Enlightenment and Suggestions on the Construction of Information Platform and Processing Mechanism of Drug Shortages in Developed Countries to China

Objective To study how to improve and perfect the information platform and processing mechanism of drug shortages in China.Methods By searching the relevant policies from official websites of FDA,European Medicines Agency(EMA),Health Canada(HC)and National Health Commission,the good experience of the United States,the European Union and Canada in the construction of information platform and processing mechanism of drug shortages was summarized for reference in China.Results and Conclusion China has initially established the processing mechanism of drug shortages,but the platform construction should be improved,and the information disclosure of drug shortages varies from province to province.We should improve the information platform of drug shortages,strengthen the disclosure and communication of information,enrich the processing tools and measures after the drug shortages occurs,and strengthen the cooperation with relevant associations and other non-governmental departments.

Evolutionary game analysis of problem processing mechanism in new collaboration

This paper analyzes a problem processing mechanism in a new collaboration system between the main manufacturer and the supplier in the"main manufacturer-supplier"mode,which has been widely applied in the collaborative development management of the complex product.This paper adopts the collaboration theory,the evolutionary game theory and numerical simulation to analyze the decision-making mechanism where one upstream supplier and one downstream manufacturer must process an unpredicted problem without any advance contract in common.Results show that both players'decision-makings are in some correlation with the initial state,income impact coefficients,and dealing cost.It is worth noting that only the initial state influences the final decision,while income impact coefficients and dealing cost just influence the decision process.This paper shows reasonable and practical suggestions for the manufacturer and supplier in a new collaboration system for the first time and is dedicated to the managerial implications on reducing risks of processing problems.

Reconstruction algorithm of super-resolution infrared image based on human vision processing mechanism

Aiming at solving the problem of low resolu- tion and visual blur in infrared imaging, a super-resolution infrared image reconstruction method using human vision processing mechanism （HVPM） was proposed. This method combined a mechanism of vision lateral inhibition with an algorithm projection onto convex sets （POCS） reconstruction, the improved vision lateral inhibition network was utilized to enhance the contrast between object and background of low-resolution image sequences, then POCS algorithm was adopted to reconstruct super- resolution image. Experimental results showed that the proposed method can significantly improve the visual effect of image, whose contrast and information entropy of reconstructed infrared images were improved by approxi- mately 5 times and 1.6 times compared with traditional POCS reconstruction algorithm, respectively.

Mechanisms underlying syntactic and semantic processing of Chinese simple sentences Evidence from event-related brain potentials

This study sought to test the processing of three types of sentences in Chinese, as correct sentences, semantic violation sentences, and sentences containing semantic and syntactic violations, based on the following sentence pattern： ＂subject （noun） ＋ yi/gang/zheng ＋ predicate （verb）＂. Event-related potentials on the scalp were recorded using 32-channel electroencephalography. Compared with correct sentences, target words elicited an early left anterior negativity （N400） and a later positivity （P600） over frontal, central and temporal sites in sentences involving semantic violations. In addition, when sentences contained both semantic and syntactic violations, the target words elicited a greater N400 and P600 distributed in posterior brain areas. These results indicate that Chinese sentence comprehension involves covert grammar processes.

Processing map and hot working mechanisms of Cu-Ag alloy in hot compression process

For Gu-Ag alloy, an important parameter called workability in the forming process of materials can be evaluated by processing maps yielded from the stress-strain data generated by hot compression tests at temperatures of 700-850 °C and strain rates of 0.01-10 s-1. And at the true strain of 0.15, 0.35 and 0.55, respectively, the responses of strain-rate sensitivity, power dissipation efficiency and instability parameter to temperature and strain rate were studied. Instability maps and power dissipation maps were superimposed to form processing maps, which reveal the determinate regions where individual metallurgical processes occur and the limiting conditions of flow instability regions. Furthermore, the optimal processing parameters for bulk metal working are identified clearly by the processing maps.

Formation mechanism of a smooth, defectfree surface of fused silica optics using rapid CO2 laser polishing

Surface defects introduced by conventional mechanical processing methods can induce irreversible damage and reduce the service life of optics applied in high-power lasers.Compared to mechanical processing,laser polishing with moving beam spot is a noncontact processing method,which is able to form a defect-free surface.This work aims to explore the mechanism of forming a smooth,defect-free fused silica surface by high-power density laser polishing with coupled multiple beams.The underlying mechanisms of laser polishing was revealed by numerical simulations and the theoretical results were verified by experiments.The simulated polishing depth and machined surface morphology were in close agreement with the experimental results.To obtain the optimized polishing quality,the effects of laser polishing parameters(e.g.overlap rate,pulse width and polishing times)on the polishing quality were experimentally investigated.It was found that the processing efficiency of fused silica materials by carbon dioxide(CO2)laser polishing could reach 8.68 mm2 s−1,and the surface roughness(Ra)was better than 25 nm.Besides,the cracks on pristine fused silica surfaces introduced by initial grinding process were completely removed by laser polishing to achieve a defect-free surface.The maximum laser polishing rate can reach 3.88μm s−1,much higher than that of the traditional mechanical polishing methods.The rapid CO2 laser polishing can effectively achieve smooth,defect-free surface,which is of great significance to improve the surface quality of fused silica optics applied in high-power laser facilities.

Mechanism of Salt Migration Driven by Tectonic Processes:Insights from Physical and Numerical Modeling

1 Introduction Physical and numerical models are constructed to investigate the evolution and mechanism of salt migration driven by tectonic processes.In recent years,we have designed and ran series of models to simulate salt

Transformation Process and Mechanism of Lithium Borates

Amounts of lithium-containing salt lake brine resources are widely distributed in the four provinces named Qinghai,Tibet,Inner Mongolia and Xinjiang province,especially the salt lakes in Qinghai-Tibet Plateau are abundant of

China's Processing Trade Development for Mechanical and Electrical Products

Since the launch of the economic reform and opening to the outside world, China has seen rapid growth in its export of mechanical and electrical products, with its export

Experimental analysis for the dynamic initiation mechanism of debris flows

Debris flow is one of the major secondary mountain hazards following the earthquake. This study explores the dynamic initiation mechanism of debris flows based on the strength reduction of soils through static and dynamic triaxial tests. A series of static and dynamic triaxial tests were conducted on samples in the lab. The samples were prepared according to different grain size distribution, degree of saturation and earthquake magnitudes. The relations of dynamic shear strength, degree of saturation, and number of cycles are summarized through analyzing experimental results. The findings show that the gravelly soil with a wide and continuous gradation has a critical degree of saturation of approximately 87%, above which debris flows will be triggered by rainfall, while the debris flow will be triggered at a critical degree of saturation of about 73% under the effect of rainfall and earthquake(M>6.5). Debris flow initiation is developed in the humidification process, and the earthquake provides energy for triggering debris flows. Debris flows are more likely to be triggered at the relatively low saturation under dynamic loading than under static loading. The resistance of debris flow triggering relies more on internal frication angle than soil cohesion under the effect of rainfall and earthquake. The conclusions provide an experimental analysis method for dynamic initiation mechanism of debris flows.

A preliminary analysis of physical mechanism of transformation process from a landed typhoon into an extratropical cyclone

A diagnostic study is performed in the paper on the process of typhoon Norris (1980) transforming into an ex-tratropical cyclone after its landing over Southeast China. The main findings are as follows:The changes of kinetic energy are mainly attributed to the generation due to non-divergent wind. During the early stage of the typhoon landing, there exits only a small quantity of kinetic energy exchanging with the environment. And after it is transformed into an extratropical cyclone, a large amount of kinetic energy is exported from the system toward the environment.The horizontal and vertical flux-divergence terms of eddy available potenlial energy are the prominent sinks in the budgets of eddy kinetic energy. The generations of eddy kinetic energy due to both the barotropic and baroclinic processes are source terms. The former is remarkable during the initial stage. But after the depression is transformed into an extratropical cyclone, the roles of the generation by the barotropic and baroclinic processes are reversed, 1. e. , the latter has become more significant than the former.Diabatic heating is the most dominant heat source. The terms of vertical heat flux by cumulus and large-scale motion are the major sinks. And the latter is prominent after the system is transformed into an extratropical cycfone.

THE APPLICATION OF MICROELECTRODE TO THE STUDY OF MULTISTEP ELECTRODE PROCESSES UNDER STEADY STATE CONDITIONS PART I EE MECHANISM

Under steady-state conditions, the general currents of EE reactions at disk,hemispherical and spherical microelectrodes are derived.From these equations, some electrode reaction parameters can be very simply obtained.

Multi-component quantitative and feed-forward neural network for pattern classification of raw and wine-processed Corni Fructus

Background:To promote the quality evaluation,clarify the processing mechanism and distinguish origins of Corni Fructus(cornus)from different regions.Methods:This study developed a high performance liquid chromatography method for simultaneous determination of 5-hydroxymethylfurfural,2 phenolic acids and 4 iridoid glycosides and the reference fingerprint of cornus from different regions.In addition,the feedforward neural network model provided a pattern classification of sample regions.Results:The content of morroniside and loganin were the highest in all raw cornus samples ranging from 9.45μg/mg to 16.3μg/mg and 6.64μg/mg to 13.7μg/mg,respectively.The level of sweroside in raw cornus from Henan(0.83μg/mg^(-1).39μg/mg)and Zhejiang(0.64μg/mg^(-1).17μg/mg)were greater than other origins.After wine-processing,the glucose or fructose were dehydrated to increase the levels of 5-hydroxymethylfurfural.The C-4 position of-COOCH3 of hot-sensitive iridoid glycosides was hydrolyzed to generate-COOH as stable components.Polyphenol derivatives may be degraded to increase the content of phenolic acid.Subsequently,an excellent feedforward neural network model for identification of raw cornus and wine-prepared cornus was established which could distinguish the sample origins.Conclusion:This work provided a trustworthy method to evaluate the quality and distinguish the sources of cornus.Meanwhile,the clear processing mechanism provided a scientific foundation for controlling the cornus quality during wine-processing.

NUMERICAL SIMULATION OF ROUND TO OVAL ROLLING PROCESS

Three dimensional thermal-mechanical coupled elasto-plastic FEM has been used for simulation of round to oval single pass rolling. The analysis was conducted using MARC/AUTOFORCE1. 2 code. The material is assumed to be elasto-plastic and it obey the Von Mises yield criterion and Prandtl- Reuss rule. Deformation of the workpiece is simulated in a step-by-step manner,updating the coordinates of material points and the property after each step, so that both nonsteady-state and stendy-state deformation can be simulated. The heat transfter between the workpiece, the rolls, and enviroment and the heat generation due to plastic work and friction force, are considered in the analys- is.Predicted the deformation shape of the workpiece, distributions of strains, stresses, strain rates and temperatures, roll-separating force and roll torque are presented.

Laboratory Simulation of the Formation Process of Surface Geochemical Anomalies Applied to Hydrocarbon Exploration

The formation mechanisms and processes of geochemical anomalies used as proxies in surface geochemistry exploration （SGE） have not been well understood. Previous studies cannot realize 3D measurement of microseeping hydrocarbons from reservoirs to the surface, which made it difficult to understand the features and pathways of deep hydrocarbon microseepages. Understanding the processes of hydrocarbon microseepages will contribute to the acceptance and effectiveness of surface geochemistry. Based on a simplified geological model of hydrocarbon microseepages, including hydrocarbon reservoir, direct caprock, overlying strata and Quaternary sediments, this work established a 3D experimental system to simulate the mechanisms and processes of deep hydrocarbon microseepes extending to the surface. The dispersive halos of microseeping hydrocarbons in the subsurface were adequately described by using this 3D experimental system. Results indicate that different migration patterns of hydrocarbons above the point gas source within the simulated caprock and overlying strata can be reflected by the ratio of i-butane to n-butane （i-C4/n-C4）, which follow diffusion and infiltration （buoyancy） mechanisms. This is not the case for vertical measurement lines far from the point gas source. A vertical gas flow in the form of a plume was found during hydrocarbon microseepage. For sampling methods, the high-density grid sampling is favorable for delineating prospecting targets. Hydrocarbon infiltration or buoyancy flow occurs in the zones of infiltration clusters, coupling with a diffusion mechanism at the top of the water table and forming surface geochemical anomalies. These results are significant in understanding hydrocarbon microseepage and interpreting SGE data.

Evolution of microstructure and mechanical properties of A356 aluminium alloy processed by hot spinning process

The evolution of microstructure and mechanical properties of A356 aluminum alloy subjected to hot spinning process has been investigated. The results indicated that the deformation process homogenized microstructure and improved mechanical properties of the A356 aluminum alloy. During the hot spinning process, eutectic Si particles and Fe-rich phases were fragmented, and porosities were eliminated. In addition, recrystallization of Al matrix and precipitation of Al Si Ti phases occurred. The mechanical property testing results indicated that there was a significant increase of ductility and a decrease of average microhardness in deformed alloy over die-cast alloy. This is attributed to uniform distribution of finer spherical eutectic Si particles, the elimination of casting defects and to the recrystallized finer grain structure.

Experimental investigation on the energy evolution of dry and water-saturated red sandstones

In order to investigate the effect of water content on the energy evolution of red sandstone, the axial loading–unloading experiments on dry and water-saturated sandstone samples were conducted, and the distribution and evolution of elastic energy and dissipated energy within the rock were measured.The results show that the saturation process from dry to fully-saturated states reduces the strength, rigidity and brittleness of the rock by 30.2%, 25.5% and 16.7%, respectively. The water-saturated sample has larger irreversible deformation in the pre-peak stage and smaller stress drop in the post-peak stage.The saturation process decreases the accumulation energy limit by 38.9%, but increases the dissipated energy and residual elastic energy density, thus greatly reducing the magnitude and rate of energy release. The water-saturated sample has lower conversion efficiency to elastic energy by 3% in the prepeak region; moreover, the elastic energy ratio falls with a smaller range in the post-peak stage.Therefore, saturation process can greatly reduce the risk of dynamic disaster, and heterogeneous water content can lead to dynamic disaster possibly on the other hand.

Nonlocal Physics in the Wave Function Terminology

Shortcomings of the Boltzmann physical kinetics and the Schrödinger wave mechanics are considered. From the position of nonlocal physics, the Schrödinger equation is a local equation;this fact leads to the great shortcomings of the linear Schrödinger wave mechanics. Nonlocal nonlinear quantum mechanics is considered using the wave function terminology.

Ecological predictors of extinction risks of endemic mammals of China

In this brief report, we analyzed ecological correlates of risk of extinction for mammals endemic to China using phylogenetic eigenvector methods to control for the effect of phylogenetic inertia. Extinction risks were based on the International Union for Conservation of Nature （IUCN） Red List and ecological explanatory attributes that include range size and climatic variables. When the effect of phylogenetic inertia were controlled, climate became the best predictor for quantifying and evaluating extinction risks of endemic mammals in China, accounting for 13% of the total variation. Range size seems to play a trivial role, explaining -1% of total variation; however, when non-phylogenetic variation partitioning analysis was done, the role of range size then explained 7.4% of total variation. Consequently, phylogenetic inertia plays a substantial role in increasing the explanatory power of range size on the extinction risks of mammals endemic to China. Limitations of the present study are discussed, with a focus on under-represented sampling of endemic mammalian species.

Broadband spectral fitting of blazars using XSPEC

The broadband spectral energy distribution（SED） of blazars is generally interpreted as radiation arising from synchrotron and inverse Compton mechanisms. Traditionally,the underlying source parameters responsible for these emission processes,like particle energy density,magnetic field,etc.,are obtained through simple visual reproduction of the observed fluxes. However,this procedure is incapable of providing confidence ranges for the estimated parameters. In this work,we propose an efficient algorithm to perform a statistical fit of the observed broadband spectrum of blazars using different emission models. Moreover,we use the observable quantities as the fit parameters,rather than the direct source parameters which govern the resultant SED. This significantly improves the convergence time and eliminates the uncertainty regarding initial guess parameters. This approach also has an added advantage of identifying the degenerate parameters,which can be removed by including more observable information and/or additional constraints. A computer code developed based on this algorithm is implemented as a user-defined routine in the standard X-ray spectral fitting package,XSPEC. Further,we demonstrate the efficacy of the algorithm by fitting the well sampled SED of blazar 3 C 279 during its gamma ray flare in 2014.