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子宫内膜癌ProMisE分子分型与临床病理特征及预后的相关性分析
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作者 刘红 罗敏 +5 位作者 彭春蓉 樊英 何静 罗古坡 王登凤 张国楠 《现代妇产科进展》 2024年第4期255-263,共9页
目的:探讨子宫内膜癌(EC)ProMisE分子分型与临床病理特征的相关性及其对患者预后的影响。方法:回顾分析81例EC患者的临床病理资料,进行ProMisE分子分型。用非参数检验检测ProMisE分子亚型与临床病理特征的相关性。卡帕系数(Kappa)进行E... 目的:探讨子宫内膜癌(EC)ProMisE分子分型与临床病理特征的相关性及其对患者预后的影响。方法:回顾分析81例EC患者的临床病理资料,进行ProMisE分子分型。用非参数检验检测ProMisE分子亚型与临床病理特征的相关性。卡帕系数(Kappa)进行ESMO风险分层与ProMisE分型的一致性检验。Kaplan-Meier法绘制生存曲线,单因素及多因素Cox回归分析法探讨影响EC患者预后的危险因素。结果:ProMisE分子分型与各临床病理因素不存在统计学意义的相关性。ProMisE分子分型与ESMO风险分层一致性不佳(Kappa=0.005,P=0.922)。多因素Cox回归分析显示,腹水细胞学阳性(HR=19.471,P=0.001)和宫颈间质侵犯(HR=9.662,P=0.032)是PFS下降的独立预后影响因素,且腹水细胞学阳性(HR=20.641,P=0.012)是OS的独立预后影响因素。ESGO-ESTRO-ESP模型和ESMO2016模型对比ProMisE模型对PFS的预测能力更好(P<0.05)。结论:ProMisE分子分型与ESMO风险分层系统一致性不佳,结合了分子分型和临床病理参数的ESGO-ESTRO-ESP预后分层模型对预测EC患者PFS能力更强。腹水细胞学阳性是影响EC患者PFS及OS的独立预后因素。 展开更多
关键词 子宫内膜癌 promise分子分型 ESMO风险分层 治疗 预后
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子宫内膜癌ProMisE分子分型与淋巴结转移及其他临床特征的关系
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作者 李园园 李倩 +2 位作者 何莲 朱延美 张新 《国际妇产科学杂志》 CAS 2023年第4期377-381,391,共6页
目的:探讨子宫内膜癌ProMisE分子分型与淋巴结转移及其他临床特征的相关性。方法:选取2014年12月—2018年12月于大连理工大学附属肿瘤医院行手术治疗的子宫内膜癌患者74例,收集患者的临床资料,采用ProMisE方法进行分子分型,比较不同分... 目的:探讨子宫内膜癌ProMisE分子分型与淋巴结转移及其他临床特征的相关性。方法:选取2014年12月—2018年12月于大连理工大学附属肿瘤医院行手术治疗的子宫内膜癌患者74例,收集患者的临床资料,采用ProMisE方法进行分子分型,比较不同分型患者的临床特征,并分析子宫内膜癌淋巴结转移的影响因素。结果:74例子宫内膜癌患者中错配修复缺陷型20例(27.0%),POLE突变型2例(2.7%),p53野生型34例(46.0%),p53突变型18例(24.3%)。4种分子分型患者在淋巴结转移(P=0.004)、临床分期(P=0.018)和病理分级(P=0.036)方面差异有统计学意义。二分类Logistic回归分析显示p53突变型(OR=27.669,95%CI:3.224~237.480,P=0.002)和肌层浸润≥1/2(OR=22.046,95%CI:4.185~116.146,P<0.001)是淋巴结转移的危险因素。结论:分子分型可为术前决策提供重要参考,对于术前诊断性刮宫标本的ProMisE分子分型为p53突变型的患者,淋巴结转移风险高,术中可能需要扩大手术范围。 展开更多
关键词 子宫内膜肿瘤 promise分子分型 DNA错配修复 突变 基因 淋巴转移
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5G Falls Short of Promised Benefits
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作者 Mitch Leslie 《Engineering》 SCIE EI CAS CSCD 2023年第10期5-7,共3页
The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The ... The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The technology would also allow surgeons to perform operations remotely on patients thousands of kilometers away,permit communications between driverless cars,and offer other life-changing benefits[2,3]. 展开更多
关键词 operations promise SERVICE
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A Foretaste of What Chinese Modernization Promises
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《China Today》 2023年第6期16-19,共4页
President Xi Jinping’s inspection tour of Hebei to promote coordinated Beijing-Tianjin-Hebei development underlines the region’s pursuit of Chinese modernization.
关键词 PURSUIT promise Hebei
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Promise在微信小程序登录中的应用 被引量:1
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作者 周岚 《电脑与电信》 2021年第3期52-55,共4页
在微信小程序登录过程中获取微信用户信息时,需要进行多个有关联的异步请求操作,获取用户加密信息,然后对其解密并返回。传统的异步回调嵌套方法造成程序可读性差,程序执行性能低下。而Promise的出现,解决了微信小程序获取微信用户信息... 在微信小程序登录过程中获取微信用户信息时,需要进行多个有关联的异步请求操作,获取用户加密信息,然后对其解密并返回。传统的异步回调嵌套方法造成程序可读性差,程序执行性能低下。而Promise的出现,解决了微信小程序获取微信用户信息时多个异步操作请求问题,对异步请求功能划分更明确,大大提高了程序的可读性,并提供了良好的错误处理逻辑。 展开更多
关键词 promise 异步回调 异步请求 微信小程序
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Promise or Threat?
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作者 许文龙 《英语知识》 2006年第12期28-28,共1页
关键词 promise or Threat
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Promise方式实现Node.js应用的实践 被引量:11
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作者 邓森泉 杨海波 《计算机系统应用》 2017年第4期218-223,共6页
Node.js是目前非常火热的技术之一,它是运行在服务器端的JavaScript执行环境.Node.js借助JavaScript的事件驱动机制加上V8高性能引擎,使得编写高性能Web服务轻而易举.Node.js在处理异步问题时一般采用的是callback回调的方式,但callbac... Node.js是目前非常火热的技术之一,它是运行在服务器端的JavaScript执行环境.Node.js借助JavaScript的事件驱动机制加上V8高性能引擎,使得编写高性能Web服务轻而易举.Node.js在处理异步问题时一般采用的是callback回调的方式,但callback回调的方式存在Callback Hell的问题,无论是阅读还是调试都很不方便,甚至无法获取代码的堆栈.基于Node.js平台,采用Promise方式,编写了一套网络爬虫的应用,在编写过程中详细的描述了如何使用Promise方式处理异步回调问题. 展开更多
关键词 Node.js promise WEB应用
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Golden Promise barley(Hordeum vulgare) is a suitable candidate model host for investigation interaction with Heterodera avenae 被引量:2
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作者 LUO Shu-jie KONG Ling-an +6 位作者 PENG Huan HUANG Wen-kun CUI Jiang-kuan LIU Jing QIAO Fen JIAN Heng PENG De-liang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2017年第7期1537-1546,共10页
Heterodera avenae (cereal cyst nematode, CCN) infects many cereal crops and causes serious yield losses worldwide. Interaction studies investigating H. avenae and its hosts are still in their infancy. In this study,... Heterodera avenae (cereal cyst nematode, CCN) infects many cereal crops and causes serious yield losses worldwide. Interaction studies investigating H. avenae and its hosts are still in their infancy. In this study, a barley model plant, the Hordeum vulgare cultivar Golden Promise, was investigated for its potential as a candidate model host to study its inter- action with H. avenae. CCN-infective juveniles were attracted by the root tips and gathered around the root elongation zones of Golden Promise on 0.7% water agar plates. The juveniles invaded the roots and developed successfully until maturation at 40 days after inoculation in sterile sand soil. The cryotomy and syncytium measurements indicated that the syncytia enlarged gradually throughout the development of the nematodes and caused the corresponding root regions to swell obviously. Quantitative real-time PCR analysis showed that the down-regulation of defence-related barley genes and up-regulation Of development-related barley ger^es contribute to the understanding of compatible interaction between H. avenae and Golden Promise. Barley stripe mosaic virus (BSMV) virus-induced gene silencing (VIGS) can be used in the roots of Golden Promise. In conclusion, the Hordeum vulgare cultivar Golden Promise is a suitable candidate model host for interaction studies with Heterodera avenae. The studies presented above document the first CCN host that no.t only has published genome context but also be compatible to BSMV VIGS. 展开更多
关键词 Golden promise barley Heterodera avenae candidate model host INTERACTION
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Gallium oxide: promise to provide more efficient life 被引量:1
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作者 Yue Hao Jincheng Zhang Yue Hao 《Journal of Semiconductors》 EI CAS CSCD 2019年第1期1-2,共2页
Despite being the long-time mainstream semiconductor for both logic and power devices, Silicon is now facing its dilemma and limitation of scalability and material potential.Especially for power devices, people are de... Despite being the long-time mainstream semiconductor for both logic and power devices, Silicon is now facing its dilemma and limitation of scalability and material potential.Especially for power devices, people are demanding escalating efficiency with higher blocking voltage while its power consumption and heat generation are less. Constrained by its narrow bandgap of 1.14 eV, Silicon only has a critical breakdown field(E_c) of 0.3 MV/cm, yielding a Baliga figureof-merit(BFOM = ε×μ× E_c^3) of unity when normalized to itself. It is hence required that the dominating factor E_c should be as high as possible such that the BFOM will be hundreds or even thousands of times when compared to Silicon so as to minimize the conduction loss. Beta-Gallium Oxide(β-Ga_2O_3) with decent μ of 250 cm2/Vs, ultra-wide bandgap of4.8 eV and high critical E_c of 8 MV/cm, yielding a superior high BFOM of more than 3000. Therefore, system made withβ-Ga_2O_3 can be thinner, lighter and capable of handling more power than the one with Silicon. In addition, low-cost and large size substrate through melt-grown method endows β-Ga_2O_3 more potentials as cost-effective power devices. After resolving the low thermal conductivity issue,unipolar devices made with ultra-wide bandgap β-Ga_2O_3 are promised to make power transition and our life more efficient. 展开更多
关键词 GALLIUM OXIDE promise provide MORE EFFICIENT LIFE
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以promise用法为例,从语义、语用学角度探讨词汇教学
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作者 郑丽梅 《卫生职业教育》 2007年第7期89-90,共2页
从语义、语用学角度探讨promise的用法。以期通过分析其定义、语义意义、语用意义及用法,给词汇教学打开一个新思路。
关键词 promise 语义学 语用学
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New US Rules Promise to Unlock Hearing Aid Availability
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作者 Mitch Leslie 《Engineering》 SCIE EI CAS 2022年第7期7-9,共3页
One day in late 2022 or early 2023,a customer somewhere in the United States will make history by purchasing the first pair of hearing aids sold over the counter(OTC).For more than 40 years,these devices have been ava... One day in late 2022 or early 2023,a customer somewhere in the United States will make history by purchasing the first pair of hearing aids sold over the counter(OTC).For more than 40 years,these devices have been available in the United States and many other countries mainly through audiologists or other hearing professionals.But updated regulations scheduled for enactment later this year by the Food and Drug Administration(FDA),the US agency that oversees drugs and medical devices,will allow retailers to sell hearing aids directly to consumers[1]. 展开更多
关键词 DRUGS promise HEARING
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Silkworm silk biomaterials for spinal cord repair: promise for combinatorial therapies
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作者 Anna Varone Ann Marie Rajnicek Wenlong Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第5期809-810,共2页
Background:Traumatic injury to the adult mammalian spinal cord results in minimal axonal regrowth,cystic cavity formation at the injury site,poor functional recovery and there is no cure available.Due to the complex ... Background:Traumatic injury to the adult mammalian spinal cord results in minimal axonal regrowth,cystic cavity formation at the injury site,poor functional recovery and there is no cure available.Due to the complex nature of spinal cord injury(SCI),a combination of therapeutic strategies may offer the most promise for successful regeneration(Ahuja et al.,2017). 展开更多
关键词 SCI Figure Silkworm silk biomaterials for spinal cord repair promise for combinatorial therapies
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AI-Driven Robotic Laboratories Show Promise
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作者 Sean O’Neill 《Engineering》 SCIE EI 2021年第10期1351-1353,共3页
Elaborate proof-of-principle experiments in several laboratories around the world have recently offered glimpses of a future in which high-throughput automatic laboratories guided by artificial intelligence(AI)might e... Elaborate proof-of-principle experiments in several laboratories around the world have recently offered glimpses of a future in which high-throughput automatic laboratories guided by artificial intelligence(AI)might enhance the process for discovery of new materials,such as those for clean energy technologies.And in chemical engineering,using AI to aid in synthesis planning and performance offers the prospect of scientists needing little more than an idea and an internet connection to generate novel molecules in state-of-the-art,remote laboratories.Announced in August 2020,International Business Machine Corporation(IBM)’s RoboRXN for Chemistry provides a high-profile example of the potential for combining AI and laboratory automation[1].The system not only provides chemical recipes to produce organic molecules of interest but can also synthesize those molecules automatically using commercially available hardware—in the case of IBM’s demonstrator,a Flex-category automated-synthesis workstation(Fig.1)manufactured by Chemspeed Technologies(Füllinsdorf,Switzerland). 展开更多
关键词 HARDWARE promise LABORATORIES
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Light-Based Chips Promise to Slash Energy Use and Increase Speed
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作者 Mitch Leslie 《Engineering》 SCIE EI 2021年第9期1195-1196,共2页
Computers already gobble a large share of the world’s electrical power,and their energy demand will likely soar with the deployment of more and more power-hungry artificial intelligence(AI)systems[1].In a step that m... Computers already gobble a large share of the world’s electrical power,and their energy demand will likely soar with the deployment of more and more power-hungry artificial intelligence(AI)systems[1].In a step that might reduce AI’s electricity use and environmental impact,Lightmatter,a startup based in Boston,MA,USA,announced that it has developed a microchip that performs calculations with light and requires about one-sixth the energy of a comparable electronic chip(Fig.1)[2].Other companies are developing similar photon-based chips for AI and for many other uses,including self-driving cars and quantum computing[3,4]. 展开更多
关键词 promise artificial SPEED
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Hydrogen Shows Promise in Vehicle Tests
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《Journal of Natural Gas Chemistry》 CAS CSCD 2004年第2期118-119,共2页
Car fleets escorted by police along Chang’an Avenue are not a rare sight for Beijing residents, who are accustomed to the practice when leaders of foreign states visit the capital of China.
关键词 Hydrogen Shows promise in Vehicle Tests PEMFC
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Belt and Road Tourism Promises Tremendous Potential
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作者 Jenny Hu 《China's Foreign Trade》 2019年第3期51-53,共3页
In recent years,with the advancement of the Belt and Road Initiative,tourism cooperation has become closer between China and the countries along the Belt and Road.Statistics from the China Tourism Academy show that Ch... In recent years,with the advancement of the Belt and Road Initiative,tourism cooperation has become closer between China and the countries along the Belt and Road.Statistics from the China Tourism Academy show that China’s outbound tourists to the countries along the Belt and Road is on the rise from 15.49 million in 2013 to 27.41 million in 2017,up by 77%during five years and with an average annual growth rate of 15.34%.The development of tourism has boosted trade and cultural exchange between China and the countries along the Belt and Road,which has become a significant force in driving the construction of the Belt and Road. 展开更多
关键词 China PRO BELT and ROAD TOURISM promises Tremendous POTENTIAL
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在PROMISE IDE接口上安装单硬盘的技巧
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作者 恶鱼 《微型计算机》 北大核心 2003年第9期82-82,共1页
关键词 硬盘 安装 IDE接口 promise芯片 RAID控制器
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为集成有PROMISE芯片的主板增设RAID功能
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作者 张章 《微型计算机》 北大核心 2000年第24期77-78,共2页
关键词 主板 promise芯片 RAID 硬盘 控制芯片
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China Cultural Center in Tel Aviv:Telling the China Story on the ‘Promised Land’
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《China & The World Cultural Exchange》 2019年第10期15-16,共2页
China Cultural Center in Tel Aviv is to take up the mission of enhancing the mutual harmony of the hearts of the two peoples and promoting cultural exchanges,of telling the China story on the "Promised Land"... China Cultural Center in Tel Aviv is to take up the mission of enhancing the mutual harmony of the hearts of the two peoples and promoting cultural exchanges,of telling the China story on the "Promised Land",so as to add more beautiful melody to the movement of friendship between the PRC and Israel. 展开更多
关键词 BEAUTIFUL promise Israel
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PROMISE“新一代存储技术论坛”在京、沪举行
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《电子商务》 2007年第4期89-89,共1页
2007年3月7日、9日由乔鼎(Promise)中国主办,EMC、希捷(Seagate)、飞康(FalconStor)、同有飞骥等众多业内知名存储厂商协办的“新一代存储技术论坛”在北京、上海两地举行。在本次大会上,主办方的高层领导、技术专家与行业用户... 2007年3月7日、9日由乔鼎(Promise)中国主办,EMC、希捷(Seagate)、飞康(FalconStor)、同有飞骥等众多业内知名存储厂商协办的“新一代存储技术论坛”在北京、上海两地举行。在本次大会上,主办方的高层领导、技术专家与行业用户代表齐聚一堂,就2007年网络存储技术的最新发展趋势、行业应用新动向等进行了广泛而深入的交流。 展开更多
关键词 网络存储技术 技术论坛 promise 行业用户 技术专家 发展趋势 行业应用 EMC
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