Two new chiral pyridine prolinol derivatives have been synthesized from N-alkylation of (S)-a,a-diphenyl-2-pyrrolidinemethanol with 2-bromomethylpyridine and 2, 6-dibromo- methyl-pyridine. The catalytic asymmetric bo...Two new chiral pyridine prolinol derivatives have been synthesized from N-alkylation of (S)-a,a-diphenyl-2-pyrrolidinemethanol with 2-bromomethylpyridine and 2, 6-dibromo- methyl-pyridine. The catalytic asymmetric borane reduction of prochiral ketones and the asymmetric addition of diethylzinc to benzaldehyde were investigated.展开更多
Asymmetric epoxidation of α,β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetr...Asymmetric epoxidation of α,β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetric epoxidation of α,β-unsaturated ketones using proline-derived α,α-diarylprolinols as catalysts. Special attention has been paid to the enantioselective epoxidation of chalcones, α,β-unsaturated trifluoromethyl, trichloromethyl ketones and β,γ-unsaturated α-keto esters based on the reseach of our group.展开更多
Atomic force microscope(AFM) can be used to investigate the surface structuxes of different kinds materials, and N-(4-nitrophenyl)-(L)-prolinol (NPP),as an organic second-order nonlinear optical crystal, has very larg...Atomic force microscope(AFM) can be used to investigate the surface structuxes of different kinds materials, and N-(4-nitrophenyl)-(L)-prolinol (NPP),as an organic second-order nonlinear optical crystal, has very large nonlinear efficiency. With our homemade AFM instrument, the topographic images of NPP surface have been obtained, The NPP crystal was grown in acetone by solvent evaporation. The AFM results indicates that the surface structure of NPP (001) surface is in well agreement with the bulk structure determined by X-ray diffraction expermients without any reconstruction.展开更多
文摘Two new chiral pyridine prolinol derivatives have been synthesized from N-alkylation of (S)-a,a-diphenyl-2-pyrrolidinemethanol with 2-bromomethylpyridine and 2, 6-dibromo- methyl-pyridine. The catalytic asymmetric borane reduction of prochiral ketones and the asymmetric addition of diethylzinc to benzaldehyde were investigated.
基金supported by the National Natural Science Foundation of China (20172064, 203900502, 20532040)QT Program, Shanghai Natural Science Council, and Excellent Young Scholars Foundation of the National Natural Science Foundation of China (20525208)
文摘Asymmetric epoxidation of α,β-unsaturated ketones has been extensively studied and several important procedures have been developed in the last decade. This review addresses the most significant advances in asymmetric epoxidation of α,β-unsaturated ketones using proline-derived α,α-diarylprolinols as catalysts. Special attention has been paid to the enantioselective epoxidation of chalcones, α,β-unsaturated trifluoromethyl, trichloromethyl ketones and β,γ-unsaturated α-keto esters based on the reseach of our group.
文摘Atomic force microscope(AFM) can be used to investigate the surface structuxes of different kinds materials, and N-(4-nitrophenyl)-(L)-prolinol (NPP),as an organic second-order nonlinear optical crystal, has very large nonlinear efficiency. With our homemade AFM instrument, the topographic images of NPP surface have been obtained, The NPP crystal was grown in acetone by solvent evaporation. The AFM results indicates that the surface structure of NPP (001) surface is in well agreement with the bulk structure determined by X-ray diffraction expermients without any reconstruction.
