AIM： To investigate the quinoline alkaloids from the roots ofDictamnus angustifolius G.Don ex Sweet （Rutaceae）. METHOD： The quinoline alkaloids were isolated by various column chromatographic methods and their str...AIM： To investigate the quinoline alkaloids from the roots ofDictamnus angustifolius G.Don ex Sweet （Rutaceae）. METHOD： The quinoline alkaloids were isolated by various column chromatographic methods and their structures were eluci- dated on the basis of spectral analysis. RESULTS： A new quinoline alkaloid, 5-methoxylrobustine （1）, along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine （2）, robustine （3）, isopteleine （4）, 7-fagarine （5）, and skimmianine （6）. Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells （MCF7）. CONCLUSION： Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other al- kaloids.展开更多
基金supported by the National New Drug Innovation Major Project of China(No.2011ZX09307-002-02)
文摘AIM： To investigate the quinoline alkaloids from the roots ofDictamnus angustifolius G.Don ex Sweet （Rutaceae）. METHOD： The quinoline alkaloids were isolated by various column chromatographic methods and their structures were eluci- dated on the basis of spectral analysis. RESULTS： A new quinoline alkaloid, 5-methoxylrobustine （1）, along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine （2）, robustine （3）, isopteleine （4）, 7-fagarine （5）, and skimmianine （6）. Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells （MCF7）. CONCLUSION： Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other al- kaloids.
