4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： pr...4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathway in anaerobes ; and gentisate cleavage pathway. The last pathway including a NIH shift reaction remains to be elucidated. In this review we emphasized on the NIH shift reaction involved in the 4HBA degrdation. The key enzymes of each 4HBA metabolic pathway also were introduced. Finnaly, we described the thermophilic Bacillus sp. B1 strain which was capable of degrading varous aromatic compounds including gHBA, and presented a direction for the research of NIH shift reaction.展开更多
The title compound 2（C22H28N＋O3）·H2O·2Cl-was synthesized by the reaction of 2-bromo-1-[4-（benzyloxy）phenyl]-1-pentone with 2,2＇-azanediyldiethanol. The crystal determined by X-ray diffraction analysis ...The title compound 2（C22H28N＋O3）·H2O·2Cl-was synthesized by the reaction of 2-bromo-1-[4-（benzyloxy）phenyl]-1-pentone with 2,2＇-azanediyldiethanol. The crystal determined by X-ray diffraction analysis belongs to the monoclinic system, space group Pc with a = 18.312（3）, b = 14.838（3）, c = 7.6227（14） , β = 97.981（4）°, Z = 2, Mr = 797.82, V = 2051.1（6） 3, Dc = 1.292 g/cm3, S = 0.956, μ = 0.21 mm-1, F（000） = 852, the final R = 0.0625 and wR = 0.1428 for 5683 observed reflections （Ⅰ 〉 2σ（Ⅰ））. Flack parameter is 0.10（9）. The title compound is composed by four non-coplanar ring systems, two benzenes and two morpholines. One morpholine ring （C（3）-C（4）-N（1）-C（1）-C（2）-O（1）） forms a chair conformation, while the other （C（4）-C（3）-O（2）-C（6）-C（5）-N（1）） assumes a boat conformation. X-ray crystal structure displays extensive N-H…Cl and O-H…Cl intermolecular hydrogen bonds. The preliminary antidepressant activity test indicates that the inhibition ratio of SERT （5-HT Transporter） was 35.9% at the dosage of 10.0 mg/L.展开更多
One of the phenolic acids is 4-hydroxybenzoic acid(HBA)which takes the form of a white crystalline solid with a molecular formula of C 7H 6O 3,a melting point of 214.5℃and a molecular weight of 138.12 g·mol^(-1)...One of the phenolic acids is 4-hydroxybenzoic acid(HBA)which takes the form of a white crystalline solid with a molecular formula of C 7H 6O 3,a melting point of 214.5℃and a molecular weight of 138.12 g·mol^(-1).It soluble in polar organic solvents like acetone and alcohols,and slightly soluble in chloroform and water.The reactions between the metal ions and the HBA were carried out under specific conditions like(molar reaction was 2∶2(ligand to metal),reaction temperature was 60℃,media was neutral(pH 7),and solvent was H 2O∶MeOH(1∶1).Under these conditions,the HBA was deprotonated to form(HOC_(6)H_(4)CO^(2);L^(-)).The ligand L-was coordinated to the metal ions forming the metal complexation.The reaction of 4-hydroxybenzoic acid(HOC 6H 4CO 2H;HL)with the Ni(Ⅱ),Mn(Ⅱ)and Cu(Ⅱ)ions afford metal-complexes with gross formula of[Ni_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],[Mn_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)]and[Cu_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],respectively.These complexes were characterized by elemental analysis(CHN),magnetic susceptibility,UV-Vis spectra,infrared(IR),and X-ray powder diffraction(XRD)techniques.The complexes of HBA are insoluble in common solvents and hence molar conductance could not be measured,but this very insolubility indicates that the complexes are neutral.Data has demonstrated that the ligand(L^(-))was coordinated to the metal ion by bidentate bridging carboxylate group(COO^(-)),with an octahedral geometry.Thus,HBA is expected to act as bidentate uninegative ions and the coordination number of the metal ions is six.XRD results showed that the complexes possess uniform and organized microstructures in the nanometer range with a main diameter in the range of 11~28 nm.展开更多
基金Supported by the National Natural Science Foundation of China(31400099)Jiangsu Science and Technology Agency Project(BK20141148 and BK20140235)Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathway in anaerobes ; and gentisate cleavage pathway. The last pathway including a NIH shift reaction remains to be elucidated. In this review we emphasized on the NIH shift reaction involved in the 4HBA degrdation. The key enzymes of each 4HBA metabolic pathway also were introduced. Finnaly, we described the thermophilic Bacillus sp. B1 strain which was capable of degrading varous aromatic compounds including gHBA, and presented a direction for the research of NIH shift reaction.
基金Project supported by the National Technology R&D Program (No. 2011 BAE06B01)
文摘The title compound 2（C22H28N＋O3）·H2O·2Cl-was synthesized by the reaction of 2-bromo-1-[4-（benzyloxy）phenyl]-1-pentone with 2,2＇-azanediyldiethanol. The crystal determined by X-ray diffraction analysis belongs to the monoclinic system, space group Pc with a = 18.312（3）, b = 14.838（3）, c = 7.6227（14） , β = 97.981（4）°, Z = 2, Mr = 797.82, V = 2051.1（6） 3, Dc = 1.292 g/cm3, S = 0.956, μ = 0.21 mm-1, F（000） = 852, the final R = 0.0625 and wR = 0.1428 for 5683 observed reflections （Ⅰ 〉 2σ（Ⅰ））. Flack parameter is 0.10（9）. The title compound is composed by four non-coplanar ring systems, two benzenes and two morpholines. One morpholine ring （C（3）-C（4）-N（1）-C（1）-C（2）-O（1）） forms a chair conformation, while the other （C（4）-C（3）-O（2）-C（6）-C（5）-N（1）） assumes a boat conformation. X-ray crystal structure displays extensive N-H…Cl and O-H…Cl intermolecular hydrogen bonds. The preliminary antidepressant activity test indicates that the inhibition ratio of SERT （5-HT Transporter） was 35.9% at the dosage of 10.0 mg/L.
基金the deanship of scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding program。
文摘One of the phenolic acids is 4-hydroxybenzoic acid(HBA)which takes the form of a white crystalline solid with a molecular formula of C 7H 6O 3,a melting point of 214.5℃and a molecular weight of 138.12 g·mol^(-1).It soluble in polar organic solvents like acetone and alcohols,and slightly soluble in chloroform and water.The reactions between the metal ions and the HBA were carried out under specific conditions like(molar reaction was 2∶2(ligand to metal),reaction temperature was 60℃,media was neutral(pH 7),and solvent was H 2O∶MeOH(1∶1).Under these conditions,the HBA was deprotonated to form(HOC_(6)H_(4)CO^(2);L^(-)).The ligand L-was coordinated to the metal ions forming the metal complexation.The reaction of 4-hydroxybenzoic acid(HOC 6H 4CO 2H;HL)with the Ni(Ⅱ),Mn(Ⅱ)and Cu(Ⅱ)ions afford metal-complexes with gross formula of[Ni_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],[Mn_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)]and[Cu_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],respectively.These complexes were characterized by elemental analysis(CHN),magnetic susceptibility,UV-Vis spectra,infrared(IR),and X-ray powder diffraction(XRD)techniques.The complexes of HBA are insoluble in common solvents and hence molar conductance could not be measured,but this very insolubility indicates that the complexes are neutral.Data has demonstrated that the ligand(L^(-))was coordinated to the metal ion by bidentate bridging carboxylate group(COO^(-)),with an octahedral geometry.Thus,HBA is expected to act as bidentate uninegative ions and the coordination number of the metal ions is six.XRD results showed that the complexes possess uniform and organized microstructures in the nanometer range with a main diameter in the range of 11~28 nm.
