Scheme of negative acoustic radiation force based on a multiple-layered spherical structure

Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are presented. Detailed theoretical calculation analysis is carried out.Numerical simulations have been performed to verify the correctness of this prediction. The conjecture that the suppression of backscattering can achieve negative ARF is verified concretely, which greatly expands the application prospect and design ideas of the ARF. This work has laid a theoretical foundation for realizing precise control of the structure.

Acoustic radiation force impulse predicts long-term outcomes in a large-scale cohort:High liver cancer,low comorbidity in hepatitis B virus

BACKGROUND Acoustic radiation force impulse(ARFI)is used to measure liver fibrosis and predict outcomes.The performance of elastography in assessment of fibrosis is poorer in hepatitis B virus(HBV)than in other etiologies of chronic liver disease.AIM To evaluate the performance of ARFI in long-term outcome prediction among different etiologies of chronic liver disease.METHODS Consecutive patients who received an ARFI study between 2011 and 2018 were enrolled.After excluding dual infection,alcoholism,autoimmune hepatitis,and others with incomplete data,this retrospective cohort were divided into hepatitis B(HBV,n=1064),hepatitis C(HCV,n=507),and non-HBV,non-HCV(NBNC,n=391)groups.The indexed cases were linked to cancer registration(1987-2020)and national mortality databases.The differences in morbidity and mortality among the groups were analyzed.RESULTS At the enrollment,the HBV group showed more males(77.5%),a higher prevalence of prediagnosed hepatocellular carcinoma(HCC),and a lower prevalence of comorbidities than the other groups(P<0.001).The HCV group was older and had a lower platelet count and higher ARFI score than the other groups(P<0.001).The NBNC group showed a higher body mass index and platelet count,a higher prevalence of pre-diagnosed non-HCC cancers(P<0.001),especially breast cancer,and a lower prevalence of cirrhosis.Male gender,ARFI score,and HBV were independent predictors of HCC.The 5-year risk of HCC was 5.9%and 9.8%for those ARFI-graded with severe fibrosis and cirrhosis.ARFI alone had an area under the receiver operating characteristic curve(AUROC)of 0.742 for prediction of HCC in 5 years.AUROC increased to 0.828 after adding etiology,gender,age,and platelet score.No difference was found in mortality rate among the groups.CONCLUSION The HBV group showed a higher prevalence of HCC but lower comorbidity that made mortality similar among the groups.Those patients with ARFI-graded severe fibrosis or cirrhosis should receive regular surveillance.

A Modified Formulation of Singular Boundary Method for Exterior Acoustics

This paper proposes amodified formulation of the singular boundarymethod(SBM)by introducing the combined Helmholtz integral equation formulation(CHIEF)and the self-regularization technique to exterior acoustics.In the SBM,the concept of the origin intensity factor(OIF)is introduced to avoid the singularities of the fundamental solutions.The SBM belongs to the meshless boundary collocation methods.The additional use of the CHIEF scheme and the self-regularization technique in the SBM guarantees the unique solution of the exterior acoustics accurately and efficiently.Consequently,by using the SBM coupled with the CHIEF scheme and the self-regularization technique,the accuracy of the numerical solution can be improved,especially near the corresponding internal characteristic frequencies.Several numerical examples of two-dimensional and threedimensional benchmark examples about exterior acoustics are used to verify the effectiveness and accuracy of the proposed method.The proposed numerical results are compared with the analytical solutions and the solutions obtained by the other numerical methods.

Three-dimensional acoustic radiation force of a eukaryotic cell arbitrarily positioned in a Gaussian beam

Expressions are derived for calculating the three-dimensional acoustic radiation force(ARF)on a multilayer microsphere positioned arbitrarily in a Gaussian beam.A theoretical model of a three-layer microsphere with a cell membrane,cytoplasm,and nucleus is established to study how particle geometry and position affect the three-dimensional ARF,and its results agree well with finite-element numerical results.The microsphere can be moved relative to the beam axis by changing its structure and position in the beam,and the axial ARF increases with increasing outer-shell thickness and core size.This study offers a theoretical foundation for selecting suitable parameters for manipulating a three-layer microsphere in a Gaussian beam.

Software for Acoustic Design

We present the СATEС software, which implements the solution to the problems of computational acoustics. The software is based on the use of the superelement method and finite element modeling algorithms, in-cluding hydrodynamic noise. The paper presents the main possibilities of software for solving acoustic design problems. .

Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal system.As PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be suspected.In these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be challenging.In this setting ultrasonography may be valuable in differential diagnosis.The aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing PSVD.Methods:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT patients.Thus,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

Vibration and Acoustic Radiation from Orthogonally Stiffened Infinite Circular Cylindrical Shells in Water

Based on the motion differential equations of vibration and acoustic coupling system for thin elastic shells with ribs, by means of the Fourier integral transformation and the Fourier inverse transformation, as well as the stationary phase method, an analytic solution, which has satisfying computational effectiveness and precision, is derived for the solution to the vibration and acoustic radiation from a submerged stiffened infinite circular cylinder with both ring and axial ribs. It is easy to analyze the effect of stiffening supports in the acoustic radiation field by use of the formulas obtained by the presented method and corresponding numerical computation. It is shown that the axial-stiffeners can improve the mechanical and acoustical characteristics. Moreover, the present method can be used to study the acoustic radiation mechanism of the type of structure.

Application of acoustic radiation force impulse imaging for the evaluation of focal liver lesion elasticity

BACKGROUND: Acoustic radiation force impulse (ARFI) imaging is a new elastography method for the evaluation of tissue stiffness. This study aims to evaluate the performance of ARFI in noninvasive assessment of the tissue stiffness of focal liver lesion (FLL) and to explore its potential value in the differential diagnosis of FLL. METHODS: ARFI was performed in 140 patients with 154 FLLs, which included 28 hemangiomas (ANGIs), 14 focal nodular hyperplasias (FNHs), 61 hepatocellular carcinomas (HCCs), 39 metastases and 12 cholangiocellular carcinomas (CCCs). Virtual touch tissue quantification (VTTQ) values were obtained, analyzed and compared. The area under the receiver operating characteristic curve (AUROC) and optimal cut-off values were obtained using a receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. All cases were definitively diagnosed using histopathology, CT, MRI or contrast-enhanced ultrasound. RESULTS: The VTTQ median values of ANGI, FNH, HCC metastasis and CCC were 1.30, 1.80, 2.52, 3.08 and 3.89 m/s respectively. A significant increase in the VTTQ values of different lesions was observed: ANGI【FNH【HCC【metastasis 【CCC (P【0.001). The AUROC (95% CI) of VTTQ values was 0.94 (0.90-0.98) for ANGI, 0.91 (0.87-0.96) for malignant lesions and 0.87 (0.79-0.94) for CCC. The sensitivity and specificity for ANGI (86.5%, 89.3%, respectively), malignancy (81.3% 92.9%, respectively), and CCC (91.7%, 72.5%, respectively) were associated with VTTQ cut-off values of 1.76, 2.22 and 3.00 m/s respectively.CONCLUSIONS: ARFI can accurately and objectively assess the elasticity of lesions by obtaining the shear wave elastic value of FLL with VTTQ. Therefore, ARFI is a novel, simple, noninvasive and useful diagnostic method for the characterization of FLL.

Acoustic dipole radiation model for magnetoacoustic tomography with magnetic induction

An acoustic dipole radiation model for magnetoacoustic tomography with magnetic induction （MAT-MI） is pro- posed, based on the analyses of one-dimensional tissue vibration, three-dimensional acoustic dipole radiation and acoustic waveform detection with a planar piston transducer. The collected waveforms provide information about the conductiv- ity boundaries in various vibration intensities and phases due to the acoustic dipole radiation pattern. Combined with the simplified back projection algorithm, the conductivity configuration of the measured layer in terms of shape and size can be reconstructed with obvious border stripes. The numerical simulation is performed for a two-layer cylindrical phantom model and it is also verified by the experimental results of MAT-MI for a tissue-like sample phantom. The proposed model suggests a potential application of conductivity differentiation and provides a universal basis for the further study of conductivity reconstruction for MAT-MI.

A NOVEL SEMI-ANALYTICAL METHOD FOR SOLVING ACOUSTIC RADIATION FROM LONGITUDINALLY STIFFENED INFINITE NON-CIRCULAR CYLINDRICAL SHELLS IN WATER

Based on the extended homogeneous capacity high precision integration method and the spectrum method of virtual boundary with a complex radius vector, a novel semi-analytical method, which has satisfactory computation efectiveness and precision, is presented for solving the acoustic radiation from a submerged infnite non-circular cylindrical shell stifened by longitudinal ribs by means of the Fourier integral transformation and stationary phase method. In this work, besides the normal interacting force, which is commonly adopted by some researchers, the other interacting forces and moments between the longitudinal ribs and the non-circular cylindrical shell are considered at the same time. The efects of the number and the size of the cross-section of longitudinal ribs on the characteristics of acoustic radiation are investigated. Numerical results show that the method proposed is more efcient than the existing mixed FE-BE method.

LAMINATED PIEZOELECTRIC PLATE FOR ACTIVE UNDERWATER ACOUSTIC CONTROL

The pressure reflected from a bi-laminated piezoelectric plate hasbeen determined using the Thomson-Haskell matrix method. The plate iscomposed of a piezoelectric layer with grounded vacuum and An elasticlayer in contact with the fluid. An incident plane wave in the fluidmedium strikes the plate at dif- Ferent angles. The required electricpotential across the piezoelectric layer to cancel the reflectionfrom the Fluid/elastic boundary has been determined for thepiezoelectric material PZT-5 at various thickness parame- Ters andincident frequencies.

A Modified Monte Carlo Model of Speckle Tracking of Shear Wave Induced by Acoustic Radiation Force for Acousto-Optic Elasticity Imaging

A modified Monte Carlo model of speckle tracking of shear wave propagation in scattering media is proposed. The established Monte Carlo model mainly concerns the variations of optical electric field and speckle. The two- dimensional intensity distribution and the time evolution of speckles in different probe locations are obtained. The fluctuation of speckle intensity tracks the acoustic-radiation-force shear wave propagation, and especially the reduction of speckle intensity implies attenuation of shear wave. Then, the shear wave velocity is estimated quantitatively on the basis of the time-to-peak algorithm and linear regression processing. The results reveal that a smaller sampling interval yields higher estimation precision and the shear wave velocity is estimated more efficiently by using speckle intensity difference than by using speckle contrast difference according to the estimation error. Hence, the shear wave velocity is estimated to be 2.25 m/s with relatively high accuracy for the estimation error reaches the minimum （0.071）.

WAVE SUPERPOSITION METHOD BASED ON VIRTUAL SOURCE BOUNDARY WITH COMPLEX RADIUS VECTOR FOR SOLVING ACOUSTIC RADIATION PROBLEMS

By virtue of the comparability between the wave superposition method and the dynamic analysis of structures, a general format for overcoming the non-uniqueness of solution induced by the wave superposition method at the eigenfrequencies of the corresponding interior problems is proposed. By adding appropriate damp to the virtual source system of the wave superposition method, the unique solutions for all wave numbers can be ensured. Based on this thought, a novel method-wave superposition method with complex radius vector is constructed. Not only is the computational time of this method approximately equal to that of the standard wave superposition method, but also the accuracy is much higher compared with other correlative methods. Finally, by taking the pulsating sphere and oscillating sphere as examples, the results of calculation show that the present method can effectively overcome the non-uniqueness problem.

Giant Magnetostrictive Material Loudspeaker System Acoustic Radiation Simulation

An infinite panel model of giant magnetostrictive material loudspeaker system （GMMLS） is proposed by making use of finite element method（FEM）. Bending wave eigenfunction is introduced to describe the acoustic radiation condition of the panel. Far-field response in different conditions is calculated by changing the mass surface density. Conclusion is obtained by analyzing the curves simulated, that panel which has larger mass surface density can hardly generate far-field acoustic radiation for lower frequency, while the panel has smaller mass surface density generates far-field acoustic radiation for lower frequency evenly and stronger.

Acoustic radiation force on a multilayered sphere in a Gaussian standing field

We develop a model for calculating the radiation force on spherically symmetric multilayered particles based on the acoustic scattering approach. An expression is derived for the radiation force on a multilayered sphere centered on the axis of a Gaussian standing wave propagating in an ideal fluid, The effects of the sound absorption of the materials and sound wave on acoustic radiation force of a multilayered sphere immersed in water are analyzed, with particular emphasis on the shell thickness of every layer, and the width of the Gaussian beam. The results reveal that the existence of particle trapping behavior depends on the choice of the non-dimensional frequency ka, as well as the shell thickness of each layer. This study provides a theoretical basis for the development of acoustical tweezers in a Gaussian standing wave, which may benefit the improvement and development of acoustic control technology, such as trapping, sorting, and assembling a cell, and drug delivery applications.

Vibration and Acoustic Radiation from Submerged Spherical Double-Shell

Based on the motion differential equations of vibration and acoustic coupling system for a thin elastic spherical double-shell with several elastic plates attached to the shells, in which Dirac-δ functions are employed to introduce the forces and moments applied by the attachments, and by means of expanding field quantities as the Legendre series, a semi-analytic solution is derived for the solution to the vibration and acoustic radiation from a submerged spherical double-shell. This solution has a satisfying computational effectiveness and precision for arbitrary frequency range excitation. It is concluded that the internal plates attached to shells can change significantly the mechanical and acoustical characteristics of shells, and make the coupling system have a very rich resonance frequency spectrum. Moreover, the present method can be used to study the acoustic radiation mechanism of the type of structure.

Acoustic radiation force on a rigid cylinder near rigid corner boundaries exerted by a Gaussian beam field

Acoustic manipulation is one of the well-known technologies of particle control and a top research in acoustic field.Calculation of acoustic radiation force on a particle nearby boundaries is one of the critical tasks,as it approximates realistic applications.Nevertheless,it is quite difficult to solve the problem by theoretical method when the boundary conditions are intricate.In this study,we present a finite element method numerical model for the acoustic radiation force exerting on a rigid cylindrical particle immersed in fluid near a rigid corner.The effects of the boundaries on acoustic radiation force of a rigid cylinder are analyzed with particular emphasis on the non-dimensional frequency and the distance from the center of cylinder to each boundary.The results reveal that these parameters play important roles in acoustic manipulation for particle-nearby complicated rigid boundaries.This study verifies the feasibility of numerical analysis on the issue of acoustic radiation force calculation close to complex boundaries,which may provide a new idea on analyzing the acoustic particle manipulation in confined space.

VIBRATION AND ACOUSTIC RADIATION FROM SUBMERGED STIFFENED SPHERICAL SHELL WITH DECK-TYPE INTERNAL PLATE

Based on the motion differential equations of vibration and acoustic coupling system for thin elastic spherical shell with an elastic plate attached to its internal surface,in which Dirac-δ functions are employed to introduce the moments and forces applied by the attachment on the surface of shell,by means of expanding field quantities as Legendre series,a semi-analytic solution is derived for the vibration and acoustic radiation from a submerged stiffened spherical shell with a deck-type internal plate,which has a satisfactory computational effectiveness and precision for an arbitrary frequency range.It is easy to analyze the effect of the internal plate on the acoustic radiation field by using the formulas obtained by the method proposed.It is concluded that the internal plate can significantly change the mechanical and acoustic characteristics of shell,and give the coupling system a very rich resonance frequency spectrum.Moreover,the method can be used to study the acoustic radiation mechanism in similar structures as the one studied here.

Tunable acoustic radiation pattern assisted by effective impedance boundary

The acoustic wave propagation from a two-dimensional subwavelength slit surrounded by metal plates decorated with Helmholtz resonators （HRs） is investigated both numerically and experimentally in this work. Owing to the presence of HRs, the effective impedance of metal surface boundary can be manipulated. By optimizing the distribution of HRs, the asymmetric effective impedance boundary will be obtained, which contributes to generating tunable acoustic radiation pattern such as directional acoustic beaming. These dipole-like radiation patterns have high radiation efficiency, no finger- print of sidelobes, and a wide tunable range of the radiation pattern directivity angle which can be steered by the spatial displacements of HRs.

Structural and Acoustic Response of A Finite Stiffened Submarine Hull

After borrowing the idea of precise integration method, a precise integration transfer matrix method （PITMM） is proposed by modifying traditional transfer matrix method. The submarine hull can be modeled as joined conical- cylindrical-spherical shells. By considering the effect of the ring-stiffeners, the field transfer matrixes of shells of revolution are obtained accurately by PITMM. After assembling the field transfer matrixes into an entire matrix, the dynamic model is established to solve the dynamic responses of the joined shell. By describing the sound pressure in fluid by modified wave superposition method （MWSM） and collocating points along the meridian line of the joined shell, finally the structural and acoustic responses of a finite stiffened submarine hull can be predicted by coupled PITMM and MWSM. The effectiveness of the present method has been verified by comparing the structural and acoustic responses of the spherical shell with existing results. Furthermore, the effects of the model truncation, stiffness and thickness on the structural and acoustic responses of the submarine hull are studied.