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Superhydrophobic melamine sponge prepared by radiation-induced grafting technology for efficient oil-water separation
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作者 Ying Sun Wen-Rui Wang +7 位作者 Dan-Yi Li Si-Yi Xu Lin Lin Man-Li Lu Kai Fan Chen-Yang Xing Lin-Fan Li Ji-Hao Li 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期103-114,共12页
This paper presents a superhydrophobic melamine(ME)sponge(ME-g-PLMA)prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate(LMA)onto an ME sponge for efficient oil... This paper presents a superhydrophobic melamine(ME)sponge(ME-g-PLMA)prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate(LMA)onto an ME sponge for efficient oil–water separation.The obtained ME-g-PLMA sponge had an excellent pore structure with superhydrophobic(water contact angle of 154°)and superoleophilic properties.It can absorb various types of oils up to 66–168 times its mass.The ME-g-PLMA sponge can continuously separate oil slicks in water by connecting a pump or separating oil underwater with a gravity-driven device.In addition,it maintained its highly hydrophobic properties even after long-term immersion in different corrosive solutions and repeated oil adsorption.The modified ME-g-PLMA sponge exhibited excellent separation properties and potential for oil spill cleanup. 展开更多
关键词 radiation-induced graft polymerization Oil–water separation SPONGE SUPERHYDROPHOBIC
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Magnetic resonance imaging findings of radiation-induced breast angiosarcoma:A case report
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作者 Wen-Pei Wu Chih-Wei Lee 《World Journal of Clinical Cases》 SCIE 2024年第13期2237-2242,共6页
BACKGROUND Breast conservation surgery(BCS)with adjuvant radiotherapy has become a gold standard in the treatment of early-stage breast cancer,significantly reducing the risk of tumor recurrence.However,this treatment... BACKGROUND Breast conservation surgery(BCS)with adjuvant radiotherapy has become a gold standard in the treatment of early-stage breast cancer,significantly reducing the risk of tumor recurrence.However,this treatment is associated with adverse effects,including the rare but aggressive radiation-induced angiosarcoma(RIAS).Despite its rarity and nonspecific initial presentation,RIAS presents a challenging diagnosis,emphasizing the importance of imaging techniques for early detection and accurate diagnosis.CASE SUMMARY We present a case of a 48-year-old post-menopausal woman who developed skin ecchymosis on the right breast seven years after receiving BCS and adjuvant radiotherapy for breast cancer.Initial mammography and ultrasound were inconclusive,showing post-treatment changes but failing to identify the underlying angiosarcoma.Contrast-enhanced breast magnetic resonance imaging(MRI)revealed diffuse skin thickening and nodularity with distinctive enhan-cement kinetics,leading to the diagnosis of RIAS.This case highlights the crucial role of MRI in diagnosing and determining the extent of RIAS,facilitating timely and appropriate surgical intervention.CONCLUSION Breast MRI is crucial for detecting RIAS,especially when mammography and ultrasound are inconclusive. 展开更多
关键词 radiation-induced angiosarcoma RADIOTHERAPY Breast conserving surgery Breast cancer Magnetic resonance imaging Case report
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Synthesis,Cytotoxicity,Apoptosis and Cell Cycle Arrest of a Ruthenium(II)-Substituted Keggin Polyoxotungstate
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作者 JIA Shifang HAO Xiuli +2 位作者 WENYanzhen SHI Shaoqi ZHANG Yan 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2024年第5期461-470,共10页
The ruthenium multi-substituted polyoxotungstate,K_7[Si W_(9)O_(37)Ru_(4)(H_(2)O)_(3)Cl_(3)]·15H_(2)O(S1),was synthesized by a conventional aqueous solution containing the trilacunary Keggin-anionsβ-Na_(9)HSi W_... The ruthenium multi-substituted polyoxotungstate,K_7[Si W_(9)O_(37)Ru_(4)(H_(2)O)_(3)Cl_(3)]·15H_(2)O(S1),was synthesized by a conventional aqueous solution containing the trilacunary Keggin-anionsβ-Na_(9)HSi W_(9)O_(34)·12H_(2)O(S2)and Ru Cl_(3)·n H_(2)O(S3).Compound S1 was charac‐terized by elemental analysis,energy-dispersive X-ray spectroscopy(EDS),thermogravimetric analysis(TG),infrared spectroscopy(IR),uliraviolet visible absorption spectroscopy(UV/Vis)and X-ray photoelectron spectroscopy(XPS).The cytotoxicitycy of S1 was tested in C33A(human cervical cancer),DLD-1(human colon cancer),Hep G2(human liver cancer)and human normal embryonic lung fibroblasts cell(MRC-5).And the viability of these treated cells was evaluated by MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro‐mide)assay.To explore the mode of cell death induced by S1,morphological study of DNA damage and apoptosis assays were conducted.These analyses revealed that S1 exerted its cytotoxic effect in a dose-dependent manner,primarily triggering apoptotic cell death.Cell cycle analysis by flow cytometry indicated that compound S1 caused cell cycle arrest and accumulated cells in S phase. 展开更多
关键词 ruthenium multi-substituted polyoxometalate cytotoxicity cell apoptosis cell cycle arrest
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Treatment of radiation-induced brain injury with bisdemethoxycurcumin 被引量:4
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作者 Yun-Qian Chang Gui-Juan Zhou +7 位作者 Hong-Mei Wen Duan-Qun He Chen-Lin Xu Ya-Rui Chen Yi-Hui Li Shuang-Xi Chen Zi-Jian Xiao Ming Xie 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第2期416-421,共6页
Radiation therapy is considered the most effective non-surgical treatment for brain tumors.However,there are no available treatments for radiation-induced brain injury.Bisdemethoxycurcumin(BDMC)is a demethoxy derivati... Radiation therapy is considered the most effective non-surgical treatment for brain tumors.However,there are no available treatments for radiation-induced brain injury.Bisdemethoxycurcumin(BDMC)is a demethoxy derivative of curcumin that has anti-proliferative,anti-inflammatory,and anti-oxidant properties.To determine whether BDMC has the potential to treat radiation-induced brain injury,in this study,we established a rat model of radiation-induced brain injury by administe ring a single 30-Gy vertical dose of irradiation to the whole brain,followed by intraperitoneal injection of 500μL of a 100 mg/kg BDMC solution every day for 5 successive weeks.Our res ults showed that BDMC increased the body weight of rats with radiation-induced brain injury,improved lea rning and memory,attenuated brain edema,inhibited astrocyte activation,and reduced oxidative stress.These findings suggest that BDMC protects against radiationinduced brain injury. 展开更多
关键词 ASTROCYTES BISDEMETHOXYCURCUMIN brain edema brain tumor CURCUMIN learning and memory neuronal injury oxidative stress radiation therapy radiation-induced brain injury
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TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator 被引量:2
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作者 Hui-Hui Xiao Ling-Ling Liu +5 位作者 Wen-Yi Li Bing-Bing Li Xiang-Li Cui Jie Li Tao-Sheng Li Zong-Tao Hu 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第4期69-78,共10页
The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse li... The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury(RILD) in mice were to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy(VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume(PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6 J mice were randomly divided into control and 25-Gy radiation groups and were examined daily for changes in body weight. They were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase(ALT), aspartate aminotransferase(AST), and alkaline phosphatase(ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ± 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25-Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from-1.5 to 6%;construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible. 展开更多
关键词 Thermoluminescent detector radiation-induced liver injury Linear accelerator Volumetric rotational intensity-modulated radiotherapy
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Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: A review 被引量:2
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作者 Chowdhury Ahmed Shahed Faiz Ahmad +4 位作者 Ebru Günister Farhana Mohd Foudzi Saad Ali Khurshid Malik Wan Sharuzi Wan Harun 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第9期3038-3058,共21页
Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial p... Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver(Ag), copper(Cu), lithium(Li), and gallium(Ga). Copper ions(Cu^(2+)) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion(Ag^(+)) kills bacteria by creating bonds with the thiol group. Gallium ion(Ga^(3+)) inhibits ferric ion(Fe^(3+)) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species(ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions. 展开更多
关键词 Biodegradable materials Biomedical implants Antibacterial mechanism cytotoxicity Reactive oxygen species
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Echinoside A from Pearsonothuria graeffei Exert the Cytotoxicity to MDA-MB-231 Cells via Mitochondrial Membrane and Modulation of PI3K/Akt/mTOR Pathway 被引量:1
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作者 LI Hongyan CUI Huanhuan +4 位作者 CONG Peixu XU Jie XIE Wancui WANG Yuming XUE Changhu 《Journal of Ocean University of China》 SCIE CAS CSCD 2023年第1期205-212,共8页
A kind of triterpene glycosides echinoside A(EA)was extracted from sea cucumber Pearsonothuria graeffei,and its yield was about 0.78%.The purity of EA was 99.0%,and its molecular weight was 1206 Da.EA was a linear tet... A kind of triterpene glycosides echinoside A(EA)was extracted from sea cucumber Pearsonothuria graeffei,and its yield was about 0.78%.The purity of EA was 99.0%,and its molecular weight was 1206 Da.EA was a linear tetrasaccharide attached to a pentacyclic triterpene aglycon.It inhibited the growth of MDA-MB-231 cells in vitro.The antitumor effect was related to elevate ROS level,decrease mitochondrial membrane potential,enhance caspase-3 expression,induce cells apoptosis and arrest cell cycle at G2/M phase.EA also dose-dependently suppressed the expressions of phophorylation proteins p-PI3K,p-Akt,and p-mTOR as analyzed by western blotting.These results suggested that EA caused MDA-MB-231 cells apoptosis via intrinsic mitochondrial and PI3K/Akt/mTOR pathway.EA can be a potential anti-breast cancer agent to enhance the clinical efficacy. 展开更多
关键词 Pearsonothuria graeffei echinoside A cytotoxicity PI3K/Akt/mTOR pathway
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A graphical user interface(GUI)for model-based radiation-induced acoustic computed tomography
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作者 Michelle Simon Prabodh Kumar Pandey +1 位作者 Leshan Sun Liangzhong Xiang 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS CSCD 2023年第1期39-53,共15页
Radiation-induced acoustic computed tomography(RACT)is an evolving biomedical imaging modality that aims to reconstruct the radiation energy deposition in tissues.Traditional backprojection(BP)reconstructions carry no... Radiation-induced acoustic computed tomography(RACT)is an evolving biomedical imaging modality that aims to reconstruct the radiation energy deposition in tissues.Traditional backprojection(BP)reconstructions carry noisy and limited-view artifacts.Model-based algorithms have been demonstrated to overcome the drawbacks of BPs.However,model-based algorithms are relatively more complex to develop and computationally demanding.Furthermore,while a plethora of novel algorithms has been developed over the past decade,most of these algorithms are either not accessible,readily available,or hard to implement for researchers who are not well versed in programming.We developed a user-friendly MATLAB-based graphical user interface(GUI;RACT2D)that facilitates back-projection and model-based image reconstructions for twodimensional RACT problems.We included numerical and experimental X-ray-induced acoustic datasets to demonstrate the capabilities of the GUI.The developed algorithms support parallel computing for evaluating reconstructions using the cores of the computer,thus further accelerating the reconstruction speed.We also share the MATLAB-based codes for evaluating RACT reconstructions,which users with MATLAB programming expertise can further modify to suit their needs.The shared GUI and codes can be of interest to researchers across the globe and assist them in e±cient evaluation of improved RACT reconstructions. 展开更多
关键词 radiation-induced acoustic computed tomography(RACT) image reconstruction graphical user interface(GUI) photoacoustic tomography
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New secondary metabolites with cytotoxicity from fungus Penicillium roqueforti
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作者 Shuyuan Mo Ziming Zhao +6 位作者 Zi Ye Zhihong Huang Yaxin Zhang Wanqi Yang Jianping Wang Zhengxi Hu Yonghui Zhang 《Natural Products and Bioprospecting》 CSCD 2023年第1期577-584,共8页
Two novel compounds including a cyclohelminthol type polyketide(namely oxaleimide K,1)and a maleimide deriva-tive(namely peniroquefortine A,2),and a new natural product(namely 2-(acetylamino)-N-[(1E)-2-phenylethenyl]-... Two novel compounds including a cyclohelminthol type polyketide(namely oxaleimide K,1)and a maleimide deriva-tive(namely peniroquefortine A,2),and a new natural product(namely 2-(acetylamino)-N-[(1E)-2-phenylethenyl]-acetamide,3),together with four known compounds(4-7),were isolated and identified from fungus Penicillium roqueforti,which was separated from the root soil of Hypericum beanii N.Robson collected from the Shennongjia For-estry District,Hubei Province.Their structures including absolute configurations were mainly established by the NMR spectroscopy analyses and single-crystal X-ray diffraction experiment.Compound 1 represents the second example of a cyclohelminthol type polyketide,which features a rare 6/6/5/5 tetracyclic system and a branched aliphatic chain containing a terminal olefin(oct-1-en-3-yl)moiety,and compound 2 possesses an unprecedented carbon skeleton that is uniquely defined by a maleimide moiety linked to the respective 4-methylene-2-(3-methylbut-2-en-1-yl)-phenol and para-substituted aromatic moieties via the carbon-carbon bonds.Remarkably,the absolute configuration of a cyclohelminthol type polyketide as exemplified by compound 1 is determined by the single-crystal diffraction analysis for the first time,highlighting an E-configuration for the linkage of a succinimide moiety and a tetrahydro-furan moiety for 1 rather than a Z-configuration as previously reported in the biosynthesis study,which gives a new insight into the structural elucidation of this category of polyketides.Additionally,compound 1 exhibited significant cytotoxic activity against multiple tumor cells,especially against the Farage and SU-DHL-2 cells(IC_(50)<20μM,48 h).Further mechanism study revealed that compound 1 significantly induced cell cycle arrest in Farage and SU-DHL-2 cells by causing abnormal ROS level and triggering oxidative stress. 展开更多
关键词 Hypericum beanii N.Robson Root soil-derived fungus Penicillium roqueforti Structural elucidation cytotoxicity
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A Review of Radiation-Induced Oral Mucositis in Traditional Chinese and Western Medicine Research
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作者 杜宁 叶霈智 +4 位作者 任爽 刘丽星 刘欣琦 张杰 冯利 《World Journal of Integrated Traditional and Western Medicine》 2023年第4期47-56,共10页
Radiation therapy is one of the main treatments for head and neck tumors,and radiationinduced oral mucositis(RIOM)is a common serious adverse effect of radiation therapy.We summarized the pathogenesis,prevention and t... Radiation therapy is one of the main treatments for head and neck tumors,and radiationinduced oral mucositis(RIOM)is a common serious adverse effect of radiation therapy.We summarized the pathogenesis,prevention and treatment methods of RIOM related to traditional Chinese and Western medicine in recent years.The treatment of RIOM in traditional Chinese medicine should be based on clearing heat and detoxifying,nourishing Yin and promoting fluid,tonifying spleen and stomach,cooling blood and removing blood stasis.Osteopontin,immunoglobulin A and saliva flow tests may be effective clinical indicators in the future.Through analysis,the author believes that the use of integrated intervention of traditional Chinese and western medicine can better benefit patients,and the prevention and predictive diagnostic tools of RIOM should become the future focus of attention. 展开更多
关键词 Radiation therapy radiation-induced oral mucositis MECHANISM Research progress
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Cytotoxic Properties on Cervical and Liver Cancer Cells of Two Plant Recipes from Burkina Faso
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作者 Estelle Ouédraogo Bagora Bayala +6 位作者 Théodora Mahoukèdè Zohoncon Samiratou Ouédraogo Olga Mélanie Lompo Essi Etonam Dovo Jean-Marie Compaoré Albert Théophane Yonli Jacques Simpore 《Journal of Biosciences and Medicines》 2024年第6期216-229,共14页
Cancer is one of the deadliest diseases in developing countries. In recent years, natural plant-based compounds have been used in the search for drugs to combat numerous diseases, including cancer. In this study, we e... Cancer is one of the deadliest diseases in developing countries. In recent years, natural plant-based compounds have been used in the search for drugs to combat numerous diseases, including cancer. In this study, we evaluate the cytotoxic properties of paanfo tiben 1 and paanfo tiben 2, two traditional herbal formulations from Burkina Faso used in the treatment of cancer in Burkina Faso. To this end, the recipes were infused and freeze-dried. The dry extracts obtained were used to determine total phenolics and flavonoids content, assess antioxidant activity using the DPPH, ABTS and FRAP methods, evaluate anti-inflammatory properties by inhibiting 15-LOX, COX 1 and 2, and assess cytotoxic activity on HeLa cervical cancer and HePG2 liver cancer cell lines using the MTT test. The paanfo tiben 1 recipe showed the highest levels of total phenolics and flavonoids, as well as the best antioxidant activities, with IC50 values of 21.020 ± 0.6 µg/ml and 22.94 ± 0.57 µg/ml for DPPH and ABTS, and 165.15 mM EAA/mg dry extract for FRAP. It also exhibited the best cytotoxic activity with IC50 values of 112.02 ± 0.025 µg/ml on HeLa cells and 80.67 ± 6.08 µg/ml on HepG2 cells. On the other hand, paanfo tiben 2 exhibited the best anti-inflammatory activities through inhibition of 15-LOX and COX 1, with inhibition percentages at 100 µg/ml of 32.523% and 24.717 % respectively. These results could justify the traditional use of these two recipes by traditional health practitioners in the treatment of cancer sufferers in Burkina Faso. 展开更多
关键词 ANTIOXIDANT ANTI-INFLAMMATORY cytotoxicity Paanfo Tiben Burkina
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Effects of Kangfuxin Solution (康复新液) Combined with Low-level Laser on Cytokines and Immune Function in Patients with Radiation-induced Oral Mucositis
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作者 董克臣 张萌 李松 《World Journal of Integrated Traditional and Western Medicine》 2023年第1期23-28,共6页
Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 na... Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients. 展开更多
关键词 radiation-induced oral mucositis Nasopharyngeal carcinoma Kangfuxin Solution Low-level laser therapy CYTOKINES Immune function
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Chronic toxicity and cytotoxicity of synthetic pyrethroid insecticide cis-bifenthrin 被引量:10
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作者 WANG Cui CHEN Fang +1 位作者 ZHANG Quan FANG Zhuo 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2009年第12期1710-1715,共6页
With the increasing use of synthetic pyrethroids (SPs), the significance of ecological safety and health risk is an emerging concern, In this study, we evaluated the chronic aquatic toxicity of eis-bifenthrin (cis... With the increasing use of synthetic pyrethroids (SPs), the significance of ecological safety and health risk is an emerging concern, In this study, we evaluated the chronic aquatic toxicity of eis-bifenthrin (cis-BF) in Daphnia magna and its cytotoxicity in Chinese hamster ovary (CHO) cells as well as human cervical carcinoma (Hela) ceils. Chronic aquatic toxicity tests showed that cis-BF could significantly affect the reproduction of D. magna. The lowest observed effective concentration and the non-observed effective concentration of cis-BF to D. magna were 0.02 and 0.01 μg/L, respectively, and the chronic value was 0.014 μg/L. The intrinsic rate of natural increase was significantly decreased (p 〈 0.05) to 0.02 μg/L. The cytotoxicity assay demonstrated that cis-BF decreased cell viability in CHO and Hela cells in a concentration- and time-dependent manner. The IC50 values for Hela and CHO cells were 4.0 × 10^-5 and 3.2 × 10^-5 mol/L, respectively. Together, these results indicated that cis-BF induced chronic toxicity in both aquatic invertebrate animals and mammalian cells. These findings assist in understanding the impact of SPs on health and environmental safety. Considering the wide spectrum of SPs, a more comprehensive understanding of the negative effects is indispensible for planning future application and regulation of these pesticides. 展开更多
关键词 cis-bifenthrin Daphnia magna chronic toxicity cytotoxicity
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Cytotoxicity Study of a Novel Implant Material Modified by Microarc Oxidation 被引量:6
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作者 杨成 孟丽娥 +2 位作者 田原 黄韬 李源莹 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2006年第6期720-722,共3页
This study examined the cytotoxicity of a new implant material modified by microarc oxidation technique. Cells on different surfaces of the implant were evaluated 2, 4 and 6 days after treatment. The results showed th... This study examined the cytotoxicity of a new implant material modified by microarc oxidation technique. Cells on different surfaces of the implant were evaluated 2, 4 and 6 days after treatment. The results showed that cell attachment, cell morphology, and cell proliferation were influenced by the different surface treatments, and a significant increase in the osteoblast cell activity was observed on the porous MAO-Ti coating. Our results suggest that the porous MAO-Ti surface has a better biocompatibility and electrochemical performance than pure titanium surface. 展开更多
关键词 implant material TITANIUM cytotoxicity MTT
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Cytotoxicity and Apoptosis Induction in Human HepG2 Hepatoma Cells by Decabromodiphenyl Ethane 被引量:6
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作者 SUN Ru Bao XI Zhu Ge +1 位作者 YAN Jun YANG Hong Lian 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第5期495-501,共7页
Abstract Objective To investigate the toxic effects of decabromodiphenyl ethane (DBDPE), used as an alternative to decabromodiphenyl ether in vitro. Methods HepG2 cells were cultured in the presence of DBDPE at vari... Abstract Objective To investigate the toxic effects of decabromodiphenyl ethane (DBDPE), used as an alternative to decabromodiphenyl ether in vitro. Methods HepG2 cells were cultured in the presence of DBDPE at various concentrations (3.125-100.0 mg/L) for 24, 48, and 72 h respectively and the toxic effect of DBDPE was studied. Results As evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and lactate dehydrogenase assays and nuclear morphological changes, DBDPE inhibited HepG2 viability in a time- and dose-dependent manner within a range of 12.5 mg/L to 100 mg/L and for 48 h and 72 h. Induction of apoptosis was detected at 12.5-100 mg/L at 48 h and 72 h by propidium iodide staining, accompanied with overproduction of reactive oxygen species (ROS). Furthermore, N-acetyI-L-cysteine, a widely used ROS scavenger, significantly reduced DBDPE-induced ROS levels and increased HepG2 cells viability. Conclusion DBDPE has cytotoxic and anti-proliferation effect and can induce apoptosis in which ROS plays an important role 展开更多
关键词 APOPTOSIS cytotoxicity Decabromodiphenyl ethane Flame retardants Reactive oxygenspecies
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Antimicrobial activity,cytotoxicity,and phytochemical screening of Voacanga globosa(Blanco) Merr.leaf extract(Apocynaceae) 被引量:5
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作者 Pierangeli G Vital Windell L Rivera 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第10期824-828,共5页
Objective:To determine the antibacterial,antifungal,antiprotozoal,cytotoxic,and phytochemical properties of ethanol extracts of leaves of Voacanga globosa(Blanco) Merr.(V.globosa). Methods:The extracts were tested aga... Objective:To determine the antibacterial,antifungal,antiprotozoal,cytotoxic,and phytochemical properties of ethanol extracts of leaves of Voacanga globosa(Blanco) Merr.(V.globosa). Methods:The extracts were tested against bacteria and fungus through disc diffusion assay; against protozoa through growth curve determination,antiprotozoal and cytotoxicity assays. Results:The extract revealed antibacterial activities,inhibiting the growth of Staphylococcus aureus,Bacillus cereus,Pseudomonas aeruginosa,Micrococcus luteus,and Salmonella typhimurium.Antifungal assay showed that it inhibited Candida albicans.The antiprotozoal assay against Trichomonas vaginalis and Entamoeba histolytica showed that V.globosa can inhibit the parasites,wherein the action can be comparable to metronidazole.With the in situ cell death detection kit.Trichomonas vaginalis and Entamoeba histolytica exposed to V.globosa leaf extract was observed to fluoresce simultaneously in red and yellow signals signifying apoptotic-like changes.Preliminary phytochemical screening revealed the chemical composition of plant extract containing alkaloids,saponins,2-deoxysugars,and hydrolysabie tannins.Conclusions: Thus,thus study provides scientific evidence on the traditional use of V.globosa leaf extract in treating microbial diseases.Further,the leaf extract can possibly be used to produce alternative forms of antimicrobials. 展开更多
关键词 Leaf extract Antibacterial ANTIFUNGAL ANTIPROTOZOAL cytotoxIC PHYTOCHEMICAL screening Voacanga GLOBOSA
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Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf 被引量:11
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作者 Mahendra Jain Rakhee Kapadia +3 位作者 Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2011年第6期443-447,共5页
Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fr... Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. 展开更多
关键词 Feronia limonia LEAF HepG2 cytotoxicity HEPATOPROTECTIVE PHYTOCHEMICAL analysis TLC HPLC HEPATOPROTECTIVE activity SGPT SGOT Isolated compound Spectroscopic assay
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Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines 被引量:4
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作者 Xin Zhai Juan Li +3 位作者 Lei He Su Zheng Yao Bin Zhang Ping Gong 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第1期29-32,共4页
Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR,1H NMR, 13C NMR, MS and elemental analysis. Their in vitro cytoto... Eight novel 1,4-disubstituted phthalazines (7-14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR,1H NMR, 13C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT- 1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin. 2007 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Phthalazine derivatives SYNTHESIS cytotoxicity
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Cytotoxicity screening of Melastoma malabathricum extracts on human breast cancer cell lines in vitro 被引量:3
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作者 Nurfariza Ahmad Roslen Nur Aizura Mat Alewi +1 位作者 Hadji Ahamada Mohammad Syaiful Bahari Abdull Rasad 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2014年第7期545-548,共4页
Objective:To screen the cytotoxic activity of Melasloma malabathricum(M,malubathricum)against human breast carreer cell line(MCF-7)in vitro.Methods:A three steps extraction protocol using n-hexane,chloroform and metha... Objective:To screen the cytotoxic activity of Melasloma malabathricum(M,malubathricum)against human breast carreer cell line(MCF-7)in vitro.Methods:A three steps extraction protocol using n-hexane,chloroform and methanol as the solvents systems was carried out on leaves,stems and flowers of M.nalabathricum.Dimethyl sulfoxide was used in extracts dilution and serial dilutions were conducted to obtain five different extract concentrations(100μg/mL,50μg/mL,25μg/mL,123μg/rnL and 6.25μg/mL).The evaluation of cell growth was determined using methylene blue assay.Results:Methanol extract from the leaves showed significant anticancer activity against MCF-7cell lines with the TC_(50)value of 7.14μg/ml while methanol and chloroform extract from the flowers exhibited a moderate activity towards MCF-7 cell line,with the IC_(50)value of 33.63μg/mL and 45.76μg/mL respectively after 72 h of treatment.Conclusions:The extracts from leaves and flowers of M.nulabatkricum showed promising anticancer activity toward human breast cancer cell lines with the lowest IC_(50)at 7.14μg/mL while the extracts from stems showed less growth inhibition activity. 展开更多
关键词 Melastoma malabathricum cytotoxicity Human BREAST CANCER MCF-7
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Cytotoxicity of lambda-cyhalothrin on the macrophage cell line RAW 264.7 被引量:3
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作者 Quan Zhang, Cui Wang, Liwei Sun, Ling Li, Meirong Zhao Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China. 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2010年第3期428-432,共5页
The wide use and wide-spectrum toxicity of synthetic pyrethroids (SPs) insecticides make them an emerging ecotoxicological concern. Some previous studies showed that SPs possessed cytotoxicity in some immune cells s... The wide use and wide-spectrum toxicity of synthetic pyrethroids (SPs) insecticides make them an emerging ecotoxicological concern. Some previous studies showed that SPs possessed cytotoxicity in some immune cells such as human lymphocytes and rat bone marrow. However, the cytotoxicity of SPs to macrophages, which are crucial to innate immunity, has not been explored. In the present report, we investigated a new pyrethroid insecticide, lambda-cyhalothrin (LCT), which may increase the generation of reactive oxygen species (ROS) and DNA damage levels and cause cytotoxicity in RAW 264.7 cells in dose- and time-dependent manners. The results for the first time implicated increased endogenous ROS and DNA damage as co-mediators of LCT-induced cytotoxicity in macrophages. Our results also suggested that macrophages were involved in synthetic pyrethroid-induced adverse immune effects. Considering the ubiquitous environmental presence of SPs, this study provided new information relative to the potential long-term physiological and immunological effects associated with chronic exposure to SPs. Hence, the potential immunotoxicity of SPs should be considered in assessing the safety of these compounds in sensitive environmental compartments. 展开更多
关键词 LAMBDA-CYHALOTHRIN MACROPHAGE reactive oxygen species cytotoxicity
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