This study aimed to explore the outcomes of progestin-primed ovarian stimulation protocol （PPOS） in aged infertile women who failed to get pregnant in the first IVF/ICSI-ET cycles with GnRH-a long protocol. A self-c...This study aimed to explore the outcomes of progestin-primed ovarian stimulation protocol （PPOS） in aged infertile women who failed to get pregnant in the first IVF/ICSI-ET cycles with GnRH-a long protocol. A self-controlled study was conducted to retrospectively investigate the clinical outcomes of 104 aged infertile patients who didn＇t get pregnant in the first IVF/ICSI-ET treatment by stimulating with GnRH-a long protocol （non-PPOS group）, and underwent PPOS protocol （PPOS group） in the second cycle between January 2016 and December 2016 in the Center for Reproductive Medicine, Renmin Hospital of Wuhan University. The primary outcomes included clinical pregnancy rate of frozen-thawed embryos transfer （FET） in PPOS group, and good-quality embryo rate in both groups. The secondary outcomes were fertilization rate, egg utilization rate and cycle cancellation rate. The results showed that there were no significant differences in basal follicle stimulating hormone （bFSH）, antral follicle count （AFC）, duration and total dosage of gonadotropin （Gn）, number of oocytes retrieved, intracytoplasmic sperm injection （ICSI） rate, fertilization rate, and cycle cancellation rate between the two groups （P〉0.05）. However, the oocyte utilization rate and good-quality embryo rate in PPOS group were significantly higher than those in non-PPOS group （P〈0.05）. By the end of April 2017, 62 FET cycles were conducted in PPOS group. The clinical pregnancy rate and embryo implantation rate were 22.58% and 12.70%, respectively. In conclusion, PPOS protocol may provide better clinical outcomes by improving the oocyte utilization rate and good-quality embryo rate for aged infertile patients who failed to get pregnant in the first IVF/ ICSI-ET cycles.展开更多
The specific bindings of estrogen,progestin and androgen were determined inthe cytosol fraction of myomatous,adenomyotic and postmenopausal uterine tissues andof the normal endometrium and myometrium as well.It was fo...The specific bindings of estrogen,progestin and androgen were determined inthe cytosol fraction of myomatous,adenomyotic and postmenopausal uterine tissues andof the normal endometrium and myometrium as well.It was found that theconcentrations of estrogen,progestin and androgen cytosol receptors were significantlyhigher in myomatous tissue than in normal myometrium;there was also an obvious differ-ence of the concentration of the sex steroid receptors between normal endometrium andadenomyotic tissue;and the uterine tissues of postmenopausal women still retained highlevels of these sex steroid receptors.In addition,the regulation of sex steroids in thepathogenesis of myoma and adenomyosis is discussed.展开更多
Estrogens and artificial progestins used in hormone replacement therapy increase breast cancer risk. This seems to bedue to a promoting and not initiating effect. A synergic effect of estradiol and hyperinsulinism has...Estrogens and artificial progestins used in hormone replacement therapy increase breast cancer risk. This seems to bedue to a promoting and not initiating effect. A synergic effect of estradiol and hyperinsulinism has been shown. Insulinplays a role in the increase of breast cancer risk when associated with android obesity, sedentariness, type II diabetes,and high glycemic index food, alcohol and trans fatty acids intake. Natural menopause induces insulin resistance anddoes not induce a risk decrease. The role of insulin gives a new outlook on the influence of HRT in breast cancer promotion:estradiol alone, which improves insulin-sensitivity, does not increase breast cancer risk. Artificial progestinsassociated with estrogens increase the risk, whereas estrogens associated with progesterone do not. This could be dueto the fact that artificial progestins increase insulin resistance, whereas natural progesterone does not. Adipose tissue,which is an endocrine gland, is insulin dependant. Breast cancer and its seriousness are correlated to adipocytokincirculating levels such as resistin, leptin, interleukin 1, adipocyte fatty acid-binding protein, and are inversely correlatedto the level of adiponectin. Insulin could play a synergic role with sexual steroids by a direct effect and by increasingadipose tissue secretions.展开更多
High-entropy materials(HEMs)have better mechanical,thermal,and electrical properties than traditional materials due to their special"high entropy effect".They can also adjust the performance of high entropy ...High-entropy materials(HEMs)have better mechanical,thermal,and electrical properties than traditional materials due to their special"high entropy effect".They can also adjust the performance of high entropy ceramics by adjusting the proportion of raw materials,and have broad application prospects in many fields.This article provides a review of the high entropy effect,preparation methods,and main applications of high entropy ceramic materials,especially exploring relevant research on high entropy perovskite ceramics.It is expected to provide reference for the promotion of scientific research and the development of further large-scale applications of high-entropy ceramic materials.展开更多
Rice tiller angle,as a component of plant architecture,affects rice grain yield via plant density.However,the molecular mechanism underlying rice tiller angle remains elusive.We report that the key domestication gene ...Rice tiller angle,as a component of plant architecture,affects rice grain yield via plant density.However,the molecular mechanism underlying rice tiller angle remains elusive.We report that the key domestication gene PROSTRATE GROWTH 1(PROG1)controls rice tiller angle by regulating shoot gravitropism and LAZY1(LA1)-mediated asymmetric distribution of auxin.Acting as a transcriptional repressor,PROG1 negatively regulates the expression of LA1 in light-grown rice seedlings.Overexpression of LA1 partially rescued the larger tiller angle of the PROG1 complementation transgenic plant(prog1-D).Double-mutant analysis showed that PROG1 acts upstream of LA1 to regulate shoot gravitropism and tiller angle.Mutation of Suppressors of lazy1(SOL1),encoding DWARF3(D3)acting in the strigolactone signal pathway,suppressed the large tiller angle of prog1-D by rescuing the transcription of LA1.The discovery of a light-sensitive PROG1-LA1 transcription regulatory module controlling rice shoot gravitropism and tiller angle sheds light on the genetic control of rice tiller angle.展开更多
Through systematic summary of domestic research documents about China's tourism-oriented poverty alleviation in recent 10 years,it is found that researches mainly focus on 5 aspects:effect of tourism-oriented pove...Through systematic summary of domestic research documents about China's tourism-oriented poverty alleviation in recent 10 years,it is found that researches mainly focus on 5 aspects:effect of tourism-oriented poverty alleviation,model and development strategy,benefit of poverty stricken people,practice of tourism-oriented poverty alleviation in specific region,and other related problems.At present,academic circle mainly has weak points of research content,method,object and region in tourism-oriented poverty alleviation.Finally,it points out key research interests:(1)Strengthening combination of qualitative and quantitative researches;(2)Expanding research fields and scope and promoting in-depth researches;(3)Analyzing benefiting mechanism of poverty-stricken people participating in tourism development in depth with poverty-stricken people as research objects;(4)Increasing scale development of perception research on effect of tourism-oriented poverty alleviation and research on measurement testing,to make subsequent research have reliability and comparability.展开更多
Objective To observe the change of the cardiova scular effect of estrogen replaceme nt therapy in rat after treated with p rogesterone.Method Thirty female rates were randomly di vided into three groups:group A:ova ri...Objective To observe the change of the cardiova scular effect of estrogen replaceme nt therapy in rat after treated with p rogesterone.Method Thirty female rates were randomly di vided into three groups:group A:ova rietcomy;group B:ovariectomy with estrogen replacement therapy and group C:ovariectomy with estrogen and progesterone replacement therapy.The estrogen receptors(ER)in the artery of the rat were measured and the serum level of nitric oxide(NO),endothelin-1(ET-1),prostacyclin(PGF 1a )and thromboxane(TXB 2 )were detected 2months later.Results(1)There was no apparent difference in ER expression,serum NO and PGF 1a level between group C and group B;these index of group B and C were higher than those of group A;(2)there was no significant difference in blood viscosity,the congregate i ndex of red blood cell and platelet adhesiveness rate between group B and C;these index of group B and C were lower than those of group A.Conclusion Estrogen replacement therapy addin g progesterone makes no influence on arterial ER expression,hemorheolo gy index and regulation of estrogen t o cardiovascular cytokines generation.It suggested that estrogen combined with progesterone replacement t herapy could be a safe and effective method to prevent coronary heart dis ease.展开更多
基金This work was supported by the National Natural Science Foundation of China （No.1471456）, and Guidance Foundation of Renmin Hospital of Wuhan University （No. RMYD2018Z13）.
文摘This study aimed to explore the outcomes of progestin-primed ovarian stimulation protocol （PPOS） in aged infertile women who failed to get pregnant in the first IVF/ICSI-ET cycles with GnRH-a long protocol. A self-controlled study was conducted to retrospectively investigate the clinical outcomes of 104 aged infertile patients who didn＇t get pregnant in the first IVF/ICSI-ET treatment by stimulating with GnRH-a long protocol （non-PPOS group）, and underwent PPOS protocol （PPOS group） in the second cycle between January 2016 and December 2016 in the Center for Reproductive Medicine, Renmin Hospital of Wuhan University. The primary outcomes included clinical pregnancy rate of frozen-thawed embryos transfer （FET） in PPOS group, and good-quality embryo rate in both groups. The secondary outcomes were fertilization rate, egg utilization rate and cycle cancellation rate. The results showed that there were no significant differences in basal follicle stimulating hormone （bFSH）, antral follicle count （AFC）, duration and total dosage of gonadotropin （Gn）, number of oocytes retrieved, intracytoplasmic sperm injection （ICSI） rate, fertilization rate, and cycle cancellation rate between the two groups （P〉0.05）. However, the oocyte utilization rate and good-quality embryo rate in PPOS group were significantly higher than those in non-PPOS group （P〈0.05）. By the end of April 2017, 62 FET cycles were conducted in PPOS group. The clinical pregnancy rate and embryo implantation rate were 22.58% and 12.70%, respectively. In conclusion, PPOS protocol may provide better clinical outcomes by improving the oocyte utilization rate and good-quality embryo rate for aged infertile patients who failed to get pregnant in the first IVF/ ICSI-ET cycles.
文摘The specific bindings of estrogen,progestin and androgen were determined inthe cytosol fraction of myomatous,adenomyotic and postmenopausal uterine tissues andof the normal endometrium and myometrium as well.It was found that theconcentrations of estrogen,progestin and androgen cytosol receptors were significantlyhigher in myomatous tissue than in normal myometrium;there was also an obvious differ-ence of the concentration of the sex steroid receptors between normal endometrium andadenomyotic tissue;and the uterine tissues of postmenopausal women still retained highlevels of these sex steroid receptors.In addition,the regulation of sex steroids in thepathogenesis of myoma and adenomyosis is discussed.
文摘Estrogens and artificial progestins used in hormone replacement therapy increase breast cancer risk. This seems to bedue to a promoting and not initiating effect. A synergic effect of estradiol and hyperinsulinism has been shown. Insulinplays a role in the increase of breast cancer risk when associated with android obesity, sedentariness, type II diabetes,and high glycemic index food, alcohol and trans fatty acids intake. Natural menopause induces insulin resistance anddoes not induce a risk decrease. The role of insulin gives a new outlook on the influence of HRT in breast cancer promotion:estradiol alone, which improves insulin-sensitivity, does not increase breast cancer risk. Artificial progestinsassociated with estrogens increase the risk, whereas estrogens associated with progesterone do not. This could be dueto the fact that artificial progestins increase insulin resistance, whereas natural progesterone does not. Adipose tissue,which is an endocrine gland, is insulin dependant. Breast cancer and its seriousness are correlated to adipocytokincirculating levels such as resistin, leptin, interleukin 1, adipocyte fatty acid-binding protein, and are inversely correlatedto the level of adiponectin. Insulin could play a synergic role with sexual steroids by a direct effect and by increasingadipose tissue secretions.
文摘High-entropy materials(HEMs)have better mechanical,thermal,and electrical properties than traditional materials due to their special"high entropy effect".They can also adjust the performance of high entropy ceramics by adjusting the proportion of raw materials,and have broad application prospects in many fields.This article provides a review of the high entropy effect,preparation methods,and main applications of high entropy ceramic materials,especially exploring relevant research on high entropy perovskite ceramics.It is expected to provide reference for the promotion of scientific research and the development of further large-scale applications of high-entropy ceramic materials.
基金supported by the Top Talents Program"One Case One Discussion(Yishiyiyi)"of Shandong Province and the Natural Science Foundation of Shandong Province(ZR2022MC082).
文摘Rice tiller angle,as a component of plant architecture,affects rice grain yield via plant density.However,the molecular mechanism underlying rice tiller angle remains elusive.We report that the key domestication gene PROSTRATE GROWTH 1(PROG1)controls rice tiller angle by regulating shoot gravitropism and LAZY1(LA1)-mediated asymmetric distribution of auxin.Acting as a transcriptional repressor,PROG1 negatively regulates the expression of LA1 in light-grown rice seedlings.Overexpression of LA1 partially rescued the larger tiller angle of the PROG1 complementation transgenic plant(prog1-D).Double-mutant analysis showed that PROG1 acts upstream of LA1 to regulate shoot gravitropism and tiller angle.Mutation of Suppressors of lazy1(SOL1),encoding DWARF3(D3)acting in the strigolactone signal pathway,suppressed the large tiller angle of prog1-D by rescuing the transcription of LA1.The discovery of a light-sensitive PROG1-LA1 transcription regulatory module controlling rice shoot gravitropism and tiller angle sheds light on the genetic control of rice tiller angle.
基金Supported by Fundamental Research Funds for the Central Universities in 2013(SWU1309219)of Southwest University
文摘Through systematic summary of domestic research documents about China's tourism-oriented poverty alleviation in recent 10 years,it is found that researches mainly focus on 5 aspects:effect of tourism-oriented poverty alleviation,model and development strategy,benefit of poverty stricken people,practice of tourism-oriented poverty alleviation in specific region,and other related problems.At present,academic circle mainly has weak points of research content,method,object and region in tourism-oriented poverty alleviation.Finally,it points out key research interests:(1)Strengthening combination of qualitative and quantitative researches;(2)Expanding research fields and scope and promoting in-depth researches;(3)Analyzing benefiting mechanism of poverty-stricken people participating in tourism development in depth with poverty-stricken people as research objects;(4)Increasing scale development of perception research on effect of tourism-oriented poverty alleviation and research on measurement testing,to make subsequent research have reliability and comparability.
文摘Objective To observe the change of the cardiova scular effect of estrogen replaceme nt therapy in rat after treated with p rogesterone.Method Thirty female rates were randomly di vided into three groups:group A:ova rietcomy;group B:ovariectomy with estrogen replacement therapy and group C:ovariectomy with estrogen and progesterone replacement therapy.The estrogen receptors(ER)in the artery of the rat were measured and the serum level of nitric oxide(NO),endothelin-1(ET-1),prostacyclin(PGF 1a )and thromboxane(TXB 2 )were detected 2months later.Results(1)There was no apparent difference in ER expression,serum NO and PGF 1a level between group C and group B;these index of group B and C were higher than those of group A;(2)there was no significant difference in blood viscosity,the congregate i ndex of red blood cell and platelet adhesiveness rate between group B and C;these index of group B and C were lower than those of group A.Conclusion Estrogen replacement therapy addin g progesterone makes no influence on arterial ER expression,hemorheolo gy index and regulation of estrogen t o cardiovascular cytokines generation.It suggested that estrogen combined with progesterone replacement t herapy could be a safe and effective method to prevent coronary heart dis ease.
