Reconstruction of the Global Economic Governance System and China’s Role under the Profound Changes

The world today is undergoing profound changes unseen in a century.In particular,under the impact of the COVID-19 pandemic and the Ukraine crisis,the global political and economic landscape has undergone unprecedentedly profound changes,and the current global economic governance system is facing multiple crises,such as the lack of legitimacy,effectiveness,and common values.Hence,promoting the reform of the global governance system is becoming the prevailing trend.

A safety evaluation of profound hypothermia-induced suspended animation for delayed resuscitation at 90 or 120min

Background: The successful treatment of military combat casualties with penetrating injuries is significantly dependent on the time needed to get the patient to an adequate treatment facility. Profound hypothermia induced suspended animation for delayed resuscitation(SADR) is a novel approach for inducing cardiac arrest and buying additional time for such injuries. However, the time used to safely administer circulatory arrest(CA) is controversial. The goal of this study was to evaluate the safety of hypothermia-induced SADR over 90 and 120 min time intervals.Methods: Sixteen male BAMA minipigs were randomized into two groups: CA90 group(90 min, n =8) and CA120 group(120 min, n =8). Cannulation of the right common carotid arteries and internal jugular veins was performed to establish cardiopulmonary bypass for each animal. Through the perfusion of cold organ preservation solution(OPS), cardioplegia and profound hypothermia(15℃) were induced. After CA, cardiopumonary bypass(CPB) was restarted, and the animals were gradually re-warmed and resuscitated. The animals were assisted with ventilators until spontaneous breathing was achieved. The index of hemodynamic perioperative serum chemistry values [alanine transaminase(ALT), aspartate aminotransferase(AST), creatinine(CR), lactic dehydrogenase(LDH) and troponin T(TnT)] and survival were observed from pre-operation to 7 days post-operation.Results: Fifteen animals were enrolled in the experiment, while 1 animal in CA120 group died from surgical error. All 8 animals in CA90 group recovered, with only 1 animal displaying mild disability. However, in CA120 group, only 2 animals survived with severe disability, and the other 5 animals died after 2 days post-operation. In CA90 group, the perioperative serum chemistry values increased at 1 day post-operation(ALT 84.43±18.65 U/L; AST 88.99±23.19 U/L; Cr 87.90±24.49μmol/L; LDH 1894.13±322.26 U/L; TnT 0.849±0.135 ng/ml) but decreased to normal or almost normal levels at 7 days post-operation(ALT 52.48±9.04 U/L; AST 75.23±21.46 U/L; Cr 82.69±18.41μmol/L; LDH 944.67±834.32 U/L; TnT 0.336±0.076 ng/ml).Conclusion: Profound hypothermia-induced SADR is an effective method for inducing cardiac arrest. Our results indicate that inducing CA for 90 min(at 15℃) is safer than doing so for 120 min. Our results indicate that 120 min of CA at 15℃ is dangerous and can result in high mortality and severe neurological complications. Further experimentation is needed to determine whether 120 min of CA at temperatures lower than 15℃ can lead to safe recovery.

PROfound研究——前列腺癌精准治疗新希望

转移性去势抵抗性前列腺癌(metastatic castrate-resistant prostate cancer,mCRPC)是前列腺癌发展的终末阶段。患者生存预后很差。尽管不断地有新的治疗手段出现,比如新型内分泌治疗以及紫杉醇类化疗,mCRPC患者的生存期依然很有限。奥拉帕利是一款聚腺苷酸二磷酸核糖基聚合酶(poly ADP-ribose polymerase,PARP)抑制剂,PARP酶在DNA修复中扮演着重要的角色。奥拉帕利已经获批用于卵巢癌和乳腺癌的治疗。目前,奥拉帕利用于mCRPC治疗的Ⅲ期临床研究PROfound的结果在2019年的欧洲肿瘤内科学会(ESMO)年会与2020年的美国临床肿瘤学会-泌尿生殖系统肿瘤研讨会(ASCO-GU)已经发布。本文将带来PROfound研究的结果以及最新的结果更新。

Otolithic organ function in patients with profound sensorineural hearing loss

Profound sensorineural hearing loss (PSHL) is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs) via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.

The Significant and Profound Impacts of Chou’s 5-Steps Rule

In this short review paper, the significant and profound impacts of the 5-steps rule have been briefly recalled with crystal clear convincingness.

The Significant and Profound Impacts of Chou’s Invariance Theorem

In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.

The Significant and Profound Impacts of Chou’s Pseudo Amino Acid Composition or PseAAC

In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.

PSYCHOLOGICAL DEVELOPMENT OF CHILDREN AFTER CARDIAC SURGERY WITH PROFOUND HYPOTHERMIA AND CIRCULATORY ARREST

ＰＳＹＣＨＯＬＯＧＩＣＡＬＤＥＶＥＬＯＰＭＥＮＴＯＦＣＨＩＬＤＲＥＮＡＦＴＥＲＣＡＲＤＩＡＣＳＵＲＧＥＲＹＷＩＴＨＰＲＯＦＯＵＮＤＨＹＰＯＴＨＥＲＭＩＡＡＮＤＣＩＲＣＵＬＡＴＯＲＹＡＲＲＥＳＴＨｕａｎｇＨｕｉｍｉｎｇ（黄惠民），ＴａｏＳｕｄｉｅ（陶素...

Effects of hemodilution on neurological injury and cerebral amino acid content after circulatory arrest during profound hypothermia in rats

To investigate the effects of different degrees of hemodilution on neurological injury and amino acid content in different brain areas after deep hypothermic circulatory arrest (DHCA).Methods Forty-eight male adult SD rats weighing 400～450 g were randomly divided into 4 groups (n=12 each):group Ⅰ Hct 10%(H1);group Ⅱ Hct 20% (H2);group Ⅲ Hct 30%(H3) and control group (C).All animals except those in control group underwent DHCA at 18℃ for 90 min (includinhg cooling and rewarming) under general anesthesia with fentanyl,ketamine and droperidol.Different degrees of hemodilution were accomplised by changing the composition and volume of priming solution used in cardiopulmonary bypass (CPB).Hct was determined before,at the initiation of CPB and beginning of rewarming.PaO2,pH and blood lactate of arterial blood and SO2 of venous blood from internal jugular vein (SjvO2) were determined at the beginning and end of cooling and rewarming.The animals were killed and brains removed after recovery of circulatory function for the count of injured neurons and detemination of glutamate (Glu),aspartate (Asp),glycine (Gly),γ-aminobutyric acid (GABA) and taurine (Tau) contents in cortex,hippocampus and thalamus.Results The number of injured neurons in hippocampus and parietal cortex were significantly smaller in Hct 30% group than in the other two groups (P<0.05).The contents of the five amino acids in hippocampus and parietal cortex were all increased after DHCA.The Glu,Asp and Gly contents in hippocampus and parietal cortex were significantly lower in Hct 30% group than in the other 2 groups (P<0.05).There was no significant difference in GABA and Tau contents among the 3 groups.Conclusion Hemodilution at Hct 30% attenuates the neuronal injury after DHCA.The inhibition of the release of the excitatory amino acids in the brain may be involved in the mechanism of neuronal protection.13 refs,1 fig,3 tabs.

The Profound Revelation of Human Social Relations and the Profound Realization of Information Right of Citizens——The social significance of network technique advancement in the perspective of “Entity Cube”

The R＆D group of relationship searching in Microsoft Asia Research Institute explains ＂Entity Cube＂ launched in 2008 as follows：

双侧极重度感音神经性聋患儿人工耳蜗植入效果分析

目的分析双侧极重度感音神经性聋患儿人工耳蜗植入效果。方法选取2018年2月~2022年2月本院接诊的80例双侧极重度感音神经性聋患儿,将40例非对称性听力损失患儿纳入对照组,行单侧人工耳蜗植入;将40例对称性听力损失患儿纳入观察组,行双侧人工耳蜗植入;分析两组开机前和干预6、12、36个月后的听觉行为分级(CAP)、言语可懂度分级(SIR),并建立多因素logistic模型,分析双侧人工耳蜗植入后影响CAP、SIR评分的独立危险因素。结果观察组干预后12、36个月CAP、SIR评分显著高于对照组(P<0.05)。多因素logistic分析显示,年龄>3岁、术前未使用助听器、植入时间<1年、内耳畸形是影响双侧人工耳蜗植入儿童CAP、SIR评分的独立危险因素(P<0.05)。结论双侧人工耳蜗植入是极重度感音神经性聋患儿听觉补偿的有效手段,年龄、植入时间、内耳畸形等因素可能影响患儿的听觉、言语功能康复,尽早为患儿植入双侧人工耳蜗,加强相关干预,才能有效促使患儿听觉言语功能康复。

“人民美好生活体育需要”:内涵解读、深刻依据与重要保障

满足“人民美好生活体育需要”是新时代新征程促进体育高质量发展、加快体育强国建设的目标所在。运用文献资料法、逻辑分析法等,认为“人民美好生活体育需要”随着人们生活水平的提升和体育发展样态的丰富而持续拓展,具有深刻的学理基础和广泛的实践需求,既以丰富多样的物质性体育需要为基础,又以社会层面的精神性体育需要为提升。满足“人民美好生活体育需要”,是马克思主义体育学说的价值体现,是中国共产党体育观的初心体现,是社会主义体育事业的本质体现,是加快体育强国建设的目标体现,需要以立足人口规模巨大的国情为基础,以推动体育高质量发展为支撑,以打造良好的生态环境为依托,以实现共同富裕取得实质性进展为导向。

Lantern Festival: The New Platform for Cultural Exchanges Between China and the World

Theincreasinglyadvanced lantern technology and the emerging Chinese-style scenes are intertwined so that the lanternfestivals across China show the characteristics of combining traditional culture and modern innovation.As for international cultural exchanges,lantern art has connected different cultures with its unique artistic charm and profound cultural connotation.

世界百年未有之大变局的时代意蕴

世界百年未有之大变局不是一时一地一域之变,而是具有系统性、全局性和长远性的深刻变化。只有坚持正确的历史观、大局观和角色观,站在时代的高度才能准确把握世界百年未有之大变局的基本性质。从时代意蕴看,世界百年未有之大变局是世界历史由一元主导走向多元并存的时代,是资本主义和社会主义竞争格局重塑的时代,是中国发展与世界变局同步交织、相互激荡的时代,是中国为人类文明发展进步作出更大贡献的时代。深刻把握世界百年未有之大变局的时代意蕴,有助于我们更好地利用大势、发挥优势、引领态势。

主编寄语

I am delighted to make this address as the Editor-in-Chief of the Shantou University Medical College Journal(The SUMC Journal)(ISSN 1007-4716).It is with great enthusiasm and a profound sense of responsibility that I extend my warmest greetings to our dedicated authors,esteemed reviewers,and the broader academic community associated with the SUMC Journal.

Insights for Africa’s Industrialisation

The First Industrial Revolution in the 18th century started the modernisation process marked by profound economic,social,and cultural transformations in the world.Research shows that the process of industrialisation is closely associated with improvements in people’s living standards and their quality of life.Industrialisation,with economic and technological change at its core,is central to modernisation.

论汉画像艺术“深沉雄大”美的内在意蕴

汉画像艺术“深沉雄大”之美中富含深刻的内在意蕴。汉画像艺术的构图逻辑和丰富元素,展现出宏大豁达的胸怀,体现了汉代的“大一统”思想与包揽一切的宇宙观。其活力四射的形象、张力十足的画面、自由流动的线条体现出了“事死如生”的生死观,凸显出汉人对于生命延续的渴望。其包容自信的艺术姿态,高度肯定人的存在价值,展露出鲜明的主体意识。

论乡村振兴与全国统一大市场建设的良性互动

乡村振兴与全国统一大市场建设良性互动既是构建新发展格局的题中之义,也是全面建设社会主义现代化国家的关键举措。乡村振兴与全国统一大市场建设良性互动意义重大,应深刻把握其基本逻辑、深刻内涵与互动路径。当前,乡村振兴与全国统一大市场建设具有相同的底层逻辑,都需要解决地区发展不平衡、解决贸易壁垒,解决要素畅通受阻、解决市场割裂等问题。因此,应坚持以市场为导向,畅通城乡商品要素双向流通,打破市场壁垒;推进乡村优势产业联动供给,激发市场活力;拓展乡村资本数据建设渠道,驱动市场发展;完善乡村基础设施配套服务,夯实市场基础;推进城乡融合区域协调发展,提升市场效能等多种途径推进乡村振兴与全国统一大市场建设的良性互动。