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Quality Assessment of Clinical Research on Liver Cancer Treated by Intra-Arterial Infusion of Chinese Medicine 被引量:5
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作者 翟笑枫 乔翠霞 +2 位作者 刘群 陈喆 凌昌全 《Chinese Journal of Integrative Medicine》 SCIE CAS 2014年第11期870-875,共6页
Objective:To assess the methodological quality of clinical research on Chinese medicine(CM)applied by infra-arterial infusion in treating primary liver cancer(PLC).Methods:Cochrane Central Register of Controlled... Objective:To assess the methodological quality of clinical research on Chinese medicine(CM)applied by infra-arterial infusion in treating primary liver cancer(PLC).Methods:Cochrane Central Register of Controlled Trials(CENTRAL),PubMed,and three Chinese databases,including Chinese BioMedical Database(CBM),China National Knowledge Infrastructure(CNKI)and China Academic Journal(VIP)were searched.Chinese articles were also searched manually in 16 journals.Two reviewers independently selected studies,the quality of literatures were assessed according to the Cochrane Collaboration method of quality assessment.Results:A total of 14 articles met the inclusion criteria for this review.Only three of these articles described the randomization method used.None of the studies was blinded.All of the articles didn't report the calculation of the sample size.Only six studies mentioned adverse reactions.All of the studies were of grade C according to the Cochrane Collaboration method.Six studies reported results of survival,and only two of these reported better efficacy in the treatment groups.Conclusions:The quality of studies concerned intra-arterial infusion of CM in treating with PLC was poor and the exact effect of these medicines still need evaluation.Well designed RCTs with large sample sizes,adequate follow-up data and reliable methods of assessment are needed to better appraise the real effect of CMs in the treatment of PLC patients. 展开更多
关键词 primary liver cancer Chinese medicine intra-arterial infusion quality assessment
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