BACKGROUND： Quantitative pharmaco-electroencephalography can be used for studying the dose-effect and time-effect relationships of drugs affecting central nervous system. Therefore, it may become an effective means f...BACKGROUND： Quantitative pharmaco-electroencephalography can be used for studying the dose-effect and time-effect relationships of drugs affecting central nervous system. Therefore, it may become an effective means for monitoring the anesthetic degree of anesthetic drug in the operation. OBJECTIVE： To observe the dose-effect relationship of propofol influencing β2-band power of quantitative pharmaco-electroencephalography in rabbits. DESIGN： A randomized block design. SETTING： Department of Anesthesiology, Xuzhou Medical College. MATERIALS： Thirty-six healthy adult rabbits of either gender, weighing （2.4 ± 0.5 ） kg, of clean grade, were provided by the Laboratory Animal Center of Xuzhou Medical College. The involved rabbits were randomly divided into 3 groups with 12 in each by table of random digit： high-dose propofol group, moderate-dose propofol group, and low-dose propofol group. The protocol was carried out in accordance with animal ethics guidelines for the use and care of animals. METHODS： This study was carried out in the Department of Anesthesiology, Xuzhou Medical College between August 1999 and April 2000. Rabbits in the high-dose propofol group, moderate-dose propofol group, and low-dose propofol group were injected with 10, 5 and 2.5 mg/kg propofol （ZENECA Company, British, Batch No. 032000）, respectively. Before and after intravenous administration of propofol, percentage of β2-band power of quantitative pharmaco-electroencephalography was measured, and the latent and persistent periods when rabbit righting reflex disappeared were observed by quantitative pharmaco-electroencephalography and power spectrum analysis. MAIN OUTCOME MEASURES： （1） Percentage of β2-band power of quantitative pharmaco-electroencephalography. （2）Latent period and persistent period of abolition of righting reflex of rabbits. RESULTS： Thirty-six rabbits were involved in the final analysis. （1）Effect of propofol on righting reflex of rabbits： Righting reflex disappeared within 1 minute after the rabbits being intravenously injected with propofol. The higher dose, the shorter latent period （r = - 0.94, P 〈 0.01）, and the longer persistent period （r =0.79, P 〈 0.01）. Both latent period and persistent period had good correlation with propofol dose. （2） Effect of propofol on the percentage of β2-band power of quantitative pharmaco-electroencephalography： In the low-dose propofol group, no significant changes in the percentage of β2-band power of quantitative pharmaco-electroencephalography existed between before and after administration within 30 minutes （P 〉 0.05）. In the moderate-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region except for left and right frontal areas was significantly decreased within 30 s to 5 minutes （P 〈 0.05）, and recovered to the level before administration 10 minutes later. In the high-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region was significantly decreased from 20 s to 5 minutes after administration （P 〈 0.05 - 0.01）, and that was gradually recovered to the level before administration 5 to 10 minutes after administration. This tendency was basically the same as the changes of latent period and persistent period. CONCLUSION： Propofol decreases the percentage of β2-band power of quantitative pharmacoelectroencephalography in dose-dependent manner, It indicates that β2-band power might become one of indexes for reflecting the anesthetic degree of propofol,展开更多
Objective:To study the evaluation value of the quantitative electroencephalogram (qEEG) for the prognosis of neonatal hypoxic ischemic encephalopathy (HIE) and its relationship with serological indicators.Methods: 76 ...Objective:To study the evaluation value of the quantitative electroencephalogram (qEEG) for the prognosis of neonatal hypoxic ischemic encephalopathy (HIE) and its relationship with serological indicators.Methods: 76 children with HIE who were born and treated in our hospital between April 2013 and February 2017 were collected as observation group, and 50 healthy newborns who were born in our hospital during the same period were collected as normal control group. qEEG parameter values of two groups of children were determined, serum levels of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes were compared between the two groups, and Pearson test was used to evaluate the inner link between qEEG parameter values and disease severity in children with HIE.Results: qEEG Fp1, Fp2, C3, C4, T3, T4, O1 and O2 loci power spectrum values of observation group were significantly lower than those of normal control group. Serum NSE, NPY, S-100B and MBP contents in observation group were higher than those in normal control group;nerve apoptosis indexes sFas, sFasL and Caspase-3 contents were higher than those in normal control group while Bcl-2 content was lower than that in normal control group;serum oxidative stress indexes AOPP and MDA contents were higher than those in normal control group while SOD content was lower than that in normal control group. Pearson test showed that qEEG Fp1, Fp2, C3, C4, T3, T4, O1 and O2 loci power spectrum values in children with HIE were directly correlated with the contents of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes. Conclusion: The qEEG parameter values in children with HIE are lower than those in normal children, and the specific values are closely related to the severity of the disease.展开更多
Background:Quantitative electroencephalogram(QEEG)is a tool that uses a computer to analyze brain activity monitored by electroencephalogram(EEG)according to measurements such as frequency,amplitude,and slope.The purp...Background:Quantitative electroencephalogram(QEEG)is a tool that uses a computer to analyze brain activity monitored by electroencephalogram(EEG)according to measurements such as frequency,amplitude,and slope.The purpose of this study was to understand the current situation of QEEG utilization in China and further compare the situations among different regions and different levels of hospitals.Methods:An online questionnaire comprising 14 questions was designed.Statistical description and analysis were made for the results of the questionnaire survey.Results:A total of 158 people from 134 medical institutions participated in the survey.The participants came from 21 provinces,accounting for 61.76%(21/34)of the 34 provincial administrative regions in China.The Eastern China region accounted for 66.42%(89/134)of all the medical institutions that participated in this survey.Among the institutions surveyed,QEEG was routinely used in only 23.88%(32/134)of them.Among the medical institutions in which QEEG was routinely used,87.50%(28/32)of them were 3A-grade hospitals.Among the institutions with routine use of QEEG,56.25%(18/32)were affiliated hospitals of medical schools.There was a significant difference in the utilization of QEEG between the 3A-grade and non-3A-grade hospitals(P=0.040)and between the hospitals affiliated to medical schools and those non-affiliated to medical schools(P=0.020).Conclusions:The utilization of QEEG is still limited in China.There are differences in the use of QEEG among different hospitals and regions.展开更多
基金the National Natural Science Foundation of China, No. 30471657,39970715Social Development Plan Project of Science Committee of Jiangsu Province, No.BS2000052the Natural Science Foundation of Jiangsu Province, No.BK2001143
文摘BACKGROUND： Quantitative pharmaco-electroencephalography can be used for studying the dose-effect and time-effect relationships of drugs affecting central nervous system. Therefore, it may become an effective means for monitoring the anesthetic degree of anesthetic drug in the operation. OBJECTIVE： To observe the dose-effect relationship of propofol influencing β2-band power of quantitative pharmaco-electroencephalography in rabbits. DESIGN： A randomized block design. SETTING： Department of Anesthesiology, Xuzhou Medical College. MATERIALS： Thirty-six healthy adult rabbits of either gender, weighing （2.4 ± 0.5 ） kg, of clean grade, were provided by the Laboratory Animal Center of Xuzhou Medical College. The involved rabbits were randomly divided into 3 groups with 12 in each by table of random digit： high-dose propofol group, moderate-dose propofol group, and low-dose propofol group. The protocol was carried out in accordance with animal ethics guidelines for the use and care of animals. METHODS： This study was carried out in the Department of Anesthesiology, Xuzhou Medical College between August 1999 and April 2000. Rabbits in the high-dose propofol group, moderate-dose propofol group, and low-dose propofol group were injected with 10, 5 and 2.5 mg/kg propofol （ZENECA Company, British, Batch No. 032000）, respectively. Before and after intravenous administration of propofol, percentage of β2-band power of quantitative pharmaco-electroencephalography was measured, and the latent and persistent periods when rabbit righting reflex disappeared were observed by quantitative pharmaco-electroencephalography and power spectrum analysis. MAIN OUTCOME MEASURES： （1） Percentage of β2-band power of quantitative pharmaco-electroencephalography. （2）Latent period and persistent period of abolition of righting reflex of rabbits. RESULTS： Thirty-six rabbits were involved in the final analysis. （1）Effect of propofol on righting reflex of rabbits： Righting reflex disappeared within 1 minute after the rabbits being intravenously injected with propofol. The higher dose, the shorter latent period （r = - 0.94, P 〈 0.01）, and the longer persistent period （r =0.79, P 〈 0.01）. Both latent period and persistent period had good correlation with propofol dose. （2） Effect of propofol on the percentage of β2-band power of quantitative pharmaco-electroencephalography： In the low-dose propofol group, no significant changes in the percentage of β2-band power of quantitative pharmaco-electroencephalography existed between before and after administration within 30 minutes （P 〉 0.05）. In the moderate-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region except for left and right frontal areas was significantly decreased within 30 s to 5 minutes （P 〈 0.05）, and recovered to the level before administration 10 minutes later. In the high-dose propofol group, the percentage of β2-band power of quantitative pharmaco-electroencephalography in each brain region was significantly decreased from 20 s to 5 minutes after administration （P 〈 0.05 - 0.01）, and that was gradually recovered to the level before administration 5 to 10 minutes after administration. This tendency was basically the same as the changes of latent period and persistent period. CONCLUSION： Propofol decreases the percentage of β2-band power of quantitative pharmacoelectroencephalography in dose-dependent manner, It indicates that β2-band power might become one of indexes for reflecting the anesthetic degree of propofol,
文摘Objective:To study the evaluation value of the quantitative electroencephalogram (qEEG) for the prognosis of neonatal hypoxic ischemic encephalopathy (HIE) and its relationship with serological indicators.Methods: 76 children with HIE who were born and treated in our hospital between April 2013 and February 2017 were collected as observation group, and 50 healthy newborns who were born in our hospital during the same period were collected as normal control group. qEEG parameter values of two groups of children were determined, serum levels of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes were compared between the two groups, and Pearson test was used to evaluate the inner link between qEEG parameter values and disease severity in children with HIE.Results: qEEG Fp1, Fp2, C3, C4, T3, T4, O1 and O2 loci power spectrum values of observation group were significantly lower than those of normal control group. Serum NSE, NPY, S-100B and MBP contents in observation group were higher than those in normal control group;nerve apoptosis indexes sFas, sFasL and Caspase-3 contents were higher than those in normal control group while Bcl-2 content was lower than that in normal control group;serum oxidative stress indexes AOPP and MDA contents were higher than those in normal control group while SOD content was lower than that in normal control group. Pearson test showed that qEEG Fp1, Fp2, C3, C4, T3, T4, O1 and O2 loci power spectrum values in children with HIE were directly correlated with the contents of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes. Conclusion: The qEEG parameter values in children with HIE are lower than those in normal children, and the specific values are closely related to the severity of the disease.
基金This work was supported by Suzhou Science and Technology Project(SLT201908)Jiangsu Provincial Excellent Young Doctors’Project(QNRC2016731).
文摘Background:Quantitative electroencephalogram(QEEG)is a tool that uses a computer to analyze brain activity monitored by electroencephalogram(EEG)according to measurements such as frequency,amplitude,and slope.The purpose of this study was to understand the current situation of QEEG utilization in China and further compare the situations among different regions and different levels of hospitals.Methods:An online questionnaire comprising 14 questions was designed.Statistical description and analysis were made for the results of the questionnaire survey.Results:A total of 158 people from 134 medical institutions participated in the survey.The participants came from 21 provinces,accounting for 61.76%(21/34)of the 34 provincial administrative regions in China.The Eastern China region accounted for 66.42%(89/134)of all the medical institutions that participated in this survey.Among the institutions surveyed,QEEG was routinely used in only 23.88%(32/134)of them.Among the medical institutions in which QEEG was routinely used,87.50%(28/32)of them were 3A-grade hospitals.Among the institutions with routine use of QEEG,56.25%(18/32)were affiliated hospitals of medical schools.There was a significant difference in the utilization of QEEG between the 3A-grade and non-3A-grade hospitals(P=0.040)and between the hospitals affiliated to medical schools and those non-affiliated to medical schools(P=0.020).Conclusions:The utilization of QEEG is still limited in China.There are differences in the use of QEEG among different hospitals and regions.
