Cloud computing provides powerful processing capabilities for large-scale intelligent Internet of things(IoT)terminals.However,the massive realtime data processing requirements challenge the existing cloud computing m...Cloud computing provides powerful processing capabilities for large-scale intelligent Internet of things(IoT)terminals.However,the massive realtime data processing requirements challenge the existing cloud computing model.The edge server is closer to the data source.The end-edge-cloud collaboration offloads the cloud computing tasks to the edge environment,which solves the shortcomings of the cloud in resource storage,computing performance,and energy consumption.IoT terminals and sensors have caused security and privacy challenges due to resource constraints and exponential growth.As the key technology of IoT,Radio-Frequency Identification(RFID)authentication protocol tremendously strengthens privacy protection and improves IoT security.However,it inevitably increases system overhead while improving security,which is a major blow to low-cost RFID tags.The existing RFID authentication protocols are difficult to balance overhead and security.This paper designs an ultra-lightweight encryption function and proposes an RFID authentication scheme based on this function for the end-edge-cloud collaborative environment.The BAN logic proof and protocol verification tools AVISPA formally verify the protocol’s security.We use VIVADO to implement the encryption function and tag’s overhead on the FPGA platform.Performance evaluation indicates that the proposed protocol balances low computing costs and high-security requirements.展开更多
Polypeptides and polypeptoids were widely used as biomedical materials because of their good biocompatibility. In this work we reported a series of pH-responsive copolypeptides and polypeptide-polypeptoid block copoly...Polypeptides and polypeptoids were widely used as biomedical materials because of their good biocompatibility. In this work we reported a series of pH-responsive copolypeptides and polypeptide-polypeptoid block copolymers, i.e. random copolymers of L-glutamic acid (Glu) with L-leucine (Leu) [poly(Glu-r-Leu)s], as well as their block copolymers with polysarcosine (polySar). Well-defined poly(Glu-r-Leu)s with predictable compositions and molecular weights were synthesized by ring opening polymerization of corresponding N-carboxyanhydride monomers. We investigated the relationship between hydrophilicity-hydrophobicity transition and copolymer composition. With increasing Leu fraction, both the pH value of cloud point and the micellar size increased. Poly(Glu-r-Leu) with 60% Leu exhibited a cloud point at the pH of 5.0 to 6.0 the same as that in endosome and lysosome. Poly(Glu-r-Leu)-b-polySars assembled in phosphate buffer and performed pH-responsive morphology change from orbicular micelles at high pH to worm-like micelles at low pH. They were potential pH-responsive carriers for drug and gene delivery to enhance cargo release in cellules.展开更多
基金supported in part by the “Pioneer” and “Leading Goose” R&D Program of Zhejiang (Grant No. 2022C03174)the National Natural Science Foundation of China (No. 92067103)+4 种基金the Key Research and Development Program of Shaanxi (No.2021ZDLGY06- 02)the Natural Science Foundation of Shaanxi Province (No.2019ZDLGY12-02)the Shaanxi Innovation Team Project (No.2018TD007)the Xi’an Science and technology Innovation Plan (No.201809168CX9JC10)National 111 Program of China B16037
文摘Cloud computing provides powerful processing capabilities for large-scale intelligent Internet of things(IoT)terminals.However,the massive realtime data processing requirements challenge the existing cloud computing model.The edge server is closer to the data source.The end-edge-cloud collaboration offloads the cloud computing tasks to the edge environment,which solves the shortcomings of the cloud in resource storage,computing performance,and energy consumption.IoT terminals and sensors have caused security and privacy challenges due to resource constraints and exponential growth.As the key technology of IoT,Radio-Frequency Identification(RFID)authentication protocol tremendously strengthens privacy protection and improves IoT security.However,it inevitably increases system overhead while improving security,which is a major blow to low-cost RFID tags.The existing RFID authentication protocols are difficult to balance overhead and security.This paper designs an ultra-lightweight encryption function and proposes an RFID authentication scheme based on this function for the end-edge-cloud collaborative environment.The BAN logic proof and protocol verification tools AVISPA formally verify the protocol’s security.We use VIVADO to implement the encryption function and tag’s overhead on the FPGA platform.Performance evaluation indicates that the proposed protocol balances low computing costs and high-security requirements.
基金financially supported by the National Natural Science Foundation of China(Nos.21174122 and 51390481)
文摘Polypeptides and polypeptoids were widely used as biomedical materials because of their good biocompatibility. In this work we reported a series of pH-responsive copolypeptides and polypeptide-polypeptoid block copolymers, i.e. random copolymers of L-glutamic acid (Glu) with L-leucine (Leu) [poly(Glu-r-Leu)s], as well as their block copolymers with polysarcosine (polySar). Well-defined poly(Glu-r-Leu)s with predictable compositions and molecular weights were synthesized by ring opening polymerization of corresponding N-carboxyanhydride monomers. We investigated the relationship between hydrophilicity-hydrophobicity transition and copolymer composition. With increasing Leu fraction, both the pH value of cloud point and the micellar size increased. Poly(Glu-r-Leu) with 60% Leu exhibited a cloud point at the pH of 5.0 to 6.0 the same as that in endosome and lysosome. Poly(Glu-r-Leu)-b-polySars assembled in phosphate buffer and performed pH-responsive morphology change from orbicular micelles at high pH to worm-like micelles at low pH. They were potential pH-responsive carriers for drug and gene delivery to enhance cargo release in cellules.