T lymphocyte proportion in Alzheimer’s disease prognosis

Bai et al investigate the predictive value of T lymphocyte proportion in Alzheimer's disease(AD)prognosis.Through a retrospective study involving 62 AD patients,they found that a decrease in T lymphocyte proportion correlated with a poorer prognosis,as indicated by higher modified Rankin scale scores.While the study highlights the potential of T lymphocyte proportion as a prognostic marker,it suggests the need for larger,multicenter studies to enhance generalizability and validity.Additionally,future research could use cognitive exams when evaluating prognosis and delve into immune mechanisms underlying AD progression.Despite limitations inherent in retrospective designs,Bai et al's work contributes to understanding the immune system's role in AD prognosis,paving the way for further exploration in this under-researched area.

A Note on an Order Level Inventory Model with Varying Two-Phased Demand and Time-Proportional Deterioration

The main purpose of this paper is to generalize the effect of two-phased demand and variable deterioration within the EOQ (Economic Order Quantity) framework. The rate of deterioration is a linear function of time. The two-phased demand function states the constant function for a certain period and the quadratic function of time for the rest part of the cycle time. No shortages as well as partial backlogging are allowed to occur. The mathematical expressions are derived for determining the optimal cycle time, order quantity and total cost function. An easy-to-use working procedure is provided to calculate the above quantities. A couple of numerical examples are cited to explain the theoretical results and sensitivity analysis of some selected examples is carried out.

Bamboo Fiber Modified Asphalt Mixture Proportion Design and Road Performances Based on Response Surface Method

In order to comprehensively utilize the remaining bamboo residue of bamboo products,this paper presents a research on recycling the bamboo fibers from bamboo residue for improving the performance of the asphalt mixtures.First of all,the basic performance parameters of sinocalamus affinis fiber,phyllostachys pubescens fiber,green bamboo fiber were tested and analyzed,and the optimal content and length were put forward.Then,the mix ratio design of the bamboo fiber modified asphalt mixture was further designed through the response surface method,and was verified the rationality of the mix ratio.Finally,the mixture specimens were made according to the experimental design mix ratio,and the high temperature,low temperature performance and moisture susceptibility of the bamboo fiber modified mixtures asphalt were tested.The results showed that the high temperature performance,low temperature performance and moisture susceptibility of bamboo fiber modified asphalt mixtures were improved compared with the performance of SBS modified asphalt mixture.When the length of bamboo fiber is 7.25 mm and the content of 0.22%,the road performance of the asphalt mixture was optimal.Consequentially,the decomposition of bamboo residue into bamboo fiber and its application in asphalt pavement can improve the reuse of bamboo waste,with remarkable environmental benefits and great promotion value.

Mixed-Effects Parametric Proportional Hazard Model with Generalized Log-Logistic Baseline Distribution

Clustered survival data are widely observed in a variety of setting. Most survival models incorporate clustering and grouping of data accounting for between-cluster variability that creates correlation in order to prevent underestimate of the standard errors of the parameter estimators but do not include random effects. In this study, we developed a mixed-effect parametric proportional hazard (MEPPH) model with a generalized log-logistic distribution baseline. The parameters of the model were estimated by the application of the maximum likelihood estimation technique with an iterative optimization procedure (quasi-Newton Raphson). The developed MEPPH model’s performance was evaluated using Monte Carlo simulation. The Leukemia dataset with right-censored data was used to demonstrate the model’s applicability. The results revealed that all covariates, except age in PH models, were significant in all considered distributions. Age and Townsend score were significant when the GLL distribution was used in MEPPH, while sex, age and Townsend score were significant in MEPPH model when other distributions were used. Based on information criteria values, the Generalized Log-Logistic Mixed-Effects Parametric Proportional Hazard model (GLL-MEPPH) outperformed other models.

Proportion Integration Differentiation(PID)Control Strategy of Belt Sander Based on Fuzzy Algorithm

Aiming at solving the problems of response lag and lack of precision and stability in constant grinding force control of industrial robot belts,a constant force control strategy combining fuzzy control and proportion integration differentiation(PID)was proposed by analyzing the signal transmission process and the dynamic characteristics of the grinding mechanism.The simulation results showed that compared with the classical PID control strategy,the system adjustment time was shortened by 98.7%,the overshoot was reduced by 5.1%,and the control error was 0.2%-0.5%when the system was stabilized.The optimized fuzzy control system had fast adjustment speeds,precise force control and stability.The experimental analysis of the surface morphology of the machined blade was carried out by the industrial robot abrasive grinding mechanism,and the correctness of the theoretical analysis and the effectiveness of the control strategy were verified.

Proportion of thyroid cancer and other cancers in the democratic republic of Congo

BACKGROUND Cancer diagnosis is increasing around the world and in the Democratic Republic of the Congo(DRC).The proportion of thyroid cancer has increased over the past three decades.There are very few studies on cancer epidemiology,and in particular on thyroid cancer in the DRC.AIM To establish the most recent proportion of thyroid cancer in the DRC compared to other cancers.METHODS This is a retrospective and descriptive study of 6106 consecutive cancer cases listed in the pathological registers of 4 Laboratories in the city of Kinshasa.This study included all cancer cases recorded in the registers between 2005 and 2019.RESULTS From a sample of 6106 patients,including all cancer types,68.3%cases were female and 31.7%were male.Breast and cervical cancer were the most common types of cancer in women and,prostate and skin cancer were the most common types in men.Thyroid cancer was sixth in proportion in women and eleventh in men compared to all cancers.Papillary carcinoma was the most common of thyroid cancers.Rare cancers such as anaplastic and medullary thyroid carcinomas had a proportion of 7%and 2%,respectively.CONCLUSION Newer diagnostic tools led to a surge in cancer diagnoses in the DRC.Thyroid cancer has more than doubled its proportion over the last several decades in the country.

Survival Analysis Using Cox Proportional Hazards Regression for Pile Bridge Piles Under Wet Service Conditions

This paper studies the deterioration of bridge substructures utilizing the Long-Term Bridge Performance(LTBP)Program InfoBridge^(TM)and develops a survival model using Cox proportional hazards regression.The survival anal­ysis is based on the National Bridge Inventory(NBI)dataset.The study calculates the survival rate of reinforced and prestressed concrete piles on bridges under marine conditions over a 29-year span(from 1992 to 2020).The state of Maryland is the primary focus of this study,with data from three neighboring regions,the District of Columbia,Vir­ginia,and Delaware to expand the sample size.The data obtained from the National Bridge Inventory are condensed and filtered to acquire the most relevant information for model development.The Cox proportional hazards regres­sion is applied to the condensed NBI data with six parameters:Age,ADT,ADTT,number of spans,span length,and structural length.Two survival models are generated for the bridge substructures:Reinforced and prestressed concrete piles in Maryland and reinforced and prestressed concrete piles in wet service conditions in the District of Columbia,Maryland,Delaware,and Virginia.Results from the Cox proportional hazards regression are used to construct Markov chains to demonstrate the sequence of the deterioration of bridge substructures.The Markov chains can be used as a tool to assist in the prediction and decision-making for repair,rehabilitation,and replacement of bridge piles.Based on the numerical model,the Pile Assessment Matrix Program(PAM)is developed to facilitate the assessment and main­tenance of current bridge structures.The program integrates the NBI database with the inspection and research reports from various states’department of transportation,to serve as a tool for condition state simulation based on mainte­nance or rehabilitation strategies.

rate,ratio,proportion辨析

rate,ratio,proportion三词都可以表示“比例”。表此义时,其差别甚是微妙,值得注意。现作如下辨析: rate指“比、比率、比例”,如:mortality rate死亡率,tax rate税率,rate of rejects废品率,rate of attendance出勤率,crime rate犯罪率,divorce rate离婚率,accident rate事故发生率。从以上例证不难看出,这里所谓的“比、比率”是指部分相对整体形成的比率,即a mea-sure of a part with respect to the whole。如“废品率”是产品“总量”减去“正品量”然后除以总量而得来的。

A New Kind of Pilot Controlled Proportional Direction Valve with Internal Flow Feedback

Proportional direction valve is one of the most fundamental elements in electronic-hydraulic control technique. Its function is to control the operating speed, direction, position, and strength of output force of the hydraulic actuator continuously. Considering the different application and the cost, the existing technique mainly includes the internal feedback valve used in open loop system, and the electronic closed loop controlled valve used in closed loop system. Because of their different mechanical structure and the gre at different in performance, it brings inconvenience for customer to select, also inconvenience for enterprise to produce. Aiming at this problem, the idea of combining the above two kinds of valves into one body is proposed first, and then the new valve＇s structure to realize this target is designed. The idea intends to apply the displacement pilot flow feedback control principle in present 2-position 2-way valve system to the proportional direction valve of 3-position 4-way system. Newly designed feed forward controller can decouple the interference between the internal feedback and the electronic closed loop. Redundant conversion is designed to electronic switch mode. Experiment on dynamic and static characteristic of new proportional direction valve in internal feedback control mode and electronic closed loop control mode is discussed to prove the new theory is correct. Although the new valve is of excellent dynamic response characteristic, its steady control characteristic in open loop control mode needs to be improved further. The research results prepare one new fundamental element for electronic-hydraulic control technology.

RESEARCH ON THE PERFORMANCE OF NEW TYPE OF PROPORTIONAL PESSURE AND FLOW CONTROL VALVE

A new closed loop flow controlling principle through correcting the valve'sopening area while load pressure is changing is carried out. Further more a principle using only oneproportional valve to compound control pressure and flow is suggested. By using very simpleproportional throttle valve in structure, the functions that five kinds of proportional valves orany two of them combined possess can be complimented. After analyzing, comparing, and testing thedynamic and static characteristics of valve with different controlling principles and main valvestructure styles, the optimized structure styles and control methods are achieved.

PILOT LEAKAGE'S INFLUENCES ON THE PERFORMANCES OF EXTRA HIGH PRESSURE PROPORTIONAL PNEUMATIC VALVE

A mathematic model is built up to analyze the influences of a pilot valve'sleakage on the performances of pneumatic pressure proportional valve, and the performances aresimulated by using MATLAB. The results indicate that using slide pilot valve in the valve system isfeasible, but the leakage's influences can not be neglected, especially it may induce instability ina low output pressure situation. A pilot valve using too large throttle window will cause the valveoscillate. To improve the working condition of pilot valve, a method adopting different widths oftwo throttle window is proposed. According to our simulation, this method balances the pressure dropbetween the two stage throttle ports, and reduces the influences of pilot valve's leakage.

Combined proportional navigation law for interception of high-speed targets

A new proportional navigation(PN) guidance law,called combined proportional navigation(CPN),is proposed.The guidance law is designed to intercept high-speed targets,which is a common case for ballistic targets.The range of target-to-interceptor speed ratio during target interception is derived when guidance laws are applied in high-speed targets interception,and the effectiveness of negative navigation ratio in the PN-based guidance law is proven analytically in some lemmas.Based on the lemmas,the lateral acceleration command of CPN is defined,and the solution to the appearance of singularity in time-varying navigation ratio is given.The simulation results show that CPN can determine headon engagement(as PN) or tail-chase engagement(as RPN) through initial path angle compared with PN and retro proportional navigation(RPN),and can adjust the value of navigation ratio for head-on engagement or tail-chase engagement.Therefore,the capture region of CPN is larger than that of other guidance laws using PN-based methods.

Ore-proportioning optimization technique with high proportion of Yandi ore in sintering

The basic sintering characteristics of Yandi ore from Australia, including assimilation ability, liquid phase fluidity, self-strength of bonding phase, forming ability of silico ferrite of calcium and aluminum （SFCA）, and so on, were investigated in detail. Besides, the high temperature behavior and function of sintering were obtained. As a result, the techniques for ore-proportioning in sintering were obtained. The results show that Yandi ore possessing higher assimilation ability, better liquid phase fluidity, lower self-strength of bonding phase, and better forming ability of SFCA, should be mixed with iron ores whose properties are opposite to those of Yandi ore. In the optimization of sintering ore-proportioning, Yandi ore, whose price is relatively low, can be mixed as high as 40wt%.

Tri-state Modulation Power Driving of Electro-hydraulic Proportional Amplifier

Switch electro-hydraulic proportional amplifier（PA） widely employs single switch modulation power driving（SSMPD） or reverse discharging power driving（RDPD） at present. SSMPD has slow dynamic response, and can＇t adjust independently the dither signal＇s amplitude and frequency; RDPD accelerates the current decay; consequently, it increases current ripple and power loss. For the purpose of solving the above mentioned problem, the tri-state modulation power driving（TSMPD） scheme was proposed for improving the performance of power driving. Detailedly, the hardware circuit for the tri-state modulation power driving is designed; the tri-state modulation algorithm is realized by digital signal processor（DSP）. The tri-state modulation power driving is investigated by experiments, comparetive experiments among the single switch modulation power driving（SSMPD）, reverse discharging power driving（RDPD）, and the TSMPD are implemented, and the experimental results demonstrate that the linearity error of TSMDP meets the requirement of PA; the current response of TSMSP is the best; the amplitude of ripple current of the TSMPD can be reduced without increasing frequency of PWM, in addition, dither signal amplitude and frequency can be adjusted independently for each other. It is very meaningful to guide the development of high performance proportional amplifier for high frequency response proportional solenoid.

Reliability estimation and remaining useful lifetime prediction for bearing based on proportional hazard model

As the central component of rotating machine,the performance reliability assessment and remaining useful lifetime prediction of bearing are of crucial importance in condition-based maintenance to reduce the maintenance cost and improve the reliability.A prognostic algorithm to assess the reliability and forecast the remaining useful lifetime(RUL) of bearings was proposed,consisting of three phases.Online vibration and temperature signals of bearings in normal state were measured during the manufacturing process and the most useful time-dependent features of vibration signals were extracted based on correlation analysis(feature selection step).Time series analysis based on neural network,as an identification model,was used to predict the features of bearing vibration signals at any horizons(feature prediction step).Furthermore,according to the features,degradation factor was defined.The proportional hazard model was generated to estimate the survival function and forecast the RUL of the bearing(RUL prediction step).The positive results show that the plausibility and effectiveness of the proposed approach can facilitate bearing reliability estimation and RUL prediction.

Effects of different proportions of two Bacillus sp. on the growth performance, small intestinal morphology, caecal microbiota and plasma biochemical profile of Chinese Huainan Partridge Shank chickens

A total of 900 one-d-old Chinese Huainan Partridge Shank chickens were randomly allocated into nine groups with five replicates of 20 each.Birds were fed with basal diet,basal diet supplemented with 150 mg kg^（–1） aureomycin,basal diet supplemented with different proportions of Bacillus licheniformis and Bacillus subtilis,which was 0：1.0×10~6,2.5×10~5：7.5×10~5,3.3×10~5：6.6×10~5,5.0×10~5：5.0×10~5,6.6×10~5：3.3×10~5,7.5×10~5：2.5×10~5 and 1.0×10~6：0,respectively.The duration of the experiment was 56 d.The results indicated that dietary supplementation of 6.6×10~5：3.3×10~5 of B.lichenifornis：B.subtilis improved final body weight,increased the average daily gain,and reduced feed/gain ratio（P〈0.05）.The numbers of total Lactobacillus and Bifidobacterium sp.in the caecum significantly increased,and the numbers of Escherichia coli and Salmonella sp.significantly declined compared to that of the control（P〈0.05）.Intestinal villous height and villous height to crypt depth ratio of the duodenum,jejunum,and ileum were significantly higher than that of the control,and intestinal crypt depth of the duodenum and ileum was significantly lower（P〈0.05）.The total antioxidant capacity,total superoxide dismutase,and glutathione peroxidase ability in plasma significantly improved,while the malondialdehyde concentration in plasma decreased（P〈0.05）.Compared to the control,plasma concentrations of ammonia,uric acid and urea nitrogen and the activity of xanthine oxidase were reduced（P〈0.05）.In conclusion,an inclusion of 6.6×10~5：3.3×10~5 of B.licheniformis：B.subtilis to the diet improved the growth performance,caecal microbiota,plasma biochemical profile,and significantly improved the small intestine morphology,while reducing the mortality rate.

Experimental research on coal seam similar material proportion and its application

In this paper, the optimization design of the low strength mechanical test and orthogonal test have been analyzed in order to simulate the mechanical properties of thick and extra-thick coal seam accurately in a similar material simulation test. The results show that the specimen can reach a wider range of strength when cement has been used compared to that of gypsum, suggesting that cement is more suitable for making coal seam in similar material simulation tests. The uniaxial compressive strength is more sensitive to cement than coal or sand. The proportion of coal and sand do not play a decisive role in uniaxial compressive strength. The uniaxial compressive strength and specimen density decrease as the mass percent of coal and aggregate–binder ratio rise. There is a positive correlation between uniaxial compressive strength and density. The No. 5 proportion(cement: sand: water: activated carbon: coal = 6:6:7:1.1:79.9)was chosen to be used in the similar material simulation test of steeply dipping and extra-thick coal seam with a density of 0.913 g/cm^3 and an uniaxial compressive strength of 0.076 MPa which are in accordance with the similarity theory. The phenomenon of overburden stratum movement, fracture development and floor pressure relief were obtained during the similar material simulation test by using the proportion.

DYNAMIC CHARACTERISTICS OF LARGE FLOW RATING ELECTROHYDRAULIC PROPORTIONAL CARTRIDGE VALVE

A kind of cartridge servo proportional valve is discussed, which can be used for controlling large flow rate with high performance. By analyzing the structure principle of the valve, the transfer fimction of the valve is derived. With the transfer function, some structure elements that may affect its performance are investigated. Through the numerical simulation and test study, some principles of optimality and effective methods for improving the dynamic performance of the valve are proposed. The test results conform to the results of the theoretical analysis and simulation, which proves the correctness of the study and simulation works. The paper provides theoretical basis for engineering applications and series expanding design works

Water-Assisted Injection Molding System Based on Water Hydraulic Proportional Control Technique

Water-assisted injection molding（WAIM）, an innovative process to mold plastic parts with hollow sections, is characterized with intermittent, periodic process and large pressure and flow rate variation. Energy savings and injection pressure control can not be .attained based on conventional valve control system. Moreover, the injection water can not be supplied directly by water hydraulic proportional control system. Poor efficiency and control performance are presented by current trial systems, which pressurize injection water by compressed air. In this paper, a novel water hydraulic system is developed applying an accumulator for energy saving. And a new differential pressure control method is proposed by using pressure cylinder and water hydraulic proportional pressure relief valve for back pressure control. Aiming at design of linear controller for injection water pressure regulation, a linear load model is approximately built through computational fluid dynamics（CFD） simulation on two-phase flow cavity filling process with variable temperature and viscosity, and a linear model of pressure control system is built with the load model and linearization of water hydraulic components. According to the simulation, model based feedback is brought forward to compensate the pressure decrease during accumulator discharge and eliminate the derivative element of the system. Meanwhile, the steady-state error can be reduced and the capacity of resisting disturbance can be enhanced, by closed-loop control of load pressure with integral compensation. Through the developed experimental system in the State Key Lab of Fluid Power Transmission and Control, Zhejiang University, China, the static characteristic of the water hydraulic proportional relief valve was tested and output pressure control of the system in Acrylonitrile Butadiene Styrene（ABS） parts molding experiments was also studied. The experiment results show that the dead band and hysteresis of the water hydraulic proportional pressure relief valve are large, but the control precision and linearity can be improved with feed-forward compensation. With the experimental results of injection water pressure control, the applicability of this WAIM system and the effect of its linear controller are verified. The novel proposed process of WAIM pressure control and study on characteristics of control system contribute to the application of water hydraulic proportional control and WAIM technology.

Proportional Fairness-Based Energy-Efficient Power Allocation in Downlink MIMO-NOMA Systems with Statistical CSI

In this paper, proportional fairness(PF)-based energy-efficient power allocation is studied for multiple-input multiple-output(MIMO) non-orthogonal multiple access(NOMA) systems. In our schemes, statistical channel state information(CSI) is utilized for perfect CSI is impossible to achieve in practice. PF is used to balance the transmission efficiency and user fairness. Energy efficiency(EE) is formulated under basic data rate requirements and maximum transmitting power constraints. Due to the non-convex nature of EE, a two-step algorithm is proposed to obtain sub-optimal solution with a low complexity. Firstly, power allocation is determined by golden section search for fixed power. Secondly total transmitting power is determined by fractional programming method in the feasible regions. Compared to the performance of MIMO-NOMA without PF constraint, fairness is obtained at expense of decreasing of EE.