Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein intake.PTEN induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates ...Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein intake.PTEN induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the body.This study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial injury.Methods A low Se and low protein animal model was established.One hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).ELISA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)levels.RT-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(P<0.05 for all).The mRNA and protein expression levels of PINK1,Parkin and MAP1LC3B were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(P<0.05 for all).Conclusion Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.展开更多
1.Introduction Spectacular advances have been made in the atmospheric sciences on a global level during a period of one hundred years or more,which is arguably most evident through"the quiet revolution of numeric...1.Introduction Spectacular advances have been made in the atmospheric sciences on a global level during a period of one hundred years or more,which is arguably most evident through"the quiet revolution of numerical weather prediction"(Bauer et展开更多
China Resources Cement in Hepu County of Beihai City is building two new type dry method cement production lines with two sets of 9 MW pure low temperatures residual heat power generating systems matched. Phase I of t...China Resources Cement in Hepu County of Beihai City is building two new type dry method cement production lines with two sets of 9 MW pure low temperatures residual heat power generating systems matched. Phase I of the project will be invested CNY I billion, and had been invested CNY 0.13 billion in 2012. China Resources Cement is shooting at putting the lines into production in May 2014.展开更多
Human civilization is currently undergoing another important turn. Following the economic globalization,cultural globalization has become an inevitable trend.
THE girls in my college were fond of forming cliques,I admit,I was one of them.We dined together,studied together,and if we fell out,factions broke off until we got over whatever grudge we were holding and the gang co...THE girls in my college were fond of forming cliques,I admit,I was one of them.We dined together,studied together,and if we fell out,factions broke off until we got over whatever grudge we were holding and the gang could reform.In Dorm 315,there were two groups among the six girls：one included five girls,Wu Shasha,Tan Fang,Zeng Li,Liu Siqi and me;the other,had only one member,Lu Xiaolu.We had to admit that展开更多
On December 8, 2021, China’s State Council Information office(SCIo) and Ministry of Foreign Affairs co-hosted the “2021 South-South Human Rights Forum” in Beijing. The forum is themed on “putting people First and ...On December 8, 2021, China’s State Council Information office(SCIo) and Ministry of Foreign Affairs co-hosted the “2021 South-South Human Rights Forum” in Beijing. The forum is themed on “putting people First and Global Human Rights Governance”. Four sub-themes, namely, “Building a Global Community of Health for All and protecting Human Rights”, “Anti-poverty Ffforts and Realization of the Right to Development”, “Multilateralism and Global Human Rights Governance”, and “The Role of Developing Countries in Global Human Rights Governance”, were discussed by delegates from more than 100 countries and international organizations. Within the framework of the theme of the forum, the delegates fully discussed on how to better respect and protect human rights, advance equal cooperation, share development outcomes, seek common and sustainable development, maintain fairness and justice in the international community, and improve the basic experience of the protection of human rights, and so on. As an important platform for the exchanges and cooperation of developing countries in human rights, the South-South Human Rights Forum has effectively promoted mutual understanding, inclusiveness and mutual learning on human rights governance.展开更多
Chinese shoe manufacturer establishes a successful operation in Ethiopia MEETING with Meles Zenawi,former Prime Minister of Ethiopia,was both a valuable personal experience and a turning point for Zhang Huarong＇s ove...Chinese shoe manufacturer establishes a successful operation in Ethiopia MEETING with Meles Zenawi,former Prime Minister of Ethiopia,was both a valuable personal experience and a turning point for Zhang Huarong＇s overseas business expansion. Zhang,55,runs the Huajian Group,a well-known shoe manufacturer employing about 25,000 workers on the Chinese mainland.Based in Dongguan,in south-China＇s Guangdong Province,Huajian makes shoes for global brands including Tommy Hilfiger and Guess.展开更多
THE news of Malawi President Joyce Banda declaring her country would not be hosting the 19th AU Summit in July caused ripple effects in the African community.
The International Conference on"The Communist Party of China and the Progress on Human Rights in China"was held on April 8,2021.It was sponsored by the China Society for Human Rights Studies and the Publicit...The International Conference on"The Communist Party of China and the Progress on Human Rights in China"was held on April 8,2021.It was sponsored by the China Society for Human Rights Studies and the Publicity Department of the CPC Jilin Provincial Committee and organized by Jilin University Human Rights Center,Jilin University School of Law,and Jilin University Center for Jurisprudence Research.At the conference,representatives from more than 20 countries discussed in depth the achievements,experience,and theories of the Communist Party of China in leading the Chinese people to strive for a better life and promoting the protection of human rights from dimensions of history and reality.The conference fully demonstrated the historical role and significance of the CPC’s path,thoughts,theories,and practices concerning human rights.展开更多
From Nov.5th to 6th, 2010, the Caixin Summit 2010: China and the World, organized by Caixin Media, was held in Beijing. Distinguished speakers were invited to provide topical and insightful
Cameroon plans to plant one million trees a year to try and limit the effects of climate change dance of equatorial forests,which make up part of the Congo Basin recognized as the second largest equatorial forest in t...Cameroon plans to plant one million trees a year to try and limit the effects of climate change dance of equatorial forests,which make up part of the Congo Basin recognized as the second largest equatorial forest in the world after the Amazon Basin.展开更多
Amazing China, a 90-minute documentary which focuses on China＇s accomplishments over the past five years, has been a huge success at the box office since it hit the screens in China on March 2. One scene, in particul...Amazing China, a 90-minute documentary which focuses on China＇s accomplishments over the past five years, has been a huge success at the box office since it hit the screens in China on March 2. One scene, in particular, struck a chord with audiences when Zhang Huarong, Chairman of Chinese shoemaker Huajian Group, sang the Chinese song Unity Is Strength with Ethiopian employees in the group＇s Ethiopian factory.展开更多
HAZAN Shoes adopts an innovative international strategy of brand building in Africa TWO decades ago,Wang Jianping set up a shoe workshop in his hometown of Wenzhou, east China’s Zhejiang Province.With only 10 workers...HAZAN Shoes adopts an innovative international strategy of brand building in Africa TWO decades ago,Wang Jianping set up a shoe workshop in his hometown of Wenzhou, east China’s Zhejiang Province.With only 10 workers and a daily output of 300展开更多
It is true that there is a double standard still at work in international justice, however, it is not the ICC but international politics and states＇ perceived political interests that are to blame.
Maria Pools National Park, the second biggest game reserve in Zimbabwe, is best known for its large bull elephants while alsobeing home to black rhinos. Located in the Zambezi River Valley, the area is characterized ...Maria Pools National Park, the second biggest game reserve in Zimbabwe, is best known for its large bull elephants while alsobeing home to black rhinos. Located in the Zambezi River Valley, the area is characterized by thick vegetation which provides camouflage for the team- ing wildlife.展开更多
On August 3,2011,83-year-old former Egyptian President Hosni Mubarak was put on trial,lying on a hospital bed an iron cage in a Cairo courtroom. Zhang Zhongxiang,Deputy Director of the Department of the West Asian and...On August 3,2011,83-year-old former Egyptian President Hosni Mubarak was put on trial,lying on a hospital bed an iron cage in a Cairo courtroom. Zhang Zhongxiang,Deputy Director of the Department of the West Asian and African Studies at the Shanghai Institutes for International Studies,believes that the Mubarak trial will not only aggravate conflict among Egyptian people, but also complicate the regional tensions and展开更多
基金supported by the Natural Science Foundation of Heilongjiang Province(No.LH2021H009).
文摘Objective Keshan disease(KD)is a myocardial mitochondrial disease closely related to insufficient selenium(Se)and protein intake.PTEN induced putative kinase 1(PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the body.This study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial injury.Methods A low Se and low protein animal model was established.One hundred Wistar rats were randomly divided into 5 groups(control group,low Se group,low protein group,low Se+low protein group,and corn from KD area group).The JC-1 method was used to detect the mitochondrial membrane potential(MMP).ELISA was used to detect serum creatine kinase MB(CK-MB),cardiac troponin I(cTnI),and mitochondrial-glutamicoxalacetic transaminase(M-GOT)levels.RT-PCR and Western blot analysis were used to detect the expression of PINK1,Parkin,sequestome 1(P62),and microtubule-associated proteins1A/1B light chain 3B(MAP1LC3B).Results The MMP was significantly decreased and the activity of CK-MB,cTnI,and M-GOT significantly increased in each experimental group(low Se group,low protein group,low Se+low protein group and corn from KD area group)compared with the control group(P<0.05 for all).The mRNA and protein expression levels of PINK1,Parkin and MAP1LC3B were profoundly increased,and those of P62 markedly decreased in the experimental groups compared with the control group(P<0.05 for all).Conclusion Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.
基金Support for this study was provided by the “Waves to Weather” initiative (SFB/TRR 165) of the German Research Foundation (DFG)
文摘1.Introduction Spectacular advances have been made in the atmospheric sciences on a global level during a period of one hundred years or more,which is arguably most evident through"the quiet revolution of numerical weather prediction"(Bauer et
文摘China Resources Cement in Hepu County of Beihai City is building two new type dry method cement production lines with two sets of 9 MW pure low temperatures residual heat power generating systems matched. Phase I of the project will be invested CNY I billion, and had been invested CNY 0.13 billion in 2012. China Resources Cement is shooting at putting the lines into production in May 2014.
文摘Human civilization is currently undergoing another important turn. Following the economic globalization,cultural globalization has become an inevitable trend.
文摘THE girls in my college were fond of forming cliques,I admit,I was one of them.We dined together,studied together,and if we fell out,factions broke off until we got over whatever grudge we were holding and the gang could reform.In Dorm 315,there were two groups among the six girls：one included five girls,Wu Shasha,Tan Fang,Zeng Li,Liu Siqi and me;the other,had only one member,Lu Xiaolu.We had to admit that
文摘On December 8, 2021, China’s State Council Information office(SCIo) and Ministry of Foreign Affairs co-hosted the “2021 South-South Human Rights Forum” in Beijing. The forum is themed on “putting people First and Global Human Rights Governance”. Four sub-themes, namely, “Building a Global Community of Health for All and protecting Human Rights”, “Anti-poverty Ffforts and Realization of the Right to Development”, “Multilateralism and Global Human Rights Governance”, and “The Role of Developing Countries in Global Human Rights Governance”, were discussed by delegates from more than 100 countries and international organizations. Within the framework of the theme of the forum, the delegates fully discussed on how to better respect and protect human rights, advance equal cooperation, share development outcomes, seek common and sustainable development, maintain fairness and justice in the international community, and improve the basic experience of the protection of human rights, and so on. As an important platform for the exchanges and cooperation of developing countries in human rights, the South-South Human Rights Forum has effectively promoted mutual understanding, inclusiveness and mutual learning on human rights governance.
文摘Chinese shoe manufacturer establishes a successful operation in Ethiopia MEETING with Meles Zenawi,former Prime Minister of Ethiopia,was both a valuable personal experience and a turning point for Zhang Huarong＇s overseas business expansion. Zhang,55,runs the Huajian Group,a well-known shoe manufacturer employing about 25,000 workers on the Chinese mainland.Based in Dongguan,in south-China＇s Guangdong Province,Huajian makes shoes for global brands including Tommy Hilfiger and Guess.
文摘THE news of Malawi President Joyce Banda declaring her country would not be hosting the 19th AU Summit in July caused ripple effects in the African community.
文摘The International Conference on"The Communist Party of China and the Progress on Human Rights in China"was held on April 8,2021.It was sponsored by the China Society for Human Rights Studies and the Publicity Department of the CPC Jilin Provincial Committee and organized by Jilin University Human Rights Center,Jilin University School of Law,and Jilin University Center for Jurisprudence Research.At the conference,representatives from more than 20 countries discussed in depth the achievements,experience,and theories of the Communist Party of China in leading the Chinese people to strive for a better life and promoting the protection of human rights from dimensions of history and reality.The conference fully demonstrated the historical role and significance of the CPC’s path,thoughts,theories,and practices concerning human rights.
文摘From Nov.5th to 6th, 2010, the Caixin Summit 2010: China and the World, organized by Caixin Media, was held in Beijing. Distinguished speakers were invited to provide topical and insightful
文摘Cameroon plans to plant one million trees a year to try and limit the effects of climate change dance of equatorial forests,which make up part of the Congo Basin recognized as the second largest equatorial forest in the world after the Amazon Basin.
文摘Amazing China, a 90-minute documentary which focuses on China＇s accomplishments over the past five years, has been a huge success at the box office since it hit the screens in China on March 2. One scene, in particular, struck a chord with audiences when Zhang Huarong, Chairman of Chinese shoemaker Huajian Group, sang the Chinese song Unity Is Strength with Ethiopian employees in the group＇s Ethiopian factory.
文摘HAZAN Shoes adopts an innovative international strategy of brand building in Africa TWO decades ago,Wang Jianping set up a shoe workshop in his hometown of Wenzhou, east China’s Zhejiang Province.With only 10 workers and a daily output of 300
文摘It is true that there is a double standard still at work in international justice, however, it is not the ICC but international politics and states＇ perceived political interests that are to blame.
文摘Maria Pools National Park, the second biggest game reserve in Zimbabwe, is best known for its large bull elephants while alsobeing home to black rhinos. Located in the Zambezi River Valley, the area is characterized by thick vegetation which provides camouflage for the team- ing wildlife.
文摘On August 3,2011,83-year-old former Egyptian President Hosni Mubarak was put on trial,lying on a hospital bed an iron cage in a Cairo courtroom. Zhang Zhongxiang,Deputy Director of the Department of the West Asian and African Studies at the Shanghai Institutes for International Studies,believes that the Mubarak trial will not only aggravate conflict among Egyptian people, but also complicate the regional tensions and
