PRiME HLB前处理技术联合超高效液相色谱-三重四极杆质谱系统检测水产品中17种磺胺类药物残留

使用通过型固相萃取小柱PRi ME HLB处理水产品样品,建立了一种水产品中17种磺胺类药物的简单、快速的筛选分析方法。水产品样品经80%乙腈水溶液(含0.2%甲酸)提取,过PRi ME HLB固相萃取柱净化,浓缩后经C_(18)色谱柱梯度洗脱分离,超高效液相色谱-三重四极杆质谱系统进行定量分析。结果表明,17种磺胺类药物在1.0~50.0 ng·mL^(-1)线性关系良好,相关系数R^(2)>0.99;该方法检出限为2μg·kg^(-1);添加浓度为10μg·kg^(-1)时方法回收率在71.3%~118.4%,RSD值均小于20%。

MRI IDEAL-IQ在2型糖尿病患者腹部脂肪量化中的应用价值

目的采用磁共振(MRI)非对称回波的最小二程估算法迭代水脂分离(IDEAL-IQ)技术评价2型糖尿病对腹部脂肪分布及内脏脂肪沉积的影响。方法前瞻性纳入温州医科大学附属第二医院29例健康志愿者(对照组)和39例2型糖尿病患者(2型糖尿病组),两组均进行3.0T磁共振IDEAL-IQ序列扫描,得到脂肪分数图像。在脂肪分数图像上测量两组右肝、椎体、两肾实质和肾窦以及胰腺的质子密度脂肪分数(PDFF)、腹腔内脂肪组织(VAT)面积和皮下脂肪组织(SAT)面积。比较两组PDFF、VAT面积和SAT面积。结果2型糖尿病组的右肝、胰腺、左肾窦、右肾窦和椎体的PDFF值均高于对照组,差异有统计学意义(均P<0.05)。2型糖尿病组的VAT面积显著大于对照组[(105.47±7.12)cm^(2)vs(81.36±6.94)cm^(2),P=0.043],而两组SAT面积差异无统计学意义(P>0.05)。在所有参与者中,VAT面积分别与右肝、胰腺、椎体、左肾窦和右肾窦PDFF呈显著正相关。结论MRI IDEAL-IQ技术可以量化成人腹部脏器及结构的脂肪情况,2型糖尿病影响患者腹部脂肪分布并导致腹腔内脏脂肪沉积。

磁共振IDEAL-IQ序列定量分析腹腔内脏脂肪含量与2型糖尿病的关系

目的探讨腹腔内脏脂肪含量与糖尿病发生的关系,进而探讨其预测T2DM发病的可行性。方法收集行腹部3.0T MRI检查并有T2DM患者45例(T2DM组),对照组80例,应用IDEAL软件进行图像自动重组,获得脂肪分数(FF图)、弛豫率(R2*)、脂相、水相、同反相位图像。将FF图传至AW 4.6工作站,由两名观察者采用双盲法对FF图进行测量。应用ITK-SNAP软件采用阈值分割法半自动勾画腹腔内脏脂肪(VAT)及皮下脂肪组织(SAT),并计算体积。采用SPSS 26.0软件对数据进行统计学分析。结果(1)T2DM组的腹腔内脏脂肪组织体积(VATV)、肝脏脂肪分数(HFF)、胰腺脂肪分数(PFF)、甘油三酯(TG)及空腹血糖(FBG)均高于对照组,高密度脂蛋白(HDL)低于对照组,差异有统计学意义(P<0.05);(2)ROC曲线分析示:PFF判断是否患T2DM的曲线下面积(AUC)为0.656(P<0.01,95%CI:0.534~0.777),截断值为8.44%,敏感度为50%,特异度为82.5%;HFF判断是否患T2DM的AUC为0.744(P<0.05,95%CI:0.637~0.851),截断值、敏感度、特异度分别为2.99%、97.5%、42.5%。男性患者VATV判断T2DM的最佳阈值为3466 cm^(3),敏感度为63.2%,特异度为89.5%,AUC为0.78(P<0.01),联合SATV、PFF及HFF时,敏感度为78.9%,特异度为84.2%,AUC为0.839(P<0.01);女性患者利用VATV诊断T2DM的最佳阈值为2103 cm^(3),利用该阈值判断T2DM的敏感度为66.7%,特异度为66.7%,AUC为0.68(P<0.05),联合SATV、PFF及HFF时,敏感度为90.5%,特异度为76.2%,AUC为0.909(P<0.01)。(3)TG和FBG每增加1个单位,患T2DM的风险就分别提升了3986.3%及417.1%,即TG和FBG是T2DM发病的独立预测因子。结论PFF、HFF及VATV单独在预测T2DM发病方面,检验效能较低。VATV联合SATV、PFF、HFF预测T2DM发生的检验效能显著提高,其敏感度及特异度亦均明显提高。IDEAL-IQ技术是评估T2DM患者腹腔内异位脂肪组织沉积定量的便捷的方法,具有简单、稳定性好及重复性高的优势。

Origin of Sexy Prime Numbers, Origin of Cousin Prime Numbers, Equations from Supposedly Prime Numbers, Origin of the Mersenne Number, Origin of the Fermat Number

We have found through calculations that the differences between the closest supposed prime numbers other than 2 and 3 defined in the articles are: 2;4: and 6. For those whose difference is equal to 6, we showed their origin then we classified them into two categories according to their classes, we showed in which context two prime numbers which differ from 6 are called sexy and in what context they are said real sexy prime. For those whose difference is equal to 4, we showed their origin then we showed that two prime numbers which differ from 4, that is to say two cousin prime numbers, are successive. We made an observation on the supposed prime numbers then we established two pairs of equations from this observation and deduced the origin of the Mersenne number and that of the Fermat number.

How Prime Numbers Are Interconnected and Built with Two Equations: Addition and Subtraction Rules the Function (6µ)

Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , for instance 5, ), an even number divisible by 3 and 2, and Group 2 for all primes that are after ζ (such that , for instance 7), then we find a simple function: for each prime in each group, , where n is any natural number. If we start a sequence of primes with 5 for Group 1 and 7 for Group 2, we can attribute a μ value for each prime. The μ value can be attributed to every prime greater than 7. Thus for Group 1, and . Using this formula, all the primes appear for , where μ is any natural number.

Preliminary Identification of a Prime Number Other Than 2 and 3, the Origin of Twin Prime Numbers, the Structure of the Chain of Prime Numbers and the Set of Prime Numbers Less Than a Given Integer

The application of the Euclidean division theorem for the positive integers allowed us to establish a set which contains all the prime numbers and this set we called it set of supposedly prime numbers and we noted it Esp. We subsequently established from the previous set the set of non-prime numbers (the set of numbers belonging to this set and which are not prime) denoted Enp. We then extracted from the set of supposedly prime numbers the numbers which are not prime and the set of remaining number constitutes the set of prime numbers denoted Ep. We have deduced from the previous set, the set of prime numbers between two natural numbers. We have explained during our demonstrations the origin of the twin prime numbers and the structure of the chain of prime numbers.

The Periodic Table of Primes

Over millennia, nobody has been able to predict where prime numbers sprout or how they spread. This study establishes the Periodic Table of Primes (PTP) using four prime numbers 2, 3, 5, and 7. We identify 48 integers out of a period 2×3×5×7=210 to be the roots of all primes as well as composites without factors of 2, 3, 5, and 7. Each prime, twin primes, or composite without factors of 2, 3, 5, and 7 is an offspring of the 48 integers uniquely allocated on the PTP. Three major establishments made in the article are the Formula of Primes, the Periodic Table of Primes, and the Counting Functions of Primes and Twin Primes.

On the Optimal Initial Inner-Core Size for Tropical Cyclone Intensification: An Idealized Numerical Study

Recent observational and numerical studies have revealed the dependence of the intensification rate on the inner-core size of tropical cyclones(TCs). In this study, with the initial inner-core size(i.e., the radius of maximum wind—RMW)varied from 20–180 km in idealized simulations using two different numerical models, we found a nonmonotonic dependence of the lifetime maximum intensification rate(LMIR) on the inner-core size. Namely, there is an optimal innercore size for the LMIR of a TC. Tangential wind budget analysis shows that, compared to large TCs, small TCs have large inward flux of absolute vorticity due to large absolute vorticity inside the RMW. However, small TCs also suffer from strong lateral diffusion across the eyewall, which partly offsets the positive contribution from large inward flux of absolute vorticity. These two competing processes ultimately lead to the TC with an intermediate initial inner-core size having the largest LMIR. Results from sensitivity experiments show that the optimal size varies in the range of 40–120 km and increases with higher sea surface temperature, lower latitude, larger horizontal mixing length, and weaker initial TC intensity. The 40–120 km RMW corresponds to the inner-core size most commonly found for intensifying TCs in observations, suggesting the natural selection of initial TC size for intensification. This study highlights the importance of accurate representation of TC inner-core size to TC intensity forecasts by numerical weather prediction models.

IDEAL-IQ序列在冈上肌腱损伤后肩袖肌群脂肪浸润定量评估中的应用

目的采用非对称采集与迭代最小二乘估算法迭代水脂分离(iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation,IDEAL-IQ)方法定量评估冈上肌腱损伤的严重程度与肩袖肌群脂肪浸润程度及受试者特征之间的关系。材料与方法回顾性分析2022年8月至2024年6月本院经肩关节镜证实的33例冈上肌腱部分撕裂患者及89例完全撕裂患者,均进行了常规MRI扫描及IDEAL-IQ序列扫描。由两名放射科医生分别对所有受试者的MRI图像进行独立评估,根据常规MRI图像的冈上肌腱损伤表现,将完全撕裂组的冈上肌腱按照Patte分型分为Patte 1型(Ⅱ级)、Patte 2型(Ⅲ级)、Patte 3型(Ⅳ级),将部分撕裂组定义为Ⅰ级。同时在斜矢状位上进行Goutallier分级及Thomazeau萎缩分级,并通过GE ADW 4.7工作站后处理软件在IDEAL-IQ序列生成的脂肪分数图像上测量冈上肌、冈下肌、肩胛下肌及小圆肌脂肪分数(fat fraction,FF)。用组内相关系数(intra-class correlation coefficient,ICC)及Kappa一致性检验评估观察者间及观察者内的一致性。采用Kruskal-Wallis H检验、单因素ANOVA检验分析FF值在不同分组之间的差异,组间两两比较用Bonferroni检验。采用Pear_(s)on相关性分析肩袖肌肉FF值与年龄、症状持续时间的相关性(相关系数r),Spearman相关性分析冈上肌腱损伤分级与肩袖肌群FF值、Goutallier分级及Thomazeau萎缩分级之间的相关性(相关系数r_(s))。结果(1)冈上肌、冈下肌、肩胛下肌的FF值在冈上肌腱损伤Ⅳ级中显著高于Ⅲ级,高于Ⅱ级和Ⅰ级,差异有统计学意义(P值分别为<0.001、<0.001、0.005);小圆肌的FF值在不同分级之间差异无统计学意义(P=0.073)。组内比较Ⅰ级和Ⅱ级的冈上肌、冈下肌、肩胛下肌、小圆肌FF值差异无统计学意义(P值分别为0.026、0.102);Ⅲ级和Ⅳ级的FF值差异有统计学意义(P<0.001)。(2)冈上肌、冈下肌、小圆肌的FF值与年龄呈中等相关(r值分别为0.381、0.339、0.349,P均<0.001),肩胛下肌的FF值与年龄呈弱相关(r=0.216,P=0.017);冈上肌、冈下肌、肩胛下肌FF值与症状持续时间呈中等程度相关(r分别为0.442、0.412、0.314,P均<0.001),小圆肌的FF值与症状持续时间呈弱相关(r=0.277,P=0.002);冈上肌腱损伤程度与冈上肌FF值呈显著相关(r_(s)=0.740,P<0.001),与冈下肌的FF值呈强相关性(r_(s)=0.596,P<0.001),与肩胛下肌、小圆肌的FF值呈弱相关(r_(s)分别为0.257、0.212,P值分别为0.004、0.019);冈上肌损伤程度分级与Goutallier分级、Thomazeau分级之间呈显著正相关(r_(s)分别为0.757、0.737,P均<0.001),且冈上肌FF值在Goutallier和Thomazeau的分级中差异具有统计学意义(P均<0.001)。结论3.0 T MR IDEAL-IQ序列能量化和客观评估肩袖肌群脂肪浸润程度,肩袖肌群脂肪浸润程度与冈上肌腱损伤分级呈正相关,与年龄、症状持续时间呈正相关。

On the Number of Primes in the Interval (x, 2x) by an Elementary Method

An elementary formula to know the number of primes in the interval (x, 2x) close to the exact figure for a fixed x is given here. A new elementary equation is derived (a relation between prime numbers and composite numbers distributed in the interval [1, 2x]). An elementary method to know the number of primes in a given magnitude is suitably placed in the form of a general formula, and we have proved it. The general formula is applied to the terms of the equation, and a tactical simplification of the terms gives rise to an expression whose verification envisages scope for its further studies.

INCOMPRESSIBLE LIMIT OF IDEAL MAGNETOHYDRODYNAMICS IN A DOMAIN WITH BOUNDARIES

We study the incompressible limit of classical solutions to compressible ideal magneto-hydrodynamics in a domain with a flat boundary.The boundary condition is characteristic and the initial data is general.We first establish the uniform existence of classical solutions with respect to the Mach number.Then,we prove that the solutions converge to the solution of the incompressible MHD system.In particular,we obtain a stronger convergence result by using the dispersion of acoustic waves in the half space.

On Perron’s Formula and the Prime Numbers

The Riemann hypothesis is intimately connected to the counting functions for the primes. In particular, Perron’s explicit formula relates the prime counting function to fixed points of iterations of the explicit formula with particular relations involving the trivial and non-trivial roots of the Riemann Zeta function and the Primes. The aim of the paper is to demonstrate this relation at the fixed points of iterations of explicit formula, defined by functions of the form limT∈Ν→∞fT(zw)=zw,where, zwis a real number.

PRiME HLB固相萃取结合UPLC-QTOF-MS测定烟液与烟丝中的依托咪酯

待测样品经乙腈提取后,使用PRi ME HLB固相萃取柱对样品提取液进行净化,经ACE EXCEL C18(2.1mm×50mm,2μm)色谱柱分离,以甲醇-5mmol·L^(-1)甲酸铵水溶液(含0.1%甲酸)作为流动相,梯度洗脱,采用电喷雾离子源正模式(ESI+),目标物二级离子模式(Targeted MS/MS)进行质谱分析。依托咪酯在2ng·m L^(-1)~200ng·m L^(-1)浓度范围内线性关系良好,相关系数r为0.999,在0.2μg·g^(-1),1.0μg·g^(-1),5.0μg·g^(-1)3个水平的加标回收率为86.6%~94.6%,RSD为3.1%~4.3%(n=9)。本方法具有操作简易快速、定性定量准确等特点。

基于“IDEAL”模式的物理问题解决能力培养研究

学生“物理问题解决能力弱”是长期困扰物理教学的问题,认知心理学关于问题解决的“IDEAL”模式为该问题的研究提供了新的视角。以2022年全国乙卷理综第25题为例,借助“IDEAL”模式可以清晰地梳理问题解决的过程,明确各阶段学生遇到的困难及成因。研究发现,借助“读思达”教学法,通过粗读、精读等过程,可以有效帮助学生建构物理模型、理清物理过程,从而提高物理问题解决能力。

PRiME HLB固相萃取-超高效液相色谱-串联质谱法测定水产品中的孔雀石绿含量

目的:建立了水产品中显色孔雀石绿(MG)及隐色孔雀石绿(LMG)残留量的超高效液相色谱-串联质谱测定方法。方法:样品用1.5%甲酸乙腈提取,离心,提取液经过PRiME HLB通过式固相萃取柱净化,氮吹后复溶,UPLC-MS/MS测定,同位素内标法定量。结果:在浓度为0.5~10.0μg/L范围内线性关系均良好,相关系数均大于0.995,检测限为0.008~0.01μg/kg,定量限为0.02~0.04μg/kg,加标回收率为86.8%~110.5%,相对标准偏差为1.6%~5.8%。结论:该方法高效快捷、准确可靠,能够满足大批量水产品中孔雀石绿及隐色孔雀石绿的检测。

Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime Conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

For the Ideal Homeland

A town planner combines British experience with Chinese concept of harmony to build green,low-carbon,and sustainable cities.YANG Wei is a woman who wears many hats.An internationally renowned town planner and urban designer,she is held in high esteem in the academic and planning communities in the U.K.and is a fellow of the U.K.Academy of Social Sciences and former president of the Royal Town Planning Institute(RTPI)based in London.She is also chief executive and co-founder of the Digital Task Force for Planning(DTFP),a non-profit social enterprise,and founding director of London-based planning and urban design firm Wei Yang&Partners.

Yeats’s Ideals:Women Old and Young

William Butler Yeats ranks among the most widely admired and intensively studied poets of the 20th century.This paper intends to explore the women who have exerted the most critical influences upon Yeats,namely Gonne,Lady Gregory,and Georgie Hyde-Lees.Even in Yeats’s poetry involved with symbolism,it is worth noting that his employment of symbols has used these women as the archetypes,and that the historical context rendered Yeats’s representations of them in his poetry all the more interesting.

Primetime Fashion Beijing hosts China Fashion Week A/W 2024

The China Fashion Week A/W 2024,hosted by the China Fashion Designers Association,took place in Beijing from March 23 to 31.Themed“Fu”(Empower),this season’s fashion week continued to focus on Chinese aesthetics,innovation in intangible cultural heritage,fusion of Chinese trends.

磁共振IDEAL-IQ序列测量肝脏脂肪含量的可行性研究

目的 探究IDEAL-IQ序列测量肝脏脂肪含量的准确性,以及影响测量准确性的因素。方法 利用GE DISCOVERY MR750 3.0T的单通道头线圈、八通道头线圈以及八通道腹部线圈,对配置的不同浓度的水脂混合溶液模体进行高参数扫描。在GE AW4.6工作站上进行多次脂肪含量测量,并对测量数值进行线性回归分析,讨论测量值与已知配置值的相关性,分析配置水脂混合模体在不同线圈中测量的准确性。结果 对于已知浓度的水脂混合溶液模型,IDEAL-IQ序列在三个线圈测量数据的一元线性回归讨论中,三个回归模型的P<0.0001,测量模型均在α=0.0001的水平上显著性明显,拟合较好,置信度达到99.99%。不同线圈在同参数扫描的情况下,由于信噪比不同,在图像中出现明显噪点,在使用小ROI测量时,会使得同一层面测量结果出现较大偏差。结论 IDEAL-IQ序列运用于脂肪含量的定量测量是可行可靠的,并且精准性较高。但扫描图像的质量对于测量稳定性以及准确性有影响,图像噪声越大则测量结果越不稳定,测量值的偏差越大。在临床扫描条件下,临床医师的测量应该采用适当ROI多点测量取平均值的方式进行肝脏脂肪含量的测量,同时还应该避开肝脏扫描层中的初始层及末端层。如果选取区域落于初始层及末端层,则可能会导致脂肪含量的过估计。