We previously determined "Tableting properties" by using a multi-functional single-punch tablet press(GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability"on the y...We previously determined "Tableting properties" by using a multi-functional single-punch tablet press(GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability"on the y-axis to allow visual evaluation of "Tableting properties". Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. We used the GTP-1 to measure "Tableting properties" with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures(capping and binding in particular) occurred when samples that had been evaluated as having poor "Compactability" or"Manufacturability" on the GTP-1 were compressed on the rotary tableting machine. Thus,our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production.展开更多
We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on t...We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on punches.We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.展开更多
针对现有中小农户大棚蔬菜穴盘栽培手工播种生产率低、劳动强度大等问题,以及国外大型播种机不适合我国中小规模种植经营户需求的现状,设计了一种应用于大棚栽培的穴盘自动化便携式播种机。该播种机一端可折叠,折叠后尺寸为500 mm×...针对现有中小农户大棚蔬菜穴盘栽培手工播种生产率低、劳动强度大等问题,以及国外大型播种机不适合我国中小规模种植经营户需求的现状,设计了一种应用于大棚栽培的穴盘自动化便携式播种机。该播种机一端可折叠,折叠后尺寸为500 mm×500 mm×750 mm,携带方便;播种机采用多功能集成化设计,将传统的穴盘打孔、播种集成于一体,通过激光传感器检测穴盘凹口位置,准确地实现了穴盘基质的自动打孔和播种。经油菜种子和黄瓜种子试验表明,当孔径处于0.6~1.2 mm时,选择真空度为8 k Pa,吸附效果较好;若选用0.6 mm孔径气吸吸头,当油菜种子气吸真空度超过6.2 k Pa,以及黄瓜种子真空度超过8.3 k Pa时,吸附成功率达到90%以上。经正交试验,发现油菜种子和黄瓜种子在孔径为0.6 mm,真空度为10 k Pa时吸附效果最好。与手工播种相比,播种机播种效率是手工播种效率12.9倍,较好地实现了蔬菜种子的穴盘播种。展开更多
文摘We previously determined "Tableting properties" by using a multi-functional single-punch tablet press(GTP-1). We plotted "Compactability" on the x-axis against "Manufacturability"on the y-axis to allow visual evaluation of "Tableting properties". Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. We used the GTP-1 to measure "Tableting properties" with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures(capping and binding in particular) occurred when samples that had been evaluated as having poor "Compactability" or"Manufacturability" on the GTP-1 were compressed on the rotary tableting machine. Thus,our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production.
文摘We previously determined 'Tableting properties' by using a multi-functional single-punch tablet press(GTP-1). We proposed plotting 'Compactability' on the x-axis against'Manufacturability' on the y-axis to allow visual evaluation of 'Tableting properties'. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure'Tableting properties' with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad 'Manufacturability', leading to sticking of powder on punches.We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine.
文摘针对现有中小农户大棚蔬菜穴盘栽培手工播种生产率低、劳动强度大等问题,以及国外大型播种机不适合我国中小规模种植经营户需求的现状,设计了一种应用于大棚栽培的穴盘自动化便携式播种机。该播种机一端可折叠,折叠后尺寸为500 mm×500 mm×750 mm,携带方便;播种机采用多功能集成化设计,将传统的穴盘打孔、播种集成于一体,通过激光传感器检测穴盘凹口位置,准确地实现了穴盘基质的自动打孔和播种。经油菜种子和黄瓜种子试验表明,当孔径处于0.6~1.2 mm时,选择真空度为8 k Pa,吸附效果较好;若选用0.6 mm孔径气吸吸头,当油菜种子气吸真空度超过6.2 k Pa,以及黄瓜种子真空度超过8.3 k Pa时,吸附成功率达到90%以上。经正交试验,发现油菜种子和黄瓜种子在孔径为0.6 mm,真空度为10 k Pa时吸附效果最好。与手工播种相比,播种机播种效率是手工播种效率12.9倍,较好地实现了蔬菜种子的穴盘播种。
