Objective: To compare the efficacy of a short messaging service (SMS) text messaging and phone reminder to im-prove attendance rates at a health promotion center. Methods: A total of 1 859 participants who had schedul...Objective: To compare the efficacy of a short messaging service (SMS) text messaging and phone reminder to im-prove attendance rates at a health promotion center. Methods: A total of 1 859 participants who had scheduled appointments in the health promotion center of our hospital from April 2007 to May 2007 were enrolled in the study and randomly assigned into 3 groups: control (no reminder) group,SMS text messaging reminder group and telephone reminder group. Attendance rates and costs of interventions were collected. Results: A total of 1848 participants were eligible for analysis. Attendance rates of control,SMS and telephone groups were 80.5%,87.5% and 88.3%,respectively. The attendance rates were significantly higher in SMS and telephone groups than that in the control group,with odds ratio 1.698,95% confidence interval 1.224 to 2.316,P=0.001 in the SMS group,and odds ratio 1.829,95% confidence interval 1.333 to 2.509,P<0.001 in the telephone group. However,there was no difference between the SMS group and the telephone group (P=0.670). The cost effectiveness analysis showed that the cost per attendance for the SMS group (0.31 Yuan) was significantly lower than that for the telephone group (0.48 Yuan). Conclusion: SMS and telephone are effective reminders for improving attendance rate at a health promotion center. SMS reminder may be more cost-effective compared with the telephone reminder.展开更多
Background: Ginkgo biloba extract EGb 761<sup>®</sup> is widely used to treat various types of vertigo. Aims: An exploratory trial was conducted to evaluate the efficacy of EGb 761<sup>&...Background: Ginkgo biloba extract EGb 761<sup>®</sup> is widely used to treat various types of vertigo. Aims: An exploratory trial was conducted to evaluate the efficacy of EGb 761<sup>®</sup> in addition to vestibular exercises in central vestibular vertigo caused by vertebro-basilar ischaemia. Subjects and Methods: In this randomised, placebo-controlled, double-blind trial, 40 patients were enrolled in the vertigo clinic of a neurological university hospital and treated with daily doses of 240 mg EGb 761<sup>®</sup> or placebo for a period of 180 days. All patients regularly performed vestibular exercises in addition. Efficacy was assessed using: a visual analogue scale for the patients to rate the overall intensity of vertigo;a numeric scale for physician-rated change;a vertigo score based on intensity, duration, and frequency of vertigo;and electronystagmography. Results: Until day 180, the mean patient-rated intensity of vertigo decreased by 46% during EGb 761<sup>®</sup> treatment and by 19% with placebo (p <sup>®</sup> group compared to the placebo group. Nystagmus or other eye movement disorders were present only in small subgroups of patients without sufficient statistical power to detect differences between treatment groups. Conclusions: EGb 761<sup>®</sup> alleviated vertigo caused by ischaemic lesions in the brainstem or cerebellum in patients undergoing vestibular exercises.展开更多
Objective To observe the clinical effect of acupuncture in combination with medicine in the treatment of mild cognitive impairment after cerebral infarction as well as the impact on patients＇ daily living ability. Me...Objective To observe the clinical effect of acupuncture in combination with medicine in the treatment of mild cognitive impairment after cerebral infarction as well as the impact on patients＇ daily living ability. Methods Seventy-two patients, in accordance with random number table, were divided into two groups, acupuncture combined with western medicine group （group A） and western medicine group （group B）, each group with 36 patients. In combination with nimodipine tablets, acupuncture which can regulate the mind and reinforce the intelligence [making Baihui （百会 GV 20）, Sishencong （四神聪EX-HN 1）, Sibai （四白 ST 2）, Fengchi （风池 GB 20）, Wanggu （完骨 GB 12）, Tianzhu （天柱 BL 10）, Shenmen （神门 HT 7）, Neiguan （内关 PC 6）, Shuigou （水沟 GV 26）, Sanyinjiao （三阴交 SP 6）, Taichong （太冲 LR 3）, Fenglong （丰隆 ST 40） as the main acupoints] was given in the treatment group （group A） while only nimodipine tablets were given in the control group （group B）. The efficacy of these two groups was evaluated by Montreal Cognitive Assessment （MoCA） Scale after the continuous treatment for three months. Results The remarkably effective rate was 69.4%.and the total effective rate was 91.7% in the treatment group, while the remarkably effective rate was 55.6% and the total effective rate was 80.6% in the control group; the differences between the two groups were statistically significant （P〈0.05）. When comparing the MoCA score before and after treatment, which was 20.23±4.67 before treatment and 26.84±3.87 after treatment in group A; 19.82±3.56 before treatment and 23.33±2.78 after treatment in group B, it was found that the score for both groups became higher after treatment than that before treatment. Furthermore, the increase of the score was higher in the treatment group （6.61±0.80） than that in the control group （3.51±0.78） and the differences were statistically significant （P〈0.05）. Conclusion Acupuncture, which can regulate the mind and reinforce the intelligence, combined with nimodipine tablets is an effective therapy for the treatment of mild cognitive impairment after cerebral infarction, which is superior to single treatment with nimodipine tablets.展开更多
Background:Randomized controlled trials(RCTs)are often considered the gold standard and the cornerstone for clinical practice.However,bibliometric studies on worldwide RCTs of ophthalmology published in the 21st centu...Background:Randomized controlled trials(RCTs)are often considered the gold standard and the cornerstone for clinical practice.However,bibliometric studies on worldwide RCTs of ophthalmology published in the 21st century have not been reported in detail yet.This study aims to perform a bibliometric study and visualization analysis of worldwide ophthalmologic RCTs in the 21st century.Methods:Global ophthalmologic RCTs from 2000 to 2022 were searched in the Web of Science Core Collection.The number of publications,country/region,institution,author,journal,and research hotspots of RCTs were analyzed using HistCite,VOSviewer,CiteSpace,and Excel software.Results:2366 institutions and 90 journals from 83 countries/regions participated in the publication of 1769 global ophthalmologic RCTs,with the United States leading in the number of volumes and research field,and the Moorfields Eye Hospital contributing to the most publications.Ophthalmology received the greatest number of publications and co-citations.Jeffrey S.Heier owned the most publications and Jost B.Jonas owned the most cocitations.The knowledge foundations of global ophthalmologic RCTs were mainly retinopathy,glaucoma,dry eye disease(DED),and cataracts,and anti-vascular endothelial growth factor(VEGF)therapy(ranibizumab),topical ocular hypotensive medication,laser trabeculoplasty.Anti-VEGF therapy for age-related macular degeneration(AMD),DME(diabetic macular edema),and DED,the use of new diagnostic tools,and myopia were the hottest research highlights.Anti-VEGF therapy,prompt laser,triamcinolone,and verteporfin photodynamic therapy for AMD,DME,and CNV(choroidal neovascularization),DED,myopia,and open-angle glaucoma were the research hotspots with the longest duration.The future research hotspots might be DED and the prevention and control of myopia.Conclusions:Overall,the number of global ophthalmologic RCTs in the 21st century was keeping growing,there was an imbalance between the regions and institutions,and more efforts are required to raise the quantity,quality,and global impact of high-quality clinical evidence in developing countries/regions.展开更多
[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF...[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF-level,and adverse reactions were analyzed.TSA 0.9 software was used to conduct sequential analysis of the total effective rate,and subgroup analysis was performed according to the average age of the experimental group.[Results]Single application of Compound Qingdai Capsule or in combination with other methods in the treatment of psoriasis was superior to non-Compound Qingdai Capsule group,and the side effects were less than non-Compound Qingdai Capsule group;the n≥40 year-old group had certain heterogeneity,suggesting that the difference was statistically significant,and the effective rate was higher than that of the control group.The funnel plot showed that the graph was asymmetrical,and there may be publication bias or the possibility of low-quality literature.The TSA results indicated that the actual sample size was far lower than the expected sample size,and the cumulative Z value did not reach the TSA cut-off value and more trials need to be included to confirm the efficacy.[Conclusions]Compound Qingdai Capsule has a clear curative effect on psoriasis,and its safety is high.This study can provide relevant evidence for the effectiveness of Chinese patent drugs(CPD)in treating psoriasis.展开更多
Objective To observe the clinical efficacy of acupuncture combined with speech rehabilitation training for post-stroke spasmodic dysphonia and compare the differences in efficacy among the therapy of acupuncture combi...Objective To observe the clinical efficacy of acupuncture combined with speech rehabilitation training for post-stroke spasmodic dysphonia and compare the differences in efficacy among the therapy of acupuncture combined with speech rehabilitation training and the monotherapy.Methods Two hundred and seventy cases of patients with post-stroke spasmodic dysarthria were randomly divided into three groups with the ratio of 1：1：1.Group A：acupuncture combined with speech rehabilitation training group（90 cases）,group B：acupuncture group（90 cases）,group C：speech rehabilitation training group（90 cases）.In the group B,acupuncture treatment was given at Baihui（百会 GV 20）,JTnjin（金津 EX-HN 12） and Yuye（玉液 EX-HN13） as well as tongue-three needles.In the group C,the treatment of speech rehabilitation training was provided.The two treatments mentioned above were combined in the group A.Patients were treated once a day for a month with improved Frenchay dysarthria rating scale as the indices of therapeutic effect evaluation.Results ① Group A：the cured and markedly effective rate was 88.7%,and total effective rate was 94.3%;group B：the cured and markedly effective rate was 44.2%and total effective rate was 81.4%;group C：the cured and markedly effective rate was 23.5%and total effective rate was 61.2%.Both the cured and markedly effective rate and the total effective rate in the group A were significantly higher than those in the group B or group C（all P0.05）;both the cured and markedly effective rate and the total effective rate in the group B were higher than those of group C（both P0.05）;② In comparison of functional recovery of tongue in accordance with the Frenchay dysarthria rating scale,the recovery rate of the tongue-stationary state was 71.74%in the group A,18.87%in the group B and 4.44%in the group C;the recovery rate of tongue lolling out was 66.23%in the group A,27.63%in the group B and 1.59%in the group C;the recovery rate of tongue up and down motion was 44.19%in the group A,4.94%in the group B and 1.35%in the group C;the recovery rate of lateral motion was 40.24%in the group A,7.59%in the group B and 0.00%in the group C;the recovery rate of alternating motion was 29.07%in the group A,7.14%in the group B and 1.23%in the group C;the recovery rate of speech was 29.07%in the group A,5.88%in the group B and 1.22%in the group C.In the three groups,the recovery rates of stationary state and tongue lolling out were superior to those of up and down movement,lateral movement,alternating movement and speech（all P0.05）.Conclusion The clinical efficacy of acupuncture combined with speech rehabilitation training for patients with post-stroke spasmodic dysarthria is significant,and the efficacy of acupuncture is superior to that of speech rehabilitation training;as for functional recovery of tongue like stationary state and tongue out,the therapy of acupuncture combined with speech rehabilitation training is effective.展开更多
Objective To observe the clinical effect of acupoint catgut embedding combined with abdominal acupuncture for treatment of abdominal obesity under the theoretical guidance of regulating the three energizer.Methods One...Objective To observe the clinical effect of acupoint catgut embedding combined with abdominal acupuncture for treatment of abdominal obesity under the theoretical guidance of regulating the three energizer.Methods One hundred and twenty patients were randomly divided into acupoint catgut embedding group（group A）,abdominal acupuncture group（group B）,acupoint catgut embedding combined with abdominal acupuncture group（group C） and blank control group（group D） based on blocked random method,with 30 cases each;the first three groups based on the principle of regulating three energizer were respectively given acupoint catgut embedding at Zhongwan（中脘 CV12）,Tianshu（天枢 ST 25）,Yinjiao（阴交 CV 7）,Zhigou（支沟 TE 6）,Guanyuan（关元 CV 4）,Zusanli（足三里 ST 36） with catgut embedding once every 7 days,three times for each course of treatment,abdominal acupuncture once every3 days,seven times for each course of treatment.Results The therapeutic effect of each group after treatment was respectively 46.7%（14/30）,43.3%（13/30）,76.7%（23/30） and 26.7%（8/30）,with statistically significant difference.For comparison of waist circumference difference,there was no statistical significance between acupoint catgut embedding combined with abdominal acupuncture and acupoint catgut embedding group（P=0.54）,and for comparison of weight difference,there was statistical significance in terms of therapeutic effect between acupoint catgut embedding combined with abdominal acupuncture and A,B,D groups（4.49±0.59 vs 2.64±0.53,2.87±0.44,1.45±0.26,all P〈0.05）.Conclusion Acupoint catgut embedding combined with abdominal acupuncture had the best effect in terms of total effective rate for treatment of abdominal obesity,equivalent therapeutic effect to simple acupoint catgut embedding in terms of waist circumference reduction,and the best therapeutic effect in terms of weight reduction.展开更多
目的:运用网状Meta分析评价7种不同饮食模式对妊娠期糖尿病血糖及妊娠结局的影响。方法:对中国知网(CNKI)、万方、维普网(VIP)、SinoMed、PubMed、Embase、Web of Science、Cochrane Library等中英文数据库进行系统检索,检索时间为建库...目的:运用网状Meta分析评价7种不同饮食模式对妊娠期糖尿病血糖及妊娠结局的影响。方法:对中国知网(CNKI)、万方、维普网(VIP)、SinoMed、PubMed、Embase、Web of Science、Cochrane Library等中英文数据库进行系统检索,检索时间为建库至2023年3月。由2名研究者独自进行文献的筛选与资料的提取,采用Cochrane偏倚风险评估工具进行质量评价,运用Review Manager5.4.1、Stata15.1软件进行数据分析。结果:共纳入25项研究,从空腹血糖方面看,网状Meta分析排序结果从优到劣依次为:低血糖指数饮食>低血糖指数饮食联合常规饮食>终止高血糖饮食(DASH)>低血糖负荷饮食>低碳水化合物饮食>低碳水化合物饮食联合DASH>常规饮食;从餐后2h血糖方面看,网状Meta分析排序结果从优到劣依次为:低血糖指数饮食>低血糖指数饮食联合常规饮食>低血糖负荷饮食>低碳水化合物饮食>常规饮食;从胰岛素抵抗方面看,网状Meta分析排序结果从优到劣依次为:DASH>低血糖指数饮食联合常规饮食>低血糖指数饮食>常规饮食;从不良妊娠结局发生率方面看,网状Meta排序结果从优到劣依次为:低血糖指数饮食>DASH>低血糖指数饮食联合常规饮食>低碳水化合物饮食>低血糖负荷饮食>常规饮食>低碳水化合物饮食联合DASH。结论:从空腹血糖、餐后2h血糖、不良妊娠结局发生率方面来看,低血糖指数饮食可达到良好的效果,在7种方法中概率排名第一。胰岛素抵抗方面,DASH排名第一。但是,还需更多有质量的随机对照试验予以进一步验证。展开更多
Objective To explore the best intervention time of peripheral facial paralysis （Bell＇ s palsy） treated with acupuncture-moxibustion and the clinical superiority of acupuncture-moxibustion by stages. Methods Multi- ...Objective To explore the best intervention time of peripheral facial paralysis （Bell＇ s palsy） treated with acupuncture-moxibustion and the clinical superiority of acupuncture-moxibustion by stages. Methods Multi- central large-sample randomized controlled trial was carried out. Nine hundred cases of Bell＇ s palsy were randomly divided into 5 treatment groups, named as acupuncture by stages group, acupuncture by stages with moxibustion group, acupuncture by stages with electroacupuncture group, acupuncture by stages with line-puncture on muscle region of meridian group and acupuncture without stages group. Four sessions of treatment were required in each group. The clinical curative effects of groups were assessed by House-Brackmann Scale, Facial Disability Index Scale and Degree of Facial Nerve Paralysis Scale during the enrollment, after 4 sessions of treatment, and during 1 and 3 months of follow-up after treatment. The systematic analysis of curative effects was provided in view of the intervention time and nerve localization of disease separately. Results The cure rates of intervention treatment were 50.1% （223/445） in acute stage and 52.1% （162/311） in resting stage, superior to that of 25.9% （35/135） in recovery stage （both P〈0.001）. There was no statistically significant differences in comparison of curative effect in 5 solutions at the same stage （all P〉0.05）. The effect of treatment intervened at acute stage was superior to that at recovery stage in acupuncture by stages group and acupuncture without stages group （both P〈0.01）. There were statistically significant differences in curative effect of the localization above and below chorda tympani nerve in acupuncture by stages with line-puncture on muscle region of meridian group （P〈0.01）. The curative effect of the localization below chorda tympani nerve was superior to that above the nerve. Conclusion The best intervention time for Bell＇ s palsy is at acute stage and resting stage, meaning 1 to 3 weeks after occurrence. All 5 solutions are clinical superiorities to Bell＇s palsy. Under the condition of limited medical sources, the simple filiform needle puncture is recommended at acute stage. For the patients with the disorder above chorda tympani nerve, line-puncture on muscle region of meridian is not recommended.展开更多
Objective To investigate the effect of moxibustion at Sanyinjiao （三阴交 SP 6） for uterine contraction pain in labor, and evaluate the safety of the parturient and newborn. Methods One hundred and seventy-four cases...Objective To investigate the effect of moxibustion at Sanyinjiao （三阴交 SP 6） for uterine contraction pain in labor, and evaluate the safety of the parturient and newborn. Methods One hundred and seventy-four cases of singleton pregnancy and cephalic presentation primipara were single blinded and randomly divided into three groups： observation group （59 cases）, placebo treated group （57 cases） and blank group （58 cases）.The observation group was treated with moxibustion at Sanyinjiao （三阴交 SP 6） for 30 min when the uterus cervix openning at 3 cm,the placebo treated group was treated with moxibustion at non-aeupoint for 30 min and the blank group was treated with routine labor nursing, the uterine contraction pain and the safety of the mother and infant were compared among three groups. Results （1） The uterine contraction pain was tested by Visual Analogue Scale （VAS）： the scores of VAS in the observation group were obviously decreased after 15 min and 30 min of moxibustion （both P〈0.05）, there were no obvious changes of the VAS scores in placebo treated group and the blank group, the scores of VAS in observation group decreased much more obviously than those in the other two groups （all P〈0.05）; （2）Midwife rating of the uterine contraction pain： after 30 min of moxibustion, the effective rate of labor analgesia was 69.5%（41/59） in observation group, which was higher than that of 45.6% （26/57） in placebo treated group and 43.1% （25/58） in blank group, with significant differences between them （both P〈0.05）; @The postpartum hemorrhage amount of the observation group was obviously lower than those of placebo treated group and blank group （both P〈0.05）; （4）The Apgar score of newborn was higher in observation group and placebo treated group than that of blank group （both P〈0.05）. Conclusion Moxibustion at Sanyinjiao （三阴交 SP 6） can relieve the uterine contraction pain, and has no side effect to mother and infant, it is one of the safe, effective and simple non-drug analgesia methods.展开更多
Objective To observe the therapeutic effect of moxibustion on pain, stiffness and physical dysfunction caused by knee osteoarthritis （KOA）, and make an assessment on the effectiveness and safety of this therapy. Met...Objective To observe the therapeutic effect of moxibustion on pain, stiffness and physical dysfunction caused by knee osteoarthritis （KOA）, and make an assessment on the effectiveness and safety of this therapy. Methods Fifty-nine cases of KOA were randomly divided into a moxibustion group （31 cases） and a sham-moxibustion group （28 cases）. The treatment of moxibustion was given at Nèixīyǎn （内膝眼 EX-LE 4）, Dúbí （犊鼻 ST 35） and Ashi points with real moxa cone in the moxibustion group and sham moxa cone in the sham-moxibustion group, 3 cones on each point per time, once every two days, 3 times per week for consecutively 6 weeks. The results were recorded in week 3 and 6 of the treatment, and the follow-up visit was performed 6 weeks after the end of treatment. The Western Ontario and Mcmaster Universities Osteoarthritis Index （WOMAC） and the shortest walking time of 46 m were adopted to evaluate the recovery situation of joint function. The UT-325 digital thermal detector was put to use to record the temperature change in the most obvious painful points of knee joint before and after the moxibustion. Results All the scores of WOMAC in the moxibustion group were apparently decreased in week 3 and 6 of the treatment as well as the follow-up visit, separately （P〈0.05, P〈0.01, P〈0.001）. The stiffness score of follow-up visit in the sham-moxibustion group, compared before the treatment, was lowered （P〈0.05）. The scores of pain, stiffness and physical function in the moxibustion group had a greater decrease than those in the sham-moxibustion group in week 6 of treatment and the follow-up visit （P〈0.01, P〈0.05）. The shortest walking time of 46 m in the moxibustion group after 6 weeks of the treatment was apparently reduced as compared with that before treatment （P〈0.01）, but there was no apparent improvement in the sham-moxibustion group （P〉0.05）, and the between-group difference was not significant statistically （P〉0.05）. The temperature of treatment point after the moxibustion was （49.81±3.10）？℃ in the moxibustion group and （40.98±1.67）？℃ in the sham-moxibustion group, which was both increased apparently as compared with that before the treatment （P〈0.001, P〈0.01）, and more obviously in the moxibustion group （P〈0.001）. Conclusion The moxibustion, which can obviously improve the clinical symptoms of the patients with KOA, such as pain, stiffness and physical dysfunction, is safe and effective.展开更多
基金Project supported by the Health Promotion Center of Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
文摘Objective: To compare the efficacy of a short messaging service (SMS) text messaging and phone reminder to im-prove attendance rates at a health promotion center. Methods: A total of 1 859 participants who had scheduled appointments in the health promotion center of our hospital from April 2007 to May 2007 were enrolled in the study and randomly assigned into 3 groups: control (no reminder) group,SMS text messaging reminder group and telephone reminder group. Attendance rates and costs of interventions were collected. Results: A total of 1848 participants were eligible for analysis. Attendance rates of control,SMS and telephone groups were 80.5%,87.5% and 88.3%,respectively. The attendance rates were significantly higher in SMS and telephone groups than that in the control group,with odds ratio 1.698,95% confidence interval 1.224 to 2.316,P=0.001 in the SMS group,and odds ratio 1.829,95% confidence interval 1.333 to 2.509,P<0.001 in the telephone group. However,there was no difference between the SMS group and the telephone group (P=0.670). The cost effectiveness analysis showed that the cost per attendance for the SMS group (0.31 Yuan) was significantly lower than that for the telephone group (0.48 Yuan). Conclusion: SMS and telephone are effective reminders for improving attendance rate at a health promotion center. SMS reminder may be more cost-effective compared with the telephone reminder.
文摘Background: Ginkgo biloba extract EGb 761<sup>®</sup> is widely used to treat various types of vertigo. Aims: An exploratory trial was conducted to evaluate the efficacy of EGb 761<sup>®</sup> in addition to vestibular exercises in central vestibular vertigo caused by vertebro-basilar ischaemia. Subjects and Methods: In this randomised, placebo-controlled, double-blind trial, 40 patients were enrolled in the vertigo clinic of a neurological university hospital and treated with daily doses of 240 mg EGb 761<sup>®</sup> or placebo for a period of 180 days. All patients regularly performed vestibular exercises in addition. Efficacy was assessed using: a visual analogue scale for the patients to rate the overall intensity of vertigo;a numeric scale for physician-rated change;a vertigo score based on intensity, duration, and frequency of vertigo;and electronystagmography. Results: Until day 180, the mean patient-rated intensity of vertigo decreased by 46% during EGb 761<sup>®</sup> treatment and by 19% with placebo (p <sup>®</sup> group compared to the placebo group. Nystagmus or other eye movement disorders were present only in small subgroups of patients without sufficient statistical power to detect differences between treatment groups. Conclusions: EGb 761<sup>®</sup> alleviated vertigo caused by ischaemic lesions in the brainstem or cerebellum in patients undergoing vestibular exercises.
基金Supported by Special Research Project for Practice Development of National TCM Clinical Research Base,State Administration of Traditional Chinese Medicine(JDZX 2012139)
文摘Objective To observe the clinical effect of acupuncture in combination with medicine in the treatment of mild cognitive impairment after cerebral infarction as well as the impact on patients＇ daily living ability. Methods Seventy-two patients, in accordance with random number table, were divided into two groups, acupuncture combined with western medicine group （group A） and western medicine group （group B）, each group with 36 patients. In combination with nimodipine tablets, acupuncture which can regulate the mind and reinforce the intelligence [making Baihui （百会 GV 20）, Sishencong （四神聪EX-HN 1）, Sibai （四白 ST 2）, Fengchi （风池 GB 20）, Wanggu （完骨 GB 12）, Tianzhu （天柱 BL 10）, Shenmen （神门 HT 7）, Neiguan （内关 PC 6）, Shuigou （水沟 GV 26）, Sanyinjiao （三阴交 SP 6）, Taichong （太冲 LR 3）, Fenglong （丰隆 ST 40） as the main acupoints] was given in the treatment group （group A） while only nimodipine tablets were given in the control group （group B）. The efficacy of these two groups was evaluated by Montreal Cognitive Assessment （MoCA） Scale after the continuous treatment for three months. Results The remarkably effective rate was 69.4%.and the total effective rate was 91.7% in the treatment group, while the remarkably effective rate was 55.6% and the total effective rate was 80.6% in the control group; the differences between the two groups were statistically significant （P〈0.05）. When comparing the MoCA score before and after treatment, which was 20.23±4.67 before treatment and 26.84±3.87 after treatment in group A; 19.82±3.56 before treatment and 23.33±2.78 after treatment in group B, it was found that the score for both groups became higher after treatment than that before treatment. Furthermore, the increase of the score was higher in the treatment group （6.61±0.80） than that in the control group （3.51±0.78） and the differences were statistically significant （P〈0.05）. Conclusion Acupuncture, which can regulate the mind and reinforce the intelligence, combined with nimodipine tablets is an effective therapy for the treatment of mild cognitive impairment after cerebral infarction, which is superior to single treatment with nimodipine tablets.
基金The present study was supported by Medical Innovation and Development Project of Lanzhou University and Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital(Item No.CYXZ2023-09 and CYXZ2021-07).
文摘Background:Randomized controlled trials(RCTs)are often considered the gold standard and the cornerstone for clinical practice.However,bibliometric studies on worldwide RCTs of ophthalmology published in the 21st century have not been reported in detail yet.This study aims to perform a bibliometric study and visualization analysis of worldwide ophthalmologic RCTs in the 21st century.Methods:Global ophthalmologic RCTs from 2000 to 2022 were searched in the Web of Science Core Collection.The number of publications,country/region,institution,author,journal,and research hotspots of RCTs were analyzed using HistCite,VOSviewer,CiteSpace,and Excel software.Results:2366 institutions and 90 journals from 83 countries/regions participated in the publication of 1769 global ophthalmologic RCTs,with the United States leading in the number of volumes and research field,and the Moorfields Eye Hospital contributing to the most publications.Ophthalmology received the greatest number of publications and co-citations.Jeffrey S.Heier owned the most publications and Jost B.Jonas owned the most cocitations.The knowledge foundations of global ophthalmologic RCTs were mainly retinopathy,glaucoma,dry eye disease(DED),and cataracts,and anti-vascular endothelial growth factor(VEGF)therapy(ranibizumab),topical ocular hypotensive medication,laser trabeculoplasty.Anti-VEGF therapy for age-related macular degeneration(AMD),DME(diabetic macular edema),and DED,the use of new diagnostic tools,and myopia were the hottest research highlights.Anti-VEGF therapy,prompt laser,triamcinolone,and verteporfin photodynamic therapy for AMD,DME,and CNV(choroidal neovascularization),DED,myopia,and open-angle glaucoma were the research hotspots with the longest duration.The future research hotspots might be DED and the prevention and control of myopia.Conclusions:Overall,the number of global ophthalmologic RCTs in the 21st century was keeping growing,there was an imbalance between the regions and institutions,and more efforts are required to raise the quantity,quality,and global impact of high-quality clinical evidence in developing countries/regions.
基金National Key Research and Development Program"Key Special Project of Traditional Chinese Medicine Modernization Research"(2018YFC1705303)Innovative Talent Promotion Program-Key Technology Innovation Team Program(2017KCT-27)。
文摘[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF-level,and adverse reactions were analyzed.TSA 0.9 software was used to conduct sequential analysis of the total effective rate,and subgroup analysis was performed according to the average age of the experimental group.[Results]Single application of Compound Qingdai Capsule or in combination with other methods in the treatment of psoriasis was superior to non-Compound Qingdai Capsule group,and the side effects were less than non-Compound Qingdai Capsule group;the n≥40 year-old group had certain heterogeneity,suggesting that the difference was statistically significant,and the effective rate was higher than that of the control group.The funnel plot showed that the graph was asymmetrical,and there may be publication bias or the possibility of low-quality literature.The TSA results indicated that the actual sample size was far lower than the expected sample size,and the cumulative Z value did not reach the TSA cut-off value and more trials need to be included to confirm the efficacy.[Conclusions]Compound Qingdai Capsule has a clear curative effect on psoriasis,and its safety is high.This study can provide relevant evidence for the effectiveness of Chinese patent drugs(CPD)in treating psoriasis.
文摘Objective To observe the clinical efficacy of acupuncture combined with speech rehabilitation training for post-stroke spasmodic dysphonia and compare the differences in efficacy among the therapy of acupuncture combined with speech rehabilitation training and the monotherapy.Methods Two hundred and seventy cases of patients with post-stroke spasmodic dysarthria were randomly divided into three groups with the ratio of 1：1：1.Group A：acupuncture combined with speech rehabilitation training group（90 cases）,group B：acupuncture group（90 cases）,group C：speech rehabilitation training group（90 cases）.In the group B,acupuncture treatment was given at Baihui（百会 GV 20）,JTnjin（金津 EX-HN 12） and Yuye（玉液 EX-HN13） as well as tongue-three needles.In the group C,the treatment of speech rehabilitation training was provided.The two treatments mentioned above were combined in the group A.Patients were treated once a day for a month with improved Frenchay dysarthria rating scale as the indices of therapeutic effect evaluation.Results ① Group A：the cured and markedly effective rate was 88.7%,and total effective rate was 94.3%;group B：the cured and markedly effective rate was 44.2%and total effective rate was 81.4%;group C：the cured and markedly effective rate was 23.5%and total effective rate was 61.2%.Both the cured and markedly effective rate and the total effective rate in the group A were significantly higher than those in the group B or group C（all P0.05）;both the cured and markedly effective rate and the total effective rate in the group B were higher than those of group C（both P0.05）;② In comparison of functional recovery of tongue in accordance with the Frenchay dysarthria rating scale,the recovery rate of the tongue-stationary state was 71.74%in the group A,18.87%in the group B and 4.44%in the group C;the recovery rate of tongue lolling out was 66.23%in the group A,27.63%in the group B and 1.59%in the group C;the recovery rate of tongue up and down motion was 44.19%in the group A,4.94%in the group B and 1.35%in the group C;the recovery rate of lateral motion was 40.24%in the group A,7.59%in the group B and 0.00%in the group C;the recovery rate of alternating motion was 29.07%in the group A,7.14%in the group B and 1.23%in the group C;the recovery rate of speech was 29.07%in the group A,5.88%in the group B and 1.22%in the group C.In the three groups,the recovery rates of stationary state and tongue lolling out were superior to those of up and down movement,lateral movement,alternating movement and speech（all P0.05）.Conclusion The clinical efficacy of acupuncture combined with speech rehabilitation training for patients with post-stroke spasmodic dysarthria is significant,and the efficacy of acupuncture is superior to that of speech rehabilitation training;as for functional recovery of tongue like stationary state and tongue out,the therapy of acupuncture combined with speech rehabilitation training is effective.
文摘Objective To observe the clinical effect of acupoint catgut embedding combined with abdominal acupuncture for treatment of abdominal obesity under the theoretical guidance of regulating the three energizer.Methods One hundred and twenty patients were randomly divided into acupoint catgut embedding group（group A）,abdominal acupuncture group（group B）,acupoint catgut embedding combined with abdominal acupuncture group（group C） and blank control group（group D） based on blocked random method,with 30 cases each;the first three groups based on the principle of regulating three energizer were respectively given acupoint catgut embedding at Zhongwan（中脘 CV12）,Tianshu（天枢 ST 25）,Yinjiao（阴交 CV 7）,Zhigou（支沟 TE 6）,Guanyuan（关元 CV 4）,Zusanli（足三里 ST 36） with catgut embedding once every 7 days,three times for each course of treatment,abdominal acupuncture once every3 days,seven times for each course of treatment.Results The therapeutic effect of each group after treatment was respectively 46.7%（14/30）,43.3%（13/30）,76.7%（23/30） and 26.7%（8/30）,with statistically significant difference.For comparison of waist circumference difference,there was no statistical significance between acupoint catgut embedding combined with abdominal acupuncture and acupoint catgut embedding group（P=0.54）,and for comparison of weight difference,there was statistical significance in terms of therapeutic effect between acupoint catgut embedding combined with abdominal acupuncture and A,B,D groups（4.49±0.59 vs 2.64±0.53,2.87±0.44,1.45±0.26,all P〈0.05）.Conclusion Acupoint catgut embedding combined with abdominal acupuncture had the best effect in terms of total effective rate for treatment of abdominal obesity,equivalent therapeutic effect to simple acupoint catgut embedding in terms of waist circumference reduction,and the best therapeutic effect in terms of weight reduction.
文摘目的:运用网状Meta分析评价7种不同饮食模式对妊娠期糖尿病血糖及妊娠结局的影响。方法:对中国知网(CNKI)、万方、维普网(VIP)、SinoMed、PubMed、Embase、Web of Science、Cochrane Library等中英文数据库进行系统检索,检索时间为建库至2023年3月。由2名研究者独自进行文献的筛选与资料的提取,采用Cochrane偏倚风险评估工具进行质量评价,运用Review Manager5.4.1、Stata15.1软件进行数据分析。结果:共纳入25项研究,从空腹血糖方面看,网状Meta分析排序结果从优到劣依次为:低血糖指数饮食>低血糖指数饮食联合常规饮食>终止高血糖饮食(DASH)>低血糖负荷饮食>低碳水化合物饮食>低碳水化合物饮食联合DASH>常规饮食;从餐后2h血糖方面看,网状Meta分析排序结果从优到劣依次为:低血糖指数饮食>低血糖指数饮食联合常规饮食>低血糖负荷饮食>低碳水化合物饮食>常规饮食;从胰岛素抵抗方面看,网状Meta分析排序结果从优到劣依次为:DASH>低血糖指数饮食联合常规饮食>低血糖指数饮食>常规饮食;从不良妊娠结局发生率方面看,网状Meta排序结果从优到劣依次为:低血糖指数饮食>DASH>低血糖指数饮食联合常规饮食>低碳水化合物饮食>低血糖负荷饮食>常规饮食>低碳水化合物饮食联合DASH。结论:从空腹血糖、餐后2h血糖、不良妊娠结局发生率方面来看,低血糖指数饮食可达到良好的效果,在7种方法中概率排名第一。胰岛素抵抗方面,DASH排名第一。但是,还需更多有质量的随机对照试验予以进一步验证。
基金Supported by 11th Five-Year Plan for Science and Technology Project: 2006 BAI 12 B 03
文摘Objective To explore the best intervention time of peripheral facial paralysis （Bell＇ s palsy） treated with acupuncture-moxibustion and the clinical superiority of acupuncture-moxibustion by stages. Methods Multi- central large-sample randomized controlled trial was carried out. Nine hundred cases of Bell＇ s palsy were randomly divided into 5 treatment groups, named as acupuncture by stages group, acupuncture by stages with moxibustion group, acupuncture by stages with electroacupuncture group, acupuncture by stages with line-puncture on muscle region of meridian group and acupuncture without stages group. Four sessions of treatment were required in each group. The clinical curative effects of groups were assessed by House-Brackmann Scale, Facial Disability Index Scale and Degree of Facial Nerve Paralysis Scale during the enrollment, after 4 sessions of treatment, and during 1 and 3 months of follow-up after treatment. The systematic analysis of curative effects was provided in view of the intervention time and nerve localization of disease separately. Results The cure rates of intervention treatment were 50.1% （223/445） in acute stage and 52.1% （162/311） in resting stage, superior to that of 25.9% （35/135） in recovery stage （both P〈0.001）. There was no statistically significant differences in comparison of curative effect in 5 solutions at the same stage （all P〉0.05）. The effect of treatment intervened at acute stage was superior to that at recovery stage in acupuncture by stages group and acupuncture without stages group （both P〈0.01）. There were statistically significant differences in curative effect of the localization above and below chorda tympani nerve in acupuncture by stages with line-puncture on muscle region of meridian group （P〈0.01）. The curative effect of the localization below chorda tympani nerve was superior to that above the nerve. Conclusion The best intervention time for Bell＇ s palsy is at acute stage and resting stage, meaning 1 to 3 weeks after occurrence. All 5 solutions are clinical superiorities to Bell＇s palsy. Under the condition of limited medical sources, the simple filiform needle puncture is recommended at acute stage. For the patients with the disorder above chorda tympani nerve, line-puncture on muscle region of meridian is not recommended.
基金Supported by Tangshan Science and Technology Research and Development Projects: 08130206CScience and Technology Research Program Projects of Hebei CM Administration Bureau: 2009055
文摘Objective To investigate the effect of moxibustion at Sanyinjiao （三阴交 SP 6） for uterine contraction pain in labor, and evaluate the safety of the parturient and newborn. Methods One hundred and seventy-four cases of singleton pregnancy and cephalic presentation primipara were single blinded and randomly divided into three groups： observation group （59 cases）, placebo treated group （57 cases） and blank group （58 cases）.The observation group was treated with moxibustion at Sanyinjiao （三阴交 SP 6） for 30 min when the uterus cervix openning at 3 cm,the placebo treated group was treated with moxibustion at non-aeupoint for 30 min and the blank group was treated with routine labor nursing, the uterine contraction pain and the safety of the mother and infant were compared among three groups. Results （1） The uterine contraction pain was tested by Visual Analogue Scale （VAS）： the scores of VAS in the observation group were obviously decreased after 15 min and 30 min of moxibustion （both P〈0.05）, there were no obvious changes of the VAS scores in placebo treated group and the blank group, the scores of VAS in observation group decreased much more obviously than those in the other two groups （all P〈0.05）; （2）Midwife rating of the uterine contraction pain： after 30 min of moxibustion, the effective rate of labor analgesia was 69.5%（41/59） in observation group, which was higher than that of 45.6% （26/57） in placebo treated group and 43.1% （25/58） in blank group, with significant differences between them （both P〈0.05）; @The postpartum hemorrhage amount of the observation group was obviously lower than those of placebo treated group and blank group （both P〈0.05）; （4）The Apgar score of newborn was higher in observation group and placebo treated group than that of blank group （both P〈0.05）. Conclusion Moxibustion at Sanyinjiao （三阴交 SP 6） can relieve the uterine contraction pain, and has no side effect to mother and infant, it is one of the safe, effective and simple non-drug analgesia methods.
基金Supported by National 973 Project: 2009 CB 522901The Leading Academic Discipline Project of State Administra on of TCM and the City of Shanghai: S 30304The Scienfic and Technological Brainstorm Project of Shanghai: 11 DZ 1973300, 11 ZR 1436700
文摘Objective To observe the therapeutic effect of moxibustion on pain, stiffness and physical dysfunction caused by knee osteoarthritis （KOA）, and make an assessment on the effectiveness and safety of this therapy. Methods Fifty-nine cases of KOA were randomly divided into a moxibustion group （31 cases） and a sham-moxibustion group （28 cases）. The treatment of moxibustion was given at Nèixīyǎn （内膝眼 EX-LE 4）, Dúbí （犊鼻 ST 35） and Ashi points with real moxa cone in the moxibustion group and sham moxa cone in the sham-moxibustion group, 3 cones on each point per time, once every two days, 3 times per week for consecutively 6 weeks. The results were recorded in week 3 and 6 of the treatment, and the follow-up visit was performed 6 weeks after the end of treatment. The Western Ontario and Mcmaster Universities Osteoarthritis Index （WOMAC） and the shortest walking time of 46 m were adopted to evaluate the recovery situation of joint function. The UT-325 digital thermal detector was put to use to record the temperature change in the most obvious painful points of knee joint before and after the moxibustion. Results All the scores of WOMAC in the moxibustion group were apparently decreased in week 3 and 6 of the treatment as well as the follow-up visit, separately （P〈0.05, P〈0.01, P〈0.001）. The stiffness score of follow-up visit in the sham-moxibustion group, compared before the treatment, was lowered （P〈0.05）. The scores of pain, stiffness and physical function in the moxibustion group had a greater decrease than those in the sham-moxibustion group in week 6 of treatment and the follow-up visit （P〈0.01, P〈0.05）. The shortest walking time of 46 m in the moxibustion group after 6 weeks of the treatment was apparently reduced as compared with that before treatment （P〈0.01）, but there was no apparent improvement in the sham-moxibustion group （P〉0.05）, and the between-group difference was not significant statistically （P〉0.05）. The temperature of treatment point after the moxibustion was （49.81±3.10）？℃ in the moxibustion group and （40.98±1.67）？℃ in the sham-moxibustion group, which was both increased apparently as compared with that before the treatment （P〈0.001, P〈0.01）, and more obviously in the moxibustion group （P〈0.001）. Conclusion The moxibustion, which can obviously improve the clinical symptoms of the patients with KOA, such as pain, stiffness and physical dysfunction, is safe and effective.
