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Method of Testing of Dynamic Forces on Digital Jet Elements 被引量:3
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作者 莫波 杨彩霞 《Journal of Beijing Institute of Technology》 EI CAS 2002年第4期393-396,共4页
Method of testing for dynamic output forces from jet elements is studied, the handwidth is large in testing with this method. By establishing a model of the test system and simulating it, principles of how inherent fe... Method of testing for dynamic output forces from jet elements is studied, the handwidth is large in testing with this method. By establishing a model of the test system and simulating it, principles of how inherent features of the test system affect the dynamic force test are found out. Thus a theoretical foundation is given for the design and error modification to the actual test system. 展开更多
关键词 digital jet element dynamic force test MODELING error analysis
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Study on Model Tests and Hydrodynamic Force Models for Free Spanning Submarine Pipelines Subjected to Earthquakes 被引量:3
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作者 李明高 李昕 +2 位作者 董汝博 周晶 关炯 《China Ocean Engineering》 SCIE EI 2010年第2期305-320,共16页
A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model ... A test rig is built to model the dynamic response of submarine pipelines with an underwater shaking table in the State Key Laboratory of Coastal and Offshore Engineering, Dalian University of Technology, China. Model tests are carried out to consider the effects of exciting wave directions and types. Based on the experimental results, two hydrodynamic force models derived from Morisen equation and Wake model are presented respectively. By use of hydrodynamic force models suitable for free spanning submarine pipelines under earthquakes, diseretized equations of motion are obtained and finite element models are established to analyze dynamic response of free spanning submarine pipeline subjected to multi-support seismic excitations. The comparison of numerical results with experimental results shows that the improved Morison and Wake hydrodynamic force models could satisfactorily predict dynamic response on the free spanning submarine pipelines subjected to earthquakes. 展开更多
关键词 free spanning submarine pipelines model tests hydrodynamic force models dynamic response analysis earthquke
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Study of the Lift Force Induced by An Interceptor on A High-Speed Mono-Hull:The Affecting Factors and Estimation Formula
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作者 DENG Rui HU Yu-xiao +3 位作者 HUANG Si-chong SONG Zhi-jie WANG Shi-gang WU Tie-cheng 《China Ocean Engineering》 SCIE EI CSCD 2024年第4期557-571,共15页
To find a better way to estimate the lift force induced by an interceptor on a high-speed mono-hull ship,a series of high-speed mono-hull ship models are designed and investigated under different conditions.Different ... To find a better way to estimate the lift force induced by an interceptor on a high-speed mono-hull ship,a series of high-speed mono-hull ship models are designed and investigated under different conditions.Different lift forces are obtained by numerical calculations and validated by a model test in a towing tank.The factors that influence the force are the interceptor height,velocity,draft,and deadrise angle.The relationship between each factor and the induced lift force is investigated and obtained.We found that the induced lift mainly depends on the interceptor height and advancing velocity,and is proportional to the square of the interceptor height and velocity.The results also showed that the effects of the draft and deadrise angle are relatively less important,and the relationship between the induced lift and these two factors is generally linear.Based on the results,a formula including the combined effect of all factors used to estimate the lift force induced by the interceptor is developed based on systematic analysis.The proposed formula could be used to estimate the lift force induced by interceptors,especially under high-speed condition. 展开更多
关键词 high-speed mono-hull ship INTERCEPTOR lift force formula lift force towing tank test computational fluid dynamics
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Numerical Simulations of Wave Impact Forces on the Open-Type Sea Access Road Using A Two-Phase SPH Model
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作者 CHEN Yong-kun Domenico D.MERINGOLO LIU Yong 《China Ocean Engineering》 SCIE EI CSCD 2024年第5期755-770,共16页
A numerical study based on a two-dimensional two-phase SPH(Smoothed Particle Hydrodynamics)model to analyze the action of water waves on open-type sea access roads is presented.The study is a continuation of the analy... A numerical study based on a two-dimensional two-phase SPH(Smoothed Particle Hydrodynamics)model to analyze the action of water waves on open-type sea access roads is presented.The study is a continuation of the analyses presented by Chen et al.(2022),in which the sea access roads are semi-immersed.In this new configuration,the sea access roads are placed above the still water level,therefore the presence of the air phase becomes a relevant issue in the determination of the wave forces acting on the structures.Indeed,the comparison of wave forces on the open-type sea access roads obtained from the single and two-phase SPH models with the experimental results shows that the latter are in much better agreement.So in the numerical simulations,a two-phaseδ-SPH model is adopted to investigate the dynamical problems.Based on the numerical results,the maximum horizontal and uplifting wave forces acting on the sea access roads are analyzed by considering different wave conditions and geometries of the structures.In particular,the presence of the girder is analyzed and the differences in the wave forces due to the air cushion effects which are created below the structure are highlighted. 展开更多
关键词 Smoothed Particle Hydrodynamics two-phase SPH wave impact forces experimental test sea access road
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An isolated similarity design method for shaking table tests on reinforced slopes 被引量:1
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作者 WANG Zhi-jia FAN Gang +1 位作者 CAO Li-cong CHANG Jin-yuan 《Journal of Mountain Science》 SCIE CSCD 2021年第9期2460-2474,共15页
Physical model test is an effective way to unveil the dynamic response of a slope under seismic condition.The similarity design is the key of physical model test.An isolated similarity design method for shaking table ... Physical model test is an effective way to unveil the dynamic response of a slope under seismic condition.The similarity design is the key of physical model test.An isolated similarity design method for shaking table tests was proposed and verified in this work.In this method,the relevant physical quantities were divided into several subsystems and subcharacteristic equations for each subsystem were then established based on the Buckingham similarity theory.Large-scale shaking table tests on a reinforced slope were adopted herein to illustrate the application of the proposed isolated similarity design method.The similarity system for the studied slope was divided into four parts in the process of similarity design.The geometrical dimension L,densityρand gravity g were selected as fundamental quantities for the similarity design,and four subcharacteristic equations were established for each subsystem.The dynamic responses of the recorded acceleration and axis force show that the seismic waves propagate well in the model slope.The proposed isolated similarity design method solves the conflict between the similarity requirement for all relevant physical quantities and the difficulty of test model fabrication to satisfy all similarity relations. 展开更多
关键词 Similarity design Shaking table test SLOPE ACCELERATION Axial force
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Performances of a Stinger PDC cutter breaking granite: Cutting force and mechanical specific energy in single cutter tests 被引量:1
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作者 Chao Xiong Zhong-Wei Huang +4 位作者 Huai-Zhong Shi Rui-Yue Yang Gang Wu Han Chen Wen-Hao He 《Petroleum Science》 SCIE EI CAS CSCD 2023年第2期1087-1103,共17页
The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive ... The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive formation. The knowledge of force response and mechanical specific energy (MSE) for the Stinger PDC cutter is of great importance for improving the cutter's performance and optimizing the hybrid PDC bit design. In this paper, 87 single cutter tests were conducted on the granite. A new method for precisely obtaining the rock broken volume was proposed. The influences of cutting depth, cutting angle, and cutting speed on cutting force and MSE were analyzed. Besides, a phenomenological cutting force model of the Stinger PDC cutter was established by regression of experimental data. Moreover, the surface topography and fracture morphology of the cutting groove and large size cuttings were measured by a 3D profilometer and a scanning electron microscope (SEM). Finally, the rock-breaking mechanism of the Stinger PDC cutter was illustrated. The results indicated that the cutting depth has the greatest influence on the cutting force and MSE, while the cutting speed has no obvious effects, especially at low cutting speeds. As the increase of cutting depth, the cutting force increases linearly, and MSE reduces with a quadratic polynomial relationship. When the cutting angle raises from 10° to 30°, the cutting force increases linearly, and the MSE firstly decreases and then increases. The optimal cutting angle for breaking rock is approximately 20°. The Stinger PDC cutter breaks granite mainly by high concentrated point loading and tensile failure, which can observably improve the rock breaking efficiency. The key findings of this work will help to reveal the rock-breaking mechanisms and optimize the cutter arrangement for the Stinger PDC cutter. 展开更多
关键词 Stinger PDC cutter Cutting force Mechanical specific energy Single cutter tests
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Prediction method of restoring force based on online AdaBoost regression tree algorithm in hybrid test 被引量:1
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作者 Wang Yanhua Lü Jing +1 位作者 Wu Jing Wang Cheng 《Journal of Southeast University(English Edition)》 EI CAS 2020年第2期181-187,共7页
In order to solve the poor generalization ability of the back-propagation(BP)neural network in the model updating hybrid test,a novel method called the AdaBoost regression tree algorithm is introduced into the model u... In order to solve the poor generalization ability of the back-propagation(BP)neural network in the model updating hybrid test,a novel method called the AdaBoost regression tree algorithm is introduced into the model updating procedure in hybrid tests.During the learning phase,the regression tree is selected as a weak regression model to be trained,and then multiple trained weak regression models are integrated into a strong regression model.Finally,the training results are generated through voting by all the selected regression models.A 2-DOF nonlinear structure was numerically simulated by utilizing the online AdaBoost regression tree algorithm and the BP neural network algorithm as a contrast.The results show that the prediction accuracy of the online AdaBoost regression algorithm is 48.3%higher than that of the BP neural network algorithm,which verifies that the online AdaBoost regression tree algorithm has better generalization ability compared to the BP neural network algorithm.Furthermore,it can effectively eliminate the influence of weight initialization and improve the prediction accuracy of the restoring force in hybrid tests. 展开更多
关键词 hybrid test restoring force prediction generalization ability AdaBoost regression tree
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Evaluation of antidepressant activity of methanolic and hydroalcoholic extracts of Acorus calamus L.rhizome through tail suspension test and forced swimming test of mice 被引量:1
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作者 Shaista Yousuf Shiekh Marifatul Haq +5 位作者 Akhtar Rasool Muhammad Zulfajri Marlia Mohd Hanafiah Huda Nafees Shoeiba Tasneem Mohammed Mahboob 《Journal of Traditional Chinese Medical Sciences》 2020年第3期301-307,共7页
Objective:Acorus calamus(AC)L.(Araceae)is an annual semi-aquatic and aromatic plant found in Europe,North America and Asia.Its rhizomes are often used by Native Americans,Americans,and Chinese as well as by other cult... Objective:Acorus calamus(AC)L.(Araceae)is an annual semi-aquatic and aromatic plant found in Europe,North America and Asia.Its rhizomes are often used by Native Americans,Americans,and Chinese as well as by other cultures.Ethnobotanical studies and documents have shown their use in various disease treatments,such as insomnia,mental disorders,diabetes mellitus,epilepsy,inflammation,asthma,neuropathic pain,and diarrhea.In this study,the antidepressant activity of methanolic and hydroalcoholic extracts of the AC rhizome part in mice was investigated.Methods:Three doses of methanolic extract of AC rhizome(MEACR)(25,50 and 100 mg/kg b.wt),three doses of hydroalcoholic extract of AC rhizome(HAACR)(100,200 and 400 mg/kg b.wt),and standards(imipramine,15 mg/kg b.wt and fluoxetine,20 mg/kg b.wt)was daily oral administration to the mice for consecutive 14 days.The extract effect on the immobility time was monitored by a tail suspension test(TST)and a forced swimming test(FST).Monoamine oxidase(MAO)levels were also analyzed using standard methods.Results:The optimum antidepressant activity was viewed at 100 mg/kg b.wt of MEACR extract and400 mg/kg b.wt of HAACR extract with 23.82%and 20.59%immobility period reduction,respectively.Besides,the extracts weakened the FST-induced elevation of MAO activity significantly and returned to near-normal levels of neurotransmitters in the brain.100 mg/kg b.wt or above of MEACR extract significantly prevented the MAO-A and MAO-B activities in mice brain at a dose-dependent fashion.But,just 400 mg/kg b.wt of HAACR extract prevented the activity of MAO-A and MAO-B.Fluoxetine and imipramine showed a tendency to prevent the activity of MAO-A and MAO-B.Conclusion:This study suggests that AC rhizome extract mediated antidepressant activity by modulating the central neurochemical and hypothalamic-pituitary-adrenal(HPA)axis in response to FST and TSTinduced stress.Therefore,AC rhizome extract can be used as a valuable plant supplement to treat depressive disorders. 展开更多
关键词 Acorus calamus RHIZOME Antidepressant activity Methanolic extract Hydroalcoholic extract Tail suspension test forced swim test Monoamine oxidase MICE
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Is forced oscillation technique the next respiratory function test of choice in childhood asthma 被引量:1
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作者 Afaf Alblooshi Alia Alkalbani +2 位作者 Ghaya Albadi Hassib Narchi Graham Hall 《World Journal of Methodology》 2017年第4期129-138,共10页
Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to pe... Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to perform forced expiratory manoeuvre. The development of novel diagnostic methods which require minimal effort, such as forced oscillation technique(FOT) is, therefore, a welcome and promising addition. FOT involves applying external, small amplitude oscillations to the respiratory system during tidal breathing. Therefore, it requires minimal effort and cooperation. The FOT has the potential to facilitate asthma diagnosis and management in preschool children by faciliting the objective measurement of baseline lung function and airway reactivity in children unable to successfully perform spirometry. Traditionally the use of FOT was limited to specialised centres. However, the availability of commercial equipment resulted in its use both in research and in clinical practice. In this article, we review the available literature on the use of FOT in childhood asthma. The technical aspects of FOT are described followed by a discussion of its practical aspects in the clinical field including the measurement of baseline lung function and associated reference ranges, bronchodilator responsiveness and bronchial hyperresponsiveness. We also highlight the difficulties and limitations that might be encountered and future research directions. 展开更多
关键词 ASTHMA forced oscillation technique Impulse oscillatory PRE-SCHOOL Children Pulmonary function test
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Establishmen and vertification of an improved similitude law for dynamic ice force model test
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作者 柳春光 贾玲玲 齐念 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2010年第6期853-857,共5页
To study the similitude laws for dynamic ice force model test which is a hot problem in ice mechanics.In this paper,a new modified similitude law for dynamic ice force model test is proposed based on ice-induced virbr... To study the similitude laws for dynamic ice force model test which is a hot problem in ice mechanics.In this paper,a new modified similitude law for dynamic ice force model test is proposed based on ice-induced virbration theory and two reasonable assumptions.And the new law is vertified with an ice-induced pier virbration example.The numerical calculation results show that,firstly,the error of frequency factor between test value and theory value is small as well as that of displacement and velocity;Secondly,the time scale completely meet the similitude relation,the waveforms anastomotic well,and the phenomenon of offset and omit do not occur;Thirdly,as the damping ratio between prototype and model is nearly equal,the improved similitude law will still be applied.Therefore,the new modified similitude law is feasible to study dynamic ice force model test and can provide reference for the ice mechanics. 展开更多
关键词 MODIFIED references laws dynamic ice force model test
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Cyclic testing of moment-shear force interaction in reinforced concrete shear wall substructures
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作者 Ke Du Huan Luo Jingjiang Sun 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2020年第2期465-481,共17页
Previous quasi-static cyclic tests of shear walls,which routinely used an incremental lateral displacement test protocol with a constant axial load,failed to reflect the character of moment-shear force interaction of ... Previous quasi-static cyclic tests of shear walls,which routinely used an incremental lateral displacement test protocol with a constant axial load,failed to reflect the character of moment-shear force interaction of prototype buildings.To study the effect of the moment-shear force interaction on the seismic performance of shear walls,three identical 2-story shear wall specimens with different loading patterns were constructed at 1/2 scale,to represent the lower portion of an 11-story high-rise building,and were tested under reversed cyclic loads.The axial force,shear force and bending moment were simultaneously applied to simulate the effects of gravity loads and earthquake excitations on the prototype.The axial force and bending moment delivered from the upper structure were applied to the top of the specimens by two vertical actuators,and the shear force was applied to the specimens by two horizontal actuators.A mixed force-displacement control test program was adopted to ensure that the bending moment and the lateral shear were increased proportionally.The experimental results show that the moment-shear force interaction had a significant effect on the failure pattern,hysteretic characteristics,ductility and energy dissipation of the specimens.It is recommended that moment-shear force interaction should be considered in the loading condition of RC shear wall substructures cyclic tests. 展开更多
关键词 shear walls QUASI-STATIC cyclic test moment-shear force INTERACTION COLLAPSE test hysteretic curves forcedisplacement mixed control test
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Shifting force control of an AMT heavy-duty truck based on manual shift test
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作者 刘海鸥 张文胜 +1 位作者 赵亦农 王康 《Journal of Beijing Institute of Technology》 EI CAS 2016年第2期187-193,共7页
Taking a heavy-duty truck as a research platform,the changing characteristics of shifting force,shift time,and slipping work are obtained through theoretical analysis and manual shift test of a real vehicle. Based on ... Taking a heavy-duty truck as a research platform,the changing characteristics of shifting force,shift time,and slipping work are obtained through theoretical analysis and manual shift test of a real vehicle. Based on the analysis of the test results,a gear-shifting control strategy of the hydraulic automated shift control system is designed and experimentally verified on the bench. By optimizing the control parameters of high-speed switching valves,a control strategy and parameters are obtained,which can meet the requirements of dynamic performance and reliability. 展开更多
关键词 shifting force control automated mechanical transmission (AMT) manual shift test
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Bond Property Test of Reinforced Concrete with All Soaking and Impressed Current Method Corrosion
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作者 张延年 卢珍 《Transactions of Tianjin University》 EI CAS 2013年第5期366-371,共6页
In order to research the bond properties between corroded reinforcement bars and concrete,reinforcement bars with different diameters and different types and concrete with different strength levels were treated specia... In order to research the bond properties between corroded reinforcement bars and concrete,reinforcement bars with different diameters and different types and concrete with different strength levels were treated specially with all soaking and impressed current method,and the bond properties were measured with the pull-out test.The comparative analysis of the bond properties of corroded reinforcement bars was carried out.The results showed that the types of reinforcement bars and concrete had great influence on the bond strength.The corrosion and volume expansion of reinforcement bars made concrete in tensile condition,which tended to produce cracks in parallel reinforced direction.The typical bond failure of plain reinforcement bars was pull-out,while the typical bond failure of ribbed reinforcement bars was split.The bond strength between corroded reinforcement bars and concrete increased with the increase of concrete strength.The bond strength of plain and ribbed reinforcement bars showed a decreasing trend after the first increase with the increase of the extent of corrosion.Through the test,the coefficients of the bond strength of plain and ribbed reinforcement bars were given,respectively. 展开更多
关键词 reinforced concrete bond property all soaking and impressed current method pull-out test bond failure
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Poroelastodynamic responses and elastic moduli of a transversely isotropic porous cylinder under forced deformation test
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作者 Chao Liu Dung T.Phan 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第7期793-800,共8页
Existing transversely isotropic poroelastodynamics solutions are limited to infinite domains and without experimental validation. Furthermore, there is a lack of analytical simulations for the elastic moduli dispersio... Existing transversely isotropic poroelastodynamics solutions are limited to infinite domains and without experimental validation. Furthermore, there is a lack of analytical simulations for the elastic moduli dispersion of fluid-saturated porous cylinders. To address these three limitations and investigate the mechanisms of moduli dispersion, we present the analytical solutions of the poromechanical responses and the elastic moduli dispersion of a transversely isotropic, fluid-saturated, finite porous cylinder subjected to a forced deformation test. Through an example, we demonstrate the effects of loading frequency, boundary conditions, and material's anisotropy, dimension, and permeability on the responses of pore pressure,force, displacement, and dynamic elastic moduli of the cylinder. The specimen's responses are significantly influenced by the frequency of the applied load, resulting in a drained state at low frequencies and an undrained state at high frequencies. At high frequencies, the sample behaves identically for an open or a closed lateral boundary, and permeability has insignificant effects. The dynamic elastic moduli are mainly controlled by the loading frequency and the ratio of the sample's radius to its height. Lastly,we show excellent matches between the newly derived analytical solution and laboratory measurements on one clay and two shale samples from Mont Terri. 展开更多
关键词 Poroelastodynamics Dynamic moduli Transversely isotropic Porous cylinder forced deformation test
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Granger Causality Test of Urban-rural Income Gap and Employment of Rural Labor Forces——A Case Study of Shouguang City 被引量:2
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作者 LU Gui-xing Weifang University, Weifang 261061, China 《Asian Agricultural Research》 2012年第1期36-39,70,共5页
Taking Shouguang City in Shandong Province as an example, this article researches the mutual relationship between urban-rural income and employment of rural labor forces, and conducting cointegration test and Granger ... Taking Shouguang City in Shandong Province as an example, this article researches the mutual relationship between urban-rural income and employment of rural labor forces, and conducting cointegration test and Granger causality test on the variable sequences using statistical data. The results show that the average annual income of rural labor forces influences the income per capita of rural residents, and there is a Granger causality relationship between the income per capita of rural residents and urban employees' average wage. Engaging in production concerning agriculture, forestry, animal husbandry and fishery makes the total income per capita in rural areas of Shouguang City higher than the average wage of urban residents in Shouguang City, even in Weifang City. The comparative advantage in terms of income causes the city to loose attraction to rural residents in Shouguang City. The comparative advantage drives more rural labor forces in Shouguang City to engage in primary industry, thereby greatly reducing the pressure of employment and transfer of rural labor forces. Finally important following measures are put forward to promote employment and on-the-spot transfer of rural labor forces: vigorously propel agricultural industrialization; increase rural residents' income; improve the living conditions for rural residents. 展开更多
关键词 Urban-rural INCOME gap RURAL LABOR forceS GRANGER
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THE COMPUTATION OF MAGNETIC FORCES OF NEW TYPE HARD MAGNETIC MATERIALS AND THE STUDY ON THE TEST SYSTEM FOR THE MECHANICAL PARAMETERS
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作者 孙景 穆宗学 +1 位作者 张安欣 孙铁麟 《Transactions of Tianjin University》 EI CAS 1996年第2期45+42-44,共4页
This paper presents theoretical computations of magnetic force bearings made of new type hard magnetic materials neodymium iron boron. A set of devices capable of simultaneously measuring magnetic eccentricity, ... This paper presents theoretical computations of magnetic force bearings made of new type hard magnetic materials neodymium iron boron. A set of devices capable of simultaneously measuring magnetic eccentricity, crosswise stiffness and magnetic pulling force is designed. 展开更多
关键词 hard magnetic material magnetic force test system
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THE MODEL TEST RESEARCH OF HORIZONTAL FORCE ON RIGID SHAFT FURNITURE IN DEEP MINE
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作者 刘志强 史天生 +1 位作者 郭晋蒲 王东权 《Journal of Coal Science & Engineering(China)》 1998年第1期15-19,共5页
The state of deep mine rigid shaft fUrniture horizontal force calculation in China is introduced and the calculating model of horizontal force is determined. Based on the interaction between hoisting vessel and shaft ... The state of deep mine rigid shaft fUrniture horizontal force calculation in China is introduced and the calculating model of horizontal force is determined. Based on the interaction between hoisting vessel and shaft furniture, the vertical mobel test device is built and a large number of model tests and analyses are carried out. At last, the relationship between horizontal force and hoisting end load, hoisting speed or bunton level interval is gained. The three parameters horizontal force calculating equation of beep mine rigid shaft furniture is given and it can guide the design and calculation of shaft engineering. 展开更多
关键词 rigid shaft furniture model test horizontal force calculating method
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Noradrenergic, glutamatergic and dopaminergic systems are implicated in antidepressant-like effect of flavonoids extracted from okra (Abelmoschus esculentus [L.] Moench.) fruit in the forced swimming test
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作者 Fuyuan Li Xiaozhuo Zhang +3 位作者 Qianqian Mao Bo Wu Ying Jia Tingxu Yan 《Journal of Polyphenols》 2022年第1期17-31,共15页
Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reporte... Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reported to have neurological properties,e.g antidepressant and antifatigue.However,its neurological protect in antidepressant-like effect of flavonoids extracted from okra have not yet been demonstrated.The present study was aimed at investigating the antidepressant-like eff ect of the flavonoids extracted from okra fruit(FOF)using the forced swimming test(FST)pattern and preliminary exploration its potential mechanism.We also used the open fi eld test(OFT)to estimate the spontaneous locomotor activity.We found that oral administration(p.o.)of FOF(300 mg/kg)alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT.The experimental data indicated the antidepressant-like eff ect of FOF involved in noradrenergic,glutamatergic and dopaminergic systems. 展开更多
关键词 OKRA ANTIDEPRESSANT forced swimming test(FST) mechanism flavonoid compound
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Helplessness-like escape deficits of NIH-HS rats predict passive behavior in the forced swimming test:Relevance for the concurrent validity of rat models of depression
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作者 Marta Palencia Sira Diaz-Moran +6 位作者 Carme Mont-Cardona Toni Canete Gloria Blazquez Esther Martinez-Membrives Regina Lopez-Aumatell Adolf Tobena Alberto Fernandez-Teruel 《World Journal of Neuroscience》 2013年第2期83-92,共10页
The genetically heterogeneous NIH-HS rat stock has been characterized by its response to anxiety- and fear-inducing situations, thus leading to the conclusion that they are a rather anxious and passive coping type of ... The genetically heterogeneous NIH-HS rat stock has been characterized by its response to anxiety- and fear-inducing situations, thus leading to the conclusion that they are a rather anxious and passive coping type of rats. Taking advantage of these profiles, and knowing that they show very poor performance in the two-way active (shuttle box) escape/avoidance task, we have tested NIH-HS rats (n = 80) in the forced swimming test (FST) as well as we have studied escape response deficits (i.e. response failures) of the same animals in the two-way shuttle box task. They were also tested for anxiety in the elevated zero-maze. The goal of such a study was that of investigating whether there are associations or relationships among helplessness-like or passive coping responses between both models of depression, i.e. the FST and the helplessness-like escape deficits in the shuttle box task. The results for the first time show associations among responses from both depression models and that selecting rats for displaying extreme (active or passive) responses in one of the models predict in a coherent manner (according to the hypothesis) their behaviour in the other model. These findings are discussed in the context of the concurrent validity of both models of depression as well as concerning the possible relevance of NIH-HS rats as a tool for future studies on this field. 展开更多
关键词 Genetically Heterogeneous Rats NIH-HS Stock forced Swimming test HELPLESSNESS Passive Coping DEPRESSION Anxiety
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Development of forced degradation and stability indicating studies of drugs——A review 被引量:11
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作者 Blessy M Ruchi D.Patel +1 位作者 Prajesh N.Prajapati Y.K.Agrawal 《Journal of Pharmaceutical Analysis》 SCIE CAS 2014年第3期159-165,共7页
Forced degradation is a degradation of new drug substance and drug product at conditions more severe than accelerated conditions. It is required to demonstrate specificity of stability indicating methods and also prov... Forced degradation is a degradation of new drug substance and drug product at conditions more severe than accelerated conditions. It is required to demonstrate specificity of stability indicating methods and also provides an insight into degradation pathways and degradation products of the drug substance and helps in elucidation of the structure of the degradation products. Forced degradation studies show the chemical behavior of the molecule which in turn helps in the development of formulation and package. In addition, the regulatory guidance is very general and does not explain about the performance of forced degradation studies. Thus, this review discusses the current trends in performance of forced degradation studies by providing a strategy for conducting studies on degradation mechanisms and also describes the analytical methods helpful for development of stability indicating method. 展开更多
关键词 Degradation conditionsDegradation product forced degradation Stability indicatingmethod Stress testing
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