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Efficiency Rankings of MBA Programs in Indian Top Public Colleges 被引量:3
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作者 Patrick Jaska Vedamuthu Kulandai Swamy 《Journal of Modern Accounting and Auditing》 2013年第9期1275-1279,共5页
This study examines the relative efficiency of the top 20 Indian public colleges that offer MBAs. These colleges were chosen from a list provided by Careers 360, a magazine in India known for its university rankings. ... This study examines the relative efficiency of the top 20 Indian public colleges that offer MBAs. These colleges were chosen from a list provided by Careers 360, a magazine in India known for its university rankings. The purpose of this study was to evaluate the colleges on an efficiency basis rather than on a total score ranking scale as is the common practice of most publications that rank universities or programs. The ranking method used in this study is based on data envelopment analysis (DEA), a nonparametric procedure for evaluating entities based upon examining inputs in relation to outputs achieved. The rankings using DEA were somewhat different than those given by Careers 360. The results of the DEA analysis of this study rank the universities that are the most efficient at getting students the best salaries and return on investment (ROI) based on the inputs of diversity, work experience, and residency. The authors conclude, as previous studies have shown, that DEA analysis is a useful and non-biased method of comparing university programs. 展开更多
关键词 aniversity academic rankings relative efficiency data envelopment analysis (DEA)
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Subject Area Risk Assessment of Four Hungarian Universities with a View to the QS University Rankings by Subject
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作者 Péter Sasvári Anna Urbanovics 《Journal of Data and Information Science》 CSCD 2022年第4期61-80,共20页
Purpose:The aim of our paper is to investigate the role of a mentor leading a research team in the overall scientific performance of an academic institution and the possible risks of their departure with a special att... Purpose:The aim of our paper is to investigate the role of a mentor leading a research team in the overall scientific performance of an academic institution and the possible risks of their departure with a special attention to their publication output.Design/methodology/approach:By using SciVal subject area data,we composed a formula describing the level of vulnerability of any given university in the case of losing any of its leading mentors,identifying other risk factors by dividing their careers into separate stages.Findings:It turns out that the higher field-weighed citation impact is,the better position universities reach in the rankings by subject and the vulnerability of institutions highly depends on the mentors,especially in view of their contribution to the topic clusters.Research limitations:The analysis covers the publication output of leading researchers working at four Hungarian universities,the scope of the analysis is worth being extended.Practical implications:Our analysis has the potential to give an applicable systemic approach as well as a data collection scheme to university managements so as to formulate an inclusive and comprehensive research strategy involving the introduction of a reward system aimed at publications and further encouraging national and international research cooperation.Originality/value:The methodology and the principles of risk assessment laid down in our paper are not restricted to measuring the vulnerability level of a limited group of academic institutions,they can be appropriately used for investigating the role of mentors or leading researchers at every university across the globe. 展开更多
关键词 QS rankings by Subject Scientific Competitiveness Risk Analysis Subject Area Exposure
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Switzerland Replaces United States at Top of Competitiveness Rankings
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《China Textile》 2009年第10期18-19,共2页
On Sep. 8,2009,Switzerland tops the overall ranking in The Global Competitiveness Report 2009-2010, released by the World Economic Forum ahead of its Annual Meeting of the New Champions 2009 in Dalian.
关键词 World Switzerland Replaces United States at Top of Competitiveness rankings
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Are University Rankings Statistically Significant?A Comparison among Chinese Universities and with the USA 被引量:1
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作者 Loet Leydesdorff Caroline SWagner Lin Zhang 《Journal of Data and Information Science》 CSCD 2021年第2期67-95,共29页
Purpose:Building on Leydesdorff,Bornmann,and Mingers(2019),we elaborate the differences between Tsinghua and Zhejiang University as an empirical example.We address the question of whether differences are statistically... Purpose:Building on Leydesdorff,Bornmann,and Mingers(2019),we elaborate the differences between Tsinghua and Zhejiang University as an empirical example.We address the question of whether differences are statistically significant in the rankings of Chinese universities.We propose methods for measuring statistical significance among different universities within or among countries.Design/methodology/approach:Based on z-testing and overlapping confidence intervals,and using data about 205 Chinese universities included in the Leiden Rankings 2020,we argue that three main groups of Chinese research universities can be distinguished(low,middle,and high).Findings:When the sample of 205 Chinese universities is merged with the 197 US universities included in Leiden Rankings 2020,the results similarly indicate three main groups:low,middle,and high.Using this data(Leiden Rankings and Web of Science),the z-scores of the Chinese universities are significantly below those of the US universities albeit with some overlap.Research limitations:We show empirically that differences in ranking may be due to changes in the data,the models,or the modeling effects on the data.The scientometric groupings are not always stable when we use different methods.Practical implications:Differences among universities can be tested for their statistical significance.The statistics relativize the values of decimals in the rankings.One can operate with a scheme of low/middle/high in policy debates and leave the more fine-grained rankings of individual universities to operational management and local settings.Originality/value:In the discussion about the rankings of universities,the question of whether differences are statistically significant,has,in our opinion,insufficiently been addressed in research evaluations. 展开更多
关键词 RANKING UNIVERSITY China Significance of differences INDICATORS
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Does a Country/Region's Economic Status Affect Its Universities' Presence in International Rankings?
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作者 Esteban Fernandez Tuesta Carlos Garcia-Zorita +1 位作者 Rosario Romera Ayllon Elias Sanz-Casado 《Journal of Data and Information Science》 CSCD 2019年第2期56-78,共23页
Purpose: Study how economic parameters affect positions in the Academic Ranking of World Universities' top 500 published by the Shanghai Jiao Tong University Graduate School of Education in countries/regions with ... Purpose: Study how economic parameters affect positions in the Academic Ranking of World Universities' top 500 published by the Shanghai Jiao Tong University Graduate School of Education in countries/regions with listed higher education institutions. Design/methodology/approach: The methodology used capitalises on the multi-variate characteristics of the data analysed. The multi-colinearity problem posed is solved by running principal components prior to regression analysis, using both classical(OLS) and robust(Huber and Tukey) methods. Findings: Our results revealed that countries/regions with long ranking traditions are highly competitive. Findings also showed that some countries/regions such as Germany, United Kingdom, Canada, and Italy, had a larger number of universities in the top positions than predicted by the regression model. In contrast, for Japan, a country where social and economic performance is high, the number of ARWU universities projected by the model was much larger than the actual figure. In much the same vein, countries/regions that invest heavily in education, such as Japan and Denmark, had lower than expected results.Research limitations: Using data from only one ranking is a limitation of this study, but the methodology used could be useful to other global rankings. Practical implications: The results provide good insights for policy makers. They indicate the existence of a relationship between research output and the number of universities per million inhabitants. Countries/regions, which have historically prioritised higher education, exhibited highest values for indicators that compose the rankings methodology; furthermore,minimum increase in welfare indicators could exhibited significant rises in the presence of their universities on the rankings.Originality/value: This study is well defined and the result answers important questions about characteristics of countries/regions and their higher education system. 展开更多
关键词 Academic Ranking of World Universities Socio-economic indicators Regression analysis
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Rankings of Universities and Power in the Digital Age
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作者 Mario Alberto Velazquez Garcia Lilian lvetthe Salado Rodriguez 《Sociology Study》 2015年第4期269-281,共13页
This paper will discuss one topic in the current debate on higher education: How power is exercised between universities? How do colleges determine what the best college is? What are the differences in the excersis... This paper will discuss one topic in the current debate on higher education: How power is exercised between universities? How do colleges determine what the best college is? What are the differences in the excersise of power in the digital age? The authors analyze one of the mechanisms of relationship and contact between different universities: the rankings. They will discuss the practices that allow certain values and organizations they are becoming central nodes between universities and the influences of the information and communication technologies in the measurement mechanisms. The authors seek to show the rankings serve as mechanisms to exercise power among universities. These measurements become a tool and justification in competition between universities for resources such as funding, prestige, and student demand. The analysis is based on the University of Mexico, the authors use the ranking of the best universities in Latin America and the best universities in Mexico. 展开更多
关键词 TECHNOLOGY POWER UNIVERSITY RANKING Mexico
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The Effect of Coding Method on Cause-of-Death Rankings
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作者 Peter Harteloh 《Open Journal of Statistics》 2023年第6期778-788,共11页
Background: Cause-of-death rankings are often used for planning or evaluating health policy measures. In the European Union, some countries produce cause-of-death statistics by a manual coding of death certificates, w... Background: Cause-of-death rankings are often used for planning or evaluating health policy measures. In the European Union, some countries produce cause-of-death statistics by a manual coding of death certificates, while other countries use an automated coding system. The outcome of these two different methods in terms of the selected underlying cause of death for statistics may vary considerably. Therefore, this study explores the effect of coding method on the ranking of countries by major causes of death. Method: Age and sex standardized rates were extracted for 33 European (related) countries from the cause-of-death registry of the European Statistical Office (Eurostat). Wilcoxon’s rank sum test was applied to the ranking of countries by major causes of death. Results: Statistically significant differences due to coding method were identified for dementia, stroke and pneumonia. These differences could be explained by a different selection of dementia or pneumonia as underlying cause of death and by a different certification practice for stroke. Conclusion: Coding method should be taken into account when constructing or interpreting rankings of countries by cause of death. 展开更多
关键词 Cause-of-Death Statistics Cause of Death RANKING Automated Coding Manual Coding EPIDEMIOLOGY Health Policy
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肉苁蓉苷A通过JNK/MAPK通路抑制破骨细胞活性
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作者 李岳尧 张民 杨家驹 《中国组织工程研究》 CAS 北大核心 2025年第6期1144-1151,共8页
背景:研究证实肉苁蓉苷A具有抗炎、抗氧化和抗骨质疏松的作用,但其对破骨细胞分化和功能的影响及潜在的机制尚缺少研究。目的:探讨肉苁蓉苷A对核因子κB受体活化因子配体诱导的体外破骨细胞分化和骨吸收功能的影响及作用机制。方法:提... 背景:研究证实肉苁蓉苷A具有抗炎、抗氧化和抗骨质疏松的作用,但其对破骨细胞分化和功能的影响及潜在的机制尚缺少研究。目的:探讨肉苁蓉苷A对核因子κB受体活化因子配体诱导的体外破骨细胞分化和骨吸收功能的影响及作用机制。方法:提取与培养4-6周龄C57BL/6小鼠股骨和胫骨中的骨髓巨噬细胞,采用CCK-8毒性实验检验不同浓度的肉苁蓉苷A(5,10,20,40,80,160μmol/L)对骨髓巨噬细胞的毒性,抗酒石酸酸性磷酸酶染色观察不同浓度的肉苁蓉苷A干预破骨细胞的分化情况,确定药物的有效干预浓度。将实验分为阳性对照组、肉苁蓉苷A低、中、高剂量组(40,80,160μmol/L),细胞贴壁后各组均加入50 ng/mL的核因子κB受体活化因子配体诱导破骨细胞分化,肉苁蓉苷A低、中、高剂量组分别加入相应剂量的肉苁蓉苷A进行干预。采用肌动蛋白环鬼笔环肽染色和DAPI染色检测肉苁蓉苷A对破骨细胞形成的影响;骨磨片甲苯胺蓝染色观察肉苁蓉苷A对破骨细胞骨吸收功能的影响;Western blot检测JNK/MAPK通路上下游蛋白的表达情况;RT-qPCR检测抗酒石酸酸性磷酸酶、DC-STAMP、Nfatc-1、Ctsk和c-Fos等破骨细胞分化和骨吸收功能相关基因的表达情况。结果与结论:①抗酒石酸酸性磷酸酶染色、肌动蛋白环染色和骨陷窝甲苯胺蓝染色结果表明,与阳性对照组相比,肉苁蓉苷A对核因子κB受体活化因子配体诱导的体外破骨细胞的分化和骨吸收功能具有呈剂量依赖性的显著抑制作用;②RT-qPCR结果表明,与阳性对照组相比,肉苁蓉苷A高剂量组和低剂量组的抗酒石酸酸性磷酸酶、DC-STAMP、Nfatc-1、Ctsk和c-Fos等的mRNA表达量均显著降低,且肉苁蓉苷A高剂量组的降低效果更加显著;③Western blot结果显示,高剂量肉苁蓉苷A干预10,20,30和60 min时显著抑制p-JNK蛋白的表达;与阳性对照组相比,肉苁蓉苷A低、中、高剂量组显著抑制Nfatc1和c-Fos蛋白的表达,且呈剂量依赖性;④结果说明,肉苁蓉苷A能够通过降低p-JNK蛋白水平,抑制MAPK通路的激活和破骨细胞关键基因的表达,进而抑制破骨细胞的形成和骨吸收功能。 展开更多
关键词 肉苁蓉苷A 破骨细胞 MAPK JNK RANKL RANK 骨质疏松 苯乙醇苷
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What Do Students Know about University Rankings?Testing Familiarity and Knowledge of Global and Domestic University League Tables in China
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作者 Ryan M.ALLEN 《Frontiers of Education in China》 2019年第1期59-89,共31页
While academics and university administrators often criticize rankings,league tables have become important tools for student decision-making,especially in the Chinese sector.Yet,research has not fully explored how stu... While academics and university administrators often criticize rankings,league tables have become important tools for student decision-making,especially in the Chinese sector.Yet,research has not fully explored how students in China have engaged with both global and local rankings,as most studies have focused on one setting or the other.Likewise,researchers have not tested students’knowledge of rankings,despite the intense focus on these actors by universities.Using a survey of over 900 students from Chinese universities,the author explored how knowledge of rankings varies in different student populations.Through multivariate analysis,it is found that students from elite institutions and those with educated parents were more attuned to university rankings in general.However,when testing students’knowledge of rankings,elite university students performed better in knowing their domestic ranking,but worse when guessing their global ranking,while associations to parental education disappeared.This study,the first of its kind in terms of testing student knowledge,illustrates that the impact from university rankings are mitigated by local and individual characteristics. 展开更多
关键词 China university rankings student perspective INTERNATIONALIZATION higher education metrics league tables
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Tangled Rankings
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作者 JING XIAOLEI 《Beijing Review》 2011年第25期18-19,共2页
Declining recognition of top university lists prompts China to look for new ways to evaluate its higher learning institutions Zhejiang University for the first time has overtaken Peking University and Tsinghua Univers... Declining recognition of top university lists prompts China to look for new ways to evaluate its higher learning institutions Zhejiang University for the first time has overtaken Peking University and Tsinghua University to rank No.1 on the latest list of Chinese college rankings.The rankings are an important part of the book Picking Your University 展开更多
关键词 Tangled rankings World
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RANKINGS
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作者 Kaylie 《网球大师》 2014年第11期141-142,共2页
关键词 德约科维奇 意大利 小威廉姆斯 阿扎伦卡 rankings 纳达尔 费雷尔
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ATP/WTA THE RANKINGS
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《网球》 2009年第11期172-173,共2页
关键词 费德勒 德约科维奇 ATP/WTA THE rankings 兹沃娜列娃 纳尔班迪安 罗迪克 克里斯特尔斯 特松加 德尔波特罗 阿扎伦卡 达维登科 WTA
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2003年女子单项总积分世界排名(World Rankings)
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《田径》 2003年第8期54-61,共8页
关键词 俄罗斯 罗马尼亚 南欧 World rankings 美国 美利坚合众国 北美洲 尼日利亚 肯尼亚 牙买加 乌克兰 斯洛文尼亚 2003 世界排名 积分 积分学 女子
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THE RANKINGS OF CONTROL SYSTEMS AND APPLICATIONS
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作者 ZHENG Yufan CAO Li Applied Mathematics Research Laboratory, East China Normal University, Shanghai 200062, China 《Systems Science and Mathematical Sciences》 SCIE EI CSCD 1993年第3期231-238,共8页
The notion of ranking was initiated into control theory by Glad a few yearsago. In this paper we mainly discuss one kind of rankings and study its invarianceproperties. This kind of rankings is closely related to the ... The notion of ranking was initiated into control theory by Glad a few yearsago. In this paper we mainly discuss one kind of rankings and study its invarianceproperties. This kind of rankings is closely related to the structure algorithm. The relationsbetween invariants of this kind of rankings and the invariants given by other studies, e.g.the invertibility indices of a system and so on, are examined. As applications of rankings,we deal with some well-known problems in "ranking technique". In this paper we mainlyintroduce a new method rather than solve new problems. 展开更多
关键词 Nonlinear CONTROL system differential VECTOR RANKING DECOUPLING CONTROL
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Joint regression and learning from pairwise rankings for personalized image aesthetic assessment
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作者 Jin Zhou Qing Zhang +2 位作者 Jian-Hao Fan Wei Sun Wei-Shi Zheng 《Computational Visual Media》 EI CSCD 2021年第2期241-252,共12页
Recent image aesthetic assessment methods have achieved remarkable progress due to the emergence of deep convolutional neural networks(CNNs).However,these methods focus primarily on predicting generally perceived pref... Recent image aesthetic assessment methods have achieved remarkable progress due to the emergence of deep convolutional neural networks(CNNs).However,these methods focus primarily on predicting generally perceived preference of an image,making them usually have limited practicability,since each user may have completely different preferences for the same image.To address this problem,this paper presents a novel approach for predicting personalized image aesthetics that fit an individual user’s personal taste.We achieve this in a coarse to fine manner,by joint regression and learning from pairwise rankings.Specifically,we first collect a small subset of personal images from a user and invite him/her to rank the preference of some randomly sampled image pairs.We then search for the K-nearest neighbors of the personal images within a large-scale dataset labeled with average human aesthetic scores,and use these images as well as the associated scores to train a generic aesthetic assessment model by CNN-based regression.Next,we fine-tune the generic model to accommodate the personal preference by training over the rankings with a pairwise hinge loss.Experiments demonstrate that our method can effectively learn personalized image aesthetic preferences,clearly outperforming state-of-the-art methods.Moreover,we show that the learned personalized image aesthetic benefits a wide variety of applications. 展开更多
关键词 s personalized image aesthetic assessment deep convolutional neural networks pairwise ranking regression
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miR-26a在血管钙化中的作用机制 被引量:1
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作者 吴伟 尚玉强 +2 位作者 程龙 王杰 杨传蕾 《中国老年学杂志》 CAS 北大核心 2024年第4期893-896,共4页
目的探讨血管钙化过程中miR-26a表达差异及其作用机制。方法通过体内和体外实验构建血管钙化模型,利用分子生物学、病理生物学及细胞生物学检测方法,验证血管钙化过程中miR-26a表达差异及可能作用机制。结果与模型组和mimic NC组相比较,... 目的探讨血管钙化过程中miR-26a表达差异及其作用机制。方法通过体内和体外实验构建血管钙化模型,利用分子生物学、病理生物学及细胞生物学检测方法,验证血管钙化过程中miR-26a表达差异及可能作用机制。结果与模型组和mimic NC组相比较,miR-26a mimic组碱性磷酸酶活性显著降低(P<0.05)。而inhibitor NC组和miR-26a inhibitor组碱性磷酸酶无显著变化(P>0.05)。与mimic NC组比较,miR-26a mimic组miR-26a、骨保护素(OPG)表达水平显著升高(P<0.05),而骨桥蛋白(OPN)、骨形态发生蛋白(BMP)-2和胶原蛋白(Collagen)Ⅱ表达水平显著降低(P<0.05)。与inhibitor NC组比较,miR-26a inhibitor组miR-26a、OPG、OPN、BMP-2和CollagenⅡ表达水平无显著差异(P>0.05)。结论miR-26a在血管钙化中的作用机制可能与OPG/核因子κB受体激活剂(RANK)/细胞核因子κB受体活化因子配体(RANKL)信号通路有关。 展开更多
关键词 miR-26a 骨保护素(OPG)/核因子κB受体激活剂(RANK)/细胞核因子κB受体活化因子配体(RANKL)信号通路 血管钙化
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全氟辛酸对成骨细胞骨形成和破骨细胞骨吸收作用研究
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作者 薛黎明 林元杰 +3 位作者 金玉娥 徐佳乐 卢大胜 汪国权 《日用化学工业(中英文)》 CAS 北大核心 2024年第6期648-655,共8页
考察全氟辛酸(PFOA)对成骨细胞骨形成和破骨细胞骨吸收的作用和机制,为探索PFOA暴露引起骨丢失提供科学依据。采用原代新生大鼠颅盖骨分离成骨细胞,考察1,10和100μmol/L PFOA对成骨细胞增殖,碱性磷酸酶(ALP)活性和骨结节形成的影响;采... 考察全氟辛酸(PFOA)对成骨细胞骨形成和破骨细胞骨吸收的作用和机制,为探索PFOA暴露引起骨丢失提供科学依据。采用原代新生大鼠颅盖骨分离成骨细胞,考察1,10和100μmol/L PFOA对成骨细胞增殖,碱性磷酸酶(ALP)活性和骨结节形成的影响;采用巨噬细胞集落刺激因子(M-CSF)及核因子κB受体激活因子配体(RANKL)诱导大鼠骨髓单核细胞分化破骨细胞模型,考察1,10和100μmol/L PFOA对破骨细胞活力,抗酒石酸酸性磷酸酶(TRAP)活性和骨吸收陷窝形成指标的影响;采用Western blot考察成骨细胞护骨素(OPG)和RANKL蛋白表达。PFOA在1和10μmol/L时促进成骨细胞活力,但对ALP活性和骨结节形成无影响。100μmol/L PFOA可显著抑制细胞增殖,ALP活性和骨结节形成,同时抑制OPG/RANKL蛋白表达的比例。PFOA对破骨细胞活力无影响,10和100μmol/L PFOA可显著抑制促进TRAP活性和骨吸收陷窝形成面积。PFOA抑制成骨细胞骨形成作用可能通过下调Wnt通路,通过抑制OPG/RANKL/RANK通路,促进破骨细胞骨吸收作用。 展开更多
关键词 全氟辛酸 骨丢失 成骨细胞 破骨细胞 OPG/RANKL/RANK通路
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Predicting Student Rankings Based on the Dual-Student Performance Comparison Model
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作者 Yijie Chen Zhengzhou Zhu 《国际计算机前沿大会会议论文集》 2022年第2期309-322,共14页
Currently,learning early warning mainly uses two methods,student classification and performance regression,both of which have some shortcomings.The granularity of student classification is not fine enough.The performa... Currently,learning early warning mainly uses two methods,student classification and performance regression,both of which have some shortcomings.The granularity of student classification is not fine enough.The performance regression gives an absolute score value,and it cannot directly show the position of a student in the class.To overcome the above shortcomings,we will focus on a rare learning early warning method-ranking prediction.We propose a dual-student performance comparison model(DSPCM)to judge the ranking relationship between a pair of students.Then,we build the model using data including class quiz scores and online behavior times and find that these two sets of features improve the Spearman correlation coefficient for the ranking prediction by 0.2986 and 0.0713,respectively.We also compare the process proposed with the method of first using a regression model to predict scores and then ranking students.The result shows that the Spearman correlation coefficient of the former is 0.1125 higher than that of the latter.This reflects the advantage of the DSPCM in ranking prediction. 展开更多
关键词 Learning early warning Student ranking prediction Class quiz score Online behavior time
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酒花提取物调控Wnt/β-catenin信号通路对去卵巢骨质疏松大鼠的作用及机制研究
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作者 李敏 扎克艳·地力夏提 +1 位作者 胡君萍 杨建华 《中药新药与临床药理》 CAS CSCD 北大核心 2024年第9期1337-1343,共7页
目的探讨酒花提取物对去卵巢骨质疏松大鼠的作用及机制。方法将60只雌性SD大鼠随机分为假手术组、模型组、阳性对照组(戊酸雌二醇,0.105 mg·kg^(-1))和酒花提取物低、中、高剂量组(65.625、131.120、196.875 mg·kg^(-1)),每... 目的探讨酒花提取物对去卵巢骨质疏松大鼠的作用及机制。方法将60只雌性SD大鼠随机分为假手术组、模型组、阳性对照组(戊酸雌二醇,0.105 mg·kg^(-1))和酒花提取物低、中、高剂量组(65.625、131.120、196.875 mg·kg^(-1)),每组10只。除假手术组外,其余各组大鼠均切除双侧卵巢,术后灌胃给药,每日1次,连续给药90 d。采用HE染色法观察大鼠骨组织病理形态变化,测定骨形态计量学参数,计算骨小梁数目(Tb.N)、骨小梁厚度(Tb.Th)、骨小梁分离度(Tb.Sp)和骨小梁面积百分数(Tb.Ar);测定大鼠骨组织生物力学指标:最大载荷、弹性模量、断裂强度;采用ELISA法测定大鼠血清雌激素(E_(2))、抗酒石酸酸性磷酸酶(TRACP5b)、骨钙素(OC)、骨特异性碱性磷酸酶(BALP)含量;采用全自动生化仪测定大鼠血清碱性磷酸酶(ALP)含量;采用RT-PCR及Western Blot法检测大鼠胫骨组织OPG、RANKL、ERα、ERβ、Wnt16、β-catenin mRNA及蛋白表达水平。结果与假手术组相比,模型组大鼠胫骨骨小梁断裂,骨髓腔变大,呈现骨质疏松结构;胫骨Tb.N、Tb.Th、Tb.Ar明显降低(P<0.05),Tb.Sp明显升高(P<0.05);股骨的最大载荷、弹性模量和断裂强度均明显降低(P<0.05);血清E_(2)含量明显降低(P<0.05),TRACP5b、OC、ALP、BALP含量均明显升高(P<0.05);胫骨组织的OPG、OPG/RANKL、ERα、ERβ、β-catenin、Wnt16 mRNA及蛋白表达明显下调(P<0.05),RANKL mRNA及蛋白表达明显上调(P<0.05)。与模型组相比,阳性对照组及酒花提取物高剂量组的上述指标均明显回调(P<0.05)。结论酒花提取物对绝经后骨质疏松症具有一定的防治作用,其作用机制可能与调控Wnt/β-catenin信号通路,进而调控OPG/RANK/RANKL信号通路有关。 展开更多
关键词 酒花提取物 骨质疏松症 去卵巢大鼠 WNT/Β-CATENIN信号通路 OPG/RANK/RANKL信号通路
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OPG/RANKL/RANK信号通路在脓毒症相关急性肾损伤小鼠中的研究
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作者 李辉 陈蔚霖 牛新荣 《海南医学院学报》 CAS 北大核心 2024年第3期168-174,共7页
目的:探讨骨保护素(OPG)/核因子⁃κB受体活化因子配体(RANKL)/核因子⁃κB受体激活因子(RANK)信号通路因子在脓毒症相关急性肾损伤(SA⁃AKI)小鼠中的改变及可能的作用,为SA⁃AKI的机制研究探索新的思路。方法:通过盲肠结扎穿孔手术(CLP)建... 目的:探讨骨保护素(OPG)/核因子⁃κB受体活化因子配体(RANKL)/核因子⁃κB受体激活因子(RANK)信号通路因子在脓毒症相关急性肾损伤(SA⁃AKI)小鼠中的改变及可能的作用,为SA⁃AKI的机制研究探索新的思路。方法:通过盲肠结扎穿孔手术(CLP)建立SA⁃AKI模型组(CLP组),对照组为假手术组(Sham组),只行开腹不做盲肠结扎穿孔操作。术后24 h采血并处死留取小鼠肾脏组织,用试剂盒检测血清Scr、BUN水平,酶联免疫测定法(ELISA)检验血清中IL⁃6、TNF⁃α、IL⁃1β水平,苏木精⁃伊红染色(HE)观测肾组织病理学变化,聚合酶链反应(RT⁃qPCR)和蛋白质印迹实验(Western blotting)检验小鼠肾组织中OPG、RANKL、RANK的mRNA和蛋白水平。结果:与Sham组对比,CLP组Scr、BUN、IL⁃6、TNF⁃α、IL⁃1β水平显著升高,差异均具有统计学意义(P<0.05);与Sham组对比,CLP组肾小球充血水肿,部分缺血皱缩,球囊间隙扩大,部分肾小管中可见坏死的上皮细胞,管腔扩大,肾间质水肿,少量炎性细胞浸润;与Sham组相比较,CLP组肾组织中OPG和RANK的mRNA表达显著上调,而RANKL的mRNA表达明显下降,差异均具有统计学意义(P<0.05);与Sham组相比较,CLP组肾脏组织中OPG及RANK的蛋白表达均升高,而RANKL的蛋白表达明显下降,差异均具有统计学意义(P<0.05)。结论:在脓毒症的小鼠模型中OPG及RANK表达升高,RANKL表达下降,表明OPG/RANKL/RANK信号通路可能参与了SA⁃AKI的病理生理过程。 展开更多
关键词 脓毒症 急性肾损伤 OPG/RANKL/RANK信号通路
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