RoBGP:A Chinese Nested Biomedical Named Entity Recognition Model Based on RoBERTa and Global Pointer

Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity types.This process can provide basic support for the automatic construction of knowledge bases.In contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER models.To address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial vectors.It then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance dependencies.Furthermore,the Global Pointer model is employed to comprehensively recognize all nested entities in the text.We conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline models.This research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.

The Impact of Model Based Offset Scaling Technique on the Amplitude Variation with Offset Responses from 3D Seismic Data Acquired from the Tano Basin, Offshore Ghana

Amplitudes have been found to be a function of incident angle and offset. Hence data required to test for amplitude variation with angle or offset needs to have its amplitudes for all offsets preserved and not stacked. Amplitude Variation with Offset (AVO)/Amplitude Variation with Angle (AVA) is necessary to account for information in the offset/angle parameter (mode converted S-wave and P-wave velocities). Since amplitudes are a function of the converted S- and P-waves, it is important to investigate the dependence of amplitudes on the elastic (P- and S-waves) parameters from the seismic data. By modelling these effects for different reservoir fluids via fluid substitution, various AVO geobody classes present along the well and in the entire seismic cube can be observed. AVO analysis was performed on one test well (Well_1) and 3D pre-stack angle gathers from the Tano Basin. The analysis involves creating a synthetic model to infer the effect of offset scaling techniques on amplitude responses in the Tano basin as compared to the effect of unscaled seismic data. The spectral balance process was performed to match the amplitude spectra of all angle stacks to that of the mid (26°) stack on the test lines. The process had an effect primarily on the far (34° - 40°) stacks. The frequency content of these stacks slightly increased to match that of the near and mid stacks. In offset scaling process, the root mean square (RMS) amplitude comparison between the synthetic and seismic suggests that the amplitude of the far traces should be reduced relative to the nears by up to 16%. However, the exact scaler values depend on the time window considered. This suggests that the amplitude scaling with offset delivered from seismic processing is only approximately correct and needs to be checked with well synthetics and adjusted accordingly prior to use for AVO studies. The AVO attribute volumes generated were better at resolving anomalies on spectrally balanced and offset scaled data than data delivered from conventional processing. A typical class II AVO anomaly is seen along the test well from the cross-plot analysis and AVO attribute cube which indicates an oil filled reservoir.

Model-Based Systems Engineering Approach to Design a Human Settlement to Better Serve Displaced People

The challenge of transitioning from temporary humanitarian settlements to more sustainable human settlements is due to a significant increase in the number of forcibly displaced people over recent decades, difficulties in providing social services that meet the required standards, and the prolongation of emergencies. Despite this challenging context, short-term considerations continue to guide their planning and management rather than more integrated, longer-term perspectives, thus preventing viable, sustainable development. Over the years, the design of humanitarian settlements has not been adapted to local contexts and perspectives, nor to the dynamics of urbanization and population growth and data. In addition, the current approach to temporary settlement harms the environment and can strain limited resources. Inefficient land use and ad hoc development models have compounded difficulties and generated new challenges. As a result, living conditions in settlements have deteriorated over the last few decades and continue to pose new challenges. The stakes are such that major shortcomings have emerged along the way, leading to disruption, budget overruns in a context marked by a steady decline in funding. However, some attempts have been made to shift towards more sustainable approaches, but these have mainly focused on vague, sector-oriented themes, failing to consider systematic and integration views. This study is a contribution in addressing these shortcomings by designing a model-driving solution, emphasizing an integrated system conceptualized as a system of systems. This paper proposes a new methodology for designing an integrated and sustainable human settlement model, based on Model-Based Systems Engineering and a Systems Modeling Language to provide valuable insights toward sustainable solutions for displaced populations aligning with the United Nations 2030 agenda for sustainable development.

Multi-agent Based Hierarchy Simulation Models of Carrier-based Aircraft Catapult Launch

With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as aggregation agents, the detailed components like catapult, landing gears, and disturbances are considered as meta-agents, which belong to their aggregation agent. Thus, the model with two layers is formed i.e. the aggregation agent layer and the meta-agent layer. The information communication among all agents is described. The meta-agents within one aggregation agent communicate with each other directly by information sharing, but the meta-agents, which belong to different aggregation agents exchange their information through the aggregation layer first, and then perceive it from the sharing environment, that is the aggregation agent. Thus, not only the hierarchy model is built, but also the environment perceived by each agent is specified. Meanwhile, the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system （MAS） is resolved. Each agent involved in carrier-based aircraft catapult launch is depicted, with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier, aircraft, and landing gears. The models of reactive agents among them are derived based on tensors, and the perceived messages and inner frameworks of each agent are characterized. Finally, some results of a simulation instance are given. The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely. The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system. This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent, and it is convenient to expand, maintain, and reuse the program codes.

Evaluation of Parametric Limitations in Simulating Greenhouse Gas Fluxes from Irish Arable Soils Using Three Process-Based Models

Globally a large number of process-based models have been assessed for quantification of agricultural greenhouse gas (GHG) emissions. Modelling approaches minimize the presence of spatial variability of biogeochemical processes, leading to improved estimates of GHGs as well as identifying mitigation and policy options. The comparative performance of the three dynamic models (e.g., DNDC v9.4, DailyDayCent and ECOSSE v5+) with minimum numbers of common input parameters was evaluated against measured variables. Simulations were performed on conventionally-tilled spring barley crops receiving N fertilizer at 135 - 159 kg·N·ha-1·yr-1 and crop residues at 3 t·ha-1·yr-1. For surface soil nitrate (0 - 10 cm), the ECOSSE and DNDC simulated values showed significant correlations with measured values (R2 = 0.31 - 0.55, p 0.05). Only the ECOSSE-simulated N2O fluxes showed a significant relationship (R2 = 0.33, p 0.05) with values measured from fertilized fields, but not with unfertilized ones. The DNDC and DailyDayCent models significantly underestimated seasonal/annual N2O fluxes compared to ECOSSE, with emission factors (EFs), based on an 8-year average, were 0.09%, 0.31% and 0.52%, respectively. Predictions of ecosystem respiration by both DailyDayCent and DNDC showed reasonable agreement with Eddy Covariance data (R2 = 0.34 - 0.41, p 0.05). Compared to the measured value (3624 kg·C·ha-1·yr-1), the ECOSSE underestimated annual heterotrophic respiration by 7% but this was smaller than the DNDC (50%) and DailyDayCent (24%) estimates. All models simulated CH4 uptake we

Research on workflow meta model supporting activity based costing

Activity based costing (ABC) is a method which can solve many limitations of the traditional cost systems in manufacturing management. In this paper, we investigate how to integrate ABC with workflow technology, and build a workflow meta model supporting ABC. Firstly, the concept and concept model of activity based costing (ABC) are introduced. Next, the meta model of P -PROCE (Process, Product, Resource, Organization, and Cost & Evaluation) is presented. Then the cost meta model is defined by adding ABC to P -PROCE model. Object constraint language (OCL) is used to express meta model and constraints. Finally, we show an enterprise modeling and simulation tool based on the workflow meta model. We can systematically construct an enterprise model and easily and efficiently conduct simulation. Moreover it enables us to analyze and evaluate business processes and its costs.

Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs

The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic(PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs. The dissolution behaviors of three lacidipine formulations including one commercial product and two self-made amorphous solid dispersions(ASDs)capsules were determined in 0.07% Tween 80 media. A randomized 3-period crossover design in 6 healthy beagle dogs after oral administration of the three formulations at a single dose of 4 mg was conducted. The PBPK modeling was utilized for the virtual bioequivalence study.In vitro dissolution experiment showed that the dissolution behaviors of lacidipine amorphous solid dispersions(ASDs) capsules, which was respectively prepared by HPMC-E5 or Soluplus, as polymer displayed similar curves compared with the reference formulation in 0.07% Tween 80 media. In vivo pharmacokinetics experiments showed that three formulations had comparable maximum plasma drug concentration(Cmax), and the time(Tmax) to reach Cmax of lacidipine tablet, which was prepared by Soluplus, as polymer was slower than other two formulations in consistency with the in vitro dissolution rate. The 90% confidence interval(CI) for the Cmax, AUC0–24 h and AUC0–∞ of the ratio of the test drug to the reference drug exceeded the acceptable bioequivalence(BE) limits(0.80–1.25). However, the 90% CI of the AUC0–24 h, AUC0–∞ and Cmax of the ratio of test to reference drug were within the BE limit,calculated using PBPK modeling when the virtual subjects reached 24 dogs. The results all demonstrated that virtual bioequivalence study can overcome the inequivalence caused by inter-subject variability of the 6 beagle dogs involved in in vivo experiments.

A Feature-Based Parametric Product Modeling System in CIMS Environment

This paper proposes an approach of developing the feature based parametric product modeling system which is suitable for integrated engineering design in CIMS environment.The architecture of ZD--MCADII and the characteristics of its each module are introduced in detail. ZD--MCADII’s product data is managed by an object--oriented database management system OSCAR, and the product model is built according to the standard STEP. The product design is established on a unified product model, and all the product data are globally associated in ZD--MCADII. ZD--MCADII provides various design features to facilitate the product design, and supports the integrity of CAD, CAPP and CAM.

Disturbance Observer Based Control for Four Wheel Steering Vehicles With Model Reference

This paper presents a disturbance observer based control strategy for four wheel steering systems in order to improve vehicle handling stability. By combination of feedforward control and feedback control, the front and rear wheel steering angles are controlled simultaneously to follow both the desired sideslip angle and the yaw rate of the reference vehicle model.A nonlinear three degree-of-freedom four wheel steering vehicle model containing lateral, yaw and roll motions is built up, which also takes the dynamic effects of crosswind into consideration.The disturbance observer based control method is provided to cope with ignored nonlinear dynamics and to handle exogenous disturbances. Finally, a simulation experiment is carried out,which shows that the proposed four wheel steering vehicle can guarantee handling stability and present strong robustness against external disturbances.

Color-texture segmentation using JSEG based on Gaussian mixture modeling

An improved approach for J-value segmentation （JSEG） is presented for unsupervised color image segmentation. Instead of color quantization algorithm, an automatic classification method based on adaptive mean shift （AMS） based clustering is used for nonparametric clustering of image data set. The clustering results are used to construct Gaussian mixture modelling （GMM） of image data for the calculation of soft J value. The region growing algorithm used in JSEG is then applied in segmenting the image based on the multiscale soft J-images. Experiments show that the synergism of JSEG and the soft classification based on AMS based clustering and GMM overcomes the limitations of JSEG successfully and is more robust.

Reduced Model Based Control of Two Link Flexible Space Robot

Model based control schemes use the inverse dynamics of the robot arm to produce the main torque component necessary for trajectory tracking. For model-based controller one is required to know the model parameters accurately. This is a very difficult task especially if the manipulator is flexible. So a reduced model based controller has been developed, which requires only the information of space robot base velocity and link parameters. The flexible link is modeled as Euler Bernoulli beam. To simplify the analysis we have considered Jacobian of rigid manipulator. Bond graph modeling is used to model the dynamics of the system and to devise the control strategy. The scheme has been verified using simulation for two links flexible space manipulator.

Application of the Improved Generalized Autoregressive Conditional Heteroskedast Model Based on the Autoregressive Integrated Moving Average Model in Data Analysis

This study firstly improved the Generalized Autoregressive Conditional Heteroskedast model for the issue that financial product sales data have singular information when applying this model, and the improved outlier detection method was used to detect the location of outliers, which were processed by the iterative method. Secondly, in order to describe the peak and fat tail of the financial time series, as well as the leverage effect, this work used the skewed-t Asymmetric Power Autoregressive Conditional Heteroskedasticity model based on the Autoregressive Integrated Moving Average Model to analyze the sales data. Empirical analysis showed that the model considering the skewed distribution is effective.

Performance-based Research Funding in Denmark: The Adoption and Translation of the Norwegian Model

Purpose: The main goal of this study is to outline and analyze the Danish adoption and translation of the Norwegian Publication Indicator. Design/methodology/approach: The study takes the form of a policy analysis mainly drawing on document analysis of policy papers, previously published studies and grey literature. Findings: The study highlights a number of crucial factors that relate both to the Danish process and to the final Danish result underscoring that the Danish BFI model is indeed a quite different system than its Norwegian counterpart. One consequence of these process-and design differences is the fact that the broader legitimacy of the Danish BFI today appears to be quite poor. Reasons for this include: unclear and shifting objectives throughout the process; limited willingness to take ownership of the model among stakeholders; lack of communication throughout the implementation process and an apparent underestimation of the challenges associated with the use of bibliometric indicators. Research limitation: The conclusions of the study are based on the authors’ interpretation of a long drawn and complex process with many different stakeholders involved. The format of this article does not allow for a detailed documentation of all elements, but further details can be provided upon request. Practical implications: The analysis may feed into current policy discussions on the future of the Danish BFI. Originality/value: Some elements of the present analysis have previously been published in Danish outlets, but this article represents the first publication on this issue targeting a broader international audience.

Physically based modeling and animation of tornado

Realistic modeling and rendering of dynamic tornado scene is recognized as a challenging task for researchers of computer graphics. In this paper a new physically based method for simulating and animating tornado scene is presented. We first propose a Two-Fluid model based on the physical theory of tornado, then we simulate the flow of tornado and its interaction with surrounding objects such as debris, etc. Taking the scattering and absorption of light by the participating media into account, the illumination effects of the tornado scene can be generated realistically. With the support of graphics hardware, various kinds of dynamic tornado scenes can be rendered at interactive rates.

Characterization of Amino Acid Based Molecular Micelles with Molecular Modeling

The enantiomers of chiral drugs often have different potencies, toxicities, and biochemical properties. Therefore, the FDA and other worldwide regulatory agencies require manufactures to test and prove the enantiomeric purity of chiral drugs. Amino acid based molecular micelles (AABMM) have been used in chiral CE separations since the 1990’s because of their low environmental impact and because their properties can easily be tuned by changing the amino acids in the chiral surfactant head groups. Using molecular dynamics simulations to investigate the structures and properties of AABMM is part of an ongoing study focusing on investigating and elucidating the factors responsible for chiral recognition with AABMM. The results will be useful for the proper design and selection of more efficient chiral selectors. The micelles investigated contained approximately twenty covalently linked surfactant monomers. Each monomer was in turn composed of an undecyl hydrocarbon chain bound to a dipeptide headgroup containing of all combinations of L-Alanine, L-Valine, and L-Leucine. These materials are of interest because they are effective chiral selectors in capillary electrophoresis separations. Molecular dynamics simulation analyses were used to investigate how the sizes and positions of the headgroup amino acid R-groups affected the solvent accessible surface areas of each AABMM chiral center. In addition, headgroup dihedral angle analyses were used to investigate how amino acid R-group size and position affected the overall headgroup conformations. Finally, distance measurements were used to study the structural and conformational flexibilities of each AABMM headgroup. All analyses were performed in the context of a broader study focused on developing structure-based predictive tools to identify the factors responsible for a) self-assembly, b) function, c) higher ordered structure and d) molecular recognition of these amino acid based molecular micelles.

An elasto-plastic constitutive model of moderate sandy clay based on BC-RBFNN

Application research of neural networks to geotechnical engineering has become a hotspot nowadays.General model may not reach the predicting precision in practical application due to different characteristics in different fields.In allusion to this,an elasto-plastic constitutive model based on clustering radial basis function neural network(BC-RBFNN) was proposed for moderate sandy clay according to its properties.Firstly,knowledge base was established on triaxial compression testing data;then the model was trained,learned and emulated using knowledge base;finally,predicting results of the BC-RBFNN model were compared and analyzed with those of other intelligent model.The results show that the BC-RBFNN model can alter the training and learning velocity and improve the predicting precision,which provides possibility for engineering practice on demanding high precision.

Urban Metabolism Based on Emergy and Slack Based Model: A Case Study of Beijing, China

The key to studying urban sustainable development depends on quantifying stores, efficiencies of urban metabolisms and capturing urban metabolisms′ mechanisms. This paper builds up the metabolic emergy account and quantifies some important concepts of emergy stores. Emphasis is placed on the urban metabolic model based on the slack based model(SBM) method to measure urban metabolic efficiencies. Urban metabolic mechanisms are discussed by using the regression method. By integrating these models, this paper analyzes the urban metabolic development in Beijing from 2001 to 2010. We conclude that the metabolic emergy stores of Beijing increased significantly from 2001 to 2010, with the emergy imported accounting for most of the increase. The metabolic efficiencies in Beijing have improved since the 2008 Olympic Games. The population, economic growth, industrial structures, and environmental governance positively affect the overall urban metabolism, while the land expansion, urbanization and environmentally technical levels hinder the improving of urban metabolic efficiencies. The SBM metabolic method and the regression model based on the emergy analysis provide insights into the urban metabolic efficiencies and the mechanism. They can promote to integrate such concepts into their sustainability analyses and policy decisions.

GENERATIVE CAPP APPROACH BASED ON RESOURCE MODEL AND FEATURE MODEL

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A Custom Manipulator for Dental Implantation Through Model-Based Design

This paper presents a Model-Based Design(MBD)approach for the design and control of a customized manipulator intended for drilling and position-ing of dental implants accurately with minimal human intervention.While performing an intra-oral surgery for a prolonged duration within a limited oral cavity,the tremor of dentist's hand is inevitable.As a result,wielding the drilling tool and inserting the dental implants safely in accurate position and orientation is highly challenging even for experienced dentists.Therefore,we introduce a customized manipulator that is designed ergonomically by taking in to account the dental chair specifications and anthropomorphic data such that it can be readily mounted onto the existing dental chair.The manipulator can be used to drill holes for dental inserts and position them with improved accuracy and safety.Further-more,a thorough multi-body motion analysis of the manipulator was carried out by creating a virtual prototype of the manipulator and simulating its controlled movements in various scenarios.The overall design was prepared and validated in simulation using Solid works,MATLAB and Simulink through Model Based Design(MBD)approach.The motion simulation results indicate that the manipulator could be built as a prototype readily.

3D Geometry-Based UAV-MIMO Channel Modeling and Simulation

A more general narrowband regular-shaped geometry-based statistical model(RS-GBSM) combined with the line of sight(LoS) and single bounce(SB) rays for unmanned aerial vehicle(UAV) multiple-input multiple-output(MIMO) channel is proposed in this paper. The channel characteristics, including space-time correlation function(STCF), Doppler power spectral density(DPSD), level crossing rate(LCR) and average fade duration(AFD), are derived based on the single sphere reference model for a non-isotropic environment. The corresponding sum-of-sinusoids(SoS) simulation models including both the deterministic model and statistical model with finite scatterers are also proposed for practicable implementation. The simulation results illustrate that the simulation models well reproduce the channel characteristics of the single sphere reference model with sufficient simulation scatterers. And the statistical model has a better approximation of the reference model in comparison with the deterministic one when the simulation trials of the stochastic model are sufficient. The effects of the parameters such as flight height, moving direction and Rice factor on the characteristics are also studied.