast and calculation. The project can be widely applied in de-temperature tasks of high temperature and heat-harm mines during the mine constructing period and in the exploiting preparing phase.展开更多
Directly buried metal optical cable is a form of erecting optical fiber ring network communication system in wind farms. Although the directly buried optical cable is much less than the overhead optical cable affected...Directly buried metal optical cable is a form of erecting optical fiber ring network communication system in wind farms. Although the directly buried optical cable is much less than the overhead optical cable affected by lightning, sometimes lightning damaging optical cable and flashover discharge accidents of optical cable port occurred. In this paper, the amplitude spectrum of lightning wave, the breakdown depth and breakdown distance of lightning wave to soil, the metal components of optical cable port and the impedance characteristics of grounding wire are systematically analyzed, and the prevention methods of directly buried optical cable in wind farm to avoid lightning damage are proposed.展开更多
Fungi that attack field crops and contaminate agricultural commodities produce mycotoxins when conditions are favorable. These are specialized metabolites made of poisonous chemical compounds created by bacteria, fung...Fungi that attack field crops and contaminate agricultural commodities produce mycotoxins when conditions are favorable. These are specialized metabolites made of poisonous chemical compounds created by bacteria, fungi, or plants that aren’t involved in the organism’s usual growth, development, or reproduction. They have an adversarial hold on humans, wildlife, and the agricultural sector, resulting in mysterious ailments and economic disruptions. Mycotoxins-tainted food and fodder can be found all over the world, posing a global concern. Consumption of contaminated food and fodder is a typical cause of epidemic outbreaks. Other mycotoxins have been associated with esophageal cancer and neural tube defects (NTDs);the immunotoxin deoxynivalenol (DON) causes diarrhea when combined with trichothecenes, and ochratoxin A (OTA) has been linked to kidney failure. The direct market costs associated with missed trade or lower revenues owing to tainted food or feed could be viewed as the economic repercussions of mycotoxins on human society. This review describes frequent groups of mycotoxins in detail, their impact on global health, their impact on the socio-economy;the methods of detection and prevention of these mycotoxins.展开更多
Background:To analyze the medication and methods of ancient traditional Chinese medicine for the prevention of plague and seasonal pathogen in order to reduce the spread of infectious diseases such as flu and protect ...Background:To analyze the medication and methods of ancient traditional Chinese medicine for the prevention of plague and seasonal pathogen in order to reduce the spread of infectious diseases such as flu and protect the susceptible people.Methods:Search the medication and the methods for preventing plague and seasonal pathogen in the Chinese Medical Code,classify and summarize the methods,perform frequency analysis and efficacy cluster analysis on Chinese medicines of involved medicines.Results:The methods of preventing ancient plague were as follows:burning and fumigating Chinese medicines,medicating nostrils,wearing bags filled with Chinese medicines,oral Chinese medicines and applying medicines to skin.The 3 main ways for drugs to work were external medication,nostril inhalation,and internal absorption.The Chinese medicines for preventing plague are mostly warm in nature and pungent in flavour,belonging to the spleen,stomach,liver,lung meridian.The 3 categories of drugs obtained by cluster analysis are C1:drugs for facilitating lung,relieving exterior and dissipating cold,such as Cangzhu(Atractylodis rhizoma)-Qianghuo(Notopterygh rhizoma et radix)-Xixin(Asari radix et rhizoma)-Baizhi(Angelicae dahuricae radix)-Fangfeng(Saposhnikoviae radix)-Zaojiao(Gleditsiae sinensis fructus);C2:drugs for promoting blood circulation and removing blood stasis,such as Xionghuang(Realgar)-Zhusha(Cinnabaris)-Dahuang(Rhei radix rhizoma)-Chuanxiong(Chuanxiong rhizoma)-Jiegeng(Platycodonis radix);C3:drugs for replenishing Qi(it is the most basic element that constitutes human body and maintains life activities in traditional Chinese medicine)and tonifying the spleen,such as Gancao(Glycyrrhizae radix et rhizoma)-Dazao(Jujubae fructus)-Ganjiang(Zingiberis rhizoma)-Rougui(Cinnamomi cortex)-Gansong(Nardostachyos radix et rhizoma)-Chenpi(Citri reticulatae pericarpium)-Baizhu(Atractylodis macrocephalae rhizoma).Conclusion:Through analysis the medication and methods of ancient traditional Chinese medicine for the prevention of plague,we can provide reference for modern research from the original plague prevention methods,and make an important contribution to the use of traditional Chinese medicine in the prevention and treatment of epidemic infectious diseases in modern clinic.展开更多
Basketball has always been loved by the majority of high school students, especially after compulsory education improved school basketball venues and facilities to make basketball an unprecedented development, because...Basketball has always been loved by the majority of high school students, especially after compulsory education improved school basketball venues and facilities to make basketball an unprecedented development, because basketball is a very physical confrontational sport, so the student damage occurring in the course of basketball movement is the more common case, which affects not only the physical development of middle school students, but also affects the popularity of basketball in this project. How to do active in basketball injury prevention, learning first aid knowledge after injury, will be beneficial in the school' s basketball further popularization and development.展开更多
[Objective] The aim was to research effects of bamboo split curing method and steely barn curing method on quality of yellow sun-cured tobacco, providing scientific references for optimization of curing technology of ...[Objective] The aim was to research effects of bamboo split curing method and steely barn curing method on quality of yellow sun-cured tobacco, providing scientific references for optimization of curing technology of yellow sun-cured tobacco. [method] The tobaccos were divided into two groups treated with two methods and the related indices of treated tobaccos were then measured to evaluate effects of curing methods on quality of yellow sun-cured tobacco. [Result] Tobaccos treated with two methods were all dominated by reddish yellow and yellow; exterior quality differed little. In detail, total sugar and reducing sugar in an average level in three locations were all higher with method A than those with method B, but nicotine and total N were lower; comprehensive chemical components in group with method B proved more appropriate with higher K. In addition, sensory qualities of leaves in moderate and bottom locations were better with method B compared with method A; sensory quality of top leaves was better; comprehensive sensory quality of leaves treated with method B proved better. On the other hand, cost for method A was 2.82 times of method B; the area of sun-curing field was 3.27 times and manage- ment work was 1.77 times, which indicated that method B is low-cost and time-saving, which would be a guarantee of tobacco quality. [Conclusion] The research provides scientific references for rational use of tobacco resources and optimization of sun-curing technology.展开更多
About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is asso...About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is associated with liver disease progression,cirrhosis,hepatocellular carcinoma,and liver-related mortality.The extrahepatic manifestations of CHC further add to the disease burden of patients.Managing CHC-related advanced liver diseases and systemic manifestations are costly for both the healthcare system and society.Loss of work productivity due to reduced well-being and quality of life in CHC patients further compounds the economic burden of the disease.Traditionally,pegylatedinterferon plus ribavirin(PR)was the standard of care.However,a substantial number of patients are ineligible for PR treatment,and only 40%–75%achieved sustained virologic response.Furthermore,PR is associated with impairment of patient-reported outcomes(PROs),high rates of adverse events,and poor adherence.With the advent of direct acting antivirals(DAAs),the treatment of CHC patients has been revolutionized.DAAs have broader eligible patient populations,higher efficacy,better PRO profiles,fewer adverse events,and better adherence rates,thereby making it possible to cure a large proportion of all CHC patients.This article aims to provide a comprehensive evaluation on the value of effective,curative hepatitis C treatment from the clinical,economic,societal,and patient experience perspectives,with a focus on recent data from China,supplemented with other Asian and international experiences where China data are not available.展开更多
This paper studies the interface curing stresses between polymethyl methacrylate (PMMA) and composite by means of digital speckle correlation method (DSCM).A new method by combining DSCM with the marker points is deve...This paper studies the interface curing stresses between polymethyl methacrylate (PMMA) and composite by means of digital speckle correlation method (DSCM).A new method by combining DSCM with the marker points is developed to measure the interface curing stresses,and the measurement principle is introduced.The interface curing stresses between PMMA and composite with different curing bonding conditions are measured and analyzed,this indicates that the residual stress for furnace heating and furnace cooling is the smallest.Finally,the measurement error is discussed by means of finite element method,the influences of glass microsphere between adhesive and PMMA can be ignored.展开更多
The infection and drug resistance rates of Helicobacter pylori(H.pylori)are high and must be prevented and treated by better strategies.Based on recent research advances in this field as well as the results from our t...The infection and drug resistance rates of Helicobacter pylori(H.pylori)are high and must be prevented and treated by better strategies.Based on recent research advances in this field as well as the results from our team and those on traditional Chinese medicine,we review the causes of drug resistance,and prevention and treatment strategies for drug-resistant H.pylori infection,with an aim to make suggestions for the development of new drugs,such as establishment of new target identification and screening systems,modification of existing drug structures,use of new technologies,application of natural products,and using a commercial compound library.This article may provide reference for eradication of drug-resistant H.pylori.展开更多
Shot cokes are frequently formed in the delayed coking unit treating the super viscous oil at PetroChina's Liaohe Petrochemical Company. Considerable work has been carded out to avoid the formation of shot cokes. The...Shot cokes are frequently formed in the delayed coking unit treating the super viscous oil at PetroChina's Liaohe Petrochemical Company. Considerable work has been carded out to avoid the formation of shot cokes. The test results obtained have shown that the property of super viscous oil has played a key role in the formation of shot cokes. After adjusting and optimizing the process indices the operating regime of the delayed coking unit at a throughput of 118t/h of the super viscous oil is specified as follows: a reaction temperature of 498-502℃, a reaction pressure of 0.17-0.25 MPa, a recycle ratio of 0.5-0.6 and a fractionation tower bottom temperature of 355-365 ℃. In the meantime, the delayed coking process has adopted measures to enhance pre-fractionation of the feedstock to rationally remove light fractions and maintain a steady gas velocity in order to avoid the formation of shot cokes.展开更多
Hypertension is the most common cardiovascular condition in clinical practice and a major risk factor for stroke and cardiovascular events.There are more than 270 million hypertension patients in China,and the prevale...Hypertension is the most common cardiovascular condition in clinical practice and a major risk factor for stroke and cardiovascular events.There are more than 270 million hypertension patients in China,and the prevalence of hypertension in the high-latitude cold areas is significantly higher than in the low-latitude warm areas.The unique epidemiological characteristics and risk factors of hypertension in the cold regions of China urge for establishment of the prevention and control system for targeted and more effective management of the condition.展开更多
The common defects of the Roe scheme are the non-physical expansion shock and shock instability. By removing the momentum interpolation mechanism(MIM), an improved method with several advantages has been presented to ...The common defects of the Roe scheme are the non-physical expansion shock and shock instability. By removing the momentum interpolation mechanism(MIM), an improved method with several advantages has been presented to suppress the shock instability. However, it cannot prevent the expansion shock and is incompatible with the traditional curing method for expansion shock. To solve the problem, the traditional curing mechanism is analyzed. Effectiveness of the traditional curing method is discussed,and several defects are identified, one of which leads to incompatibility between curing shock instability and expansion shock. Consequently, an improved Roe scheme is proposed, which is with low computational costs, concise, easy to implement, and robust.More importantly, the proposed scheme can simultaneously solve the problem of shock instability and expansion shock without additional costs.展开更多
This paper applies the stochastic finite element method to analyse the statistics of stresses in earth dams and assess the safety and reliability of the dams. Formulations of the stochastic finite element method are b...This paper applies the stochastic finite element method to analyse the statistics of stresses in earth dams and assess the safety and reliability of the dams. Formulations of the stochastic finite element method are briefly reviewed and the procedure for assessing dam's strength and stability is described. As an example, a detailed analysis for an actual dam Nululin dam is performed. A practical method for studying built-dams based on the prototype observation data is described.展开更多
Zika virus disease is a disease of public health importance and was declared a “Public Health Emergency of International Concern”, by the World Health Organization on February 1, 2016. It is mostly transmitted throu...Zika virus disease is a disease of public health importance and was declared a “Public Health Emergency of International Concern”, by the World Health Organization on February 1, 2016. It is mostly transmitted through the bite of <em>Aedes aegypti</em> and <em>Aedes albopictus</em> mosquitos. Transmission can also occur through blood transfusion and sexual intercourse. It could cause microcephaly and other neurological problems in newborns and adults, such as <em>Guillain-Barre syndrome</em>. It could also lead to abortion and stillbirth in pregnant women. Prevention methods are essentially targeted at transmission routes, which are mosquito bite, sexual intercourse, and blood transfusion. The study was of observational, descriptive, cross-sectional design, and conducted in a tertiary health institution in the Southeast geopolitical zone of Nigeria. Two hundred and fifty-six female caregivers participated in the study, with most of them being within the childbearing age group, and educated up to tertiary level. The objective was to assess the knowledge of Zika virus infection prevention methods, among female caregivers that bring babies for immunization in a Teaching Hospital, Southeast Nigeria. Out of the eight questions that sought to assess the knowledge level of the respondents, they scored 50% and above only in three, which were on prevention through protection against mosquito bite (60.5%), avoiding unnecessary blood transfusion in endemic areas (53.9%), and avoidance of oily meals not being a preventive measure (51.2%). Respondents in the childbearing age group, and those with higher educational qualifications, generally exhibited higher knowledge level than the other respondents. Scores on questions that sought to assess their knowledge on prevention aspects related to sexual behavior, and vaccination were poor. Sensitization, or awareness creation activities for persons in this study area, ought to be designed to address the observed gaps.展开更多
The tea green leafhopper Empoasca vitis Gothe, one of major tea insect pests in China's Mainland, grows concealed with small size, rapid reproduction and overlapped generations, which has become the most serious i...The tea green leafhopper Empoasca vitis Gothe, one of major tea insect pests in China's Mainland, grows concealed with small size, rapid reproduction and overlapped generations, which has become the most serious insect pest in tea garden. This paper described the morphological features, damage modes and occur- rence characteristics of E. vitis, and preliminarily summarized the main control methods in recent years. Therefore, from pollution-free and green control perspec- tive, controlling population quantity of E. vitis safely and effectively and reducing the yield loss of tea has become a hot issue in prevention and control of insect pests in tea garden. The paper provided a reference in green comprehensive prevention of insect pests in tea garden.展开更多
According to a mathematical model which describes the curing process of composites constructed from continuous fiber-reinforced, thermosetting resin matrix prepreg materials, and the consolidation of the composites, t...According to a mathematical model which describes the curing process of composites constructed from continuous fiber-reinforced, thermosetting resin matrix prepreg materials, and the consolidation of the composites, the solution method to the model is made and a computer code is developed, which for flat-plate composites cured by a specified cure cycle, provides the variation of temperature distribution, the cure reaction process in the resin, the resin flow and fibers stress inside the composite, the void variation and the residual stress distribution.展开更多
[Objectives]To compare the benefits of different tobacco loading methods and supporting baking processes in intensive curing houses.[Methods]Flue-cured tobacco variety K326 was taken as material,and comparative experi...[Objectives]To compare the benefits of different tobacco loading methods and supporting baking processes in intensive curing houses.[Methods]Flue-cured tobacco variety K326 was taken as material,and comparative experiment on baking effects of six tobacco loading methods(traditional hanging pole,loose leaf stacking,loose leaf binding and inserting,loose leaf inserting,loose leaf net basket,loose leaf grid)was conducted.[Results]Cost of dry tobacco loading equipment for hanging pole and loose leaf stacking was 0.01 and 0.1 yuan/kg,and cost of tobacco loading by loose leaf basket reached 0.36 yuan/kg.Labor cost for baking dry tobacco by direct stacking of loose leaves reached 2.02 yuan/kg,which was the lowest,while labor cost for binding and inserting loose leaves reached 2.44 yuan/kg,which was the highest.Energy consumption cost of dry tobacco baking with loose leaf grid was 1.06 yuan/kg,which was the lowest,while baking energy consumption cost of loose leaf stacking reached 1.23 yuan/kg,which was the highest.From the perspective of baking income,loose leaf inserting reached 21.36 yuan/kg,which was the lowest,while net basket reached 27.79 yuan/kg,which was the highest,followed by grid(23.46 yuan/kg)and loose leaf binding and inserting(22.5 yuan/kg).[Conclusions]It is worth popularizing the loose leaf binding and inserting and the loose leaf grid baking.展开更多
The characteristics of chicken colibacillosis are introduced from the aspects of pathogen,epidemiology,clinical symptoms and necropsy,and clinical comprehensive diagnosis and laboratory diagnosis methods are given.The...The characteristics of chicken colibacillosis are introduced from the aspects of pathogen,epidemiology,clinical symptoms and necropsy,and clinical comprehensive diagnosis and laboratory diagnosis methods are given.The disease is distinguished from diseases with similar symptoms such as chicken chlamydia,chicken streptococcus,chicken necrotic enteritis,broiler ascites syndrome and chicken paratyphoid infections.Eventually,the preventive and therapeutic measures against the disease are put forward.展开更多
文摘With the mine exploitation depth getting deeper and deeper, the mine heat-harm turns into another natural disaster after the five disasters, which are the roof, the gas, the fire, the dust and the flood disaster. Compared with other researches on prevention and cure against the heat-harm, the research on prevention and cure against the heat-harm in constructing mine are less. Referring to the experience of prevention and cure against the heat-harm home and 'abroad, analyzing the characteristic of cooling in the constructing mine, and based on the ground former freezing equipments and the modified mine temporary cooling equipments, the paper proposed four technical projects. By comparing with the four technical projects, the second project is preponderant both in technology and economy and can solve the heat-harm of the constructing mine, which is proved by the forecast and calculation. The project can be widely applied in de-temperature tasks of high temperature and heat-harm mines during the mine constructing period and in the exploiting preparing phase.
基金Supported by Regional Lightning Protection Engineering Technology Research and Development Project in Guangdong Yuedian Dianbai Wind Farm (GDW-PK-21022 Phase II)。
文摘Directly buried metal optical cable is a form of erecting optical fiber ring network communication system in wind farms. Although the directly buried optical cable is much less than the overhead optical cable affected by lightning, sometimes lightning damaging optical cable and flashover discharge accidents of optical cable port occurred. In this paper, the amplitude spectrum of lightning wave, the breakdown depth and breakdown distance of lightning wave to soil, the metal components of optical cable port and the impedance characteristics of grounding wire are systematically analyzed, and the prevention methods of directly buried optical cable in wind farm to avoid lightning damage are proposed.
文摘Fungi that attack field crops and contaminate agricultural commodities produce mycotoxins when conditions are favorable. These are specialized metabolites made of poisonous chemical compounds created by bacteria, fungi, or plants that aren’t involved in the organism’s usual growth, development, or reproduction. They have an adversarial hold on humans, wildlife, and the agricultural sector, resulting in mysterious ailments and economic disruptions. Mycotoxins-tainted food and fodder can be found all over the world, posing a global concern. Consumption of contaminated food and fodder is a typical cause of epidemic outbreaks. Other mycotoxins have been associated with esophageal cancer and neural tube defects (NTDs);the immunotoxin deoxynivalenol (DON) causes diarrhea when combined with trichothecenes, and ochratoxin A (OTA) has been linked to kidney failure. The direct market costs associated with missed trade or lower revenues owing to tainted food or feed could be viewed as the economic repercussions of mycotoxins on human society. This review describes frequent groups of mycotoxins in detail, their impact on global health, their impact on the socio-economy;the methods of detection and prevention of these mycotoxins.
文摘Background:To analyze the medication and methods of ancient traditional Chinese medicine for the prevention of plague and seasonal pathogen in order to reduce the spread of infectious diseases such as flu and protect the susceptible people.Methods:Search the medication and the methods for preventing plague and seasonal pathogen in the Chinese Medical Code,classify and summarize the methods,perform frequency analysis and efficacy cluster analysis on Chinese medicines of involved medicines.Results:The methods of preventing ancient plague were as follows:burning and fumigating Chinese medicines,medicating nostrils,wearing bags filled with Chinese medicines,oral Chinese medicines and applying medicines to skin.The 3 main ways for drugs to work were external medication,nostril inhalation,and internal absorption.The Chinese medicines for preventing plague are mostly warm in nature and pungent in flavour,belonging to the spleen,stomach,liver,lung meridian.The 3 categories of drugs obtained by cluster analysis are C1:drugs for facilitating lung,relieving exterior and dissipating cold,such as Cangzhu(Atractylodis rhizoma)-Qianghuo(Notopterygh rhizoma et radix)-Xixin(Asari radix et rhizoma)-Baizhi(Angelicae dahuricae radix)-Fangfeng(Saposhnikoviae radix)-Zaojiao(Gleditsiae sinensis fructus);C2:drugs for promoting blood circulation and removing blood stasis,such as Xionghuang(Realgar)-Zhusha(Cinnabaris)-Dahuang(Rhei radix rhizoma)-Chuanxiong(Chuanxiong rhizoma)-Jiegeng(Platycodonis radix);C3:drugs for replenishing Qi(it is the most basic element that constitutes human body and maintains life activities in traditional Chinese medicine)and tonifying the spleen,such as Gancao(Glycyrrhizae radix et rhizoma)-Dazao(Jujubae fructus)-Ganjiang(Zingiberis rhizoma)-Rougui(Cinnamomi cortex)-Gansong(Nardostachyos radix et rhizoma)-Chenpi(Citri reticulatae pericarpium)-Baizhu(Atractylodis macrocephalae rhizoma).Conclusion:Through analysis the medication and methods of ancient traditional Chinese medicine for the prevention of plague,we can provide reference for modern research from the original plague prevention methods,and make an important contribution to the use of traditional Chinese medicine in the prevention and treatment of epidemic infectious diseases in modern clinic.
文摘Basketball has always been loved by the majority of high school students, especially after compulsory education improved school basketball venues and facilities to make basketball an unprecedented development, because basketball is a very physical confrontational sport, so the student damage occurring in the course of basketball movement is the more common case, which affects not only the physical development of middle school students, but also affects the popularity of basketball in this project. How to do active in basketball injury prevention, learning first aid knowledge after injury, will be beneficial in the school' s basketball further popularization and development.
基金Supported by China Tobacco Yunnan Indutrial Co.Ltd Scientific Program(2010YL02)~~
文摘[Objective] The aim was to research effects of bamboo split curing method and steely barn curing method on quality of yellow sun-cured tobacco, providing scientific references for optimization of curing technology of yellow sun-cured tobacco. [method] The tobaccos were divided into two groups treated with two methods and the related indices of treated tobaccos were then measured to evaluate effects of curing methods on quality of yellow sun-cured tobacco. [Result] Tobaccos treated with two methods were all dominated by reddish yellow and yellow; exterior quality differed little. In detail, total sugar and reducing sugar in an average level in three locations were all higher with method A than those with method B, but nicotine and total N were lower; comprehensive chemical components in group with method B proved more appropriate with higher K. In addition, sensory qualities of leaves in moderate and bottom locations were better with method B compared with method A; sensory quality of top leaves was better; comprehensive sensory quality of leaves treated with method B proved better. On the other hand, cost for method A was 2.82 times of method B; the area of sun-curing field was 3.27 times and manage- ment work was 1.77 times, which indicated that method B is low-cost and time-saving, which would be a guarantee of tobacco quality. [Conclusion] The research provides scientific references for rational use of tobacco resources and optimization of sun-curing technology.
文摘About 10 million people in China are infected with hepatitis C virus(HCV),with the seroprevalence of anti-HCV in the general population estimated at 0.6%.Delaying effective treatment of chronic hepatitis C(CHC)is associated with liver disease progression,cirrhosis,hepatocellular carcinoma,and liver-related mortality.The extrahepatic manifestations of CHC further add to the disease burden of patients.Managing CHC-related advanced liver diseases and systemic manifestations are costly for both the healthcare system and society.Loss of work productivity due to reduced well-being and quality of life in CHC patients further compounds the economic burden of the disease.Traditionally,pegylatedinterferon plus ribavirin(PR)was the standard of care.However,a substantial number of patients are ineligible for PR treatment,and only 40%–75%achieved sustained virologic response.Furthermore,PR is associated with impairment of patient-reported outcomes(PROs),high rates of adverse events,and poor adherence.With the advent of direct acting antivirals(DAAs),the treatment of CHC patients has been revolutionized.DAAs have broader eligible patient populations,higher efficacy,better PRO profiles,fewer adverse events,and better adherence rates,thereby making it possible to cure a large proportion of all CHC patients.This article aims to provide a comprehensive evaluation on the value of effective,curative hepatitis C treatment from the clinical,economic,societal,and patient experience perspectives,with a focus on recent data from China,supplemented with other Asian and international experiences where China data are not available.
基金supported by the National Basic Research Program (973 Program) of China (2011CB606105)
文摘This paper studies the interface curing stresses between polymethyl methacrylate (PMMA) and composite by means of digital speckle correlation method (DSCM).A new method by combining DSCM with the marker points is developed to measure the interface curing stresses,and the measurement principle is introduced.The interface curing stresses between PMMA and composite with different curing bonding conditions are measured and analyzed,this indicates that the residual stress for furnace heating and furnace cooling is the smallest.Finally,the measurement error is discussed by means of finite element method,the influences of glass microsphere between adhesive and PMMA can be ignored.
基金Supported by National Natural Science Foundation of China,No.81760739 and No.31460023.
文摘The infection and drug resistance rates of Helicobacter pylori(H.pylori)are high and must be prevented and treated by better strategies.Based on recent research advances in this field as well as the results from our team and those on traditional Chinese medicine,we review the causes of drug resistance,and prevention and treatment strategies for drug-resistant H.pylori infection,with an aim to make suggestions for the development of new drugs,such as establishment of new target identification and screening systems,modification of existing drug structures,use of new technologies,application of natural products,and using a commercial compound library.This article may provide reference for eradication of drug-resistant H.pylori.
文摘Shot cokes are frequently formed in the delayed coking unit treating the super viscous oil at PetroChina's Liaohe Petrochemical Company. Considerable work has been carded out to avoid the formation of shot cokes. The test results obtained have shown that the property of super viscous oil has played a key role in the formation of shot cokes. After adjusting and optimizing the process indices the operating regime of the delayed coking unit at a throughput of 118t/h of the super viscous oil is specified as follows: a reaction temperature of 498-502℃, a reaction pressure of 0.17-0.25 MPa, a recycle ratio of 0.5-0.6 and a fractionation tower bottom temperature of 355-365 ℃. In the meantime, the delayed coking process has adopted measures to enhance pre-fractionation of the feedstock to rationally remove light fractions and maintain a steady gas velocity in order to avoid the formation of shot cokes.
基金supported by National Natural Science Foundation of China(81730012,81861128022 to B.Y.)Heilongjiang Touyan Innovation Team Program,and CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-078 to B.Y.).
文摘Hypertension is the most common cardiovascular condition in clinical practice and a major risk factor for stroke and cardiovascular events.There are more than 270 million hypertension patients in China,and the prevalence of hypertension in the high-latitude cold areas is significantly higher than in the low-latitude warm areas.The unique epidemiological characteristics and risk factors of hypertension in the cold regions of China urge for establishment of the prevention and control system for targeted and more effective management of the condition.
基金Project supported by the National Natural Science Foundation of China(Nos.51736008 and 51276092)
文摘The common defects of the Roe scheme are the non-physical expansion shock and shock instability. By removing the momentum interpolation mechanism(MIM), an improved method with several advantages has been presented to suppress the shock instability. However, it cannot prevent the expansion shock and is incompatible with the traditional curing method for expansion shock. To solve the problem, the traditional curing mechanism is analyzed. Effectiveness of the traditional curing method is discussed,and several defects are identified, one of which leads to incompatibility between curing shock instability and expansion shock. Consequently, an improved Roe scheme is proposed, which is with low computational costs, concise, easy to implement, and robust.More importantly, the proposed scheme can simultaneously solve the problem of shock instability and expansion shock without additional costs.
文摘This paper applies the stochastic finite element method to analyse the statistics of stresses in earth dams and assess the safety and reliability of the dams. Formulations of the stochastic finite element method are briefly reviewed and the procedure for assessing dam's strength and stability is described. As an example, a detailed analysis for an actual dam Nululin dam is performed. A practical method for studying built-dams based on the prototype observation data is described.
文摘Zika virus disease is a disease of public health importance and was declared a “Public Health Emergency of International Concern”, by the World Health Organization on February 1, 2016. It is mostly transmitted through the bite of <em>Aedes aegypti</em> and <em>Aedes albopictus</em> mosquitos. Transmission can also occur through blood transfusion and sexual intercourse. It could cause microcephaly and other neurological problems in newborns and adults, such as <em>Guillain-Barre syndrome</em>. It could also lead to abortion and stillbirth in pregnant women. Prevention methods are essentially targeted at transmission routes, which are mosquito bite, sexual intercourse, and blood transfusion. The study was of observational, descriptive, cross-sectional design, and conducted in a tertiary health institution in the Southeast geopolitical zone of Nigeria. Two hundred and fifty-six female caregivers participated in the study, with most of them being within the childbearing age group, and educated up to tertiary level. The objective was to assess the knowledge of Zika virus infection prevention methods, among female caregivers that bring babies for immunization in a Teaching Hospital, Southeast Nigeria. Out of the eight questions that sought to assess the knowledge level of the respondents, they scored 50% and above only in three, which were on prevention through protection against mosquito bite (60.5%), avoiding unnecessary blood transfusion in endemic areas (53.9%), and avoidance of oily meals not being a preventive measure (51.2%). Respondents in the childbearing age group, and those with higher educational qualifications, generally exhibited higher knowledge level than the other respondents. Scores on questions that sought to assess their knowledge on prevention aspects related to sexual behavior, and vaccination were poor. Sensitization, or awareness creation activities for persons in this study area, ought to be designed to address the observed gaps.
基金Supported by Key Project on Agricultural Development by Department of Science and Technology of Guizhou Province(QKH LH[2014]3024)Key Project on Natural Science Development by Department of Education of Guizhou Province(QJH KY[2013]159)
文摘The tea green leafhopper Empoasca vitis Gothe, one of major tea insect pests in China's Mainland, grows concealed with small size, rapid reproduction and overlapped generations, which has become the most serious insect pest in tea garden. This paper described the morphological features, damage modes and occur- rence characteristics of E. vitis, and preliminarily summarized the main control methods in recent years. Therefore, from pollution-free and green control perspec- tive, controlling population quantity of E. vitis safely and effectively and reducing the yield loss of tea has become a hot issue in prevention and control of insect pests in tea garden. The paper provided a reference in green comprehensive prevention of insect pests in tea garden.
文摘According to a mathematical model which describes the curing process of composites constructed from continuous fiber-reinforced, thermosetting resin matrix prepreg materials, and the consolidation of the composites, the solution method to the model is made and a computer code is developed, which for flat-plate composites cured by a specified cure cycle, provides the variation of temperature distribution, the cure reaction process in the resin, the resin flow and fibers stress inside the composite, the void variation and the residual stress distribution.
文摘[Objectives]To compare the benefits of different tobacco loading methods and supporting baking processes in intensive curing houses.[Methods]Flue-cured tobacco variety K326 was taken as material,and comparative experiment on baking effects of six tobacco loading methods(traditional hanging pole,loose leaf stacking,loose leaf binding and inserting,loose leaf inserting,loose leaf net basket,loose leaf grid)was conducted.[Results]Cost of dry tobacco loading equipment for hanging pole and loose leaf stacking was 0.01 and 0.1 yuan/kg,and cost of tobacco loading by loose leaf basket reached 0.36 yuan/kg.Labor cost for baking dry tobacco by direct stacking of loose leaves reached 2.02 yuan/kg,which was the lowest,while labor cost for binding and inserting loose leaves reached 2.44 yuan/kg,which was the highest.Energy consumption cost of dry tobacco baking with loose leaf grid was 1.06 yuan/kg,which was the lowest,while baking energy consumption cost of loose leaf stacking reached 1.23 yuan/kg,which was the highest.From the perspective of baking income,loose leaf inserting reached 21.36 yuan/kg,which was the lowest,while net basket reached 27.79 yuan/kg,which was the highest,followed by grid(23.46 yuan/kg)and loose leaf binding and inserting(22.5 yuan/kg).[Conclusions]It is worth popularizing the loose leaf binding and inserting and the loose leaf grid baking.
文摘The characteristics of chicken colibacillosis are introduced from the aspects of pathogen,epidemiology,clinical symptoms and necropsy,and clinical comprehensive diagnosis and laboratory diagnosis methods are given.The disease is distinguished from diseases with similar symptoms such as chicken chlamydia,chicken streptococcus,chicken necrotic enteritis,broiler ascites syndrome and chicken paratyphoid infections.Eventually,the preventive and therapeutic measures against the disease are put forward.