A simple, sensitive and accurate method based on high performance liquid chromato- graphy （HPLC） with diode array detector （DAD） was developed and validated for systematic quality evaluation of one type of traditi...A simple, sensitive and accurate method based on high performance liquid chromato- graphy （HPLC） with diode array detector （DAD） was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu （XKS） tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common peaks to evaluate the similarities among different batches of XKS samples, which were manufactured in a long time span of three years. Additionally, simultaneous quantification of six markers in XKS tablet, including Danshensu, Protocatechuic aldehyde, Puerarin, Daidzin, Salvianolic acid B and Daidzein, was performed. The validation results showed that the developed method was specific, accurate, precise and robust. The preliminary explanation on why a close similarity between fingerprints did not exactly mean similar contents of chemical components in samples was given. The contribution of each chromatographic peak to similarity was also evaluated. The developed method offers an efficient, reliable and practical approach for systematic quality evaluation of XKS tablet.展开更多
文章针对汽车起重机液压缸故障,建立了一个比较完整的故障树;针对液压缸故障树分析时存在底事件故障概率获取不足的特点,将模糊集合理论和专家判断法引入故障树分析法(fault tree analysis,FTA)中,使故障树具有处理模糊信息的能力;在对...文章针对汽车起重机液压缸故障,建立了一个比较完整的故障树;针对液压缸故障树分析时存在底事件故障概率获取不足的特点,将模糊集合理论和专家判断法引入故障树分析法(fault tree analysis,FTA)中,使故障树具有处理模糊信息的能力;在对故障树进行传统定性分析的基础上,将底事件发生概率的可靠性数据与通过模糊计算获得的模糊概率相结合进行故障树定量分析。结合某型号汽车起重机实例数据进行分析,估计出了故障树子树顶事件的模糊故障概率及其各底事件的重要度。展开更多
基金supported by the Major Projects of Independent Innovation Achievements of Shandong Province(No. 2010ZDZX1A0406)partly by the Scientific and Technological Projects of Shandong Province (No. 2009GG10002081)+1 种基金Independent Innovation Foundation of Shandong University(No. 2010TS054)Shandong Province Natural Science Foundation, China (No. ZR2011HM080)
文摘A simple, sensitive and accurate method based on high performance liquid chromato- graphy （HPLC） with diode array detector （DAD） was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu （XKS） tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common peaks to evaluate the similarities among different batches of XKS samples, which were manufactured in a long time span of three years. Additionally, simultaneous quantification of six markers in XKS tablet, including Danshensu, Protocatechuic aldehyde, Puerarin, Daidzin, Salvianolic acid B and Daidzein, was performed. The validation results showed that the developed method was specific, accurate, precise and robust. The preliminary explanation on why a close similarity between fingerprints did not exactly mean similar contents of chemical components in samples was given. The contribution of each chromatographic peak to similarity was also evaluated. The developed method offers an efficient, reliable and practical approach for systematic quality evaluation of XKS tablet.
文摘文章针对汽车起重机液压缸故障,建立了一个比较完整的故障树;针对液压缸故障树分析时存在底事件故障概率获取不足的特点,将模糊集合理论和专家判断法引入故障树分析法(fault tree analysis,FTA)中,使故障树具有处理模糊信息的能力;在对故障树进行传统定性分析的基础上,将底事件发生概率的可靠性数据与通过模糊计算获得的模糊概率相结合进行故障树定量分析。结合某型号汽车起重机实例数据进行分析,估计出了故障树子树顶事件的模糊故障概率及其各底事件的重要度。
