As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in pra...As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.展开更多
The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generationand transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structur...The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generationand transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structures, the two ferromagneticlayers demonstrate in-phase and out-of-phase states, corresponding to acoustic and optical precession modes. Withinthis context, our study explores the spin pumping effect in Py/Ru/Py synthetic antiferromagnetic structures across differentmodes. The heightened magnetic damping resulting from the spin pumping effect in the in-phase state initially decreaseswith increasing Py thickness before stabilizing. Conversely, in the out-of-phase state, the amplified damping exceeds thatof the in-phase state, suggesting a greater spin relaxation within this configuration, which demonstrates sensitivity to alterationsin static exchange interactions. These findings contribute to advancing the application of synthetic antiferromagneticstructures in magnonic devices.展开更多
High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well operations.Deep learning-based method for classifying the dynamometer card(DC)of oil wells is an eff...High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well operations.Deep learning-based method for classifying the dynamometer card(DC)of oil wells is an efficient diagnosis method.However,the input of the DC as a two-dimensional image into the deep learning framework suffers from low feature utilization and high computational effort.Additionally,different SRPSs in an oil field have various system parameters,and the same SRPS generates different DCs at different moments.Thus,there is heterogeneity in field data,which can dramatically impair the diagnostic accuracy.To solve the above problems,a working condition recognition method based on 4-segment time-frequency signature matrix(4S-TFSM)and deep learning is presented in this paper.First,the 4-segment time-frequency signature(4S-TFS)method that can reduce the computing power requirements is proposed for feature extraction of DC data.Subsequently,the 4S-TFSM is constructed by relative normalization and matrix calculation to synthesize the features of multiple data and solve the problem of data heterogeneity.Finally,a convolutional neural network(CNN),one of the deep learning frameworks,is used to determine the functioning conditions based on the 4S-TFSM.Experiments on field data verify that the proposed diagnostic method based on 4S-TFSM and CNN(4S-TFSM-CNN)can significantly improve the accuracy of working condition recognition with lower computational cost.To the best of our knowledge,this is the first work to discuss the effect of data heterogeneity on the working condition recognition performance of SRPS.展开更多
In the dry tropical zone where access to water is increasingly difficult for populations, solar pumping units are increasingly installed to provide water to population. In the local market, there are essentially two t...In the dry tropical zone where access to water is increasingly difficult for populations, solar pumping units are increasingly installed to provide water to population. In the local market, there are essentially two types of solar panels, namely monocrystalline and polycrystalline. However, the part of the local market is more dominated by the polycrystalline panel. In this work, comparative studies are carried out in order to characterize the two types of solar panels with regard to local constraints. Tests were carried out over the course of the sun to establish the performance of each type. The panels used have the same electrical characteristics and are connected to loads with same characteristics. Under the set operating conditions, the monocrystalline panel presents more performance than the polycrystalline panel. Although the local market is dominated by the polycrystalline panel, dust deposition tests on the surface of the panels show that the performance of the polycrystalline panel is more affected compared to the performance of the monocrystalline panel.展开更多
This article examines the determinants of the adoption of solar pumping systems (PV) by vegetable farmers in the Niayes area of Senegal. To measure the determinants, we used a sequential logit model to translate the a...This article examines the determinants of the adoption of solar pumping systems (PV) by vegetable farmers in the Niayes area of Senegal. To measure the determinants, we used a sequential logit model to translate the adoption process from becoming aware of solar pumping systems to testing them, i.e. using them at least once, and then continuing to use them over time. The results show that the main variables affecting awareness of the use of solar pumping systems (PV) are age, marital status, experience, access to credit, the farmer’s knowledge of climate change, the farmer’s origin in the Thiès region and length of time in the Niayes area. The first use of PVs is influenced by factors such as the size of the plot, the distance of the plot from the main road or from the market. Finally, the decision to adopt or continue use is influenced by gender, experience, household size and access to credit. Surprisingly, access to credit does not affect the first use of solar pumping systems, but plays a key role in their continued use.展开更多
BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term...BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.展开更多
Tonoplast-enriched vesicles were prepared from suspension-cultured Populus euphratica Oliv. cells by differential centrifugation and discontinuous sucrose density gradient centrifugation. The properties of the proton ...Tonoplast-enriched vesicles were prepared from suspension-cultured Populus euphratica Oliv. cells by differential centrifugation and discontinuous sucrose density gradient centrifugation. The properties of the proton pumping activity of H+-ATPases in tonoplast vesicles were studied by acridine orange fluorescent quenching measured at 22 degreesC. The proton pumping activity of ATPase was ATP-dependent with apparent Michaelis-Menten Constant (K-m) for ATP about 0.65 mmol/L. The optimal pH for H+-ATPases activity was 7.5. The proton pumping activity of H+-ATPase could be initiated by some divalent cations, Mg2+ being highly efficient, much more than Fe2+; and Ca2+, Cu2+ and Zn2+ were inefficient under the experimental condition. The proton translocation could be stimulated by halide anions, with potencies decreasing in the order Cl- > Br- > I- > F-. The proton pumping activity was greatly inhibited by N-ethylmaleimide (NEM), N, N'-dicyclohexylcarbodiimide (DCCD), NO3- and Bafilomycin A(1), but not by orthovanadate and azide. These results demonstrated that the H+-ATPase in the tonoplast of Populus euphratica belonged to vacuolar type ATPase. This work was the first time that tonoplast-enriched vesicles were isolated from Populus euphratica cells.展开更多
Using the Keldysh-Green function,we present a theoretical study on the electron transport properties of two coupled quantum dots under optical pumping. Plateaus in the I-V curve and resonant peaks in the transmission ...Using the Keldysh-Green function,we present a theoretical study on the electron transport properties of two coupled quantum dots under optical pumping. Plateaus in the I-V curve and resonant peaks in the transmission coefficient occur and can be explained by the local electron density of states in the quantum dots. The effects of the optical pumping frequency and intensity on the transport properties of the system are also discussed. The electron dynamical localization phenomenon occurs when the optical pumping frequency is equal to the discrete hole energy level. This result can be used to realize optical control switches.展开更多
A three-dimensional model is used to investigate the mechanism of the South China Sea (SCS) winter counter-current (also known as the SCS Warm Current, or the SCSWC), which flows against the wind. The model can re...A three-dimensional model is used to investigate the mechanism of the South China Sea (SCS) winter counter-current (also known as the SCS Warm Current, or the SCSWC), which flows against the wind. The model can reproduce the structure of the band-like currents over the northern shelf of the SCS, including the westward coastal current and slop current, and the SCSWC sandwiched in between. Sensitivity experiments are designed to understand the different roles of Ekman pumping of the SCSWC at different longitude. The results show that the Ekman pumping drives the SCSWC in the west segment. In the east, it is not the Ekman pumping but the intrusion of the Kuroshio that drives the SCSWC.展开更多
Downhole working conditions of sucker rod pumping wells are automatically identified on a computer from the analysis of dynamometer cards. In this process, extraction of feature parameters and pattern classification a...Downhole working conditions of sucker rod pumping wells are automatically identified on a computer from the analysis of dynamometer cards. In this process, extraction of feature parameters and pattern classification are two key steps. The dynamometer card is firstly divided into four parts which include different production information according to the "four point method" used in actual oilfield production, and then the moment invariants for pattern recognition are extracted. An improved support vector machine (SVM) method is used for pattern classification whose error penalty parameter C and kernel function parameter g are optimally chosen by the particle swarm optimization (PSO) algorithm. The simulation results show the method proposed in this paper has good classification results.展开更多
It is important to achieve continuous, stable and efficient pumping well operation in actual oilfield operation. Down-hole pumping well working conditions can be monitored in real-time and a reasonable production sche...It is important to achieve continuous, stable and efficient pumping well operation in actual oilfield operation. Down-hole pumping well working conditions can be monitored in real-time and a reasonable production scheme can be designed when computer diagnosis is used. However, it is difficult to make a comprehensive analysis to supply efficient technical guidance for operation of the pumping well with multiple faults of down-hole conditions, which cannot be effectively dealt with by the common methods. To solve this problem, a method based on designated component analysis (DCA) is used in this paper. Freeman chain code is used to represent the down-hole dynamometer card whose important characteristics are extracted to construct a designated mode set. A control chart is used as a basis for fault detection. The upper and lower control lines on the control chart are determined from standard samples in normal working conditions. In an incompletely orthogonal mode, the designated mode set could be divided into some subsets in which the modes are completely orthogonal. The observed data is projected into each designated mode to realize fault detection according to the upper and lower control lines. The examples show that the proposed method can effectively diagnose multiple faults of down-hole conditions.展开更多
Dynamometer cards are commonly used to analyze down-hole working conditions of pumping systems in actual oil production. Nowadays, the traditional supervised learning methods heavily rely on the classification accurac...Dynamometer cards are commonly used to analyze down-hole working conditions of pumping systems in actual oil production. Nowadays, the traditional supervised learning methods heavily rely on the classification accuracy of the training samples. In order to reduce the errors of manual classification, an automatic clustering algorithm is proposed and applied to diagnose down-hole conditions of pumping systems. The spectral clustering (SC) is a new clustering algorithm, which is suitable for any data distribution. However, it is sensitive to initial cluster centers and scale parameters, and needs to predefine the cluster number. In order to overcome these shortcom- ings, we propose an automatic clustering algorithm, fast black hole-spectral clustering (FBH-SC). The FBH algo- rithm is used to replace the K-mean method in SC, and a CritC index function is used as the target function to automatically choose the best scale parameter and clus- tering number in the clustering process. Different simulation experiments were designed to define the relationship among scale parameter, clustering number, CritC index value, and clustering accuracy. Finally, an example is given to validate the effectiveness of the proposed algorithm.展开更多
Baoying pumping station is a part of source pumping stations in East Route Project of South-to-North Water Transfer in China. Aiming at the characteristics of head varying, and making use of the function of pump adjus...Baoying pumping station is a part of source pumping stations in East Route Project of South-to-North Water Transfer in China. Aiming at the characteristics of head varying, and making use of the function of pump adjustable blade, mathematical models of pumping station optimal operation are established and solved with genetic algorithm. For different total pumping discharge and total pumping volume of water per day, in order to minimize pumping station operation cost, the number and operation duties of running pump units are respectively determined at different periods of time in a day. The results indicate that the saving of electrical cost is significantly effected by the schemes of adjusting blade angles and time-varying electrical price when pumping certain water volume of water per day, and compared with conventional operation schemes (namely, the schemes of pumping station operation at design blade angles based on certain pumping discharge), the electrical cost is saved by 4.73%-31.27%. Also, compared with the electrical cost of conventional operation schemes, the electrical cost is saved by 2.03%-5.79% by the schemes of adjusting blade angles when pumping certain discharge.展开更多
A new technology of offshore oil rod pumping production is developed for offshore heavy oil recovery. A new type of miniature hydraulic pumping unit with long-stroke, low pumping speed and compact structure is designe...A new technology of offshore oil rod pumping production is developed for offshore heavy oil recovery. A new type of miniature hydraulic pumping unit with long-stroke, low pumping speed and compact structure is designed based on the spatial characteristics of offshore platforms. By combining the strengths of sinusoidal velocity curve and trapezoidal velocity curve, a kinematical model of the acceleration, the velocity and displacement of the pumping unit's hanging point is established. The results show that the pumping unit has good kinematic characteristics of smooth motion and small dynamic load. The multi-degree-of-freedom dynamic model of the single-well pumping unit is established. The first and second order natural frequencies of the sucker rod string subsystem and the pumping unit subsystem are studied. The results show that the first and the second order natural frequencies among the pumping rod string, pumping unit-platform subsystem and the dynamic excitation have differences over 5 times from each other, indicating that resonance phenomenon will not appear during the operation and the dynamic requirements for field use are met in the system.展开更多
In the adiabatic and weak-modulation quantum pump, net electron flow is driven from one reservoir to another by absorbing or emitting an energy quantum nω from or to the reservoirs. This paper considers high-order de...In the adiabatic and weak-modulation quantum pump, net electron flow is driven from one reservoir to another by absorbing or emitting an energy quantum nω from or to the reservoirs. This paper considers high-order dependence of the scattering matrix on the time. Non-sinusoidal behaviour of strong pumping is revealed. The relation between the pumped current and the ac driving amplitude varies from power of 2, 1 to 1/2 when stronger modulation is exerted. Open experimental observation can be interpreted by multi-energy-quantum-related processes.展开更多
Spin currents, which are excited in indium tin oxide(ITO)/yttrium iron garnet(YIG) by the methods of spin pumping and spin Seebeck effect, are investigated through the inverse spin Hall effect(ISHE). It is demonstrate...Spin currents, which are excited in indium tin oxide(ITO)/yttrium iron garnet(YIG) by the methods of spin pumping and spin Seebeck effect, are investigated through the inverse spin Hall effect(ISHE). It is demonstrated that the ISHE voltage can be generated in ITO by spin pumping under both in-plane and out-of-plane magnetization configurations.Moreover, it is observed that the enhancement of spin Hall angle and interfacial spin mixing conductance can be achieved by an appropriate annealing process. However, the ISHE voltage is hardly seen in the presence of a longitudinal temperature gradient. The absence of the longitudinal spin Seebeck effect can be ascribed to the almost equal thermal conductivity of ITO and YIG and specific interface structure, or to the large negative temperature dependent spin mixing conductance.展开更多
基金supported by the National Natural Science Foundation of China(Nos.51922023,61874011)Fundamental Research Funds for the Central Universities(E1EG6804)
文摘As an emerging technology to convert environmental high-entropy energy into electrical energy,triboelectric nanogenerator(TENG)has great demands for further enhancing the service lifetime and output performance in practical applications.Here,an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG)by bearing charge pumping is proposed.The R-TENG composes of a pumping TENG(P-TENG),an output TENG(O-TENG),a voltage-multiplying circuit(VMC),and a buffer capacitor.The P-TENG is designed with freestanding mode based on a rolling ball bearing,which can also act as the rotating mechanical energy harvester.The output low charge from the P-TENG is accumulated and pumped to the non-contact O-TENG,which can simultaneously realize ultralow mechanical wear and high output performance.The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min.Furthermore,the transferring charge of R-TENG can remain 95%during 15 days(6.4×10^(6)cycles)continuous operation.This work presents a realizable method to further enhance the durability of TENG,which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.
基金National Key Research and De-velopment Program of China(Grant No.2023YFA1406603)the National Natural Science Foundation of China(Grant Nos.52071079,12274071,12374112,and T2394473)Jiangsu Funding Program for Excellent Postdoctoral Talent(Grant No.2023ZB491).
文摘The spin pumping effect in magnetic heterostructures and multilayers is a highly effective method for the generationand transmission of spin currents. In the increasingly prominent synthetic antiferromagnetic structures, the two ferromagneticlayers demonstrate in-phase and out-of-phase states, corresponding to acoustic and optical precession modes. Withinthis context, our study explores the spin pumping effect in Py/Ru/Py synthetic antiferromagnetic structures across differentmodes. The heightened magnetic damping resulting from the spin pumping effect in the in-phase state initially decreaseswith increasing Py thickness before stabilizing. Conversely, in the out-of-phase state, the amplified damping exceeds thatof the in-phase state, suggesting a greater spin relaxation within this configuration, which demonstrates sensitivity to alterationsin static exchange interactions. These findings contribute to advancing the application of synthetic antiferromagneticstructures in magnonic devices.
基金We would like to thank the associate editor and the reviewers for their constructive comments.This work was supported in part by the National Natural Science Foundation of China under Grant 62203234in part by the State Key Laboratory of Robotics of China under Grant 2023-Z03+1 种基金in part by the Natural Science Foundation of Liaoning Province under Grant 2023-BS-025in part by the Research Program of Liaoning Liaohe Laboratory under Grant LLL23ZZ-02-02.
文摘High-precision and real-time diagnosis of sucker rod pumping system(SRPS)is important for quickly mastering oil well operations.Deep learning-based method for classifying the dynamometer card(DC)of oil wells is an efficient diagnosis method.However,the input of the DC as a two-dimensional image into the deep learning framework suffers from low feature utilization and high computational effort.Additionally,different SRPSs in an oil field have various system parameters,and the same SRPS generates different DCs at different moments.Thus,there is heterogeneity in field data,which can dramatically impair the diagnostic accuracy.To solve the above problems,a working condition recognition method based on 4-segment time-frequency signature matrix(4S-TFSM)and deep learning is presented in this paper.First,the 4-segment time-frequency signature(4S-TFS)method that can reduce the computing power requirements is proposed for feature extraction of DC data.Subsequently,the 4S-TFSM is constructed by relative normalization and matrix calculation to synthesize the features of multiple data and solve the problem of data heterogeneity.Finally,a convolutional neural network(CNN),one of the deep learning frameworks,is used to determine the functioning conditions based on the 4S-TFSM.Experiments on field data verify that the proposed diagnostic method based on 4S-TFSM and CNN(4S-TFSM-CNN)can significantly improve the accuracy of working condition recognition with lower computational cost.To the best of our knowledge,this is the first work to discuss the effect of data heterogeneity on the working condition recognition performance of SRPS.
文摘In the dry tropical zone where access to water is increasingly difficult for populations, solar pumping units are increasingly installed to provide water to population. In the local market, there are essentially two types of solar panels, namely monocrystalline and polycrystalline. However, the part of the local market is more dominated by the polycrystalline panel. In this work, comparative studies are carried out in order to characterize the two types of solar panels with regard to local constraints. Tests were carried out over the course of the sun to establish the performance of each type. The panels used have the same electrical characteristics and are connected to loads with same characteristics. Under the set operating conditions, the monocrystalline panel presents more performance than the polycrystalline panel. Although the local market is dominated by the polycrystalline panel, dust deposition tests on the surface of the panels show that the performance of the polycrystalline panel is more affected compared to the performance of the monocrystalline panel.
文摘This article examines the determinants of the adoption of solar pumping systems (PV) by vegetable farmers in the Niayes area of Senegal. To measure the determinants, we used a sequential logit model to translate the adoption process from becoming aware of solar pumping systems to testing them, i.e. using them at least once, and then continuing to use them over time. The results show that the main variables affecting awareness of the use of solar pumping systems (PV) are age, marital status, experience, access to credit, the farmer’s knowledge of climate change, the farmer’s origin in the Thiès region and length of time in the Niayes area. The first use of PVs is influenced by factors such as the size of the plot, the distance of the plot from the main road or from the market. Finally, the decision to adopt or continue use is influenced by gender, experience, household size and access to credit. Surprisingly, access to credit does not affect the first use of solar pumping systems, but plays a key role in their continued use.
文摘BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related disorders.Recent evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater mortality.AIM To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize bias.METHODS This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare organizations.The study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer patients.Newly prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)users.The primary outcome was all-cause mortality.Each patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding effects.Multivariable Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these findings.In a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individuals who have never used PPIs,providing insights into the long-term effects of past PPI use.In addition,at 1-year follow-up,the analysis revealed a significant difference in mortality rates between former PPI users and non-users(HR:1.84;95%CI:1.82-1.96).CONCLUSION PPI use among cancer patients was associated with a higher risk of all-cause mortality compared to non-users or H2RA users.These findings emphasize the need for cautious use of PPIs in cancer patients and suggest that alternative treatments should be considered when clinically feasible.However,further studies are needed to corroborate our findings,given the significant adverse outcomes in cancer patients.
文摘Tonoplast-enriched vesicles were prepared from suspension-cultured Populus euphratica Oliv. cells by differential centrifugation and discontinuous sucrose density gradient centrifugation. The properties of the proton pumping activity of H+-ATPases in tonoplast vesicles were studied by acridine orange fluorescent quenching measured at 22 degreesC. The proton pumping activity of ATPase was ATP-dependent with apparent Michaelis-Menten Constant (K-m) for ATP about 0.65 mmol/L. The optimal pH for H+-ATPases activity was 7.5. The proton pumping activity of H+-ATPase could be initiated by some divalent cations, Mg2+ being highly efficient, much more than Fe2+; and Ca2+, Cu2+ and Zn2+ were inefficient under the experimental condition. The proton translocation could be stimulated by halide anions, with potencies decreasing in the order Cl- > Br- > I- > F-. The proton pumping activity was greatly inhibited by N-ethylmaleimide (NEM), N, N'-dicyclohexylcarbodiimide (DCCD), NO3- and Bafilomycin A(1), but not by orthovanadate and azide. These results demonstrated that the H+-ATPase in the tonoplast of Populus euphratica belonged to vacuolar type ATPase. This work was the first time that tonoplast-enriched vesicles were isolated from Populus euphratica cells.
文摘Using the Keldysh-Green function,we present a theoretical study on the electron transport properties of two coupled quantum dots under optical pumping. Plateaus in the I-V curve and resonant peaks in the transmission coefficient occur and can be explained by the local electron density of states in the quantum dots. The effects of the optical pumping frequency and intensity on the transport properties of the system are also discussed. The electron dynamical localization phenomenon occurs when the optical pumping frequency is equal to the discrete hole energy level. This result can be used to realize optical control switches.
基金The Knowledge Innovation Program of the Chinese Academy of Sciences under contract No.KZCX1-YW-12-01the National Science Fund for Distinguished Young Scholars under contract No.40625017+1 种基金the National Natural Science Foundation of China(Key Program)under contract No.40830851the National Program on Key Basic Research Project(973Program)under contract No.2007CB816004
文摘A three-dimensional model is used to investigate the mechanism of the South China Sea (SCS) winter counter-current (also known as the SCS Warm Current, or the SCSWC), which flows against the wind. The model can reproduce the structure of the band-like currents over the northern shelf of the SCS, including the westward coastal current and slop current, and the SCSWC sandwiched in between. Sensitivity experiments are designed to understand the different roles of Ekman pumping of the SCSWC at different longitude. The results show that the Ekman pumping drives the SCSWC in the west segment. In the east, it is not the Ekman pumping but the intrusion of the Kuroshio that drives the SCSWC.
基金support from the Key Project of the National Natural Science Foundation of China (61034005)Postgraduate Scientific Research and Innovation Projects of Basic Scientific Research Operating Expenses of Ministry of Education (N100604001)
文摘Downhole working conditions of sucker rod pumping wells are automatically identified on a computer from the analysis of dynamometer cards. In this process, extraction of feature parameters and pattern classification are two key steps. The dynamometer card is firstly divided into four parts which include different production information according to the "four point method" used in actual oilfield production, and then the moment invariants for pattern recognition are extracted. An improved support vector machine (SVM) method is used for pattern classification whose error penalty parameter C and kernel function parameter g are optimally chosen by the particle swarm optimization (PSO) algorithm. The simulation results show the method proposed in this paper has good classification results.
基金supported by the Key Program of National Natural Science Foundation of China (61034005)Postgraduate Scientific Research and Innovation Projects of Basic Scientific Research Operating Expensesof Ministry of Education (N100604001)Excellent Doctoral Dissertations Cultivation Project of Northeastern University
文摘It is important to achieve continuous, stable and efficient pumping well operation in actual oilfield operation. Down-hole pumping well working conditions can be monitored in real-time and a reasonable production scheme can be designed when computer diagnosis is used. However, it is difficult to make a comprehensive analysis to supply efficient technical guidance for operation of the pumping well with multiple faults of down-hole conditions, which cannot be effectively dealt with by the common methods. To solve this problem, a method based on designated component analysis (DCA) is used in this paper. Freeman chain code is used to represent the down-hole dynamometer card whose important characteristics are extracted to construct a designated mode set. A control chart is used as a basis for fault detection. The upper and lower control lines on the control chart are determined from standard samples in normal working conditions. In an incompletely orthogonal mode, the designated mode set could be divided into some subsets in which the modes are completely orthogonal. The observed data is projected into each designated mode to realize fault detection according to the upper and lower control lines. The examples show that the proposed method can effectively diagnose multiple faults of down-hole conditions.
基金the National Natural Science Foundation of China (Grant No. 61403040)
文摘Dynamometer cards are commonly used to analyze down-hole working conditions of pumping systems in actual oil production. Nowadays, the traditional supervised learning methods heavily rely on the classification accuracy of the training samples. In order to reduce the errors of manual classification, an automatic clustering algorithm is proposed and applied to diagnose down-hole conditions of pumping systems. The spectral clustering (SC) is a new clustering algorithm, which is suitable for any data distribution. However, it is sensitive to initial cluster centers and scale parameters, and needs to predefine the cluster number. In order to overcome these shortcom- ings, we propose an automatic clustering algorithm, fast black hole-spectral clustering (FBH-SC). The FBH algo- rithm is used to replace the K-mean method in SC, and a CritC index function is used as the target function to automatically choose the best scale parameter and clus- tering number in the clustering process. Different simulation experiments were designed to define the relationship among scale parameter, clustering number, CritC index value, and clustering accuracy. Finally, an example is given to validate the effectiveness of the proposed algorithm.
基金supported by Author Special Foundation of National Excellent Doctoral Dissertation of China (Grant No. 2007B41)Jiangsu Provincial Foundation of "333 Talents Engineering" of ChinaJiangsu Provincial Academic Header Foundation of Qinglan Engineering of China
文摘Baoying pumping station is a part of source pumping stations in East Route Project of South-to-North Water Transfer in China. Aiming at the characteristics of head varying, and making use of the function of pump adjustable blade, mathematical models of pumping station optimal operation are established and solved with genetic algorithm. For different total pumping discharge and total pumping volume of water per day, in order to minimize pumping station operation cost, the number and operation duties of running pump units are respectively determined at different periods of time in a day. The results indicate that the saving of electrical cost is significantly effected by the schemes of adjusting blade angles and time-varying electrical price when pumping certain water volume of water per day, and compared with conventional operation schemes (namely, the schemes of pumping station operation at design blade angles based on certain pumping discharge), the electrical cost is saved by 4.73%-31.27%. Also, compared with the electrical cost of conventional operation schemes, the electrical cost is saved by 2.03%-5.79% by the schemes of adjusting blade angles when pumping certain discharge.
基金financially supported by the National Natural Science Foundation of China(Grant No.51174224)the National Science and Technology Major Projects of Oil and Gas(Grant Nos.2016ZX05066 and 2016ZX05042)the Natural Science Foundation of Shandong Province(Grant No.ZR2014El015)
文摘A new technology of offshore oil rod pumping production is developed for offshore heavy oil recovery. A new type of miniature hydraulic pumping unit with long-stroke, low pumping speed and compact structure is designed based on the spatial characteristics of offshore platforms. By combining the strengths of sinusoidal velocity curve and trapezoidal velocity curve, a kinematical model of the acceleration, the velocity and displacement of the pumping unit's hanging point is established. The results show that the pumping unit has good kinematic characteristics of smooth motion and small dynamic load. The multi-degree-of-freedom dynamic model of the single-well pumping unit is established. The first and second order natural frequencies of the sucker rod string subsystem and the pumping unit subsystem are studied. The results show that the first and the second order natural frequencies among the pumping rod string, pumping unit-platform subsystem and the dynamic excitation have differences over 5 times from each other, indicating that resonance phenomenon will not appear during the operation and the dynamic requirements for field use are met in the system.
基金Project supported by the National Natural Science Foundation of China(Grant No.11004063)the Fundamental Research Funds for the Central Universities(Grant No.2009ZM0299)+1 种基金the Natural Science Foundation of South China University of Technology (Grant No.x2lxE5090410)the Graduate Course Construction Project of South China University of Technology(Grant No.yjzk2009001)
文摘In the adiabatic and weak-modulation quantum pump, net electron flow is driven from one reservoir to another by absorbing or emitting an energy quantum nω from or to the reservoirs. This paper considers high-order dependence of the scattering matrix on the time. Non-sinusoidal behaviour of strong pumping is revealed. The relation between the pumped current and the ac driving amplitude varies from power of 2, 1 to 1/2 when stronger modulation is exerted. Open experimental observation can be interpreted by multi-energy-quantum-related processes.
基金Project supported by the National Key Basic Research Project of China(Grant No.2016YFA0300600)Chinese Academy of Sciences(Grant No.KJCX2-YW-W24)+1 种基金the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.11604375)the Laboratory of Microfabrication of Institute of Physics,Chinese Academy of Sciences
文摘Spin currents, which are excited in indium tin oxide(ITO)/yttrium iron garnet(YIG) by the methods of spin pumping and spin Seebeck effect, are investigated through the inverse spin Hall effect(ISHE). It is demonstrated that the ISHE voltage can be generated in ITO by spin pumping under both in-plane and out-of-plane magnetization configurations.Moreover, it is observed that the enhancement of spin Hall angle and interfacial spin mixing conductance can be achieved by an appropriate annealing process. However, the ISHE voltage is hardly seen in the presence of a longitudinal temperature gradient. The absence of the longitudinal spin Seebeck effect can be ascribed to the almost equal thermal conductivity of ITO and YIG and specific interface structure, or to the large negative temperature dependent spin mixing conductance.