Objective: Smoking cessation during pregnancy is a modifiable intervention that can improve maternal and neonatal outcomes. Encouraging smoking cessation is an assessed measure of the Meaningful Use incentives to ensu...Objective: Smoking cessation during pregnancy is a modifiable intervention that can improve maternal and neonatal outcomes. Encouraging smoking cessation is an assessed measure of the Meaningful Use incentives to ensure best practices with the increased use of the electronic medical record (EMR). Physician EMR prompts have been used shown to be successful with preventive care but there is a paucity of data evaluating prompts within obstetrics. The objective of this study is to determine the effectiveness of enhanced smoking cessation prompts in a prenatal EMR. Methods: A retrospective cohort study of an enhanced smoking cessation prompting system within our prenatal EMR was performed. Pregnant women who reported tobacco use at first prenatal visit were included. The number of times a smoking cessation method was offered and documented, the number of documented attempts at smoking cessation, and the final number of cigarettes smoked were compared pre and post the enhancement of the smoking cessation prompting system. Results: 95 patients were included (48 pre-enhancement;47 post-enhancement). Post-enhancement, the documentation of smoking cessation method offered increased (0 vs. 1, p = 0.03) and documentation of smoking cessation attempts increased (1 vs. 2, p = 0.006). There was no change in the final number of cigarettes smoked (p = 0.9). Conclusions: Enhanced prompting systems increase documentation related to smoking cessation with no change in number of cigarettes smoked. In the era of Meaningful Use guidelines which focus on documentation in the EMR, continued research must be done to assure that software enhancements and improved documentation truly result in improved patient care.展开更多
Dear Editor,Chibanian(Middle Pleistocene)hominin fossils that could not be easily assigned to Homo erectus,H.neanderthalensis,or H.sapiens have traditionally been as-signed to an alinclusive group:"archaic H.sapi...Dear Editor,Chibanian(Middle Pleistocene)hominin fossils that could not be easily assigned to Homo erectus,H.neanderthalensis,or H.sapiens have traditionally been as-signed to an alinclusive group:"archaic H.sapiens."In an insightful observation of the Chibanian record almost four decades ago however,Tattersall railed against the use of the word"archaic"in this sense when referring to the human fossil record,as he justifiably noted that no other biological organism has the word"archaic"attached to it'For example,no one refers to an earlier version of Canis domesticus as"archaic"C.domesticus.The ancestor of the domestic dog is,and always has been,considered to be C.lupus.In Tattersall's opinion,it would seem that these"archaic H.sapiens"fossils should be assigned to one or more formal taxonomic names.As such,terms such as"archaic H.sapiens,""mid-Pleistocene Homo,"and"Middle Pleistocene Homo"have al-ways been considered to be wastebasket taxa that include way too much morphological variabilty for one proposed taxonomic group.Continuing to use wastebasket taxa only hinders any attempts to understand true phylogenetic and evolutionary relationships.展开更多
ChatGPT has emerged as a promising advanced large language model that needs prompt to gain information.However,designing a good prompt is not an easy task for many end-users.Therefore,this study intends to determine t...ChatGPT has emerged as a promising advanced large language model that needs prompt to gain information.However,designing a good prompt is not an easy task for many end-users.Therefore,this study intends to determine the amount of information gained because of varied amounts of information in the prompt.This study used two types of prompts,initial and improved,to query the introduction sections of 327 highly cited articles on traffic safety.The queried introduction sections were then matched with the corresponding human-written introduction sections from the same articles.Similarity tests and text network analysis were used to understand the level of similarities and the content of ChatGPT-generated and human-written introductions.The findings indicate the improved prompts,which have the addition of generic persona and information about the citations and references,changed the ChatGPT's output insignificantly.While the perfect similar contents are supposed to have a 1.0 similarity score,the initial and improved prompt's introduction materials have average similarity scores of 0.5387 and 0.5567,respectively.Further,the content analysis revealed that themes such as statistics,trends,safety measures,and safety technologies are more likely to have high similarity scores,irrespective of the amount of information provided in the prompt.On the other hand,themes such as human behavior,policy and regulations,public perception,and emerging technologies require a detailed level of information in their prompt to produce materials that are close to human-written materials.The prompt engineers can use the findings to evaluate their outputs and improve their prompting skills.展开更多
INSPIRED by the insight from American political scientist Lasswell, who summarized the environmental role in societal surveillance [1], Schramm coined the term “social radar” [2] as it resembles the activities of ra...INSPIRED by the insight from American political scientist Lasswell, who summarized the environmental role in societal surveillance [1], Schramm coined the term “social radar” [2] as it resembles the activities of radar in collecting and processing information, playing a crucial role in helping humans perceive changes in the internal and external environment and promptly adjusting adaptive behaviors.展开更多
García-Hermoso and colleagues1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2diabetes mellitus patients,providing a c...García-Hermoso and colleagues1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2diabetes mellitus patients,providing a contemporary view on how exerkines respond to exercise training.That review prompted us to highlight 2 additional considerations that should be taken into account when studying the response of exerkines to exercise training.Firstly,whether exerkines can exhibit discordant responses to acute exercise compared to exercise training,and secondly,the need to consider the residual effects of the most recent exercise bout.展开更多
Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth sense.The perception of...Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth sense.The perception of external signals through the senses is essential to an organism's survival,transmitting signals to the central nervous system(CNS)and prompting physiological changes in other biological systems.In addition to the direct effects of sense-induced mediators in the brain.展开更多
The continuously growing importance of batteries for powering(hybrid)electric vehicles and storing renewable energy has prompted a renewed focus on lithium-metal batteries(LMBs)in recent years,as its high theoretical ...The continuously growing importance of batteries for powering(hybrid)electric vehicles and storing renewable energy has prompted a renewed focus on lithium-metal batteries(LMBs)in recent years,as its high theoretical specific capacity of about 3860 mA h g^(-1) and very low redox potential(-3.04 V vs.the standard hydrogen electrode)promise substantially higher energy densities compared to current lithium-ion batteries(LIBs)[1].However,lithium metal electrodes face severe challenges associated with the risk of dendritic lithium deposition and the high reactivity with traditional organic liquid electrolytes,resulting in a continuous loss of electrochemically active lithium and a relatively low Coulombic efficiency[2].To address these challenges,solid inorganic and polymer electrolytes have emerged as a potentially saferalternative.展开更多
Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm.The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and...Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm.The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress.Sinensetin(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant activities.Our study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular mechanisms.We found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory conditions.Administered Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in vivo.By molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence assays.Chromatin immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor HO-1.Further functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant effects.Additionally,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative stress.Overall,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.展开更多
The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration.Driven by this petawatt laser facility,proton beams with energy up to 200 ...The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration.Driven by this petawatt laser facility,proton beams with energy up to 200 MeV are expected to be generated for tumor therapy.During high-repetition operation,both prompt radiation and residual radiation may cause safety problems.Therefore,human radiological safety assessment before commissioning is essential.In this paper,we simulate both prompt and residual radiation using the Geant4 and FLUKA Monte Carlo codes with reasonable proton and as-produced electron beam parameters.We find that the prompt radiation can be shielded well by the concrete wall of the experimental hall,but the risk from residual radiation is nonnegligible and necessitates adequate radiation cooling.On the basis of the simulation results,we discuss the constraints imposed by radiation safety considerations on the annual working time,and we propose radiation cooling strategies for different shooting modes.展开更多
Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific i...Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics, astronautics and civil aviation.展开更多
Vaccination plays a vital role in protecting against communicable infections like measles and their associated complications[1,2].While vaccination doesn't guarantee complete immunity,the authors also highlighted ...Vaccination plays a vital role in protecting against communicable infections like measles and their associated complications[1,2].While vaccination doesn't guarantee complete immunity,the authors also highlighted that vaccinated individuals tend to experience milder infections compared to those who are unvaccinated[1].Despite the availability of free vaccines for measles,polio,and pertussis through the national vaccination program[3],the Philippines faced outbreaks of measles and pertussis across its islands in 2024[4].The Bangsamoro Autonomous Region in Muslim Mindanao reported 500 measles cases,while pertussis outbreaks were recorded in various parts of Luzon and Visayas,prompting several cities to declare states of calamity[4,5].Additionally,despite successfully eradicating poliomyelitis in 2000,approximately 70 percent of provinces and cities remained at high risk of polio outbreaks[3,4].展开更多
Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific i...Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics, astronautics and civil aviation.展开更多
Transactions of Nanjing University of Aeronautics&Astronautics(TNUAA)is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific ins...Transactions of Nanjing University of Aeronautics&Astronautics(TNUAA)is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics,astronautics and civil aviation.展开更多
Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community. Emphasizing prompt and effective dissemination of key data and new scientific ...Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community. Emphasizing prompt and effective dissemination of key data and new scientific insights, TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics,astronautics and civil aviation.展开更多
文摘Objective: Smoking cessation during pregnancy is a modifiable intervention that can improve maternal and neonatal outcomes. Encouraging smoking cessation is an assessed measure of the Meaningful Use incentives to ensure best practices with the increased use of the electronic medical record (EMR). Physician EMR prompts have been used shown to be successful with preventive care but there is a paucity of data evaluating prompts within obstetrics. The objective of this study is to determine the effectiveness of enhanced smoking cessation prompts in a prenatal EMR. Methods: A retrospective cohort study of an enhanced smoking cessation prompting system within our prenatal EMR was performed. Pregnant women who reported tobacco use at first prenatal visit were included. The number of times a smoking cessation method was offered and documented, the number of documented attempts at smoking cessation, and the final number of cigarettes smoked were compared pre and post the enhancement of the smoking cessation prompting system. Results: 95 patients were included (48 pre-enhancement;47 post-enhancement). Post-enhancement, the documentation of smoking cessation method offered increased (0 vs. 1, p = 0.03) and documentation of smoking cessation attempts increased (1 vs. 2, p = 0.006). There was no change in the final number of cigarettes smoked (p = 0.9). Conclusions: Enhanced prompting systems increase documentation related to smoking cessation with no change in number of cigarettes smoked. In the era of Meaningful Use guidelines which focus on documentation in the EMR, continued research must be done to assure that software enhancements and improved documentation truly result in improved patient care.
基金National Natural Science Foundation of China Grant 42372001.
文摘Dear Editor,Chibanian(Middle Pleistocene)hominin fossils that could not be easily assigned to Homo erectus,H.neanderthalensis,or H.sapiens have traditionally been as-signed to an alinclusive group:"archaic H.sapiens."In an insightful observation of the Chibanian record almost four decades ago however,Tattersall railed against the use of the word"archaic"in this sense when referring to the human fossil record,as he justifiably noted that no other biological organism has the word"archaic"attached to it'For example,no one refers to an earlier version of Canis domesticus as"archaic"C.domesticus.The ancestor of the domestic dog is,and always has been,considered to be C.lupus.In Tattersall's opinion,it would seem that these"archaic H.sapiens"fossils should be assigned to one or more formal taxonomic names.As such,terms such as"archaic H.sapiens,""mid-Pleistocene Homo,"and"Middle Pleistocene Homo"have al-ways been considered to be wastebasket taxa that include way too much morphological variabilty for one proposed taxonomic group.Continuing to use wastebasket taxa only hinders any attempts to understand true phylogenetic and evolutionary relationships.
文摘ChatGPT has emerged as a promising advanced large language model that needs prompt to gain information.However,designing a good prompt is not an easy task for many end-users.Therefore,this study intends to determine the amount of information gained because of varied amounts of information in the prompt.This study used two types of prompts,initial and improved,to query the introduction sections of 327 highly cited articles on traffic safety.The queried introduction sections were then matched with the corresponding human-written introduction sections from the same articles.Similarity tests and text network analysis were used to understand the level of similarities and the content of ChatGPT-generated and human-written introductions.The findings indicate the improved prompts,which have the addition of generic persona and information about the citations and references,changed the ChatGPT's output insignificantly.While the perfect similar contents are supposed to have a 1.0 similarity score,the initial and improved prompt's introduction materials have average similarity scores of 0.5387 and 0.5567,respectively.Further,the content analysis revealed that themes such as statistics,trends,safety measures,and safety technologies are more likely to have high similarity scores,irrespective of the amount of information provided in the prompt.On the other hand,themes such as human behavior,policy and regulations,public perception,and emerging technologies require a detailed level of information in their prompt to produce materials that are close to human-written materials.The prompt engineers can use the findings to evaluate their outputs and improve their prompting skills.
基金partially supported by the National Key Research and Development Program of China (2023YFB3209800)China Postdoctoral Science Foundation (2023M740264)。
文摘INSPIRED by the insight from American political scientist Lasswell, who summarized the environmental role in societal surveillance [1], Schramm coined the term “social radar” [2] as it resembles the activities of radar in collecting and processing information, playing a crucial role in helping humans perceive changes in the internal and external environment and promptly adjusting adaptive behaviors.
基金supported by funding from The Irish Research Council through both the Government of Ireland Postgraduate Scholarship Programme to IAJD and BE(Grant No.GOIPG/2020/162)。
文摘García-Hermoso and colleagues1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2diabetes mellitus patients,providing a contemporary view on how exerkines respond to exercise training.That review prompted us to highlight 2 additional considerations that should be taken into account when studying the response of exerkines to exercise training.Firstly,whether exerkines can exhibit discordant responses to acute exercise compared to exercise training,and secondly,the need to consider the residual effects of the most recent exercise bout.
基金supported by a grant from the Department of Economic and Business Development from the Government of Navarra(INNOLFACT project,Ref.0011-1411-2023-000094)。
文摘Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth sense.The perception of external signals through the senses is essential to an organism's survival,transmitting signals to the central nervous system(CNS)and prompting physiological changes in other biological systems.In addition to the direct effects of sense-induced mediators in the brain.
基金financial support from the Federal Ministry of Education and Research (BMBF) within the FestBatt project (03XP0175B)the FB2-Poly project(03XP0429B)the Helmholtz Association
文摘The continuously growing importance of batteries for powering(hybrid)electric vehicles and storing renewable energy has prompted a renewed focus on lithium-metal batteries(LMBs)in recent years,as its high theoretical specific capacity of about 3860 mA h g^(-1) and very low redox potential(-3.04 V vs.the standard hydrogen electrode)promise substantially higher energy densities compared to current lithium-ion batteries(LIBs)[1].However,lithium metal electrodes face severe challenges associated with the risk of dendritic lithium deposition and the high reactivity with traditional organic liquid electrolytes,resulting in a continuous loss of electrochemically active lithium and a relatively low Coulombic efficiency[2].To address these challenges,solid inorganic and polymer electrolytes have emerged as a potentially saferalternative.
基金supported by National Natural Science Foundation of China(82001050,82173871)Natural Science Foundation of Jiangsu Province(BK20190135)+2 种基金Fundamental Research Funds for the Central Universities(021414380503)“3456”Cultivation Program for Junior Talents of Nanjing Stomatological Hospital,Medical School of Nanjing University(0222R209)Jiangsu Provincial Medical Key Discipline Cultivation Unit(JSDW202246).
文摘Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm.The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress.Sinensetin(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant activities.Our study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular mechanisms.We found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory conditions.Administered Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in vivo.By molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence assays.Chromatin immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor HO-1.Further functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant effects.Additionally,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative stress.Overall,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.
基金supported by the National Natural Science Foundation of China(Grant No.12205008)the NSFC Innovation Group Project(Grant No.11921006)+1 种基金the National Grand Instrument Project(Grant Nos.2019YFF01014402 and 2019YFF01014403)the National Science Fund for Distinguished Young Scholars(Grant No.12225501).
文摘The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs duration.Driven by this petawatt laser facility,proton beams with energy up to 200 MeV are expected to be generated for tumor therapy.During high-repetition operation,both prompt radiation and residual radiation may cause safety problems.Therefore,human radiological safety assessment before commissioning is essential.In this paper,we simulate both prompt and residual radiation using the Geant4 and FLUKA Monte Carlo codes with reasonable proton and as-produced electron beam parameters.We find that the prompt radiation can be shielded well by the concrete wall of the experimental hall,but the risk from residual radiation is nonnegligible and necessitates adequate radiation cooling.On the basis of the simulation results,we discuss the constraints imposed by radiation safety considerations on the annual working time,and we propose radiation cooling strategies for different shooting modes.
文摘Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics, astronautics and civil aviation.
文摘Vaccination plays a vital role in protecting against communicable infections like measles and their associated complications[1,2].While vaccination doesn't guarantee complete immunity,the authors also highlighted that vaccinated individuals tend to experience milder infections compared to those who are unvaccinated[1].Despite the availability of free vaccines for measles,polio,and pertussis through the national vaccination program[3],the Philippines faced outbreaks of measles and pertussis across its islands in 2024[4].The Bangsamoro Autonomous Region in Muslim Mindanao reported 500 measles cases,while pertussis outbreaks were recorded in various parts of Luzon and Visayas,prompting several cities to declare states of calamity[4,5].Additionally,despite successfully eradicating poliomyelitis in 2000,approximately 70 percent of provinces and cities remained at high risk of polio outbreaks[3,4].
文摘Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics, astronautics and civil aviation.
文摘Transactions of Nanjing University of Aeronautics&Astronautics(TNUAA)is a bimonthly journal facing international academic community.Emphasizing prompt and effective dissemination of key data and new scientific insights,TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics,astronautics and civil aviation.
文摘Transactions of Nanjing University of Aeronautics&Astronautics (TNUAA) is a bimonthly journal facing international academic community. Emphasizing prompt and effective dissemination of key data and new scientific insights, TNUAA publishes experimental and theoretical papers bearing on applications to all branches of aeronautics,astronautics and civil aviation.