Clogging caused by coupled grain migration and compaction effect during groundwater recharge for unconsolidated sandstone reservoir in groundwater-source heat pump

In unconsolidated sandstone reservoirs,presence of numerous movable grains and a complex grain size composition necessitates a clear understanding of the physical clogging process for effective groundwater recharge in groundwater-source heat pump systems.To investigate this,a series of seepage experiments was conducted under in situ stress conditions using unconsolidated sandstone samples with varying grain compositions.The clogging phenomenon arises from the combined effects of grain migration and compaction,wherein the migration of both original and secondary crushed fine-grain particles blocks the seepage channels.Notably,grain composition influences the migration and transport properties of the grains.For samples composed of smaller grains,the apparent permeability demonstrates a transition from stability to decrease.In contrast,samples with larger grains experience a skip at the stability stage and directly enter the decrease stage,with a minor exception of a slight increase observed.Furthermore,a unique failure mode characterized by diameter shrinkage in the upper part of the sample is observed due to the combined effects of grain migration and in situ stress-induced compaction.These testing results contribute to a better understanding of the clogging mechanism caused by the coupled effects of grain migration and compaction during groundwater recharge in unconsolidated sandstone reservoirs used in groundwater-source heat pump systems.

Inverse spin Hall effect in ITO/YIG exited by spin pumping and spin Seebeck experiments

Spin currents, which are excited in indium tin oxide(ITO)/yttrium iron garnet(YIG) by the methods of spin pumping and spin Seebeck effect, are investigated through the inverse spin Hall effect(ISHE). It is demonstrated that the ISHE voltage can be generated in ITO by spin pumping under both in-plane and out-of-plane magnetization configurations.Moreover, it is observed that the enhancement of spin Hall angle and interfacial spin mixing conductance can be achieved by an appropriate annealing process. However, the ISHE voltage is hardly seen in the presence of a longitudinal temperature gradient. The absence of the longitudinal spin Seebeck effect can be ascribed to the almost equal thermal conductivity of ITO and YIG and specific interface structure, or to the large negative temperature dependent spin mixing conductance.

Influence of the biological carbon pump effect on the sources and deposition of organic matter in Fuxian Lake, a deep oligotrophic lake in southwest China

Biological carbon pumping(BCP)is a key process in which dissolved inorganic carbon in terrestrial aquatic ecosystems is utilized by aquatic autotrophs for photosynthesis and transformed into autochthonous organic matter(AOC).However,the mechanisms underlying BCP and the amount of generated AOC deposited effectively,are still poorly understood.Therefore,we conducted a systematic study combining modern hydrochemical monitoring and a sediment trap experiment in Fuxian Lake(Yunnan,SW China),the second-deepest plateau,oligotrophic freshwater lake in China.Temperature,pH,EC(electrical conductivity),DO(dissolved O2),[HCO3^-],[Ca^2+],SIc,partial CO2(pCO2)pressure,and carbon isotopic compositions of HCO3^-(δ^13CDIc)in water from Fuxian Lake all displayed distinct seasonal and vertical variations.This was especially apparent in an inverse correlation between pCO2 and DO,indicating that variations of hydrochemistry in the lake water were mainly controlled by the metabolism of the aquatic phototrophs.Furthermore,the lowest C/N ratios and highestδ^13Corg were recorded in the trap sediments.Analyses of the C/N ratio demonstrated that the proportions of AOC ranged from 30%to 100%of all OC,indicating that AOC was an important contributor to sedimentary organic matter(OC).It was calculated that the AOC flux in Fuxian Lake was 20.43 t C km^-2 in 2017.Therefore,AOC produced by carbonate weathering and aquatic photosynthesis could potentially be a significant carbon sink and may have an important contribution to solving the lack of carbon sinks in the global carbon cycle.

Self-Mixing Interference Effects in LD Pumped Multi-Mode Solid-State Laser

Based on the effective structure of the self-mixing interference effects,a general model for the self-mixing interference effects in the LD pumped solid-state laser has been established for the first time.The numerical simulation of the self-mixing interference signal has been done,the results show that when the external cavity length is integral times of 1/2,1/3,2/3,1/4,3/4 of the effective cavity length,the intensity of the self-mixing interference signals reach maximum in value.While that of single mode laser is integral times of half of the effective cavity length,the measuring precision of displacement of single mode laser is λ/2.A conclusion can be drawn from the above results that the measuring precision of displacement of multi-mode laser is higher than that of single mode laser.

Effects of walk-off on cross-phase modulation induced modulation instability in an optical fibre with high-order dispersion

This paper investigates the effects of walk-off among optical pulses on cross-phase modulation induced modulation instability in the normal dispersion region of an optical fibre with high-order dispersion. The results indicate that, in the case of high-order dispersion, the walk-off effect takes on new characteristics and will influence considerably the shape, position and especially the number of the spectral regions of the gain spectra of modulation instability. Not only the group-velocity mismatch, but also the difference of the third-order dispersion of two optical waves will alter the gain spectra of modulation instability but in different ways. Depending on the values of the walk-off parameters, the number of the spectral regions may increase from two to at most four, and the spectral shape and position may change too.

Effect of ultraviolet blood irradiation and oxygenation on nerve function and function of the red blood cell membrane pump in patients with acute cerebral infarction

BACKGROUND： Ultraviolet blood irradiation and oxygenation （UBIO） has obtained better clinical effect in treating acute cerebral infarction, but the mechanism underlying this effect remains unclear. OBJECTIVE： To observe the effect of UBIO on the nerve function and activities of K^＋-Na^＋-ATPase and Ca2^＋-Mg2^＋-ATPase activities on the red blood cell （RBC） membrane of patients with acute cerebral infarction. DESIGN： A randomized and controlled study.SETTING： Department of Neurology, Xiangfan Central Hospital.PARTICIPANTS： From January 2000 to December 2001, excluding those above 70 years old, 58 cases of 700 patients with acute cerebral infarction admitted in the Department of Neurology, Xiangfan Central Hospital, were recruited and divided into two groups according to the random number table： UBIO treated group （n=28）, including 17 males and 11 females, aged 40-68 years; and control group （n=30）, including 20 males and 10 females, aged 44-69 years. All the patients agreed to participate in the therapeutic program and detected items. The general informations were comparable without obvious differences between the two groups （P 〉 0.05）.METHODS： ① The patients in both groups received routine treatments, besides, those in the UBIO treated group were given UBIO treatment by using the XL-200 type therapeutic apparatus produced in Shijiazhuang, whose ultraviolet wave was set at 253.7 nm with the energy density of 0.568 J/m^2 per second, UBIO treatment started from the second day after admission, once every other day, with a single course consisting of 5-7 treatments. ② In the UBIO treated group, the venous blood was sampled before and after the first, third and the completion of the treatment course respectively, the venous blood was taken at each corresponding time point in the control group. After centrifugation of the blood at 10 000 rounds per minute, the RBC membrane was separated and then the activities of K^＋-Na^＋-ATPase and Ca2^＋-Mg2^＋-ATPase were detected by means of phosphorus determination.③ The nerve function was scored before and after treatment in both groups with European stroke scale, which included 13 items, the total score was 0-100 points, the higher the score, the better the nerve function. MAIN OUTCOME MEASURES ：①Score of European stroke scale before and after treatment in both groups.② Comparison of the activities of K^＋-Na^＋-ATPase and Ca2^＋-Mg2^＋-ATPase on RBC membrane between the two groups before treatment and after the first, third and the completion of the treatment. RESULTS： All the 58 patients with cerebral infarction were involved in the analysis of results.① The score of European stroke scale had no obvious difference between the two groups [（49.31±11.48）, （50.58±12.63）, P 〉 0.05], and it was obviously higher in the UBIO treated group than in the control group after treatment [84.66±13.75）, （77.05±11.17）, P 〈 0.05].②The activity of K^＋-Na^＋-ATPase on RBC membrane in the UBIO treated group was significantly increased after the first and third treatment as compared with before treatment [（31.56±19.25）, （27.64±15.83）, （17.67±13.83）, P 〈 0.01], it was still higher after the completion of the treatment than before treatment without obvious difference [（20.86±14.53）, P 〉 0.05]. After the first and third treatment, it was obviously higher in the UBIO treated group than in the control group [19.31±11.88）, （17.44±10.42）, P 〈 0.01]. ③ In the UBIO treated group, Ca2^＋-Mg2^＋-ATPase activity on RBC membrane significantly increased after the first treatment and remained higher than the pre-treatment level throughout the treatment [（27.49±14.72）, （17.41±4.82）, P 〈 0.01]. The activity of Ca2^＋-Mg2^＋-ATPase on RBC membrane was markedly higher in the UBIO treated group than in the control group after after the first, third and the completion of treatment respectively [（24.83±12.88）, （17.70±5.69）; （28.08±13.44）, （16.32±5.29）; （17.42±6.04）, P〈 0.05-0.01]. CONCLUSION： The effect of UBIO treatment against acute cerebral infarction may be mediated by the increased K^＋-Na^＋ ATPase and Ca2^＋-Mg2^＋-ATPase activities on RBC membrane, which enhances the RBC transformation ability so as to lower RBC aggregation and correct high blood viscosity.

The cardiac assistant effect of extra-aortic balloon pump on animals

Objective The aim of this study was to determine the effect of a new method of cardiac assistant therapy with an extra-aortic balloon pump on the experimental dogs in which myocardial ischemia or infarction were induced,and to observe its effectiveness and feasibility. Methods Twelve animal models of myocardia,1 infarction were established with the method of left

Analytical model for thermal lensing and spherical aberration in diode side-pumped Nd:YAG laser rod having Gaussian pump profile

In this paper, according to the temperature and strain distribution obtained by considering the Gaussian pump profile and dependence of physical properties on temperature, we derive an analytical model for refractive index variations of the diode side-pumped Nd：YAG laser rod. Then we evaluate this model by numerical solution and our maximum relative errors are 5% and 10% for variations caused by thermo–optical and thermo–mechanical effects; respectively. Finally, we present an analytical model for calculating the focal length of the thermal lens and spherical aberration. This model is evaluated by experimental results.

Effect of prolonged omeprazole administration on segmental intestinal Mg2+ absorption in male Sprague-Dawley rats

BACKGROUND The exact mechanism of proton pump inhibitors(PPIs)-induced hypomagnesemia(PPIH) is largely unknown. Previous studies proposed that PPIH is a consequence of intestinal Mg2+ malabsorption. However, the mechanism of PPIs-suppressed intestinal Mg2+ absorption is under debate.AIM To investigate the effect of 12-wk and 24-wk omeprazole injection on the total,transcellular, and paracellular Mg2+ absorption in the duodenum, jejunum, ileum,and colon of male Sprague-Dawley rats.METHODS The rats received 20 mg/kg·d subcutaneous omeprazole injection for 12 or 24 wk.Plasma and urinary Mg2+, Ca2+, and PO43-levels were measured. The plasma concentrations of 1α,25-dihydroxyvitamin D3(1α,25(OH)2D3), parathyroid hormone(PTH), fibroblast growth factor 23(FGF-23), epidermal growth factor(EGF), and insulin were also observed. The duodenum, jejunum, ileum, and colon of each rat were mounted onto individual modified Using chamber setups to study the rates of total, transcellular, and paracellular Mg2+ absorption simultaneously. The expression of transient receptor potential melastatin 6(TRPM6) and cyclin M4(CNNM4) in the entire intestinal tract was also measured.RESULTS Single-dose omeprazole injection significantly increased the intraluminal p H of the stomach, duodenum, and jejunum. Omeprazole injection for 12 and 24 wk induced hypomagnesemia with reduced urinary Mg2+ excretion. The plasma Ca2+ was normal but the urinary Ca2+ excretion was reduced in rats with PPIH. The plasma and urinary PO43-levels increased in PPIH rats. The levels of1α,25(OH)2D3 and FGF-23 increased, whereas that of plasma EGF decreased in the omeprazole-treated rats. The rates of the total, transcellular, and paracellular Mg2+ absorption was significantly lower in the duodenum, jejunum, ileum, and colon of the rats with PPIH than in those of the control rats. The percent suppression of Mg2+ absorption in the duodenum, jejunum, ileum, and colon of the rats with PPIH compared with the control rats was 81.86%, 70.59%, 69.45%,and 39.25%, respectively. Compared with the control rats, the rats with PPIH had significantly higher TRPM6 and CNNM4 expression levels throughout the intestinal tract.CONCLUSION Intestinal Mg2+ malabsorption was observed throughout the intestinal tract of rats with PPIH. PPIs mainly suppressed small intestinal Mg2+ absorption. Omeprazole exerted no effect on the intraluminal acidic pH in the colon. Thus, the lowest percent suppression of total Mg2+ absorption was found in the colon. The expression levels of TRPM6 and CNNM4 increased, indicating the presence of a compensatory response to Mg2+ malabsorption in rats with PPIH. Therefore, the small intestine is an appropriate segment that should be modulated to counteract PPIH.

Effect of spatial pattern on nutrient reduction in the Liaohe Delta

The effect of spatial pattern on the nutrient reduction is investigated based on the spatial simulation model developed for the study area of the Liaohe Delta, China. Four scenarios are designed to test the effect of different landscape components on the nutrient reduction in the reed marsh: Canal density, reed area size, reed area shrinking pattern, and pumping station position. Based on a spatial model designed for the study area, the nutrient reduction in each case of these scenarios is simulated. The results indicate that each factor brings less than 10% change in the total nutrient reduction rate. More canals will not help much to improve nutrient reduction. Smaller areas are more efficient than larger ones. The shrinkage pattern is better than others in keeping a higher nutrient reduction rate. It is also more efficient to keep the pumping station near the border of the area to be irrigated. These conclusions provide theoretical supports to strategy makers for local land use planning, and contribute to the understanding of the relationship between landscape patterns and functions.

Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication

Magnesium deficiency can cause a variety of symptoms, including potentially life-threatening complications such as seizures, cardiac arrhythmias and secondary electrolyte disturbances. Hypomagnesemia can be a serious adverse effect to proton pump inhibitor(PPI) therapy, which is worrying due to the widespread use of PPIs. Current evidence suggest that the mechanism of PPI induced hypomagnesemia is impaired intestinal magnesium absorption. In this report, we present the case of a long-term PPI user with persistent hypomagnesemia with severe symptoms at presentation. He was unable to stop PPI treatment because of severe reflux symptoms, and was dependent on weekly intravenous magnesium infusions, until his magnesium levels finally normalized without the need for supplementation after a successful laparoscopic fundoplication.

Association Between Proton Pump Inhibitor Therapy and Spontaneous Bacterial Peritonitis Occurrence in Cirrhotic Patients:A Clinical Review

Spontaneous bacterial peritonitis(SBP)is one of the most common complications in patients with end-stage liver disease(ESLD),which increases the risk of short-term mortality.Proton pump inhibitors(PPIs)are frequently used in patients with ESLD,in which controversies about the risk of PPI treatment in the occurrence of SBP are largely raised and the pathogenic mechanism of PPI-associated SBP remains unclear.We conducted a systematic literature search through PubMed/MEDLINE for publications mainly from 1 January 2000 to 1 January 2021.Our narrative review summarized the adverse effect of specific PPI therapy on the occurrence and prognosis of SBP in cirrhotic patients,described the potential mechanisms by which PPI induces the development of SBP,and discussed the risk factors associated with the development of SBP and the strategy of PPI therapy in cirrhotic patients.Although controversy regarding the association between PPI use and the occurrence of SBP exists,PPIs use should be restricted to patients with clear benefit indications,and be cautious for elderly patients with severe liver damage.

Transient Characteristics of a High-Capacity Centrifugal Pump during Rapidly Regulating Discharge Valve

In order to reveal the instantaneous characteristics of a high-capacity centrifugal pump during rapidly regulating discharge valve,theoretical analysis and numerical simulation are employed.The transient characteristics of the pump model under off-design condition were theoretically analyzed based on the generalized basic equation of vane pumps.The study showed that a centrifugal pump with radial straight blades at off-design condition almost had no transient effect,whereas a centrifugal pump with common backward-curved blades had transient effects that were directly related to the regularity of adjusting flowrate.Calculation examples show that transient effects are insignificant.The finite volume method and re-normalization group(RNG)κ-ε turbulence model were adopted to accomplish a 3D numerical calculation of a mediumspecific-speed centrifugal pump under the off-design condition.The transient process at the off-design condition is mainly caused by the time-varying intrinsic pulsation from the stator-rotor interference and by the time-varying consequent pulsation from the changes in flow rate.

Large-scale gas accumulation mechanisms and reservoir-forming geological effects in sandstones of Central and Western China

Large-scale gas accumulation areas in large oil-gas basins in central and Western China have multiple special accumulation mechanisms and different accumulation effects.Based on the geological theory and method of natural gas reservoir formation,this study examined the regional geological and structural background,formation burial evolution,basic characteristics of gas reservoirs,and fluid geology and geochemistry of typical petroliferous basins.The results show that the geological processes such as structural pumping,mudstone water absorption,water-soluble gas degasification and fluid sequestration caused by uplift and denudation since Himalayan stage all can form large-scale gas accumulation and different geological effects of gas accumulation.For example,the large-scale structural pumping effect and fluid sequestration effect are conducive to the occurrence of regional ultra-high pressure fluid and the formation of large-scale ultra-high pressure gas field;mudstone water absorption effect in the formation with low thickness ratio of sandstone to formation is conducive to the development of regional low-pressure and water free gas reservoir;the water-soluble gas degasification effect in large-scale thick sandstone can not only form large-scale natural gas accumulation;moreover,the degasification of water-soluble gas produced by the lateral migration of formation water will produce regional and regular isotopic fractionation effect of natural gas,that is,the farther the migration distance of water-soluble gas is,the heavier the carbon isotopic composition of methane formed by the accumulation.

Theoretical and Numerical Study of Stress and Thermo-Optic in Photonic Crystal Fiber Laser in Different Pump Schemes

In this paper, we present a study of thermal, average power scaling, change in index of refraction and stress in photonic crystal fiber lasers with different pump schemes: forward pump scheme, backward pump scheme, forward pump scheme with reflection of 98%, backward pump scheme with reflection of 98% and bi-directional pump scheme. We show that management of thermal effects in fiber lasers will determine the efficiency and success of scaling-up efforts. In addition, we show that the most suitable scheme is the bi-directional.

Temperature dependence of spin pumping in YIG/NiO(x)/W multilayer

We report the temperature dependence of the spin pumping effect for Y_(3)Fe_(5)O_(12)(YIG,0.9μm)/NiO(tNiO)/W(6 nm)(tNiO=0 nm,1 nm,2 nm,and 10 nm)heterostructures.All samples exhibit a strong temperature-dependent inverse spin Hall effect(ISHE)signal I_(c)and sensitivity to the NiO layer thickness.We observe a dramatic decrease of I_(c)with inserting thin NiO layer between YIG and W layers indicating that the inserting of NiO layer significantly suppresses the spin transport from YIG to W.In contrast to the noticeable enhancement in YIG/NiO(tNiO≈1-2 nm)/Pt,the suppression of spin transport may be closely related to the specific interface-dependent spin scattering,spin memory loss,and spin conductance at the NiO/W interface.Besides,the I_(c)of YIG/Ni O/W exhibits a maximum near the TNof the AF NiO layer because the spins are transported dominantly by incoherent thermal magnons.

Investigation on the Gain of Multi wavelength Pumping Broadband Raman Amplifier

The Stokes spectrum in the stimulated Raman scattering (SRS) is very complicated. In this article, we use both Gaussian and Lorentz approximation to investigate the gain properties of multi pumping broadband Raman amplifier, and present some schemes for flattening the gain. All the results show that the flatness of the gain spectrum is closely related to the pumping frequency grid. By researching the gain properties of Raman amplifiers of such ITU-T fibers as G.652, G.653, G.655 and large effective area non zero dispersion flattening fiber, we find that the Raman gain is associated with the fiber type and its transmission characteristics, especially it decreases with the increase of the effective core area.

Correction of walk-off-induced wavefront distortion for continuous-wave laser

We theoretically and experimentally investigate the wave front distortion in critically phase-matched continuouswave（CW） second harmonic generation（SHG）.Due to the walk-off effect in the nonlinear crystal,the generated second harmonic is extremely elliptical and quite non-Gaussian,which causes a very low matching and coupling efficiency in experiment.Cylindrical lenses and walk-off compensating crystals are adopted to correct distorted wave fronts,and obtain a good TEM00 mode efficiently.Theoretically,we simulate the correction effect of 266-nm laser generated with SHG.The experiment results accord well with the theoretical simulation and an above 80% TEM_（00） component is obtained for 266-nm continuous-wave laser with a 4.8？-walk-off angle in beta barium borate（BBO） crystal.

基于PumpLinx的汽车水泵结构改进及散热效果研究

针对水封干烧导致水封漏水的难点问题,根据现行水泵的结构剖析了干烧现象的成因,提出了增设高压反馈回水孔的泵体结构改进方案。基于Pump Linx进行了数值模拟实验;搭建实验系统并进行了结构改进前后水泵在湿式和干湿交变状态下的散热效果比对实验。研究结果表明,泵体的结构改进明显提升了叶轮与水封之间区域的散热效果,可有效防止水封干烧现象的产生。