Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related...Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.展开更多
In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ...In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ”.We researched and analyzed the“θ-τ”mystery,discussed the parity non-conservation in weak interactions,suggested possible experiments to test the parity non-conservation in weak interactions,and gave our research and analysis conclusions:The parity non-conservation in weak interactions,is still a“conjecture”;The experimental scheme suggested in the papers by C.N.Yang et al.cannot determine whether the weak interaction can separate left and right,and it is impossible to directly answer whetherθandτin the“θ-τ”mystery are the same particle;The Co60βdecay experiment such as C.S.Wu is a pseudo-mirror experiment,whether the experimental result violates parity conservation is only based on the assumption of C.N.Yang et al.In fact,experiments such as polarized Co60 did not overturn the so-called“law of parity conservation”.The mirror image principle does not have any physical meaning,does not correspond to any physical conservation quantity,and cannot be destroyed by any physical experiment.In the process of turning“mirror symmetry”and“mirror asymmetry”into so-called physical“common sense”and scientific“facts”respectively,the methods of transformation are“stealing concepts”and“circular argumentation”.The“θ-τ”mystery is a“man-made”mystery.θandτare two different particles,which may be the result of the same precursor particle being divided into two.The work of C.N.Yang,T.D.Lee,C.S.Wu et al.has brought quantum physicists from the“small black room”to the“bigger black room”or“smaller black room”.The right and wise choice is to go back through the door that came in.With the development of science today,it is time for some contents to reform from the bottom.展开更多
A synchronous electronic let-off and take-up device isdesigned.The device is controlled by a single-chipcomputer and driven by two step motors.It has somefunctions such as keeping the warp tension constant dur-ing the...A synchronous electronic let-off and take-up device isdesigned.The device is controlled by a single-chipcomputer and driven by two step motors.It has somefunctions such as keeping the warp tension constant dur-ing the weaving instant,releasing the warp tension whenloom is stopping and straining warp when loom is start-ing.By means of these functions,the stop mark of thewoven fabrics is eliminated.In addition,this device canapply to weaving variant-pick-density fabrics.展开更多
A new video-based measurement is proposed to collect and investigate traffic flow parameters. The output of the measurement is velocity-headway distance data pairs. Because density can be directly acquired by the reci...A new video-based measurement is proposed to collect and investigate traffic flow parameters. The output of the measurement is velocity-headway distance data pairs. Because density can be directly acquired by the reciprocal of headway distance, the data pairs have the advantage of better simultaneity than those from common detectors. By now, over 33 000 pairs of data have been collected from two road sections in the cities of Shanghai and Zhengzhou. Through analyzing the video files recording traffic movements on urban expressways, the following issues are studied：laws of vehicle velocity changing with headway distance, proportions of di0erent driving behaviors in the traffic system, and characteristics of traffic flow in snowy days. The results show that the real road traffic is very complex, and factors such as location and climate need to be taken into consideration in the formation of traffic flow models.展开更多
This paper analyzed the characteristics of welding solidification crack of stainless steels,and clearly re- vealed the the of the deformation in the molten - the pool and the solidification shrinkage on the stress -...This paper analyzed the characteristics of welding solidification crack of stainless steels,and clearly re- vealed the the of the deformation in the molten - the pool and the solidification shrinkage on the stress - strain fields in the trail of molten - weld pool.Moreover, rheologic properties of the alloys in solid - liquid zone were also obtained by measuring the hading and unloading deform curves of the steels.As a result, a numerical model for simulation of stress - strain distributions of welding solidifi- cation crack was developed. On the basis of the model,the thesis simulated the driving force of solidifi- cation crack of stainless steels, that is, stress - strain fields in the trail of molten-weld pool with fi- nite element method.展开更多
Using the ligand bis（3-（1H-imidazol-1-yl）-1-phenylpropan-1-one） L, two novel complexes [CuL2（ph））]·H2O 1 and [ZnL2（tp）] 2 （ph = phthalic acid, tp = terephthalic acid） have been synthesized and their cr...Using the ligand bis（3-（1H-imidazol-1-yl）-1-phenylpropan-1-one） L, two novel complexes [CuL2（ph））]·H2O 1 and [ZnL2（tp）] 2 （ph = phthalic acid, tp = terephthalic acid） have been synthesized and their crystal structures were determined by single-crystal X-ray diffraction analysis. Crystal data for 1： triclinic, space group P1^-, a = 9.4300（17）, b = 12.148（2）, c = 13.721（2） A, a = 109.620（2）,β = 94.351（2）, y = 94.830（2）°, C32H30N4O7Cu, Mr = 646.14, V= 1466.2（4） A^3, Z = 2, Dc = 1.464 g/cm3, It（MoKa） = 0.801 mm^-1, F（000） = 670, the final R = 0.0337 and wR = 0.0859 for 5122 observed reflections with I 〉 2σ（I）, And those for 2： monoclinic, space group P2/n, a = 7.1866（11）, b = 14.144（2）, c = 14.407（2）/k, β = 101.427（2）°, C32H28N4O6Zn, Mr = 629.95, V = 1435.4（4） A3, Z = 2, Dc = 1.457 g/cm3, μ（MoKa） = 0.908 mm^-1, F（000） = 652, the final R = 0.0438 and wR= 0.0821 for 2546 observed reflections with I〉 2σ（I）. In 1 and 2, ph or tp ligauds bridge the six-coordinated copper（Ⅱ） or four-coordinated zinc（Ⅱ） ions forming 1D zigzag chains while L ligands act as the terminal monodentate ligand. It is noted that weak non-classical C-H…O plays the important and dominating roles in the formation of 2D supramolecular architectures of 1, but in 2 non-classical C-H…O and aromatic π…π Stacking interactions are quite important and play dominant roles in the self-assembly of 2D supramolecular architectures.展开更多
文摘Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.
文摘In order to reasonably explain the phenomenon of cell bioelectricity,we proposed the conservation law of cell membrane area,established the ion inequality equation,and therefore paid attention to the mystery of“θ-τ”.We researched and analyzed the“θ-τ”mystery,discussed the parity non-conservation in weak interactions,suggested possible experiments to test the parity non-conservation in weak interactions,and gave our research and analysis conclusions:The parity non-conservation in weak interactions,is still a“conjecture”;The experimental scheme suggested in the papers by C.N.Yang et al.cannot determine whether the weak interaction can separate left and right,and it is impossible to directly answer whetherθandτin the“θ-τ”mystery are the same particle;The Co60βdecay experiment such as C.S.Wu is a pseudo-mirror experiment,whether the experimental result violates parity conservation is only based on the assumption of C.N.Yang et al.In fact,experiments such as polarized Co60 did not overturn the so-called“law of parity conservation”.The mirror image principle does not have any physical meaning,does not correspond to any physical conservation quantity,and cannot be destroyed by any physical experiment.In the process of turning“mirror symmetry”and“mirror asymmetry”into so-called physical“common sense”and scientific“facts”respectively,the methods of transformation are“stealing concepts”and“circular argumentation”.The“θ-τ”mystery is a“man-made”mystery.θandτare two different particles,which may be the result of the same precursor particle being divided into two.The work of C.N.Yang,T.D.Lee,C.S.Wu et al.has brought quantum physicists from the“small black room”to the“bigger black room”or“smaller black room”.The right and wise choice is to go back through the door that came in.With the development of science today,it is time for some contents to reform from the bottom.
文摘A synchronous electronic let-off and take-up device isdesigned.The device is controlled by a single-chipcomputer and driven by two step motors.It has somefunctions such as keeping the warp tension constant dur-ing the weaving instant,releasing the warp tension whenloom is stopping and straining warp when loom is start-ing.By means of these functions,the stop mark of thewoven fabrics is eliminated.In addition,this device canapply to weaving variant-pick-density fabrics.
基金supported by the National Natural Science Foundation of China (10772050)
文摘A new video-based measurement is proposed to collect and investigate traffic flow parameters. The output of the measurement is velocity-headway distance data pairs. Because density can be directly acquired by the reciprocal of headway distance, the data pairs have the advantage of better simultaneity than those from common detectors. By now, over 33 000 pairs of data have been collected from two road sections in the cities of Shanghai and Zhengzhou. Through analyzing the video files recording traffic movements on urban expressways, the following issues are studied：laws of vehicle velocity changing with headway distance, proportions of di0erent driving behaviors in the traffic system, and characteristics of traffic flow in snowy days. The results show that the real road traffic is very complex, and factors such as location and climate need to be taken into consideration in the formation of traffic flow models.
文摘This paper analyzed the characteristics of welding solidification crack of stainless steels,and clearly re- vealed the the of the deformation in the molten - the pool and the solidification shrinkage on the stress - strain fields in the trail of molten - weld pool.Moreover, rheologic properties of the alloys in solid - liquid zone were also obtained by measuring the hading and unloading deform curves of the steels.As a result, a numerical model for simulation of stress - strain distributions of welding solidifi- cation crack was developed. On the basis of the model,the thesis simulated the driving force of solidifi- cation crack of stainless steels, that is, stress - strain fields in the trail of molten-weld pool with fi- nite element method.
基金Fund for Central Universities (ZXH2009D011)Natural Science Foundation of Tianjin (09JCYBJC04200)+1 种基金National Natural Science Foundation of China Civil Aviation Administration of China (61079010) Scientific Research Foundation of Civil Aviation University of China (2011KYS05)
文摘Using the ligand bis（3-（1H-imidazol-1-yl）-1-phenylpropan-1-one） L, two novel complexes [CuL2（ph））]·H2O 1 and [ZnL2（tp）] 2 （ph = phthalic acid, tp = terephthalic acid） have been synthesized and their crystal structures were determined by single-crystal X-ray diffraction analysis. Crystal data for 1： triclinic, space group P1^-, a = 9.4300（17）, b = 12.148（2）, c = 13.721（2） A, a = 109.620（2）,β = 94.351（2）, y = 94.830（2）°, C32H30N4O7Cu, Mr = 646.14, V= 1466.2（4） A^3, Z = 2, Dc = 1.464 g/cm3, It（MoKa） = 0.801 mm^-1, F（000） = 670, the final R = 0.0337 and wR = 0.0859 for 5122 observed reflections with I 〉 2σ（I）, And those for 2： monoclinic, space group P2/n, a = 7.1866（11）, b = 14.144（2）, c = 14.407（2）/k, β = 101.427（2）°, C32H28N4O6Zn, Mr = 629.95, V = 1435.4（4） A3, Z = 2, Dc = 1.457 g/cm3, μ（MoKa） = 0.908 mm^-1, F（000） = 652, the final R = 0.0438 and wR= 0.0821 for 2546 observed reflections with I〉 2σ（I）. In 1 and 2, ph or tp ligauds bridge the six-coordinated copper（Ⅱ） or four-coordinated zinc（Ⅱ） ions forming 1D zigzag chains while L ligands act as the terminal monodentate ligand. It is noted that weak non-classical C-H…O plays the important and dominating roles in the formation of 2D supramolecular architectures of 1, but in 2 non-classical C-H…O and aromatic π…π Stacking interactions are quite important and play dominant roles in the self-assembly of 2D supramolecular architectures.
