Primary hepatic carcinoma （PHC） is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine （TCM）. TCM has been widely used to i...Primary hepatic carcinoma （PHC） is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine （TCM）. TCM has been widely used to improve the quality of fife, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials （RCTs） involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.展开更多
Objective： To investigate the relationship between the abnormal characteristics of sublingual collateral （SC） and portal vein hemodynamic changes in patients with primary hepatic carcinoma （PHC）. Methods： A tota...Objective： To investigate the relationship between the abnormal characteristics of sublingual collateral （SC） and portal vein hemodynamic changes in patients with primary hepatic carcinoma （PHC）. Methods： A total of 123 patients of PHC with abnormal SC were enrolled. The SC characteristics were classified and evaluated. The principal components （PC） of SC extracted from them by principal component analysis and the relationship between PC and the dynamic changes of portal vein flow were analyzed by correlation analysis. Results： Three groups of PC were extracted, namely PC-1 （length, width, presentation type of visualization）, PC-2 （circuitous, vesicular change）, and PC-3 （color, collateral hemostasis, petechiae, ecchymosis）. Their total accumulative contribution degree reached 56.803%. Correlation analysis shows that PC-1 was significantly positively correlated with the hemodynamic parameters of the portal vein （P〈0.01）, while PC-2 and PC-3 were not （P〉0.05）. Conclusion： Length, width and presentation type of SC could be used for predicting the changes of portal venous pressure in PHC patients.展开更多
目的:评价甲胎蛋白(alpha-fetoprotein,AFP)联合高尔基体蛋白73(Golgi protein 73,G P73)检测对原发性肝癌诊断的价值,以期为临床医生提供参考.方法:检索Pub Med、EMbase、Medline、万方数据知识服务平台、CNKI、中国生物医学文献数据...目的:评价甲胎蛋白(alpha-fetoprotein,AFP)联合高尔基体蛋白73(Golgi protein 73,G P73)检测对原发性肝癌诊断的价值,以期为临床医生提供参考.方法:检索Pub Med、EMbase、Medline、万方数据知识服务平台、CNKI、中国生物医学文献数据库等中外数据库2015-02之前发表的,关于AFP联合GP73检测对原发性肝癌诊断价值的研究,并对纳入文献的参考文献进行二次检索.严格按照纳入标准和排除标准选择文献、提取数据,并对纳入的文献行质量评价、异质性分析.采用Meta Disc1.4、Stata12.0软件进行Meta分析.结果:共纳入符合标准的文献19篇.AFP、G P 7 3单项检测对原发性肝癌诊断合并后的敏感度、特异度、曲线下面积(area under the curve,A U C)、Q指数分别为0.58(0.56-0.61)、0.84(0.83-0.86)、0.7642、0.7052和0.78(0.76-0.80)、0.97(0.86-0.88)、0.8848、0.8153.A F P联合G P73检测合并后的敏感度、特异度、AUC、Q指数分别为0.88(0.87-0.90)、0.82(0.80-0.83)、0.9461、0.8853.联合检测的A U C、Q指数明显高于AFP、GP73单项检测,Z检验提示差异有统计学意义(均P<0.05).结论:AFP联合GP73检测对原发性肝癌的诊断价值较高,对临床医生有一定的参考价值.展开更多
文摘Primary hepatic carcinoma （PHC） is a common malignant tumor in China. Cancer is comprehensively treated with various therapeutic regimes, including traditional Chinese medicine （TCM）. TCM has been widely used to improve the quality of fife, delay the time of cancer progression, and prolong the median survival time. This systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma. A comprehensive literature search was conducted in six databases, including CNKI, VIP, Wan-Fang Database, CBM, PubMed, and Cochrane library. A total of 44 randomized controlled trials （RCTs） involving 3429 participants suffering from PHC were selected. Meta-analysis results indicated that the overall effect of TCM and Western integrative treatment on PHC was higher than that of Western intervention alone, which can postpone tumor recurrence and metastasis and prolong the overall survival time of patients with PHC. Although the obtained evidence remained weak because of the poor methodological quality of the included studies, this review provided relevant data supporting the efficacy and safety of TCM combined with Western therapies. In future research, individual RCT studies should incorporate accepted standards for trial design and reporting, proper outcome indicators according to international standards, blinding in allocation concealment, and valid follow-up periods.
基金Supported by the National Natural Science Foundation of China No.30572434,30500669,30772698)
文摘Objective： To investigate the relationship between the abnormal characteristics of sublingual collateral （SC） and portal vein hemodynamic changes in patients with primary hepatic carcinoma （PHC）. Methods： A total of 123 patients of PHC with abnormal SC were enrolled. The SC characteristics were classified and evaluated. The principal components （PC） of SC extracted from them by principal component analysis and the relationship between PC and the dynamic changes of portal vein flow were analyzed by correlation analysis. Results： Three groups of PC were extracted, namely PC-1 （length, width, presentation type of visualization）, PC-2 （circuitous, vesicular change）, and PC-3 （color, collateral hemostasis, petechiae, ecchymosis）. Their total accumulative contribution degree reached 56.803%. Correlation analysis shows that PC-1 was significantly positively correlated with the hemodynamic parameters of the portal vein （P〈0.01）, while PC-2 and PC-3 were not （P〉0.05）. Conclusion： Length, width and presentation type of SC could be used for predicting the changes of portal venous pressure in PHC patients.
文摘目的:采用Meta分析方法对榄香烯注射液联合经导管肝动脉化学栓塞术(TACE)治疗原发性肝癌的疗效与安全性进行系统评价。方法:检索Pubmed、EMbase、Cochrane Library、中国知网CNKI全文数据库、维普数据库、万方数据库和中国生物医学文献数据库,查找自建库至2016年1月公开发表的研究榄香烯注射液联合TACE治疗原发性肝癌的临床随机对照试验。按照纳入与排除标准选择文献,质量评估,资料提取,采用Rev Man 5.2软件进行Meta分析。结果:共纳入6篇中文RCT文献,均为高质量研究。Meta分析结果显示,榄香烯注射液联合TACE组治疗原发性肝癌的近期有效率[OR=2.68,95%CI(1.63,4.40),P<0.000 1]、近期缓解率[OR=2.52,95%CI(1.25,5.08),P=0.010]高于单纯TACE组;而胃肠道反应[OR=1.16,95%CI(0.55,2.46),P=0.69]、骨髓抑制[OR=0.66,95%CI(0.32,1.36),P=0.26]在两组中无明显统计学差异。结论:榄香烯注射液可以提高TACE对原发性肝癌的疗效,且安全性较好。
文摘目的:评价甲胎蛋白(alpha-fetoprotein,AFP)联合高尔基体蛋白73(Golgi protein 73,G P73)检测对原发性肝癌诊断的价值,以期为临床医生提供参考.方法:检索Pub Med、EMbase、Medline、万方数据知识服务平台、CNKI、中国生物医学文献数据库等中外数据库2015-02之前发表的,关于AFP联合GP73检测对原发性肝癌诊断价值的研究,并对纳入文献的参考文献进行二次检索.严格按照纳入标准和排除标准选择文献、提取数据,并对纳入的文献行质量评价、异质性分析.采用Meta Disc1.4、Stata12.0软件进行Meta分析.结果:共纳入符合标准的文献19篇.AFP、G P 7 3单项检测对原发性肝癌诊断合并后的敏感度、特异度、曲线下面积(area under the curve,A U C)、Q指数分别为0.58(0.56-0.61)、0.84(0.83-0.86)、0.7642、0.7052和0.78(0.76-0.80)、0.97(0.86-0.88)、0.8848、0.8153.A F P联合G P73检测合并后的敏感度、特异度、AUC、Q指数分别为0.88(0.87-0.90)、0.82(0.80-0.83)、0.9461、0.8853.联合检测的A U C、Q指数明显高于AFP、GP73单项检测,Z检验提示差异有统计学意义(均P<0.05).结论:AFP联合GP73检测对原发性肝癌的诊断价值较高,对临床医生有一定的参考价值.
