Interpretation of Chinese Expert Consensus on the Diagnosis and Management Strategy of Patients with Statin Intolerance: A guiding file for helping to lipid management for Chinese population

It is well-known that elevated low-density lipoprotein cholesterol(LDL-C)is a causal risk factor for atheroscler-otic cardiovascular disease(ASCVD),statins are cornerstone drugs for the cause-based treatment of ASCVD,which has created a new era for ASCVD therapy.However,statin intolerance is not clinically uncommon,which there are several issues with confu-sion and misunderstandings.Hence,a file named Chinese Expert Consensus on the Diagnosis and Management Strategy of Pa-tients With Statin Intolerance,like a navigator,has recently been published written by a team of experts from the Cardiovascular Metabolic Medicine Professional Committee,Expert Committee of the National Center for Cardiovascular Diseases aiming to en-hance the standardized clinical application of statins and improve the prevention and clinical outcome.In this article,author briefly summarized the key points of above consensus in order to helping to comprehending the content of the consensus sugges-tions.

The Caching and Pricing Strategy for Information-Centric Networking with Advertisers’Participation

As users’access to the network has evolved into the acquisition of mass contents instead of IP addresses,the IP network architecture based on end-to-end communication cannot meet users’needs.Therefore,the Information-Centric Networking(ICN)came into being.From a technical point of view,ICN is a promising future network architecture.Researching and customizing a reasonable pricing mechanism plays a positive role in promoting the deployment of ICN.The current research on ICN pricing mechanism is focused on paid content.Therefore,we study an ICN pricing model for free content,which uses game theory based on Nash equilibrium to analysis.In this work,advertisers are considered,and an advertiser model is established to describe the economic interaction between advertisers and ICN entities.This solution can formulate the best pricing strategy for all ICN entities and maximize the benefits of each entity.Our extensive analysis and numerical results show that the proposed pricing framework is significantly better than existing solutions when it comes to free content.

Machine learning solution for regional landslide susceptibility based on fault zone division strategy

Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study performed qualitative analysis of fault zones and proposed a zoning method to assess the landslide susceptibility in Chengkou County, Chongqing Municipality, China. The region within a distance of 1 km from the faults was designated as sub-zone A, while the remaining area was labeled as sub-zone B. To accomplish the assessment, a dataset comprising 388 historical landslides and 388 non-landslide points was used to train the random forest model. 10-fold cross-validation was utilized to select the training and testing datasets for the model. The results of the models were analyzed and discussed, with a focus on model performance and prediction uncertainty. By implementing the proposed division strategy based on fault zone, the accuracy, precision, recall, F-score, and AUC of both two sub-zones surpassed those of the whole region. In comparison to the results obtained for the whole region, sub-zone B exhibited an increase in AUC by 6.15%, while sub-zone A demonstrated a corresponding increase of 1.66%. Moreover, the results of 100 random realizations indicated that the division strategy has little effect on the prediction uncertainty. This study introduces a novel approach to enhance the prediction accuracy of the landslide susceptibility mapping model in areas with multiple fault zones.

Impacts of bus holding strategy on the performance and pollutant emissions of a two-lane mixed traffic system

This paper investigates the impacts of a bus holding strategy on the mutual interference between buses and passenger cars in a non-dedicated bus route,as well as the impacts on the characteristics of pollutant emissions of passenger cars.The dynamic behaviors of these two types of vehicles are described using cellular automata(CA)models under open boundary conditions.Numerical simulations are carried out to obtain the phase diagrams of the bus system and the trajectories of buses and passenger cars before and after the implementation of the bus holding strategy under different probabilities of passenger cars entering a two-lane mixed traffic system.Then,we analyze the flow rate,satisfaction rate,and pollutant emission rates of passenger cars together with the performance of a mixed traffic system.The results show that the bus holding strategy can effectively alleviate bus bunching,whereas it has no significant impact on the flow rate and pollutant emission rates of passenger cars;the flow rate,satisfaction rate,and pollutant emission rates of passenger cars for either the traffic system or for each lane are influenced by the bus departure interval and the number of passengers arriving at bus stops.

Evolution of United States Technology Alliance Strategy and Reshaping of International Strategic Landscape

Building a technology alliance is the main strategy for the United States to maintain its scientific and technological hegemony under its technopolitical strategic framework.After Joe Biden took office,the United States implemented“small yard with high fences”strategy for scientific and technological competition,as the first step toward building a technology alliance.The main goal is to restrict the flow of strategic emerging technologies and factors of innovation to rival countries.

Artificial Intelligence in US Military Strategy:Trends and Implications

Since 2017,the United States has been advancing the utilization of artificial intelligence(AI)in its military strategy.Academic studies of AI’s impact on national security generally fall into four groups.The first group deals with the specific areas where AI empowers the military,such as intelligence acquisition and analysis,new weapon manufacturing,command and control decision-making and implementation,and man-machine relationship.

Treatment strategy and therapy based on immune response in patients with gastric cancers

In this editorial,we highlight the significance of a retrospective study“Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis”performed by Liu et al.The authors utilized data collected from gastric cancer(GC)patients and assessed immunotherapy effectiveness and survival status.They found significant differences in treatment response.Because immunotherapy seems to be a beneficial strategy for advanced GC patients,strati-fication of the data based on metastasis status may further improve treatment strategies.

Adverse Pregnancy Outcomes Following Cryotherapy, Thermal Ablation and Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia Treatment: A Pilot Study among Zambian Women

Background: Cervical Intraepithelial neoplasia treatments have become essential interventions to manage cervical lesions. Majority of the recipients of these treatments are women within the reproductive age group, who according to literature may be at risk of adverse pregnancy outcomes. This pilot study is part of a study investigating adverse pregnancy outcomes among women who received Cryotherapy, Thermal ablation and Loop Electrosurgical Excision Procedure compared to the untreated women in Zambia. Materials and Methods: This descriptive study analyzed records of 886 (n = 443 treated and n = 443 untreated) women aged 15 - 49 years. The women were either screened with Visual Inspection with Acetic Acid or treated for Cervical Intraepithelial neoplasia at the Adult Infectious Disease Centre between January 2010 and December 2020. Women meeting the criteria were identified using the Visual Inspection with Acetic Acid screening records and telephone interviews to obtain the adverse pregnancy outcome experienced. Data were analysed using STATA version 16 to determine the prevalence and obtain frequency distribution of outcomes of interest. Univariate and multivariable binary logistic regression estimated odds of adverse pregnancy outcomes across the three treatments. Results: The respondents were aged 15 to 49 years. Adverse pregnancy outcomes were observed to be more prevalent in the treatment group (18.5%) compared to the untreated group (5.4%). Normal pregnancy outcomes were lower in the treated (46.3%;n = 443) than the untreated (53.7%;n = 443). The treated group accounted for the majority of abortions (85.2%), prolonged labour (85.7%) and low birth weight (80%), whereas, the untreated accounted for the majority of still births (72.7%). Women treated with cryotherapy (aOR = 2.43, 95% CI = 1.32 - 4.49, p = 0.004), thermal ablation (aOR = 6.37, 95% CI = 0.99 - 41.2, p = 0.052) and Loop Electrosurgical Excision Procedure (aOR = 9.67, 95% CI = 2.17 - 43.1, p = 0.003) had two-, six- and ten-times higher odds of adverse pregnancy outcomes respectively, relative to women who required no treatment. Conclusion: Adverse pregnancy outcomes are prevalent among women who have received treatment in Zambia. The findings indicate that treating Cervical Intraepithelial Neoplasia has been linked to higher chances of experiencing abortion, delivering low birth weight babies and enduring prolonged labor that may result in a caesarean section delivery. Cervical neoplasia treatments, particularly Loop Electrosurgical Excision Procedure, are associated with significantly increased odds of adverse pregnancy outcomes. It is essential to include information about prior Cervical Intraepithelial neoplasia treatment outcomes in obstetric care.

The surface electron transfer strategy promotes the hole of PDI release and enhances emerging organic pollutant degradation

In semiconductor photocatalysts,the easy recombination of photogenerated carriers seriously affects the application of photocatalytic materials in water treatment.To solve the serious problem of electron−hole pair recombination in perylene diimide(PDI)organic semiconductors,we loaded ferric hydroxyl oxide(FeOOH)on PDI materials,successfully prepared novel FeOOH@PDI photocatalytic materials,and constructed a photo-Fenton system.The system was able to achieve highly efficient degradation of BPA under visible light,with a degradation rate of 0.112 min^(−1)that was 20 times higher than the PDI system,and it also showed universal degradation performances for a variety of emerging organic pollutants and anti-interference ability.The mechanism research revealed that the FeOOH has the electron trapping property,which can capture the photogenerated electrons on the surface of PDI,effectively reducing the compounding rate of photogenerated carriers of PDI and accelerating the iron cycling and H2O2 activation on the surface of FeOOH at the same time.This work provides new insights and methods for solving the problem of easy recombination of carriers in semiconductor photocatalysts and degrading emerging organic pollutants.

A guidance strategy for rendezvous and docking to the space station in the Earth-Moon NRHO orbit

With the development of space technology,it is possible to build a space station in Earth-Moon space as a transit for Earth-Moon round-trip and entering in the deep space.Rendezvous and docking is one of the key technologies for building an Earth-Moon space station.A guidance strategy for rendezvous and docking from the Earth orbit to the space station in the Earth-Moon NRHO orbit is proposed in this paper,which is suitable for engineering applications.Firstly,the rendezvous and docking process is divided into three sections,i.e.,the large-range orbit transfer section,far-range guidance section,and close-range approaching section.The suitable terminal of large-range orbit transfer is selected according to the eigenvalue of NRHO orbit state transition matrix.The two-impulse guidance method based on the relative motion equation in the three-body problem is adopted for the far-range guidance section.The impulse time and amplitude are solved with the optimization algorithm.The linear constant three-body relative motion equation is proposed for the close-range approaching section,and the rendezvous and docking is completed by a two-stage linear approximation.Finally,a simulation analysis is carried out,and the simulation results show that the adopted dynamics equations and the designed guidance law are effective,and the three flight phases are naturally connected to accomplish the rendezvous and docking mission from the Earth orbit to the space station on the Earth-Moon NRHO.

Reshaping Li–Mg hybrid batteries:Epitaxial electrodeposition and spatial confinement on MgMOF substrates via the lattice‐matching strategy

The emergence of Li–Mg hybrid batteries has been receiving attention,owing to their enhanced electrochemical kinetics and reduced overpotential.Nevertheless,the persistent challenge of uneven Mg electrodeposition remains a significant impediment to their practical integration.Herein,we developed an ingenious approach that centered around epitaxial electrocrystallization and meticulously controlled growth of magnesium crystals on a specialized MgMOF substrate.The chosen MgMOF substrate demonstrated a robust affinity for magnesium and showed minimal lattice misfit with Mg,establishing the crucial prerequisites for successful heteroepitaxial electrocrystallization.Moreover,the incorporation of periodic electric fields and successive nanochannels within the MgMOF structure created a spatially confined environment that considerably promoted uniform magnesium nucleation at the molecular scale.Taking inspiration from the“blockchain”concept prevalent in the realm of big data,we seamlessly integrated a conductive polypyrrole framework,acting as a connecting“chain,”to interlink the“blocks”comprising the MgMOF cavities.This innovative design significantly amplified charge‐transfer efficiency,thereby increasing overall electrochemical kinetics.The resulting architecture(MgMOF@PPy@CC)served as an exceptional host for heteroepitaxial Mg electrodeposition,showcasing remarkable electrostripping/plating kinetics and excellent cycling performance.Surprisingly,a symmetrical cell incorporating the MgMOF@PPy@CC electrode demonstrated impressive stability even under ultrahigh current density conditions(10mAcm^(–2)),maintaining operation for an extended 1200 h,surpassing previously reported benchmarks.Significantly,on coupling the MgMOF@PPy@CC anode with a Mo_(6)S_(8) cathode,the assembled battery showed an extended lifespan of 10,000 cycles at 70 C,with an outstanding capacity retention of 96.23%.This study provides a fresh perspective on the rational design of epitaxial electrocrystallization driven by metal–organic framework(MOF)substrates,paving the way toward the advancement of cuttingedge batteries.

Enhancing the Efficiency of Multi-Electrolyzer Clusters with Lye Mixer:Topology Design and Control Strategy

The rise in hydrogen production powered by renewable energy is driving the field toward the adoption of systems comprising multiple alkaline water electrolyzers.These setups present various operational modes:independent operation and multi-electrolyzer parallelization,each with distinct advantages and challenges.This study introduces an innovative configuration that incorporates a mutual lye mixer among electrolyzers,establishing a weakly coupled system that combines the advantages of two modes.This approach enables efficient heat utilization for faster hot-startup and maintains heat conservation post-lye interconnection,while preserving the option for independent operation after decoupling.A specialized thermal exchange model is developed for this topology,according to the dynamics of the lye mixer.The study further details startup procedures and proposes optimized control strategies tailored to this structural design.Waste heat from the caustic fully heats up the multiple electrolyzers connected to the lye mixing system,enabling a rapid hot start to enhance the system’s ability to track renewable energy.A control strategy is established to reduce heat loss and increase startup speed,and the optimal valve openings of the diverter valve and the manifold valve are determined.Simulation results indicate a considerable enhancement in operational efficiency,marked by an 18.28%improvement in startup speed and a 6.11%reduction in startup energy consumption inmulti-electrolyzer cluster systems,particularlywhen the systems are synchronized with photovoltaic energy sources.The findings represent a significant stride toward efficient and sustainable hydrogen production,offering a promising path for large-scale integration of renewable energy.

Genome-wide SNP markers provided insights into the reproductive strategy and genetic diversity of the green tide causative species Ulva prolifera in China

Ulva prolifera is the causative species of the annually occurring large-scale green tides in China since 2007.Its specific biological features on reproductivity strategies,as well as intra-species genetic diversity,are still largely unknown,especially at the genome level,despite their importance in understanding the formation and outbreak of massive green tides.In the present study,the restriction site-associated DNA genotyping approach(2b-RAD)was adopted to identify the genome-wide single-nucleotide polymorphisms(SNPs)of 54 individual thalli including samples collected from Subei Shoal in 2019 and Qingdao coast from 2019 to 2021.SNPs genotype results revealed that most of the thalli in 2019 and 2020 were haploid gametophytes,while only half of the thalli were gametophytes in 2021,indicating flexibility in the reproductive strategies for the formation of the green tides among different years and the dominance of asexual and vegetative reproductive mode for the floating period.Besides,population analysis was conducted,and it revealed a very low genetic diversity among samples from Subei Shoal and the Qingdao coast in the same year and a higher divergence among samples in different years.The results showed the efficiency of 2b-RAD in the exploration of SNPs in U.prolifera and provided the first genome-wide scale evidence for the origin of the large-scale green tides on the Qingdao coast.This study improved our understanding of the reproductive strategy and genetic diversity of the green tide causative species and will help further reveal the biological causes of the green tide in China.

Clinical application of eight-zone laparoscopic dissection strategy for rectal cancer:Experience and discussion

BACKGROUND The incidence of rectal cancer is increasing worldwide,and surgery remains the primary treatment modality.With the advent of total mesorectal excision(TME)technique,the probability of tumor recurrence post-surgery has significantly decreased.Surgeons'focus has gradually shifted towards minimizing the impact of surgery on urinary and sexual functions.Among these concerns,the optimal dissection of the rectal lateral ligaments and preservation of the pelvic floor neuro-vascular bundle have become critical.To explore the optimal surgical technique for TME and establish a standardized surgical protocol to minimize the impact on urinary and sexual functions,we propose the eight-zone dissection strategy for pelvic floor anatomy.AIM To compare the differences in surgical specimen integrity and postoperative quality of life satisfaction between the traditional pelvic floor dissection strategy and the innovative eight-zone dissection strategy.METHODS We analyzed the perioperative data of patients who underwent laparoscopic radical resection of rectal cancer at Qilu Hospital of Shandong University between January 1,2021 and December 1,2023.This study included a total of 218 patients undergoing laparoscopic radical surgery for rectal cancer,among whom 109 patients underwent traditional pelvic floor dissection strategy,and 109 patients received the eight-zone dissection strategy.RESULTS There were no significant differences in general characteristics between the two groups.Patients in the eight-zone dissection group had higher postoperative specimen integrity(88.1%vs 78.0%,P=0.047).At the 3-month followup,patients in the eight-zone surgery group had better scores in urinary issues(6.8±3.3 vs 5.3±2.5,P=0.045)and male sexual desire(2.2±0.6 vs 2.5±0.5,P=0.047)compared to the traditional surgery strategy group.CONCLUSION This study demonstrates that the eight-zone dissection strategy for laparoscopic lateral ligament dissection of rectal cancer is safe and effective.Compared with the traditional pelvic floor dissection strategy,this approach can reduce the risk of nerve injury and minimize the impact on urinary and sexual functions.Therefore,we recommend the clinical application of this strategy to better serve patients with rectal cancer.

Interplay of Development and Governance in China's Modernization Strategy

High-quality development requires both development-oriented and government-oriented reforms.SINCE 1978,China's policy of reform and opening-up has been pivotal in propelling the nation toward big achievements.Its distinct and unique path of development has been a success due to a system and mechanisms that have been continually fine-tuned and strengthened through ongoing reforms.

China’s Africa Policy:the Interplay Between Continent-Based Policy and Global Strategy

Valerie Hansen,a historian of Yale University,put forward in the book The Year 1000:When Explorers Connected the World and Globalization Began that the beginning of globalization was marked by the Vikings’landing in North America in A.D.1000.Why cannot the global expansion and continuous migration of Africans be defined as globalization?

European Economic Security Strategy and Its Impact

The EU has long been seen as a major force for multilateralism and free trade due to its open and liberal economic policies and single market.However,that changed in June 2023 when the European Commission unveiled the European Economic Security Strategy for the first time.

Understanding the concept of health literacy: A strategy to improve nursing practice

Health literacy(HL)is an effective approach for improved health status and measures the capacity of individuals to engage in health promotion and disease prevention activities as low HL constitutes a global problem in health-care delivery.Nurses play a significant role in providing adequate information to the client and as such it becomes imperative for them to understand the concept of HL.Clinical approach of HL refers to ability to utilize literacy skills in relation to appointments,prescriptions,and instructions for self-management.Public health approach presents HL as means of empowering individuals to take control of their health and factors that influences health.HL is a hierarchy of skills that can be assessed and managed through health education and effective communication.Nurses’understanding of the concept of HL and strategies to reduce HL demands is crucial to delivery of effective nursing practice.This review will provide a clear understanding of the concept of HL which is essential for nurses to effectively educate patients and provide holistic care.More so,nurses will be able to assess literacy level of the patients,plan and develop better educational program tailored to patients’level of literacy.This could invariably improve patients’comprehension and adherence to treatment plans and overall health outcomes.

Peak Shaving Strategy of Concentrating Solar Power Generation Based on Multi-Time-Scale and Considering Demand Response

According to the multi-time-scale characteristics of power generation and demand-side response(DR)resources,as well as the improvement of prediction accuracy along with the approaching operating point,a rolling peak shaving optimization model consisting of three different time scales has been proposed.The proposed peak shaving optimization model considers not only the generation resources of two different response speeds but also the two different DR resources and determines each unit combination,generation power,and demand response strategy on different time scales so as to participate in the peaking of the power system by taking full advantage of the fast response characteristics of the concentrating solar power(CSP).At the same time,in order to improve the accuracy of the scheduling results,the combination of the day-ahead peak shaving phase with scenario-based stochastic programming can further reduce the influence of wind power prediction errors on scheduling results.The testing results have shown that by optimizing the allocation of scheduling resources in each phase,it can effectively reduce the number of starts and stops of thermal power units and improve the economic efficiency of system operation.The spinning reserve capacity is reduced,and the effectiveness of the peak shaving strategy is verified.

Research on Scheduling Strategy of Flexible Interconnection Distribution Network Considering Distributed Photovoltaic and Hydrogen Energy Storage

Distributed photovoltaic(PV)is one of the important power sources for building a new power system with new energy as the main body.The rapid development of distributed PV has brought new challenges to the operation of distribution networks.In order to improve the absorption ability of large-scale distributed PV access to the distribution network,the AC/DC hybrid distribution network is constructed based on flexible interconnection technology,and a coordinated scheduling strategy model of hydrogen energy storage(HS)and distributed PV is established.Firstly,the mathematical model of distributed PV and HS system is established,and a comprehensive energy storage system combining seasonal hydrogen energy storage(SHS)and battery(BT)is proposed.Then,a flexible interconnected distribution network scheduling optimization model is established to minimize the total active power loss,voltage deviation and system operating cost.Finally,simulation analysis is carried out on the improved IEEE33 node,the NSGA-II algorithm is used to solve specific examples,and the optimal scheduling results of the comprehensive economy and power quality of the distribution network are obtained.Compared with the method that does not consider HS and flexible interconnection technology,the network loss and voltage deviation of this method are lower,and the total system cost can be reduced by 3.55%,which verifies the effectiveness of the proposed method.