Protective mechanism of quercetin compounds against acrylamide-induced hepatotoxicity

Quercetin compounds have antioxidant,anti-inflammatory and anticancer pharmacological functions.Longterm exposure to acrylamide(AA)can cause liver injury and endanger human health.However,whether quercetin compounds can attenuate AA-induced liver injury and the specific mechanism are not clear.Here,we studied the mechanism and structure-activity relationship of quercetin compounds in reducing AA-induced hepatotoxicity in vivo and in vitro.In vivo studies found that quercetin-like compounds protect against AAinduced liver injury by reducing oxidative stress levels,activating the Akt/m TOR signaling pathway to attenuate autophagy,and improving mitochondrial apoptosis and endoplasmic reticulum stress-mediated apoptosis.In vitro studies found that quercetin compounds protected Hep G2 cells from AA by attenuating the activation of AA-induced autophagy,lowering reactive oxygen species(ROS)levels by exerting antioxidant effects and thus attenuating oxidative stress,increasing mitochondrial membrane potential(MMP),and improving apoptosis-related proteins,thus attenuating AA-induced apoptosis.Furthermore,the conformational differences between quercetin compounds correlated with their protective capacity against AA-induced hepatotoxicity,with quercetin showing the best protective capacity due to its strongest antioxidant activity.In conclusion,quercetin compounds can protect against AA-induced liver injury through multiple pathways of oxidative stress,autophagy and apoptosis,and their protective capacity correlates with antioxidant activity.

Antioxidant Protection Mechanisms Reveal Significant Response in Drought-Induced Oxidative Stress in Some Traditional Rice of Assam, India

Drought tolerance levels and antioxidant protection mechanisms were evaluated for 21 traditional rice varieties of Assam, India, along with Sahbhagi Dhan （drought tolerant） and IR64 （drought sensitive） as controls. Drought was imposed in hydroponic culture with polyethylene glycol 6000 （PEG6000） that was initially standardized with different concentrations. All the rice varieties showed apparent decreases in growth characteristics under drought stress （initially at 15% for 7 d followed by 20% PEG6000 for 7 d in Yoshida medium）. On the basis of standard evaluation score （SES）, eight rice varieties showed high drought tolerance which were carried forward for further biochemical analyses. Based on different morpho- physiological parameters, SN03 （Bora）, SN04 （Prosad Bhog）, SN05 （Kola Joha）, SN06 （Helash Bora）, SN08 （Salihoi Bao）, SN12 （Kola Amona）, SN20 （Ronga Bora） and SN21 （Sok-Bonglong） were identified as promising drought tolerant varieties. The non-enzymatic antioxidants activities viz., glutathione, ascorbate and enzymatic antioxidant activities such as superoxide dismutase （SOD）, catalase （CAT）, guaiacol peroxidase （GPX）, ascorbate peroxidase （APX）, glutathione reductase （GR） in shoots and roots of all the selected varieties revealed significant level of protection mechanisms as compared with controls. Enhancement in activities of the overall antioxidant enzymes including SOD, GPX, CAT, GR and APX under drought stress reflects their role in the adaptation process under water stress.

User location privacy protection mechanism for location-based services

With the rapid development of the Internet of Things(IoT),Location-Based Services(LBS)are becoming more and more popular.However,for the users being served,how to protect their location privacy has become a growing concern.This has led to great difficulty in establishing trust between the users and the service providers,hindering the development of LBS for more comprehensive functions.In this paper,we first establish a strong identity verification mechanism to ensure the authentication security of the system and then design a new location privacy protection mechanism based on the privacy proximity test problem.This mechanism not only guarantees the confidentiality of the user s information during the subsequent information interaction and dynamic data transmission,but also meets the service provider's requirements for related data.

Protection and Ecological Restoration of Water Level Fluctuation Zone in the Three Gorges Reservoir

Water level fluctuation zone(hereinafter referred to as "WLFZ") is a transitional ecosystem between terrestrial ecosystem and aquatic ecosystem,and also a key area to control its neighboring terrestrial and aquatic ecosystem. After the Three Gorges Reservoir was put into use,ecological environment of its WLFZ has aroused wide concern from domestic and foreign experts. On the basis of introducing characteristics of WLFZ of the Three Gorges Reservoir,current ecological environment and main problems of this area were analyzed,plant selection and configuration was elaborated as well as the implementation effect of many WLFZ protection and ecological restoration modes. In view of the actual conditions,pertinent suggestions were proposed for WLFZ of the Three Gorges Reservoir,namely classified protection and ecological restoration,enhancing monitoring and assessment of current situation and change tendency,carrying out technical researches and demonstration of WLFZ wetland ecological restoration.

Study on Mechanism and Control Effect of Highway Slope Ecological Protection

At present,with the rapid development of social economy,people's awareness of environmental protection continues to increase,and environmental construction and environmental protection work are put on the agenda.Highway slope greening protection is an important means to achieve social sustainable development.Developed countries carried out research earlier in this area,and China's research in this area started later.In engineering construction,ecological protection is to realize slope reinforcement and slope protection depending on the water storage and soil fixation effects of vegetation.Its slope protection can be summarized as the mechanical effect of root system and the hydrological effect of vegetation.As a basic form of slope greening protection,it is necessary for us to understand the mechanism of ecological protection and to enhance the design of ecological protection accordingly.Based on this,the article analyzed the development of slope greening protection technology and ecological protection mechanism from different angles,so as to establish a theoretical framework for future research.

Study on DeviceNet communication mechanism and its application in protection measurement and control system

To fit in with the developing requirement of int and communication of protective relays, a protection egrated functions of protection measurement, control measurement and control system based on DeviceNet fieldbus is designed. The communication mechanism of DeviceNet is studied and data trigger modes, communication connection, message types and other key technologies are analyzed. The object modeling and device description of the device are realized too. Results of network test, dynamic simulation and test in the field indicate that this system can accomplish all the communication tasks in real time and can make precise response to every kind of faults of the motor, transformer, line and capacitor. Moreover, this system has higher measurement precision and better control capability.

Thoughts and Practice of Ecological Protection and Restoration of Mountains, Rivers, Forests, Farmlands, Lakes and Grasslands

The report of the 19th National Congress of the Communist Party of China stated that it was necessary to establish and practice the concept that lucid waters and lush mountains are invaluable assets,treat the ecological environment as life,and coordinate the management of mountains,rivers,forests,farmlands,lakes and grasslands.In recent years,China has organized a series of pilot projects for the ecological protection and restoration of mountains,rivers,forests,farmlands,lakes and grasslands,breaking the boundary between administrative divisions,departmental management and ecological elements,and implementing conservation and restoration oriented towards the improvement of ecosystem services,so as to solve the problem of the lack of overall planning for ecological protection and restoration projects and the separated management of ecological elements.This study systematically elaborated the theoretical basis and connotation characteristics of ecological protection and restoration of mountains,rivers,forests,farmlands,lakes and grasslands.It proposed the implementation path of ecological protection and restoration project of mountains,rivers,forests,farmlands,lakes and grasslands by taking the water source conservation area of Beijing-Tianjin-Hebei as a case,so as to provide reference for the implementation and decision-making management of ecological protection and restoration projects in various regions.

Current Situation and Ideas of Protection and Restoration of Aquatic Ecosystems in Rivers and Lakes of China

Based on the investigation and analysis of protection and restoration of aquatic ecosystems in rivers and lakes of China, the ideas and measures of restoring aquatic ecosystems were proposed to build healthy aquatic ecosystems of rivers and lakes in China, such as setting scientific and clear goals, improving the standard adopted by wastewater treatment plants, controlling sources of pollutants and intercepting pollutants, collec- tion of blue-green algae, water transfer, dredging, reducing the quantity of blue-green algae, restoring reed wetlands on a large scale, combing dredging and base raise of restored reed wetlands, making full use of microorganisms, and implementing effective management, technology integra- tion and innovation.

Study on Key Problems of a New Environmental Dredging Based on Ecological Protection and Subsequent Ecological Restoration

[Objective] The research aimed to study key problems of a new environmental dredging based on ecological protection and subsequent ecological restoration. [Method] People paid more attention to sediment pollutant removal in environmental dredging, without considering coming aquatic eco-restoration work after dredging. Factor affecting aquatic ecosystem existence and growth was screened, and ecological dredging manner was put forward. [Result] On the basis of analyzing dredging objective, effect and influence, started from ecological protection and subsequent ecological restoration, water depth and substrate were screened as priority control factors of the environmental sediment dredging. New manner of combining sediment dredging to reshape underwater terrain was put forward. [Conclusion] The research provided solution for water depth and substrate demands of the subsequent ecological restoration.

Coordination Mechanism of the Legal Protection of Resource Security with Its Relative Laws

The basis of the legal protection of resource security is its relative laws, which have four main characteristics, which are foundational, divergent, comprehensive and of long-term social benefits in view. The coordination mechanism of the legal protection of resource security with its relative laws meets the needs of the sustainable development of the economy, society and environment. It also facilitates and is facilitated by the modern transformation of the legal system in China, and upholds the legal system as a logically self-perfecting entity. Furthermore, this coordination bears scientific feasibility.

Game Analysis and Mechanism Design of Ecological Protection Red Line for Ecologically Vulnerable Areas in Western China

Drawing the ecological protection red line is to maintain the integrity and benign operation of the ecosystem within the area,and to ensure that the ecological environment is within the boundary of controllable ecological security.Taking the ecologically vulnerable areas in western China as the research object and using the game theory and literature analysis,this paper studied the game behavior of ecological protection red line in these areas.In addition,this paper also analyzed the stakeholders such as government,enterprises and the masses in the drawing of the ecological protection red line,and comprehensively analyzed the game strategies between the government and the masses,the government and enterprises,and the central and local governments and enterprises.On the basis of the analysis,it came up with a safeguard mechanism for the coordination of the interests of the ecological protection red line.

Study on Protection Mechanism of Viscum coloratum (Kom.) Nakai f. lutescens kitag Fruit Polysaccharides on Mice with Acute Alcoholic Liver Injury

This study was conducted to investigate the protective mechanism of V. coloratum fruit polysaccharides（ VCFP） on mice with acute alcoholic liver injury. Acute liver injury model was built by one-time alcohol gavage. The mice were randomly divided into VCFP-treated groups（ low-,medium-,and highdose）,alcohol model group and normal control group at the same time. VCFP-treated groups were administrated polysaccharide intragastrically continuously for4 weeks; and the alcohol model group and normal control group were administrated intragastrically the same amount of normal saline. The general situation and liver tissue morphological structure changes were observed. The results showed that the levels of ALT,AST,TC,TG,MDA contents,and CAT and GSH-Px activity of mice in the model group increased significantly（ P 〈 0. 01）,while the activity of SOD and weight and liver index decreased significantly（ P 〈 0. 01） compared with the normal control group. After 4 weeks of gavage,VCFP could significantly improve weight,liver index and SOD activity,and significantly reduce ALT,AST,TC and TG levels,MDA content and CAT and GSH-Px activity. These results suggest that VCFP can improve antioxidant enzyme activity,remove oxygen free radical and reduce membrane lipid peroxidation reaction,thereby protecting liver cells.

Protection and Restoration of Soil and Water Ecology to Achieve Harmonious Coexistence between Human and Nature

At present,the ecological environment crisis of global concern,such as climate warming and biodiversity loss,the fundamental reason is the change and destruction of the earth's soil and water ecology.Therefore,protecting and restoring the authenticity,diversity,cleanliness and integrity of soil and water ecology,we should coordinate and deal with the relationship between human beings and soil and water ecology,and realize the harmonious coexistence between human beings and nature from the three aspects of protecting natural soil and water ecology,protecting and restoring natural soil and water ecology,building and regenerating artificial soil and water ecology.

Research on the Environmental Protection Mechanism under the Framework of WTO

WTO, as the most influencing international economic organization, has given rise to some problems worthy of thinking deeply when creating a great trade platform for all countries. For example, the original ecological environment has been destroyed by the development of trade and economy, so that the countries from all over the world are encountering serious environmental crisis. In this paper, the current situation under the new economic environment is introduced first, the environmental protection mechanism in the report of the WTO panel, and also comprehensive countermeasures performed in the new environmental protection mechanism are proposed. Hopefully, this paper can play a help in the further researches.

Persist in Law-based Protection of Human Rights and Improve the Mechanism for the Protection of Human Rights by the Rule of Law

General Secretary Xi Jinping delivered an important speech on China’s Path of Human Rights at a group study session of the Political Bureau of the CPC Central Committee on February 25,2022.Persisting with the law-based protection of human rights and improving the mechanism for the protection of human rights by the rule of law are essential for unswervingly following the development path of human rights in China.The improvement of the mechanism for the protection of human rights by the rule of law necessitates adhering to the principle of respecting the dominant role of the people and removing the institutional obstacles in rule of law protection of human rights;to comprehensively strengthen the implementation of the Constitution,advance the filing and examination of the Constitution,and safeguard the authority of the Constitution;to accelerate the theoretical innovation of human rights and the construction of the discipline system,the academic system and the discourse system of human rights that meet the needs of the new era in China,and to actively participate in and contribute to the global governance on human rights,etc.Improving the mechanism for the protection of human rights by the rule of law can provide a solid protection for people enjoying a better life.

Study of Human Rights Protection Mechanisms for Suspects at the Investigation Stage

When criminal suspects are being investigated for criminal responsibil- ity, they are the most vulnerable to infringement by public power. Thus, they need more special attention and protection. It is the in- evitable requirement of the modern democratic rule of law, and also the inevitable historic choice of respecting and protecting human rights.

Formation mechanism of the graphite-rich protective layer in blast furnace hearths

A long campaign life of blast furnaces is heavily linked to the existence of a protective layer in their hearths. In this work, we conducted dissection studies and investigated damage in blast furnace hearths to estimate the formation mechanism of the protective layer. The results illustrate that a significant amount of graphite phase was trapped within the hearth protective layer. Furthermore, on the basis of the thermodynamic and kinetic calculations of the graphite precipitation process, a precipitation potential index related to the formation of the graphite-rich protective layer was proposed to characterize the formation ability of this layer. We determined that, under normal operating conditions, the precipitation of graphite phase ~om hot metal was thermodynamically possible. Among elements that exist in hot metal, C, Si, and P favor graphite precipitation, whereas Mn and Cr inhibit this process. Moreover, at the same hot-face temperature, an increase of carbon concentration in hot metal can shorten the precipitation time. Finally, the results suggest that measures such as reducing the hot-face tem- perature and increasing the degree of carbon saturation in hot metal are critically important to improve the precipitation potential index.

Evolution mechanism and treatment timing of penetrating fissures

The Inner Mongolia mining area in western China are characterized by the development of numerous penetrating fissures,resulting in severe land damage.It is significant to reveal the underlying evolution mechanism and identify treatment timing for restoring the ecological environment.The Guanbanwusu mining subsidence area in Inner Mongolia,China was selected as the research case for this study.The evolution mechanism of different penetrating fissures was revealed by field measurement,physical simulation and theoretical analysis.The treatment timing prediction model for the mining subsidence area was established based on the enhanced Weibull time function.The results show that the ground fissures are mainly step-type and collapse-type fissures.The breaking form of overlying strata determines their vertical opening and horizontal dislocation.The high mining intensity in the western mining area results in a shortened period of dynamic fissure expansion and reduced closure degree.The damage extent of the overlying strata exhibits zoning characteristics both vertically and horizontally.The relative standard deviation of the prediction model is only 3.7%.Concurrently,the prediction model is employed to determine the optimal timing for treatment in the study area,estimated to be 259 days.Subsequently,once this threshold is reached,the study area undergoes treatment and restoration of its e cological environment.This study addresses the knowledge gap in this field by highlighting the interconnectedness between rock strata structure and evolution mechanism of penetrating fissures,thereby providing a method for determining the treatment timing in mining subsidence areas.

Protective Effects of Ginsenoside Rb1 on Septic Rats and Its Mechanism

This study aims to observe the protective effects of ginsenoside Rbl on liver and lung in rats with septic shock and reveal its mechanism. Rats were randomly divided into three groups： sham, cecal ligation and puncture （CLP）, and CLP with ginsenoside Rb1. Then, the survival rate, arterial blood pressure, TLR4 mRNA, and TNF-α levels were determined. The liver and lung tissues were stained with hematoxylin-eosin （HE）. The overall survival rate of the Rb1 group was significantly higher than that of the CLP group. Mean arterial blood pressure went down in both the CLP and Rb1 groups after CLP, and there was a significant difference both in the sham and Rb1 groups when compared with the CLP group. The Rb1 treatment group had markedly lower TLR4 mRNA expression and TNF-a levels than the CLP group. In the CLP group, pathology showed swelling, degeneration, necrosis, and neutrophii infiltration in the liver and alveolar epithelial cells. However, in the Rb1 group, there was mild degeneration and slight neutrophil infiltration, but no obvious necrosis. Rb1 may improve the survival rate, ameliorate arterial blood pressure, and protect the liver and lung in septic shock rats by downregulating the expression of TLR4 mRNA and inhibiting the production of TNF-α.

A Cover-Independent Deep Image Hiding Method Based on Domain Attention Mechanism

Recently,deep image-hiding techniques have attracted considerable attention in covert communication and high-capacity information hiding.However,these approaches have some limitations.For example,a cover image lacks self-adaptability,information leakage,or weak concealment.To address these issues,this study proposes a universal and adaptable image-hiding method.First,a domain attention mechanism is designed by combining the Atrous convolution,which makes better use of the relationship between the secret image domain and the cover image domain.Second,to improve perceived human similarity,perceptual loss is incorporated into the training process.The experimental results are promising,with the proposed method achieving an average pixel discrepancy(APD)of 1.83 and a peak signal-to-noise ratio(PSNR)value of 40.72 dB between the cover and stego images,indicative of its high-quality output.Furthermore,the structural similarity index measure(SSIM)reaches 0.985 while the learned perceptual image patch similarity(LPIPS)remarkably registers at 0.0001.Moreover,self-testing and cross-experiments demonstrate the model’s adaptability and generalization in unknown hidden spaces,making it suitable for diverse computer vision tasks.