Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity...Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(</=800 mgm(-2)h(-1)),and reduced DI(MTX)(</=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-展开更多
The DNA of P3 promoter region of IGF-Ⅱ gene was obtained by means of PCR technique. The examination of DNA polymorphism by restriction endonuclease BstE Ⅱ and the examination of AFP by bioluminescence immunoassay te...The DNA of P3 promoter region of IGF-Ⅱ gene was obtained by means of PCR technique. The examination of DNA polymorphism by restriction endonuclease BstE Ⅱ and the examination of AFP by bioluminescence immunoassay technique were carried out. The results have a significant difference( P <0.005). But the positive rate of AFP is higher than that of DNA polymorphism. The experimental result shows that the change of the DNA polymorphism of IGF-Ⅱis not the only carcinogenic factor. The suggested unite examination is the best method for the diagnosis of the primary hepatocellular carcinoma.展开更多
The paper demonstrates how electromagnetic processing of materials(EPM)provides significant opportunities for saving primary energy and reducing carbon emissions in industrial thermal processes.Potentially electricity...The paper demonstrates how electromagnetic processing of materials(EPM)provides significant opportunities for saving primary energy and reducing carbon emissions in industrial thermal processes.Potentially electricity can replace up to 100%of other energy carriers currently used for process heat.For the time horizon from now to the year 2050 a transition scenario is developed and described.In this scenario the industrial processes are gradually switched from the actual situation to a situation with 100%electrically operated industrial processes.The developed scenarios take into account the most energy intensive industrial thermal processes,which could be replaced by electrothermal technologies and offer obviously the biggest future potential in terms of saving of primary energy and reducing of carbon emissions.As the average primary energy factor(PEF)gradually decreases from 2.5 currently,to 1 for a 100%renewable electricity system,the benefits of EPM will gradually increase.For each step in the development of the PEF the annual primary energy savings and annual reductions in greenhouse gas emissions are calculated and described in this paper.展开更多
文摘Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(</=800 mgm(-2)h(-1)),and reduced DI(MTX)(</=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-
文摘The DNA of P3 promoter region of IGF-Ⅱ gene was obtained by means of PCR technique. The examination of DNA polymorphism by restriction endonuclease BstE Ⅱ and the examination of AFP by bioluminescence immunoassay technique were carried out. The results have a significant difference( P <0.005). But the positive rate of AFP is higher than that of DNA polymorphism. The experimental result shows that the change of the DNA polymorphism of IGF-Ⅱis not the only carcinogenic factor. The suggested unite examination is the best method for the diagnosis of the primary hepatocellular carcinoma.
文摘The paper demonstrates how electromagnetic processing of materials(EPM)provides significant opportunities for saving primary energy and reducing carbon emissions in industrial thermal processes.Potentially electricity can replace up to 100%of other energy carriers currently used for process heat.For the time horizon from now to the year 2050 a transition scenario is developed and described.In this scenario the industrial processes are gradually switched from the actual situation to a situation with 100%electrically operated industrial processes.The developed scenarios take into account the most energy intensive industrial thermal processes,which could be replaced by electrothermal technologies and offer obviously the biggest future potential in terms of saving of primary energy and reducing of carbon emissions.As the average primary energy factor(PEF)gradually decreases from 2.5 currently,to 1 for a 100%renewable electricity system,the benefits of EPM will gradually increase.For each step in the development of the PEF the annual primary energy savings and annual reductions in greenhouse gas emissions are calculated and described in this paper.
