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Putative roles of cathepsin B in Alzheimer's disease pathology: the good, the bad, and the ugly in one? 被引量:2
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作者 Hans-Gert Bernstein Gerburg Keilhoff 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第12期2100-2101,共2页
Alzheimer's disease(AD)is a fatal progressive neurodegenerative disorder characterized by loss in memory,cognition,and executive function and activities of daily living.AD pathogenesis has been shown to involve los... Alzheimer's disease(AD)is a fatal progressive neurodegenerative disorder characterized by loss in memory,cognition,and executive function and activities of daily living.AD pathogenesis has been shown to involve loss of neurons and synapses,cholinergic deficits,amyloid-beta protein(Aβ)deposition,tau protein hyperphosphorylation, and neuroinflammation. 展开更多
关键词 AD and the ugly in one the bad the good putative roles of cathepsin B in Alzheimer’s disease pathology
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Eco-mindfulness in Buddhism
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作者 Kenneth Lee 《Journal of Literature and Art Studies》 2017年第12期1645-1650,共6页
Many of those involved in the ecological movement have found inspiration and parallels within the Buddhist tradition. The Buddhist philosophy of karmic causality and dependent origination (pratitya-samutpada) convey... Many of those involved in the ecological movement have found inspiration and parallels within the Buddhist tradition. The Buddhist philosophy of karmic causality and dependent origination (pratitya-samutpada) convey the notion of interdependence of humans and nature. Today, especially in the United States, there are many movements, such as the Buddhist Peace Fellowship, to promote eco-living and sustainable communities, which call for humans to be mindful of the environment and make conscientious choices for the benefit of all sentient beings and non-sentient entities. Just as humans have been the cause of the gradual deterioration of Nature, we can also be the solution towards an coo-conscious living, which not only fosters a healthy environment, but also enables us to build good merit. The core Buddhist teaching, which must be embraced by all eco-minded practitioners is the notion of interdependence, which has been expounded by notable Japanese Buddhist figures in the eighth century, such as Kukai (774-835) of the Shingon School and Dogen (1200-1253) of the Soto Zen sect, who both viewed that non-living life forms--trees, plants, and the earth--could also achieve enlightenment. Their view is based on the ontological notions of Buddha-nature (tathagata-garbha) and Indra's Jewel Net, which is a powerful image found in Huayen's (Jpn. Kegon) Avatamsaka Sutra. This paper examines Buddhist teachings and sutras, which support eco-friendly and sustainable movements in our society and world today. 展开更多
关键词 mindFULNEss BUDDHIsM nature environment dependent origination Eco-living Indra's Net
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The state of the Mind in a Revolutionary state of the State
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作者 Nditsheni Emmanuel Tshikwatamba 《Sociology Study》 2014年第1期69-84,共16页
The article epitomises its foundations by providing definitional and explanative dichotomy among the State, Nation, and Nation State. It affords a depiction of the centrality of the mind, the interface of the body and... The article epitomises its foundations by providing definitional and explanative dichotomy among the State, Nation, and Nation State. It affords a depiction of the centrality of the mind, the interface of the body and mind in behavioural manifestations. It furthermore acknowledges that nothing occurs in a vacuum but in the context of the fullness of the mind. The visible manifestations of human behaviour are contended to be informed by the noiselessness invisible aspects of the mind. The same noiseless mind that informs the behavioural visibility that becomes somewhat active and busier in its conspicuousness. The dual existence of things and events in a revolutionary context that transcends to other behavioural undertones is discoursed. In the context application of the revolutionary mapping, the mind is presented as a culprit revolutionarist that wages revolutions without fear of external threats through arrests, danger, pain, terror, dread, apprehension, detentions, and any other similar means including death. The article settles that the mind is the determinant factor of human behaviours and it therefore defines the state of the State in any revolutionary circumstance. It denotes a functional separatism of the mind from the brain which is an organ of the body thereby equally accepting that the brain functionalises the mind. The equal essential role of the mind in post revolution construction to establish and promote an acceptable system of government that responds to socio-economic factors is detailed herein the manuscript. A deliberate attempt is made not to be suggestive and prescriptive on the shape and form of such a post revolution system of government. 展开更多
关键词 Revolutionary mind DUALIsM state(s CONsTRUCTs
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A Review on the Evolution and Development of Searle' s Philosophy of Mind
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作者 Zhao Yingji 《学术界》 CSSCI 北大核心 2013年第12期291-299,共9页
The evolution and development of Searle’s philosophy of mind can be divided into two important stages,i.e.the origin and beginning stage between 1960sand 1970s,the formation and development stage since 1980s.Searle’... The evolution and development of Searle’s philosophy of mind can be divided into two important stages,i.e.the origin and beginning stage between 1960sand 1970s,the formation and development stage since 1980s.Searle’s Speech Act Theory started the research on philosophy of mind,which is considered as the origin of his philosophy of mind.The Theories of Intentionality and Chinese Room Argument are the most important and most influential academic findings in his research in the field of philosophy of mind,which lay a solid theoretical foundation for the formation and development of his theories of philosophy of mind.Searle’s philosophy of mind finds wide prospect in the research field,which provides a new direction to understand the world and probe into mind,proposes a new perspective and methodology for the study of language,and promotes the new development of the study of language. 展开更多
关键词 心灵哲学 塞尔 述评 演进 心境 言语行为理论 学术成果 意向性
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Nature's Influence on Children: Wordsworth's Concern with Children's Mind
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作者 王晓东 《海外英语》 2010年第8X期205-208,共4页
Romanticism is an important stage in the evolution of man's self-consciousness. It shows new interest in and new concern with man and nature. Wordsworth is well-known as a nature poet. The theme of human mind and ... Romanticism is an important stage in the evolution of man's self-consciousness. It shows new interest in and new concern with man and nature. Wordsworth is well-known as a nature poet. The theme of human mind and nature in his poems has long attracted readers' attention. However, he does not indulge in nature itself but takes it as consolation and inspiration for human kind. In order to highlight the poet's concern with human mind, the present paper chooses to explore Wordsworth's concern with children's mind, based on the analysis of Wordsworth's The Prelude and many of his poems about children. 展开更多
关键词 ROMANTICIsM WORDsWORTH children’s mind
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The Research of the Relationship Between Yangming’s Yixue and His Xinxue
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作者 LIAO Yiming 《Cultural and Religious Studies》 2023年第4期174-182,共9页
Yangming’s Yixue had been developed several times in his life since originated in Longchang.Yangming’s Yixue and his Xinxue are both sides of the same corn.The Yangming’s Yixue can be roughly divided into two perio... Yangming’s Yixue had been developed several times in his life since originated in Longchang.Yangming’s Yixue and his Xinxue are both sides of the same corn.The Yangming’s Yixue can be roughly divided into two periods.There were the early and middle period of Yangming’s Yixue,which is intended to explain the principles of Yi Zhuan(《易传》)with the theory of Xinxue.The finish of Yangming’s Yixue was a second stage in Yangming’s later years.From the perspective of form and content,there are differences that cannot be ignored between Yangming’s early and middle period and his later years.In the first stage of Yangming’s study,the“Virtuousness”(贞)in Book of Changes is the principle and nature in university.In the later period,Yangming had not focused on interpreting the“Yi Zhuan”,but on the interpretation of ZhouYi’s(《周易》)principles to supplement the connotation of the propositions of Xinxue.This article intends to understand the relationship between Yangming’s Yixue and his Xinxue by dividing the different stages of Yangming’s Yixue firstly.Then by focusing on the influence of Yangming’s later years’Yixue on his Xinxue,we can observe the relation between his Yixue and Xinxue. 展开更多
关键词 Yangming’s Yixue Conscience is Yi nothing kind outside the mind the four-sentence teaching
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B-S期权定价模型在保险费计量中的应用 被引量:10
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作者 彭斌 韩玉启 《江西财经大学学报》 2004年第1期32-34,共3页
基于期权的角度,保险合同实质上就是一份看跌期权,保险费就是该看跌期权的价格。因此,可以构建一种基于B-S期权定价模型的看跌期权定价公式,以计量保险费的大小。这为实践中合理确定保险费提供了参考价格。
关键词 B-s期权定价模型 保险费 保险合同 看跌期权 定价公式 保险市场 无风险利率 保险公司
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基于MAS的电网新设备启动方案智能编制系统的设计与实现 被引量:13
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作者 李永刚 刘艳 +1 位作者 王鑫明 翟万生 《电力系统保护与控制》 EI CSCD 北大核心 2016年第12期119-124,共6页
电网的快速发展使得新设备投运工作量日益增大。现有运行方式人员手工编制启动方案的模式效率低,安全风险难以管控,无法满足电网运维精益化的要求。通过分析新设备投运操作的技术特点和启动方案编制流程的实际需要,建立了基于多智能体... 电网的快速发展使得新设备投运工作量日益增大。现有运行方式人员手工编制启动方案的模式效率低,安全风险难以管控,无法满足电网运维精益化的要求。通过分析新设备投运操作的技术特点和启动方案编制流程的实际需要,建立了基于多智能体技术的电网新设备启动方案编制模型。该模型强调了数据源端免维护、启动方案编制的智能性、通用性、易维护和界面友好等特点,突出了模型中人机交互Agent的功能和各个智能体间的协调控制策略。最后以D5000平台为数据源,结合B/S模式,采用VC#语言开发出基于该模型的实际系统,充分提高新设备启动方案编制的智能化水平,满足多部门流转会签的使用需求,实现对新设备投运工作风险的管控。 展开更多
关键词 新设备投运 启动方案编制 多智能体 人机交互 B/s模式
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环磷酰胺激活小鼠肝微粒体谷胱甘肽S-转移酶Ⅰ的机制研究 被引量:2
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作者 郑英 邹晓华 +3 位作者 付再林 方慧 陈素红 吕圭源 《中国药理学通报》 CAS CSCD 北大核心 2013年第10期1387-1390,共4页
目的探讨环磷酰胺(CP)在体内对小鼠肝微粒体谷胱甘肽S-转移酶Ⅰ(mGST-Ⅰ)活性的影响及其可能的机制。方法用苯巴比妥75 mg·kg-1诱导小鼠CYP2B后,ip CP,测定9 h内mGST-Ⅰ酶活性,观察二巯基丁二醇(DTT)对酶激活的逆转作用和巯基烷化... 目的探讨环磷酰胺(CP)在体内对小鼠肝微粒体谷胱甘肽S-转移酶Ⅰ(mGST-Ⅰ)活性的影响及其可能的机制。方法用苯巴比妥75 mg·kg-1诱导小鼠CYP2B后,ip CP,测定9 h内mGST-Ⅰ酶活性,观察二巯基丁二醇(DTT)对酶激活的逆转作用和巯基烷化剂N-乙基马来酰亚胺(NEM)对酶再激活效应,用SDS-PAGE和负染凝胶法评价CP对mGST-Ⅰ蛋白表达的影响。结果 CP引起小鼠微粒体中mGST-Ⅰ活性增加;NEM在mGST-Ⅰ半胱氨酸-49-巯基(cys-49-SH)上的活化效应减弱,而CP引起的mGST-Ⅰ激活效应不被二硫键还原剂DTT逆转。激活的mGST-Ⅰ电泳图谱未见蛋白分子量变迁及蛋白表达增加。结论大剂量CP致mGST-Ⅰ激活效应机制主要是酶分子cys-49-SH上单个巯基的修饰作用。 展开更多
关键词 环磷酰胺 微粒体 谷胱甘肽s-转移酶Ⅰ 二巯基丁二醇 N-乙基马来酰亚胺 半胱氨酸-49-巯基 机制
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欧式重设卖权的Esscher变换定价
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作者 邓英东 肖庆宪 《大学数学》 2012年第1期124-127,共4页
介绍了Esscher变换的方法,对标的资产价格遵循B-S模型的条件下,给出了有支付红利和不支付红利的欧式重设型卖权的定价公式.并说明在适当的条件下,著名的B-S模型下的欧式卖权公式将是本文的特例.
关键词 EssCHER变换 B-s模型 重设型卖权
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邹元标的学术实践对铸牢中华民族共同体意识的启示
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作者 梁胜兴 《黔南民族师范学院学报》 2024年第5期22-28,共7页
邹元标作为“贵州三迁客”之一,探讨其在都匀的文化实践活动对铸牢中华民族共同体意识的启示具有重要的意义。邹元标在都匀创立南皋书院,招收弟子,传道授业,为民族地区培养了大量的人才,促进了儒学、阳明心学在民族地区的传播,推动了汉... 邹元标作为“贵州三迁客”之一,探讨其在都匀的文化实践活动对铸牢中华民族共同体意识的启示具有重要的意义。邹元标在都匀创立南皋书院,招收弟子,传道授业,为民族地区培养了大量的人才,促进了儒学、阳明心学在民族地区的传播,推动了汉文化与少数民族文化的深度交融,为当代中国的民族团结与共同体建设提供了宝贵的理论依据和实践经验。这不仅是对都匀历史的还原,更是对中华文明多元性的深度挖掘,为中华民族文化共同体的认同构建提供新的视角和启示。 展开更多
关键词 邹元标 阳明心学 中华民族共同体意识
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Hempel' s Dilemma and the Threat of Being Misjudged
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作者 Li Nan 《学术界》 CSSCI 北大核心 2013年第9期249-254,共6页
Recently P.Bokulich suggests a newway to grab the first horn of Hempel’s Dilemma.His strategy is to define "the physical" with "the stuff recognized by currently well-understood parts of physics",... Recently P.Bokulich suggests a newway to grab the first horn of Hempel’s Dilemma.His strategy is to define "the physical" with "the stuff recognized by currently well-understood parts of physics",such as Quantum electrodynamics,as far as the mindbody problem is concerned.I argue that the physicalism doctrine formulated following Bokulich’s suggestion is still under the threat of being misjudged and also will not be welcomed by the physicalists.After considering some potential objections,I conclude that Bokulich’s strategy fails. 展开更多
关键词 威胁 量子电动力学 物理
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Study on the Organic Correlation of Prana Energy
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作者 Hae-Young Won 《Journal of Philosophy Study》 2013年第12期1061-1070,共10页
Since India's philosophical discussion on the correlation between the mind and the body, the goal achieved through practice has been imbued with much meaning under the influences of yoga. Self-transcendence can be re... Since India's philosophical discussion on the correlation between the mind and the body, the goal achieved through practice has been imbued with much meaning under the influences of yoga. Self-transcendence can be reached through self-discipline that is founded upon the fundamental change and potential for existential practice. The mind and the body do not comprise a binary relationship but instead maintain an intimate relationship bound by the medium of organic energy of breathing, breath, and pr^0a. Of these medium that form the relationship, the pr^-0a has a natural healing tendency, which has been well documented within classics such as Upani.sads and Bhagavad G^ta. Classic yoga explains that pr^0a imbues within it a vivacious passion and energy that will connect the human body with the human mind. Thus, the pr^0a functions as bio-energy. From ancient Indian philosophy to Buddhism, yoga therapy actively utilizes practice as a main element. In particular, the Patafijali yoga's methodology details the organic correlation within its eight limbs (支) yoga practices. The prana is breath. This is the only sense in which Patafijali has used this word. Breath is called prana because it moves on continuously throughout the body and reaches the basic circle of the individual self. It pervades mouth, nostrils, heart, navel region and toes. As a result, it is a healing method that achieves far more than the scientific healing methods common in society. 展开更多
关键词 India's philosophical between the mind and the body fundamental change eight limbs (支) yogapractices heating method the organic energy of breathing BREATH pr~ .ha
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Transition to adulthood: A critical role for exercise in building overall well-being
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作者 Channakeshava Sokke Umeshappa Ryan Punambolam 《Health》 2013年第7期1158-1163,共6页
A growing number of multidisciplinary studies have reported the beneficial effects of physical activities towards the development of overall well-being and the reduction of chronic illnesses. Physical inactivity is a ... A growing number of multidisciplinary studies have reported the beneficial effects of physical activities towards the development of overall well-being and the reduction of chronic illnesses. Physical inactivity is a serious worldwide problem and is considered the key lifestyle factor that negatively influences health and function of individuals. Here we propose that growth kinetics of body and mind and associated disproportionate physical activity may have considerable effects on the increased physical and mental illnesses and premature death rates currently observed in mid to late adulthood people. Children and young adults, being in exponential growth phase and self-motivated to engage in physical activity, possess more cognition, resilience, and mind-body-emotion-spirit integration. In contrast, as our body transitions into adulthood, there is a decline in the growth of body and mind. Furthermore, in this period, adults experience the increased stressors of career and financial demands, time pressure, and family responsibilities. The decline in growth combined with prolonged stress appears to result in reduced cognition, resilience, and mind-body-emotion-spirit integration, leading to sedentary and other faulty lifestyles, which could further lead to a predisposition to maladaptive behaviours and various chronic diseases at a later stage. In agreement with this, currently more than two thirds of the adult population across the world are physically inactive and are failing to perform the daily recommended guidelines of moderate to vigorous exercise. As negative changes and faulty lifestyles begin to occur during and after adulthood transition, creating awareness in people between 29 to 35 years of age about mindful exercise should be considered a national priority. This would allow adults to achieve overall well-being, and increased productivity and life expectancy, reducing health care-associated economic burden placed on the nation. 展开更多
关键词 PHYsICAL Activity Adult Transition Phase s-shaped Human mind and Body sIGMOID Curve WELL-BEING Chronic PHYsICAL and MENTAL Illnesses
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整车Change of Mind耐久试验的实现
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作者 翟成超 孙毅 +5 位作者 钟玲亮 刘慧芳 周伦 潘伟 瞿天骄 冯文龙 《汽车电器》 2021年第6期72-75,共4页
为了减少燃油消耗,降低尾气排放,启停技术应势而生。特别适用于交通拥堵的城市路况。启停起动机作为现代汽车启动系统的重要组成部分,其可靠性、耐久性影响行驶过程中的车辆安全。针对当前汽车启动系统用起动机越来越严格的试验要求,给... 为了减少燃油消耗,降低尾气排放,启停技术应势而生。特别适用于交通拥堵的城市路况。启停起动机作为现代汽车启动系统的重要组成部分,其可靠性、耐久性影响行驶过程中的车辆安全。针对当前汽车启动系统用起动机越来越严格的试验要求,给出了以单片机为控制单元的整车Change of Mind耐久试验方案。该实验能满足整车Change of Mind耐久试验要求,模拟交通拥堵的实车工况,为产品提供可靠的试验数据,提高长寿命起动机产品品质和竞争力。 展开更多
关键词 起动机 起停 Change of mind 耐久 单片机
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B-S-M期权定价模型和二叉树模型运用对比分析
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作者 段一超 《中阿科技论坛(中英文)》 2021年第9期90-93,共4页
B-S-M期权定价模型和二叉树模型作为两大期权定价方法,在理论和实际应用上有所差异,而且对认购虚值期权和认沽虚值期权,运用两种期权定价模型的效果也有所差异。本文以阿里巴巴(BABA)在纽交所上市的股票期权为例,分别利用B-S-M期权定价... B-S-M期权定价模型和二叉树模型作为两大期权定价方法,在理论和实际应用上有所差异,而且对认购虚值期权和认沽虚值期权,运用两种期权定价模型的效果也有所差异。本文以阿里巴巴(BABA)在纽交所上市的股票期权为例,分别利用B-S-M期权定价模型和二叉树模型为阿里巴巴股票2021年12月17日即将到期的虚值认购期权和虚值认沽期权进行期权定价。研究结果表明:两种期权定价模型对看跌虚值期权的定价效率更高,而两种期权定价模型中B-S-M的定价效率更高。 展开更多
关键词 B-s-M期权定价模型 二叉树模型 认购虚值期权 认沽虚值期权
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从心身同治角度针灸对乳腺癌关节痛患者生命质量改善的临床研究
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作者 卢静 刘晓蒙 +3 位作者 陈莹 徐海萍 薛明新 唐金海 《世界中医药》 CAS 2023年第2期249-254,共6页
目的:评价基于《黄帝内经》心身疾病病因的整体选穴与乳腺癌芳香化酶抑制剂(AI)关节痛局部配穴相结合的针灸方法,对乳腺癌康复期AI关节痛患者生命质量及局部关节症状的临床疗效。方法:选取2019年1月至2021年5月南京医科大学第一附属医... 目的:评价基于《黄帝内经》心身疾病病因的整体选穴与乳腺癌芳香化酶抑制剂(AI)关节痛局部配穴相结合的针灸方法,对乳腺癌康复期AI关节痛患者生命质量及局部关节症状的临床疗效。方法:选取2019年1月至2021年5月南京医科大学第一附属医院乳腺外科筛选使用唑来膦酸的乳腺癌AI患者232例作为研究对象,依据针灸意愿分为对照组(n=19)和观察组(n=16),对照组采用唑来膦酸常规镇痛,观察组在唑来膦酸的基础上采用整体及局部取穴相结合的方法针灸治疗,共治疗4周,分别评价治疗前、治疗2周、4周、8周时的乳腺癌患者生命质量量表(FACT-B)生命质量评分以及简明疼痛评估量表(BPI-SF)关节痛评分,同时评估针灸治疗的安全性。结果:治疗4周以及8周时观察组FACT-B生命质量评分较对照组高,治疗4周时观察组BPI-SF疼痛评分较对照组低,差异有统计学意义(P<0.05)。结论:采用整体配穴调和心身与局部选穴缓急止痛相结合的针灸方法对乳腺癌康复期AI患者的生命质量以及局部关节症状有较好的临床疗效。 展开更多
关键词 针灸 乳腺癌 生命质量 关节痛 心身同治 黄帝内经 背俞穴
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阳明心学与《周易》的内在关联试析
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作者 谭振江 《山西高等学校社会科学学报》 2023年第10期65-71,共7页
宏博深邃的《周易》是中华文化不竭的智慧源泉。家学、出身使王阳明与《周易》有特殊的渊源。王阳明于困厄中研习《周易》,促成了龙场悟道,《周易》对他及其观念学说的影响由此开启。《周易》整体、直觉体悟、见仁见智的观念,启发他形... 宏博深邃的《周易》是中华文化不竭的智慧源泉。家学、出身使王阳明与《周易》有特殊的渊源。王阳明于困厄中研习《周易》,促成了龙场悟道,《周易》对他及其观念学说的影响由此开启。《周易》整体、直觉体悟、见仁见智的观念,启发他形成了以内心体认为特征的阳明心学。王阳明从《周易》中汲取智慧的表现形式是多样的,其中,对《周易》观念的化用最为常见。那些内化为阳明心学的观念学说与《周易》有内在的关联,这反映出阳明心学对《周易》观念的嬗变。 展开更多
关键词 阳明心学 《周易》 体认 直觉思维 关联
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王阳明领导思想在现代企业管理中的应用研究
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作者 孙怀平 马成章 《中国文化与管理》 2023年第2期189-200,256,共13页
王阳明是我国古代著名的儒家思想代表、阳明心学创始人,其领导力思想是阳明心学在军事行动中的具体体现。王阳明领导和指挥的三次军事行动集中反映出了其领导力的基本结构:有效的领导沟通能力、领导组织变革能力和战略领导能力。在企业... 王阳明是我国古代著名的儒家思想代表、阳明心学创始人,其领导力思想是阳明心学在军事行动中的具体体现。王阳明领导和指挥的三次军事行动集中反映出了其领导力的基本结构:有效的领导沟通能力、领导组织变革能力和战略领导能力。在企业管理实践中,企业领导者需要通过出色的战略领导能力、沟通交流能力引导企业组织实施变革,促进企业更好适应内外部环境的变化,从而实现企业的战略目标。 展开更多
关键词 阳明心学 领导力 领导沟通 组织变革 战略领导
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Putting Perspective on China’s Defense Spending
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《Beijing Review》 2009年第14期16-17,共2页
The Second Session of the 11th National People’s Congress an-nounced in March that China’s 2009 defense budget is 480.686 billion yuan($70.7 billion),increasing by 62.482 billion yuan($9.2 billion),or 14.9 percent,o... The Second Session of the 11th National People’s Congress an-nounced in March that China’s 2009 defense budget is 480.686 billion yuan($70.7 billion),increasing by 62.482 billion yuan($9.2 billion),or 14.9 percent,over the previous year.On March 16,Beijing-based Guangming Daily published an interview with Quan Linyuan,a professor at the University of National Defense of the People’s Liberation Army and Chen Xiaojing,a doctoral candi-date there,who both shared their perspectives on the increase of China’s military expenditures. 展开更多
关键词 putting Perspective on China’s Defense spending
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