Si-Mo-Tang（SMT） oral liquid preparation, a traditional Chinese medicine, was prepared from four crude herbal drugs, Fructus Aurantii Submaturus, Radix Aucklandiae, Semen Arecae and Radix Linderae Aggregatae. A combi...Si-Mo-Tang（SMT） oral liquid preparation, a traditional Chinese medicine, was prepared from four crude herbal drugs, Fructus Aurantii Submaturus, Radix Aucklandiae, Semen Arecae and Radix Linderae Aggregatae. A combinative method using HPLC fingerprint and quantitative analysis was developed and validated for quality consistency evaluation of SMT. Individual HPLC chromatograms were evaluated against the mean chromatogram generated via a similarity evaluation computer program. Data from chromatographic fingerprints were also processed with principal component analysis（PCA） and hierarchical cluster analysis（HCA）. Additionally, six components （naringin, isonaringin, hesperidin, neohesperidin, norisoboldine and potassium sorbate） in SMT were simultaneously determined to interpret the quality consistency. For fingerprint analysis, 20 peaks were selected as the characteristic peaks to evaluate the similarities of 26 SMT collected from different manufacturers. Among the 20 characteristic peaks, 10 peaks were assigned to be naringin, hesperidin, neohesperidin, isonaringin, neoeriocitrin, tangeretin, nobiletin, norisoboldine, 5-（ethoxymethyl）furan-2-carbaldehyde and potassium sorbate, respectively. The results of similarity analysis, PCA and HCA, indicate that the samples from different manufacturers were consistent with each other in composition. The results from the quantitative data show that the contents of six compounds were significantly different in SMT oral liquid preparations from different manufacturers. The combinative method of chromatographic fingerprint with quantitative analysis developed here offered an efficient way for the quality consistency evaluation of the traditional Chinese medicine SMT.展开更多
Through morphology observation on silicon particles of Al-Si-Cu-Mg cast alloy, it is found that during solution treatment the evolution of eutectic silicon morphology and their effect on mechanical properties can be c...Through morphology observation on silicon particles of Al-Si-Cu-Mg cast alloy, it is found that during solution treatment the evolution of eutectic silicon morphology and their effect on mechanical properties can be classified into three stages. In the initial stage, necking, stubbing and fragmentation of silicon particles result in the improvement of plasticity of alloy. In the intermediate stage, the mechanical properties of 354 alloy attain peak values due to spheroidization of silicon particles. In the final stage, the drop of hardness and strength is related to the deterioration of silicon morphology. The facets and lap occur in silicon particles and the coarsening process of silicon follows LSW model. During aging, the clusters of excess silicon can work as barriers for dislocation movement and thus enhance the strength of alloy. On the other hand, excess Si affects the process of aging precipitation and leads to a fine and highly dense distribution of GP zones, finally effectively strengthens the alloy.展开更多
To investigate the physical properties of HII regions and some PNe about 4＇ in size, a DEFPOS Fabry-Perot spectrometer has been redesigned and set up at the coude exit of the 150cm RTT150 telescope （f/48） at TUBITA...To investigate the physical properties of HII regions and some PNe about 4＇ in size, a DEFPOS Fabry-Perot spectrometer has been redesigned and set up at the coude exit of the 150cm RTT150 telescope （f/48） at TUBITAK National Observatory （Antalya/Baklrhtepe, Turkey）. The spectrometer has a 4＇ circular field of view and a velocity resolution of 27.27 km s^-1 （a spectral resolving power of 11000） over a 200 km s^-1 spectral window near Hα. This work presents the details of the newly redesigned instrument for coude observations, the data reduction techniques and finally presents some physical results of our new Hα observations selected from the Reynolds et al. （2005） and Fich et al. （1990） papers. The DEFPOS system has been fully tested and the first observations of HII regions and PNe in the Galaxy are used to illustrate the power of the instrument. We feel that our first Fabry-Perot observations can provide a powerful tool for the study of objects with small angular size. In the future, we are planning to prepare a catalog including some physical properties such as radial velocity, line width, and intensity of some PNe and HII regions close to the 4＇ field of view.展开更多
基金Supported by the National Basic Research Program of China(No.2009CB523002)the National Action of Technology Personnel Servicing Enterprise Program of China(No.2009FJ5049)+1 种基金the Foundation of Hunan Science and Technology Committee, China(No.2009XK6032, 2009-152)the Foundation of Hunan Educational Committee, China(No.09CY001)
文摘Si-Mo-Tang（SMT） oral liquid preparation, a traditional Chinese medicine, was prepared from four crude herbal drugs, Fructus Aurantii Submaturus, Radix Aucklandiae, Semen Arecae and Radix Linderae Aggregatae. A combinative method using HPLC fingerprint and quantitative analysis was developed and validated for quality consistency evaluation of SMT. Individual HPLC chromatograms were evaluated against the mean chromatogram generated via a similarity evaluation computer program. Data from chromatographic fingerprints were also processed with principal component analysis（PCA） and hierarchical cluster analysis（HCA）. Additionally, six components （naringin, isonaringin, hesperidin, neohesperidin, norisoboldine and potassium sorbate） in SMT were simultaneously determined to interpret the quality consistency. For fingerprint analysis, 20 peaks were selected as the characteristic peaks to evaluate the similarities of 26 SMT collected from different manufacturers. Among the 20 characteristic peaks, 10 peaks were assigned to be naringin, hesperidin, neohesperidin, isonaringin, neoeriocitrin, tangeretin, nobiletin, norisoboldine, 5-（ethoxymethyl）furan-2-carbaldehyde and potassium sorbate, respectively. The results of similarity analysis, PCA and HCA, indicate that the samples from different manufacturers were consistent with each other in composition. The results from the quantitative data show that the contents of six compounds were significantly different in SMT oral liquid preparations from different manufacturers. The combinative method of chromatographic fingerprint with quantitative analysis developed here offered an efficient way for the quality consistency evaluation of the traditional Chinese medicine SMT.
文摘Through morphology observation on silicon particles of Al-Si-Cu-Mg cast alloy, it is found that during solution treatment the evolution of eutectic silicon morphology and their effect on mechanical properties can be classified into three stages. In the initial stage, necking, stubbing and fragmentation of silicon particles result in the improvement of plasticity of alloy. In the intermediate stage, the mechanical properties of 354 alloy attain peak values due to spheroidization of silicon particles. In the final stage, the drop of hardness and strength is related to the deterioration of silicon morphology. The facets and lap occur in silicon particles and the coarsening process of silicon follows LSW model. During aging, the clusters of excess silicon can work as barriers for dislocation movement and thus enhance the strength of alloy. On the other hand, excess Si affects the process of aging precipitation and leads to a fine and highly dense distribution of GP zones, finally effectively strengthens the alloy.
基金This work is supported by TUBITAK (the Scientific and Technical Research Council of Turkey) with grant number 104T252.
文摘To investigate the physical properties of HII regions and some PNe about 4＇ in size, a DEFPOS Fabry-Perot spectrometer has been redesigned and set up at the coude exit of the 150cm RTT150 telescope （f/48） at TUBITAK National Observatory （Antalya/Baklrhtepe, Turkey）. The spectrometer has a 4＇ circular field of view and a velocity resolution of 27.27 km s^-1 （a spectral resolving power of 11000） over a 200 km s^-1 spectral window near Hα. This work presents the details of the newly redesigned instrument for coude observations, the data reduction techniques and finally presents some physical results of our new Hα observations selected from the Reynolds et al. （2005） and Fich et al. （1990） papers. The DEFPOS system has been fully tested and the first observations of HII regions and PNe in the Galaxy are used to illustrate the power of the instrument. We feel that our first Fabry-Perot observations can provide a powerful tool for the study of objects with small angular size. In the future, we are planning to prepare a catalog including some physical properties such as radial velocity, line width, and intensity of some PNe and HII regions close to the 4＇ field of view.
