Establishment of Regional Green Innovation Value Chains:A Case Study on Tackling the Impeded Diffusion of Green Products

The green innovation value chain is a key step in transforming green,innovative scientific,and technological achievements into productive forces.The establishment of green innovation value chains based on value distribution rather than technical conditions can effectively overcome the common bottleneck faced by different nations during their green innovation endeavors,namely,the substitution of conventional products with green alternatives.This study investigates the impeded diffusion of green products and their underlying causes,analyzes the internal structure and mechanism of the green innovation value chain,and explores the establishment of regional green innovation value chains and the models available for value chain upgrading.

An Intelligent Turn With a focus on innovation and digitisation,the new quality productive forces will have far-reaching impact on the society

Chinese President Xi Jinping has put forward a series of theoretical explanations on new quality productive forces.He has stressed that high-quality development has to be supported by a new productivity theory.Since new productive forces have emerged and played a strong role in driving and supporting high-quality development,they should be theorised systematically to guide further development.

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and treatment.Compared with the global average,Asia,notably China,reports disproportionately high GC incidences.The disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised out-comes.Thus,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce mortality.METHODS Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December 2023.The associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were examined.RESULTS Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM stage.Hence,abnormal coagulation system activation was closely related to disease progression.Elevated FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic risk.CONCLUSION Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

Scalable Ir‑Doped NiFe_(2)O_(4)/TiO_(2)Heterojunction Anode for Decentralized Saline Wastewater Treatment and H_(2)Production

Wastewater electrolysis cells(WECs)for decentralized wastewater treatment/reuse coupled with H_(2)production can reduce the carbon footprint associated with transportation of water,waste,and energy carrier.This study reports Ir-doped NiFe_(2)O_(4)(NFI,~5 at%Ir)spinel layer with TiO_(2)overlayer(NFI/TiO_(2)),as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment cell.In dilute(0.1 M)NaCl solutions,the NFI/TiO_(2)marks superior activity and selectivity for chlorine evolution reaction,outperforming the benchmark IrO_(2).Robust operation in near-neutral pH was confirmed.Electroanalyses including operando X-ray absorption spectroscopy unveiled crucial roles of TiO_(2) which serves both as the primary site for Cl−chemisorption and a protective layer for NFI as an ohmic contact.Galvanostatic electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO_(2)not only achieves quasi-stoichiometric NH_(4)^(+)-to-N_(2)conversion,but also enhances H_(2)generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive chlorine.The scaled-up WEC with NFI/TiO_(2)was demonstrated for electrolysis of toilet wastewater.

Review of renewable energy-based hydrogen production processes for sustainable energy innovation

In this review,we primarily analyze the hydrogen production technologies based on water and biomass,including the economic,technological,and environmental impacts of different types of hydrogen production technologies based on these materials,and comprehensively compare them.Our analyses indicate that all renewable energy-based approaches for hydrogen production are more environmentally friendly than fossil-based hydrogen generation approaches.However,the technical ease and economic efficiency of hydrogen production from renewable sources of energy needs to be further improved in order to be applied on a large scale.Compared with other renewable energy-based methods,hydrogen production via biomass electrolysis has several advantages,including the ease of directly using raw biomass.Furthermore,its environmental impact is smaller than other approaches.Moreover,using a noble metal,catalyst-free anode for this approach can ensure a considerably low power consumption,which makes it a promising candidate for clean and efficient hydrogen production in the future.

Impact of the Built Environment on the Spatial Heterogeneity of Regional Innovation Productivity:Evidence from the Pearl River Delta,China

With the global economy increasingly dependent on innovation,urban discourse has shifted to consider what kinds of spatial designs may best nurture innovation.We examined the relationship between the built environment and the spatial heterogeneity of regional innovation productivity(RIP)using the example of China's Pearl River Delta(PRD).Based on a spatial database of 522546 patent data from 2017,this study proposed an innovation-based built environment framework with the following five aspects:healthy en-vironment,daily interaction,mixed land use,commuting convenience,and technology atmosphere.Combining negative binomial regression and Geodetector to examine the impact of the built environment on RIP,the results show that the spatial distribution of innovation productivity in the PRD region is extremely uneven.The negative binomial regression results show that the built environment has a significant impact on the spatial differentiation of RIP,and,specifically,that healthy environment,mixed land use,commuting convenience,and technology atmosphere all demonstrate significant positive impacts.Meanwhile,the Geodetector results show that the built environment factor impacts the spatial heterogeneity of RIP to varying degrees,with technology atmosphere demonstrating the greatest impact intensity.We conclude that as regional development discourse shifts focus to the knowledge and innovation economy,the innovation-oriented design and updating of built environments will become extremely important to policymakers.

Can environmental regulation promote industrial innovation and productivity?Based on the strong and weak Porter hypothesis

This paper constructed extended CDM model to study the effects of environmental regulation on industrial innovation and productivity based on the perspective of strong and weak "Porter hypothesis",by using 28 manufacturing industry panel data of 2003-2014. The findings reveal that:(1) the impact of environmental regulation on R&D intensity lags behind. In the long run,environmental regulation intensity has a significant role in promoting R&D investment in manufacturing industry.(2) The R&D has a significant role in promoting the substantial innovation of manufacturing industry, and has a strong lag and continuity. However, the R&D intensity has no obvious effect on strategic innovation of manufacturing industry.(3) The substantial innovation doesn't significantly promote the economic performance of manufacturing industry, but it has a significant role in promoting the energy performance of manufacturing industry, and the substantial innovation plays a significant role in promoting environmental performance in the long term. The strategic innovation significantly promotes the economic performance of manufacturing industry, and it inhibits the energy performance and has no significant effect on environmental performance in the short term. It can promote the energy performance of manufacturing industry, but significantly inhibit environmental performance in the long term.(4) Environmental regulation has significantly suppressed the substantive innovation and strategic innovation of manufacturing industry, and the weak Porter hypothesis has not yet been supported. In the short term, environmental regulation inhibits manufacturing economic performance, but it can promote energy and environmental performance. In the long run, environmental regulation promotes the economic and energy performance of manufacturing industry, but it inhibits environmental performance. The establishment of strong Porter hypothesis has a certain scenario.

Personalization for Massive Product Innovation Using Open Architecture

Product innovation is creation of new concepts to plan and realize technological and functional details in the product to satisfy market and customer needs. One of the key drivers to product innovation is reactions of the product to users’ needs. Product innovation needs a cognitive design method based on needs of variant users for the product personalization. In this paper, an open concept is introduced to provide ways to meet user’s individual need in product lifespan. It is for industries to propose product concepts based on open sources, develop and support the product on the public capability. Using the open concept in the product architecture, called open?architecture product(OAP), can improve the product personalization leading to massive product innovation. To promote this promise of the OAP, effective methods are discussed for the OAP development. This paper introduces research on OAPs using adaptable design methods to meet product personalization. Adaptable design is based on the modular structure for product adaptability using function modules and adaptable interfaces. The proposed method provides solutions for planning modules and implementation of OAPs. Methods of OAP module planning, detail and interface design are described for transformation of product concepts into physical structures. A multiple?purpose electrical car is developed in a case study to show effectiveness of the proposed method.

Creative Industries Agglomeration,Regional Innovation and Productivity Growth in China

This paper falls into the broad area of economic geography and economics of creativity,and it presents an alternative approach to explain why total factor productivity(TFP)growth is different across China′s regions.It establishes an empirical model to estimate the spatial agglomeration effects of creative industries on regional TFP growth,using China′s provincial panel data during the period of 2003 to 2010.We found that the creative industries agglomeration(CIA)has significant and positive impact on regional TFP growth.The result also implies that the CIA can facilitate regional TFP growth through promoting regional innovation instead of improving regional efficiency.Therefore,we argue that policy makers should take some measures to retain and establish more creative zones.

Potential Applications of Milk Fractions and Valorization of Dairy By-Products: A Review of the State-of-the-Art Available Data, Outlining the Innovation Potential from a Bigger Data Standpoint

The unique composition of milk makes this basic foodstuff into an exceptional raw material for the production of new ingredients with desired properties and diverse applications in the food industry. The fractionation of milk is the key in the development of those ingredients and products;hence continuous research and development on this field, especially various levels of fractionation and separation by filtration, have been carried out. This review focuses on the production of milk fractions as well as their particular properties, applications and processes that increase their exploitation. Whey proteins and caseins from the protein fraction are excellent emulsifiers and protein supplements. Besides, they can be chemically or enzymatically modified to obtain bioactive peptides with numerous functional and nutritional properties. In this context, valorization techniques of cheese-whey proteins, by-product of dairy industry that constitutes both economic and environmental problems, are being developed. Phospholipids from the milk fat fraction are powerful emulsifiers and also have exclusive nutraceutical properties. In addition, enzyme modification of milk phospholipids makes it possible to tailor emulsifiers with particular properties. However, several aspects remain to be overcome;those refer to a deeper understanding of the healthy, functional and nutritional properties of these new ingredients that might be barriers for its use and acceptability. Additionally, in this review, alternative applications of milk constituents in the non-food area such as in the manufacture of plastic materials and textile fibers are also introduced. The unmet needs, the cross-fertilization in between various protein domains,the carbon footprint requirements, the environmental necessities, the health and wellness new demand, etc., are dominant factors in the search for innovation approaches;these factors are also outlining the further innovation potential deriving from those “apparent” constrains obliging science and technology to take them into account.

Expansion of Technical Innovation and Demand Determines Production Organization Pattern in Strategic Emerging Industries——Taking Example of TFT-LCD Industry

Taking the evolution process of TFT-LCD industry as an example,this paper applied history-friendly model to analyze the effect of technology innovation and learning,and market demand growth and fluctuation on the evolution of production organization pattern in strategic emerging industries.Our research indicates that:(1) when market demand maintains linear growth,continuous technology innovation capabilities of vertically integrated enterprises in leading position of an industry are the key factor in deciding whether dominant production organization pattern will shift from vertical integration to specialization;(2) when market demand is in cyclical fluctuation,the technology learning capabilities of specialized enterprises in catch-up position are the key factor in deciding whether dominant production organization pattern will shift from vertical integration to specialization;(3) when market demand growth is under cyclical fluctuation,if the relative gap between technology innovation capabilities of vertically integrated enterprises and technology learning capabilities of specialized enterprises remains constant,the phase when industry cycle moves from trough to plateau is the best time window for specialized enterprises to catch up with and overtake vertically integrated enterprises.Hence,policy design supporting the development of strategic emerging industries should give full consideration to factors like market demand environment and technology innovation and learning capabilities of domestic enterprises.

Popular Science Animation for the Future Intelligent Agricultural Ecology of Agricultural Products Innovation Design and Promotion

The form of agricultural products promotion is also constantly updated with the continuous development of science and technology in recent years.Intelligent agriculture gradually leads the scientific and technological process of agricultural products planting,production,promotion and other fields,making agricultural production more efficient and controllable.The use of popular science animation in the innovative design and promotion of agricultural products will help to drive the agricultural economy,conform to the current new situation,and improve the competitiveness of agricultural products with the help of scientific and technological strength and innovation consciousness in this environment.

Fuzzy integral based measurement and assessment of medium and small enterprises'product innovation

A fuzzy integral based way of measurement assessment has been established by using linguistic varia-bles and combining fuzzy integral with hierarchy analysis for measurement of medium and small enterprises'product innovation. The conclusions drawn from analyses made with 20 medium and small enterprises providebases for governments to formulate applicable policies and for medium and small enterprises to enhance theirproduct innovation.

RESEARCH ON PRODUCT INNOVATION DESIGN IN VIRTUAL PRODUCT DEVELOPMENT

An integrated template of virtual product development alters primarilysequential tradition mode of product life cycle. The template integrates all processes of productdevelopment using digital modem. An environment of virtual product development provides productdevelopment environment of integration, communion, network, concurrent and collaboration. Combiningdevelopment of new rapier loom, an innovated design process is researched in virtual productdevelopment, which consists three portions: constructing an integration development environment,innovation design and manufacturing simulation. The innovated design process realizes reversedesign, mechanism concept design, structural design and analysis, performance analysis andmanufacturing process simulation of virtual product, which can enhance greatly product performanceand reduce cost and development cycle of new product.

Study on Customer Demands for Product Innovation

In order to improve the satisfaction degree of customers’individual demands for products and reduce the risk of the product innovation,the characteristics of customer demands for product innovation are analyzed,and the type and content of customer demands are discussed.Then the framework of customer demands acquisition for product innovation is established.Final- ly,the prototype system of customer demands information acquisition and product customization for product innovation which takes mobile phone as the example is developed successfully.

Study on Customer Demands for Product Innovation

In order to improve the satisfaction degree of customers’ individual demands on products and reduce the risk of the product innovation,the characteristics of customer demands for product innovation are analyzed,and their type and content are discussed. Then the framework of customer demands acquisition for product innovation is established. Finally,the prototype system of customer demands information acquisition and product customization for product innovation which takes mobile phone as the example is developed successfully.

Knowledge-Based Platform for Collaborative Innovation Development of Products

The platform of distributed design and resource sharing is important for medium-sized and small companies in developing products to improve competitiveness. As a background of creative product design, a knowledge model based on product collaborative innovation development of products (CIDP) is proposed. Characteristics of CIDP are analyzed, and the framework and key technologies of the CIDP-platform based knowledge studied. Through integration of existing system and interface designs, a development platform has been built to support the PCID within knowledge-based engineering (KBE). An example is presented, indicating that the prototype system is maneuverable and practical.

Mechanical Modeling and Analysis of Stability Deterioration of Production Well During Marine Hydrate Depressurization Production

Different from oil and gas production,hydrate reservoirs are shallow and unconsolidated,whose mechanical properties deteriorate with hydrate decomposition.Therefore,the formations will undergo significant subsidence during depressurization,which will destroy the original force state of the production well.However,existing research on the stability of oil and gas production wells assumes the formation to be stable,and lacks consideration of the force exerted on the hydrate production well by formation subsidence caused by hydrate decomposition during production.To fill this gap,this paper proposes an analytical method for the dynamic evolution of the stability of hydrate production well considering the effects of hydrate decomposition.Based on the mechanical model of the production well,the basis for stability analysis has been proposed.A multi-field coupling model of the force state of the production well considering the effect of hydrate decomposition and formation subsidence is established,and a solver is developed.The analytical approach is verified by its good agreement with the results from the numerical method.A case study found that the decomposition of hydrate will increase the pulling-down force and reduce the supporting force,which is the main reason for the stability deterioration.The higher the initial hydrate saturation,the larger the reservoir thickness,and the lower the production pressure,the worse the stability or even instability.This work can provide a theoretical reference for the stability maintaining of the production well.

Classification and technical target of water electrolysis for hydrogen production

Continuous efforts are underway to reduce carbon emissions worldwide in response to global climate change.Water electrolysis technology,in conjunction with renewable energy,is considered the most feasible hydrogen production technology based on the viable possibility of large-scale hydrogen production and the zero-carbon-emission nature of the process.However,for hydrogen produced via water electrolysis systems to be utilized in various fields in practice,the unit cost of hydrogen production must be reduced to$1/kg H_(2).To achieve this unit cost,technical targets for water electrolysis have been suggested regarding components in the system.In this paper,the types of water electrolysis systems and the limitations of water electrolysis system components are explained.We suggest guideline with recent trend for achieving this technical target and insights for the potential utilization of water electrolysis technology.