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Temperature-Triggered Hardware Trojan Based Algebraic Fault Analysis of SKINNY-64-64 Lightweight Block Cipher
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作者 Lei Zhu Jinyue Gong +1 位作者 Liang Dong Cong Zhang 《Computers, Materials & Continua》 SCIE EI 2023年第6期5521-5537,共17页
SKINNY-64-64 is a lightweight block cipher with a 64-bit block length and key length,and it is mainly used on the Internet of Things(IoT).Currently,faults can be injected into cryptographic devices by attackers in a v... SKINNY-64-64 is a lightweight block cipher with a 64-bit block length and key length,and it is mainly used on the Internet of Things(IoT).Currently,faults can be injected into cryptographic devices by attackers in a variety of ways,but it is still difficult to achieve a precisely located fault attacks at a low cost,whereas a Hardware Trojan(HT)can realize this.Temperature,as a physical quantity incidental to the operation of a cryptographic device,is easily overlooked.In this paper,a temperature-triggered HT(THT)is designed,which,when activated,causes a specific bit of the intermediate state of the SKINNY-64-64 to be flipped.Further,in this paper,a THT-based algebraic fault analysis(THT-AFA)method is proposed.To demonstrate the effectiveness of the method,experiments on algebraic fault analysis(AFA)and THT-AFA have been carried out on SKINNY-64-64.In the THT-AFA for SKINNY-64-64,it is only required to activate the THT 3 times to obtain the master key with a 100%success rate,and the average time for the attack is 64.57 s.However,when performing AFA on this cipher,we provide a relation-ship between the number of different faults and the residual entropy of the key.In comparison,our proposed THT-AFA method has better performance in terms of attack efficiency.To the best of our knowledge,this is the first HT attack on SKINNY-64-64. 展开更多
关键词 SKINNY-64-64 lightweight block cipher algebraic fault analysis Hardware Trojan residual entropy
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A Comparative Analysis of the New -3(-n) - 1 Remer Conjecture and a Proof of the 3n + 1 Collatz Conjecture
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作者 Mike Remer 《Journal of Applied Mathematics and Physics》 2023年第8期2216-2220,共5页
This scientific paper is a comparative analysis of two mathematical conjectures. The newly proposed -3(-n) - 1 Remer conjecture and how it is related to and a proof of the more well known 3n + 1 Collatz conjecture. An... This scientific paper is a comparative analysis of two mathematical conjectures. The newly proposed -3(-n) - 1 Remer conjecture and how it is related to and a proof of the more well known 3n + 1 Collatz conjecture. An overview of both conjectures and their respective iterative processes will be presented. Showcasing their unique properties and behavior to each other. Through a detailed comparison, we highlight the similarities and differences between these two conjectures and discuss their significance in the field of mathematics. And how they prove each other to be true. 展开更多
关键词 -3(-n) - 1 Remer Conjecture 3n + 1 Collatz Conjecture Comparative analysis PROOF Natural Numbers Integer Sequences Factorial Processes Par-tial Differential Equations Bounded Values Collatz Conjecture Collatz Algo-rithm Collatz Operator Collatz Compliance And Mathematical Conjectures
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Analysis of Difficulties in Simultaneous Interpreting(SI) from a Psycho-linguistic Perspective
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作者 刘安琪 《海外英语》 2017年第21期146-148,共3页
Nowadays,simultaneous interpreting(SI) plays a prominent role in global communications,especially for important international affairs.This kind of interpretation delivers information in an instantaneous way without wa... Nowadays,simultaneous interpreting(SI) plays a prominent role in global communications,especially for important international affairs.This kind of interpretation delivers information in an instantaneous way without wasting extra time for language processing.Performing well in SI requires long-time training and abundant experience.Making a comprehensive categorization and analysis on the difficulties in SI on the basis of psycho-linguistic theories are the key points.Due to the distinctive features of these difficulties,corresponding suggestions will be offered to improve the efficiency in SI training and to level up the performance of SI interpreters. 展开更多
关键词 Simultaneous Interpreting(SI) difficulty analysis SI training psycho-linguistics
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Integrated use of GIS, remote sensing and multi-criteria decision analysis to assess ecological land suitability in multi-functional forestry 被引量:5
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作者 Naser Ahmadi Sani Sasan Babaie Kafaky +1 位作者 Timo Pukkala Asadollah Mataji 《Journal of Forestry Research》 SCIE CAS CSCD 2016年第5期1127-1135,共9页
The Zagros forests are a treasure of valuable oak forests, but they have been severely degraded from long-term misuse. Geographic information systems (GIS) and multi-criteria decision analysis (MCDA) have been inc... The Zagros forests are a treasure of valuable oak forests, but they have been severely degraded from long-term misuse. Geographic information systems (GIS) and multi-criteria decision analysis (MCDA) have been increasingly used to improve the management of vulnerable ecosystems to prevent further degradation and increase the sustainability of land use. This study presents a methodology to assess land suitability using remote sensing (RS) to obtain wall-to-wall data for the calculations, GIS to analyze the data, and MCDA to rank alternative land uses. The criteria and subcriteria affecting the suitability of land for different uses were identified and weighted using an analytic hierarchy process. Variables used as subcriteria were assessed using satellite data and other sources of information such as existing maps and field surveys. Numerical values for the subcriteria were classified, and each class was given a priority rating according to expert judgments. Based on the ratings and weights of the subcriteria, a priority map was created for each land use using the weighted linear combination method. The priority maps for different land uses were overlaid to obtain a preliminary land use map, which often indicated several simultaneous land uses for the same location. The preliminary map was further edited by removing unrealistic, mutually exclusive land-use combinations. The study tested and demonstrated the potential of integrating RS, G1S and MCDA techniques for solving complicated land allocation problems in forested regions using a scientifically sound and practical approach for efficient and sustainable allocation of forestland for different uses. 展开更多
关键词 Analytic hierarchy process Decisionanalysis Ecological suitability Land allocation Land-use planning - Spatial analysis - Zagros forests
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Symplectic analysis for elastic wave propagation in two-dimensional cellular structures 被引量:5
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作者 Xiu-Hui Hou Zi-Chen Deng +1 位作者 Jia-Xi Zhou Tie-Quan Liu 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第5期711-720,共10页
On the basis of the finite element analysis, the elastic wave propagation in cellular structures is investigated using the symplectic algorithm. The variation principle is first applied to obtain the dual variables an... On the basis of the finite element analysis, the elastic wave propagation in cellular structures is investigated using the symplectic algorithm. The variation principle is first applied to obtain the dual variables and the wave propagation problem is then transformed into two-dimensional (2D) symplectic eigenvalue problems, where the extended Wittrick-Williams algorithm is used to ensure that no phase propagation eigenvalues are missed during computation. Three typical cellular structures, square, triangle and hexagon, are introduced to illustrate the unique feature of the symplectic algorithm in higher-frequency calculation, which is due to the conserved properties of the structure-preserving symplectic algorithm. On the basis of the dispersion relations and phase constant surface analysis, the band structure is shown to be insensitive to the material type at lower frequencies, however, much more related at higher frequencies. This paper also demonstrates how the boundary conditions adopted in the finite element modeling process and the structures' configurations affect the band structures. The hexagonal cells are demonstrated to be more efficient for sound insulation at higher frequencies, while the triangular cells are preferred at lower frequencies. No complete band gaps are observed for the square cells with fixed-end boundary conditions. The analysis of phase constant surfaces guides the design of 2D cellular structures where waves at certain frequencies do not propagate in specified directions. The findings from the present study will provide invaluable guidelines for the future application of cellular structures in sound insulation. 展开更多
关键词 Cellular structures Symplectic analysis Dispersion relation - Phase constant surface Sound insulation
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Algebraic Solution for the Forward Displacement Analysis of the General 6-6 Stewart Mechanism 被引量:8
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作者 WEI Feng WEI Shimin +1 位作者 ZHANG Ying LIAO Qizheng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第1期56-62,共7页
The solution for the forward displacement analysis(FDA) of the general 6-6 Stewart mechanism(i.e., the connection points of the moving and fixed platforms are not restricted to lying in a plane) has been extensive... The solution for the forward displacement analysis(FDA) of the general 6-6 Stewart mechanism(i.e., the connection points of the moving and fixed platforms are not restricted to lying in a plane) has been extensively studied, but the efficiency of the solution remains to be effectively addressed. To this end, an algebraic elimination method is proposed for the FDA of the general 6-6 Stewart mechanism. The kinematic constraint equations are built using conformal geometric algebra(CGA). The kinematic constraint equations are transformed by a substitution of variables into seven equations with seven unknown variables. According to the characteristic of anti-symmetric matrices, the aforementioned seven equations can be further transformed into seven equations with four unknown variables by a substitution of variables using the Grobner basis. Its elimination weight is increased through changing the degree of one variable, and sixteen equations with four unknown variables can be obtained using the Grobner basis. A 40th-degree univariate polynomial equation is derived by constructing a relatively small-sized 9 × 9 Sylvester resultant matrix. Finally, two numerical examples are employed to verify the proposed method. The results indicate that the proposed method can effectively improve the efficiency of solution and reduce the computational burden because of the small-sized resultant matrix. 展开更多
关键词 general 6-6 Stewart mechanism forward displacement analysis (FDA) conformal geometric algebra (CGA) Gr6bner basis Sylvester resultant
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Numerical Analysis of the Adhesive Forces in Nano-Scale Structure 被引量:1
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作者 Young-Sam Cho Houkseop Han Wan-Doo Kim 《Journal of Bionic Engineering》 SCIE EI CSCD 2006年第4期209-216,共8页
Nanohairs, which can be found on the epidermis of Tokay gecko's toes, contribute to the adhesion by means of van der Waals force, capillary force, etc. This structure has inspired many researchers to fabricate the at... Nanohairs, which can be found on the epidermis of Tokay gecko's toes, contribute to the adhesion by means of van der Waals force, capillary force, etc. This structure has inspired many researchers to fabricate the attachable nano-scale structures. However, the efficiency of artificial nano-scale structures is not reliable sufficiently. Moreover, the mechanical parameters related to the nano-hair attachment are not yet revealed qualitatively. The mechanical parameters which have influence on the ability of adhesive nano-hairs were investigated through numerical simulation in which only van der Waals force was considered. For the numerical analysis, finite element method was utilized and van der Waals force, assumed as 12-6 Lennard-Jones potential, was implemented as the body force term in the finite element formulation. 展开更多
关键词 NUMERICAL analysis adhesive force nano-scale structure finite element model van der Waals force 12-6 L-J potential
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Multiple Regression Analysis of Influencing Factors on Yield of New Sugarcane Variety Yuetang 03-373
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作者 Fangyin PAN Fuye LIU +1 位作者 Mingfu WEN Qingwen LUO 《Asian Agricultural Research》 2020年第5期47-49,共3页
[Objectives]The purpose of this study was to provide reference for cultivation and promotion of a new sugarcane variety Yuetang 03-373,on the basis of analyzing and summarizing the characters of the variety.[Methods]C... [Objectives]The purpose of this study was to provide reference for cultivation and promotion of a new sugarcane variety Yuetang 03-373,on the basis of analyzing and summarizing the characters of the variety.[Methods]Correlation,multiple regression and path analyses were performed for the yield and yield components of Yuetang 03-373.[Results]Correlation analysis shows that cane yield was significantly correlated with millable stalk number,stalk length and stalk diameter,and among them,the correlation with millable stalk number was the strongest.Multiple regression and path analyses show that millable stalk number contributed the most to cane yield,followed by stalk length,and stalk diameter contributed the least.The regression equation of cane yield against the three yield components was y=-2.8713+1.5497x1+5.8990x2-395.4294x3(R=0.9672**).[Conclusions]Millable stalk number and stalk length were the important and major factors for high yield of Yuetang 03-373,indicating that Yuetang 03-373 is a sugarcane variety of millable stalk type.In cultivation,full play should be given to the advantage of Yuetang 03-373 in millable stalk number,as well as stalk length(plant height),in order to achieve the purpose of increasing yield. 展开更多
关键词 Yuetang 03-373 Yield traits Correlation analysis Multiple regression analysis
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A search for evidence of small-scale inhomogeneities in dense cores from line profile analysis
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作者 Lev Pirogov 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2018年第8期97-102,共6页
In order to search for intensity fluctuations on the HCN(1-0) and HCO+(1-0) line pro- files, which could arise due to possible small-scale inhomogeneous structure, long-term observations of high-mass star-forming... In order to search for intensity fluctuations on the HCN(1-0) and HCO+(1-0) line pro- files, which could arise due to possible small-scale inhomogeneous structure, long-term observations of high-mass star-forming cores S140 and S199 were carried out. The data were processed by the Fourier filtering method. Line temperature fluctuations that exceed the noise level were detected. Assuming the cores consist of a large number of randomly moving small thermal fragments, the total number of frag- ments is - 4 × 106 for the region with linear size - 0.1 pc in S140 and - 106 for the region with linear size - 0.3 pc in S 199. Physical parameters of fragments in S 140 were obtained from detailed modeling of the HCN emission in the framework of the clumpy cloud model. 展开更多
关键词 LINES profiles - molecular data - methods data analysis - ISM clouds - ISM molecules - ISM structure - ISM individual objects (S 140)
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An analysis on El Nino processes during 1949-1987
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《Acta Oceanologica Sinica》 SCIE CAS CSCD 1990年第2期219-226,共8页
-In this paper, the outset, evolution and intensity of El Nino were analyzed. Different features were found in each El Nino process. The El Nino of 1986 was also analyzed and outlined.
关键词 Nino Pro An analysis on El Nino processes during 1949-1987 SST El
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Entropy Analysis of Vapor-Compression Refrigeration System by Using the Second Law of Thermodynamics
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作者 杨洪海 《Journal of China Textile University(English Edition)》 EI CAS 1999年第4期42-44,共3页
By means of the Second Law of Thermodynamics,thispaper gives out the entropy analysis method for vapor-comperession refrigeration system.The thermal irrevers-ibility of the system charged with R12 and its hopeful al-t... By means of the Second Law of Thermodynamics,thispaper gives out the entropy analysis method for vapor-comperession refrigeration system.The thermal irrevers-ibility of the system charged with R12 and its hopeful al-ternative refrlgerant R134a have been studied respective-ly.On the basis of all the research results of this paper,the measure used to save energy for vapor-compressionrefrigeration system has been put out. 展开更多
关键词 Vapor - Compression REFRIGERATION System Sec-ond Law of THERMODYNAMICS ENTROPY analysis Alternative REFRIGERANT of CFC’s
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Differential interformational velocity analysis as an effective direct hydrocarbon indicator under velocity reversal conditions,an example from the anomalously high temperature and over-pressured DF1-1 Gas Field in the Yinggehai Basin,South China Sea
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作者 Zhu Hongtao Liu Keyu +2 位作者 Chen Kaiyuan Li Min Huang Shengbing 《Petroleum Science》 SCIE CAS CSCD 2009年第4期339-346,共8页
In the DF1-1 Gas Field in the Yinggehai Basin, South China Sea, the velocity-depth plot and velocity spectra show significant variations from a linear trend, exhibiting a distinct reversal phenomenon. Velocity paramet... In the DF1-1 Gas Field in the Yinggehai Basin, South China Sea, the velocity-depth plot and velocity spectra show significant variations from a linear trend, exhibiting a distinct reversal phenomenon. Velocity parameters derived from velocity spectral analysis of the seismic data and sonic logs indicate that the interval velocity reverses below 2,100 m (2.2 s two-way time (TWT)) in the DF1-1 Gas Field. Some direct hydrocarbon indicators (DHIs) models developed for the shallow strata cannot be simply applied to the moderately to deeply buried strata for direct exploration target recognition because the velocity reversal has caused the middle-deep gas reservoirs to exhibit a moderate or weak seismic amplitude. The hydrocarbon indicator method of “Differential Interformational Velocity Analysis (DIVA)” with the aid of other hydrocarbon indicating techniques was employed to effectively identify DHIs in the middle-deep strata under velocity inversion. The result has shown that the DIVA technique can be effectively used as a DHI in both the shallow and the middle-deep strata in the study area with the shallow strata characterized by Type I DIVA anomaly and the middle-deep strata characterized by the Type II DIVA anomaly. 展开更多
关键词 DF1-1 Gas Field velocity reversal direct hydrocarbon indicator differential interformational velocity analysis South China Sea
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Extending and analysis of X-Code
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作者 金超 冯丹 刘景宁 《Journal of Shanghai University(English Edition)》 CAS 2011年第3期194-200,共7页
X-Code is one of the most important redundant array of independent disk (RAID)-6 codes which are capable of tolerating double disk failures. However, the code length of X-Code is restricted to be a prime number, and... X-Code is one of the most important redundant array of independent disk (RAID)-6 codes which are capable of tolerating double disk failures. However, the code length of X-Code is restricted to be a prime number, and such code length restriction of X-Code limits its usage in the real storage systems. Moreover, as a vertical RAID-6 code, X-Code can not be extended easily to an arbitrary code length like horizontal RAID-6 codes. In this paper, a novel and efficient code shortening algorithm for X-Code is proposed to extend X-Code to an arbitrary length. It can be further proved that the code shortening algorithm maintains the maximum-distance-separable (MDS) property of X-Code, and namely, the shortened X-Code is still MDS code with the optimal space efficiency. In the context of the shortening algorithm for X-Code, an in-depth performance analysis on X-Code at consecutive code lengths is conducted, and the impacts of the code shortening algorithm on the performance of X-Code in various performance metrics are revealed. 展开更多
关键词 redundant array of independent disk (RAID)-6 X-Code vertical code code shortening performance analysis
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ANALYSIS OF PSYCHOLOGIC HEALTH STATE AND INFLUENCING FACTORS IN COLLEGE AND SECONDARY SCHOOL STUDENTS IN SHAANXI PROVINCE
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作者 高成阁 王友平 +1 位作者 谭新 亢万虎 《Academic Journal of Xi'an Jiaotong University》 2000年第2期168-171,共5页
Objective The psychologic health level of college and secondaryschool students and the relevant factors were investigated to scientific basis and guidance for school mental health work.Methods Standard 1251 cases were... Objective The psychologic health level of college and secondaryschool students and the relevant factors were investigated to scientific basis and guidance for school mental health work.Methods Standard 1251 cases were drawn from 1‰ of students in colleges and middle schools of Shaanxi province.Taking 14 psychic health level indexes in SCL 90 as dependent variable and 109 indexes of psychic health back ground as in dependent variable, multi factor analyses have been made.Results 22.6% of students had relatively serious psychological problems.The score of SCL 90 in females was a little bit higher than that in males.The scores of students at both universities and senior middle schools were higher than that in junior middle schools students.The score of SCL 90 of students who came from the countryside was higher than that of city students.The score of the whole students was higher than that of the normal.The students with psychic problems showed obsession,interpersonal sensitivity,depression,anxiety,paranoia and hostility.Factor analysis showed that influencing factors included history of positive individual risking behavior,physical conditions,grade,address,family influences,menses and sexual prombles,bad relation with others,poor self assessment.Conclusion The psychologic health level of the students investigated is lower than that of the whole society.The factors,which hamper psychic health of students, are biological,psychological and social in nature. 展开更多
关键词 school psychologic health SCL -90 multi factor analysis influencing factors
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Example-based super-resolution for single-image analysis from the Chang'e-1 Mission
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作者 Fan-Lu Wu Xiang-Jun Wang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2016年第11期57-60,共4页
Due to the low spatial resolution of images taken from the Chang'e-1 (CE-I) orbiter, the details of the lunar surface are blurred and lost. Considering the limited spatial resolution of image data obtained by a CCD... Due to the low spatial resolution of images taken from the Chang'e-1 (CE-I) orbiter, the details of the lunar surface are blurred and lost. Considering the limited spatial resolution of image data obtained by a CCD camera on CE-1, an example-based super-resolution (SR) algorithm is employed to obtain high- resolution (HR) images. SR reconstruction is important for the application of image data to increase the resolution of images. In this article, a novel example-based algorithm is proposed to implement SR reconstruction by single-image analysis, and the computational cost is reduced compared to other example-based SR methods. The results show that this method can enhance the resolution of images using SR and recover detailed information about the lunar surface. Thus it can be used for surveying HR terrain and geological features. Moreover, the algorithm is significant for the HR processing of remotely sensed images obtained by other imaging systems. 展开更多
关键词 Moon - methods: data analysis - techniques: image processing
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A Diagnostic Analysis of Winter Atmospheric Circulation during the 1982-1983 ENSO Event
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作者 滕星林 符淙斌 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 1990年第1期57-66,共10页
In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure o... In this paper, the winter atmospheric circulation, the convection along the equator and their variations of 1982 and 1983 are investigated. It is suggested that there was a well organized three dimensional structure of anomalies of the atmospheric circulations during 1982 winter which may be related to the variations of the convection in the equatorial region. 展开更多
关键词 A Diagnostic analysis of Winter Atmospheric Circulation during the 1982-1983 ENSO Event ENSO
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A Hydrometeorological Analysis of the Severe Rainstorm of 20-22 September 1900 over the Gangetic West Bengal
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作者 P. R. Rakhecha B. N. Mandal +1 位作者 A. K. Kulkarni R. B. Sangam 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 1993年第1期113-120,共8页
A hydrometeorological study is made of the September, 1900 severe rainstorm which led up to the record rainfalls over Gangetic West Bengal with subsequent disastrous flooding in the Damodar and the Hooghly rivers. The... A hydrometeorological study is made of the September, 1900 severe rainstorm which led up to the record rainfalls over Gangetic West Bengal with subsequent disastrous flooding in the Damodar and the Hooghly rivers. The spatial extent of the rainstorm for different durations has been examined by constructing the isohyetal patterns based on rainfall records of stations affected by the storm. Areal rainfalls for 1,2 and 3-day periods are calculated and the values have been compared with similar values from other major rainstorms of the region. The comparison revealed that the September, 1900 rainstorm was the heaviest for 1,2 and 3-day durations for all the areas. The storm contributed rainfalls of 33.0 cm, 52.0 cm and 62.0 cm over an area of 10,000 km2 in 1,2 and 3 days respectively. This rainstorm could, therefore, be considered as an important input in flood and design storm studies in the Gangetic West Bengal region. A relationship between point to areal rainfall has also been developed with a view to evaluate areal PMP estimates. 展开更多
关键词 A Hydrometeorological analysis of the Severe Rainstorm of 20-22 September 1900 over the Gangetic West Bengal OVER WEST
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Time-resolved spectral analysis of prompt emission from long gamma-ray bursts with GeV emission
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作者 Arikkala Raghurama Rao Rupal Basak +4 位作者 Jishnu Bhattacharya Sarthak Chandra Nikunj Maheshwari Manojendu Choudhury Ranjeev Misra 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第1期35-46,共12页
We performed detailed time-resolved spectroscopy of bright tong gamma- ray bursts (GRBs) which show significant GeV emissions (GRB 080916C, GRB 090902B and GRB 090926A). In addition to the standard Band model, we ... We performed detailed time-resolved spectroscopy of bright tong gamma- ray bursts (GRBs) which show significant GeV emissions (GRB 080916C, GRB 090902B and GRB 090926A). In addition to the standard Band model, we also use a model consisting of a black body and a power law to fit the spectra. We find that for the latter model there are indications of an additional soft component in the spectra. While previous studies have shown that such models are required for GRB 090902B, here we find that a composite spectral model consisting of two blackbodies and a power law adequately fits the data of all the three bright GRBs. We investigate the evolution of the spectral parameters and find several interesting features that appear in all three GRBs, like (a) temperatures of the blackbodies are strongly correlated with each other, (b) fluxes in the black body components are strongly correlated with each other, (c) the temperatures of the black body trace the profile of the individual pulses of the GRBs, and (d) the characteristics of power law components like the spectral index and the delayed onset bear a close similarity to the emission characteristics in the GeV regions. We discuss the implications of these results and the possibility of identifying the radiation mechanisms during the prompt emission of GRBs. 展开更多
关键词 gamma rays: bursts - gamma rays: observations - methods: data analysis
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Systematic pharmacology analysis of Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate
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作者 Ze-Ping Luo Li-Wei Pan +1 位作者 Hai-Lin Chen Jun-Yu Lu 《Drug Combination Therapy》 2019年第4期186-198,共13页
The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the mo... The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the molecule was analyzed by using a series of Systematic pharmacology methods.The results show that the M molecule has a higher drug-like DL value of 0.59 and better molecular property parameters,namely Hdon=4,Hacc=10 and AlogP=0.94;A total of 11 M molecules related targets,namely F2,ESR1,AR,F10,CA2,DPP4,CCNA2,PRSS1,CDK2,GSK3B and PTPN1;A total of 140 diseases are associated with M molecule targets,and these diseases are mainly related to cancer and cardiovascular diseases;A total of 52 pathways involve the pharmacological mechanisms of M molecules,which are mainly related to cancer and other related diseases;GO-enriched analysis showed that these targets are closely related to the regulation of peptidase activity and biological processes such as blood coagulation and hemostasis.This article clearly demonstrated the pharmacological mechanism of M molecule,which provides references for exploring the pharmacological mechanism of new compounds. 展开更多
关键词 Sodium 8-(((carboxymethyl)amino)methyl)-4' 7-bishydroxy-isoflavone-3'-sulfonate Systematic PHARMACOLOGY analysis
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Multi-time Scale Analysis of the Precipitation Series in Chengde City in Recent 58 Years
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作者 ZHANG Yue-cong ZHANG Cai-yu +2 位作者 CHENG Fu-wei MENG Xian-feng YANG Yi-tian 《Meteorological and Environmental Research》 2012年第1期21-25,共5页
[ Objective] The research aimed to analyze variation rule of the precipitation series in Chengde City in recent 58 years. [Method] Mexi- can hat wavelet was used to analyze multi-scale characteristics of the monthly p... [ Objective] The research aimed to analyze variation rule of the precipitation series in Chengde City in recent 58 years. [Method] Mexi- can hat wavelet was used to analyze multi-scale characteristics of the monthly precipitation data in Chengde from 1951 to 2008. We revealed multi- time-scale complex structure of the precipitation change in Chengde, analyzed change cycles and mutation points of the precipitation series under different time scales, and identified primary period in each series. [ Result]There were high/low value centers of the precipitation under interdec- adal scale (more than 10 years). Under interannual scale (below 10 years), oscillation was complex and variable, but 4-year scale had obvious high-frequency oscillation. Wavelet variance analysis verified existence of the 4-year precipitation cycle, and M - K test also confirmed conclusions of the wavelet analysis. [ Conclusion] We could judge from alternating wet and dry conditions that the wet year decreased significantly, and the cur- rent Drecioitation was still less than normal. 展开更多
关键词 Wavelet analysis PRECIPITATION M - K test Chengde City China
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