Poly(1,1,2,2- tetrahydroperfluorodecyl acrylate) (poly (TA-N)) was synthesized in laboratory. The resulting morphology of rapid expansion of supercritical solution (RESS) sprays of poly(TA - N) was investigated. At ap...Poly(1,1,2,2- tetrahydroperfluorodecyl acrylate) (poly (TA-N)) was synthesized in laboratory. The resulting morphology of rapid expansion of supercritical solution (RESS) sprays of poly(TA - N) was investigated. At apre - expansion temperature of 45℃), amorphous polymer was formed. At temperature around 60 ℃ to 80 ℃ , fibers were formed. Increase of temperature increasesparticle size slightly. At temperature of 105℃ , most of particles are spheres. The RESS is an attractive process. To apply the polymers desired for coating applications in an organic solvent - free process that is economically viable , and it will have implications for pollution prevention during polymer film展开更多
A searching-machining system of RL & SM (Rapid Location and State Memory) universal fixture is here introduced, and the concept of rapid searching technology and manufacturing information transformation is then de...A searching-machining system of RL & SM (Rapid Location and State Memory) universal fixture is here introduced, and the concept of rapid searching technology and manufacturing information transformation is then described, with the appropriate control methods and key techniques for its realization being proposed and also practically realized. Theoretical analysis and experimental results show that the proposed idea and methods are feasible to serve as in the practical application of the RL & SM system.展开更多
BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased s...BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations.展开更多
The Bohai Bay Basin is a typical oil-prone basin, in which natural gas geological reserves have a small proportion. In this basin, the gas source rock is largely medium-deep lake mudstone with oil-prone type Ⅱ2-Ⅱ1 k...The Bohai Bay Basin is a typical oil-prone basin, in which natural gas geological reserves have a small proportion. In this basin, the gas source rock is largely medium-deep lake mudstone with oil-prone type Ⅱ2-Ⅱ1 kerogens, and natural gas preservation conditions are poor due to active late tectonic movements. The formation conditions of large natural gas fields in the Bohai Bay Basin have been elusive. Based on the exploration results of Bohai Bay Basin and comparison with large gas fields in China and abroad, the formation conditions of conventional large-scale natural gas reservoirs in the Bohai Bay Basin were examined from accumulation dynamics, structure and sedimentation. The results show that the formation conditions of conventional large natural gas reservoirs in Bohai Bay Basin mainly include one core element and two key elements. The core factor is the strong sealing of Paleogene "quilt-like" overpressure mudstone. The two key factors include the rapid maturation and high-intensity gas generation of source rock in the late stage and large scale reservoir. On this basis, large-scale nature gas accumulation models in the Bohai Bay Basin have been worked out, including regional overpressure mudstone enriching model, local overpressure mudstone depleting model, sand-rich sedimentary subsag depleting model and late strongly-developed fault depleting model. It is found that Bozhong sag, northern Liaozhong sag and Banqiao sag have favorable conditions for the formation of large-scale natural gas reservoirs, and are worth exploring. The study results have important guidance for exploration of large scale natural gas reservoirs in the Bohai Bay Basin.展开更多
We present a new strategy to estimate the geometry of a rupture on a finite fault for rapid reporting of seismic intensity. We use envelope attenuation relationships which were presented by Huo et al. （Acta Seismol S...We present a new strategy to estimate the geometry of a rupture on a finite fault for rapid reporting of seismic intensity. We use envelope attenuation relationships which were presented by Huo et al. （Acta Seismol Sin 16：519-525, 1994）. An important base of this work is the fault finiteness theory. We propose a new model to simulate high-frequency motions from earthquakes with large rupture dimension. The envelope of high-frequency ground motion from a large earthquake can be expressed as a rootmean-squared combination of envelope functions from smaller earthquakes. We use simulated envelopes of ground acceleration to estimate the direction and alongstrike length of a rupture. Using the Wenchuan and Jiji （Chi-Chi） earthquake dataset, we parameterize the fault geometry with an epicenter, a fault strike, and along-strike rupture lengths. So this methodology seems quite appropriate for the rapid reporting systems of seismic intensity.展开更多
Late-stage is defined here as the period when Neotectonism occurred since 5.1 Ma. Most petroliferous basins in China lie in the areas where Neotectonism occurred intensively. In recent years, Chinese petroleum geologi...Late-stage is defined here as the period when Neotectonism occurred since 5.1 Ma. Most petroliferous basins in China lie in the areas where Neotectonism occurred intensively. In recent years, Chinese petroleum geologists have paid much attention to late-stage petroleum accumulation. The PL19-3 giant oilfield is situated where faulting activities occurred violently during Neotectonism. To understand the mechanism of lat-stage rapid accumulation, we discussed the most important aspects responsible for the formation of the giant oilfield, including oil generation, active oil-source rock occurrence, fault activity and fault conduits, late-stage rapid oil injection as well as the distinguishing indicators. This study shows that: (1) sufficient oil was supplied to the PL19-3 field since 5.1 Ma because the PL19-3 structure was surrounded by four sags in which three intervals of high-quality source rocks remained active during Neotectonism; (2) densely distributed faults and high porosity/permeability sandstone carrier beds comprised the effective conduit system for oil migration and injection; (3) oil migrated along the faults and charged the PL19-3 structure rapidly by means of seismic pumping which was triggered by frequent earthquakes during Neotetonism. It is documented that elevated reservoir temperature, abnormal geothermal gradients and abnormally high homogenization temperatures of the fluid inclusions are the indicators for late-stage rapid oil accumulation.展开更多
The crystalline sponge method is a pragmatic and promising strategy for molecular structure determination.However,the dominant metal-organic framework crystal sponge platforms always face poor chemical stability,espec...The crystalline sponge method is a pragmatic and promising strategy for molecular structure determination.However,the dominant metal-organic framework crystal sponge platforms always face poor chemical stability,especially solvent instability,hampering their application in a vaster domain.Herein,we report an ultrastable π-π stacked porous organic molecular framework which exhibits permanent porosity,high thermal stability,and good chemical resistance.It can efficiently implement an approach to molecular structure determination via a single-crystal-to-single-crystal transformation.This is the first example utilizing π-π stacked porous organic molecular framework as“crystalline sponge”to determine a wide variety of guests,ranging from hydrophilic to hydrophobic,and from aliphatic to aromatic,which complements the crystalline sponges based on the famous metal-organic frameworks.More importantly,it can achieve rapid structure determination of small molecules within 3 h.展开更多
This paper presents an investigation on depo- sition of Inconel-625 using laser rapid manufacturing （LRM） and plasma transferred arc （PTA） deposition in individual and tandem mode. LRM has advantages in terms of d...This paper presents an investigation on depo- sition of Inconel-625 using laser rapid manufacturing （LRM） and plasma transferred arc （PTA） deposition in individual and tandem mode. LRM has advantages in terms of dimensional accuracy, improved mechanical properties, finer process control, reduced heat input and lower thermal distortion, while PTA scores more in terms of lower initial investment, lower running cost and higher deposition rate. To quantify the clubbed advantages and limitations of both processes, these were studied individually and in tandem. A number of samples were deposited at different process parameters like power, scan speed, powder feed rate. They were subjected to tensile test, adhesion-cohesion test, impact test and micro hardness measurement. The results of individual tests showed the comparable mechanical prop- erties with i20% variation. The mixed dendritic-cellular and dendritic-columnar microstructures were respectively observed for LRM and PTA deposits with a distinct inter- face for the case of tandem deposition. The interface strength of tandem deposits was evaluated employing adhesion-cohesion test, and it was found to be （325 i 35） MPa. The study confirmed the viability of LRM and PTA deposition in tandem for hybrid manufacturing.展开更多
文摘Poly(1,1,2,2- tetrahydroperfluorodecyl acrylate) (poly (TA-N)) was synthesized in laboratory. The resulting morphology of rapid expansion of supercritical solution (RESS) sprays of poly(TA - N) was investigated. At apre - expansion temperature of 45℃), amorphous polymer was formed. At temperature around 60 ℃ to 80 ℃ , fibers were formed. Increase of temperature increasesparticle size slightly. At temperature of 105℃ , most of particles are spheres. The RESS is an attractive process. To apply the polymers desired for coating applications in an organic solvent - free process that is economically viable , and it will have implications for pollution prevention during polymer film
文摘A searching-machining system of RL & SM (Rapid Location and State Memory) universal fixture is here introduced, and the concept of rapid searching technology and manufacturing information transformation is then described, with the appropriate control methods and key techniques for its realization being proposed and also practically realized. Theoretical analysis and experimental results show that the proposed idea and methods are feasible to serve as in the practical application of the RL & SM system.
基金Fundationde AmparoàPesquisa do Estado de Minas Gerais,No.APQ-02320-18.
文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations.
基金Supported by the China National Science and Technology Major Project (2016ZX05024-003)
文摘The Bohai Bay Basin is a typical oil-prone basin, in which natural gas geological reserves have a small proportion. In this basin, the gas source rock is largely medium-deep lake mudstone with oil-prone type Ⅱ2-Ⅱ1 kerogens, and natural gas preservation conditions are poor due to active late tectonic movements. The formation conditions of large natural gas fields in the Bohai Bay Basin have been elusive. Based on the exploration results of Bohai Bay Basin and comparison with large gas fields in China and abroad, the formation conditions of conventional large-scale natural gas reservoirs in the Bohai Bay Basin were examined from accumulation dynamics, structure and sedimentation. The results show that the formation conditions of conventional large natural gas reservoirs in Bohai Bay Basin mainly include one core element and two key elements. The core factor is the strong sealing of Paleogene "quilt-like" overpressure mudstone. The two key factors include the rapid maturation and high-intensity gas generation of source rock in the late stage and large scale reservoir. On this basis, large-scale nature gas accumulation models in the Bohai Bay Basin have been worked out, including regional overpressure mudstone enriching model, local overpressure mudstone depleting model, sand-rich sedimentary subsag depleting model and late strongly-developed fault depleting model. It is found that Bozhong sag, northern Liaozhong sag and Banqiao sag have favorable conditions for the formation of large-scale natural gas reservoirs, and are worth exploring. The study results have important guidance for exploration of large scale natural gas reservoirs in the Bohai Bay Basin.
基金Spark program of earthquake sciences (XH13012, XH12026Y) National Key Technology R&D Program (2009BAK55B01)
文摘We present a new strategy to estimate the geometry of a rupture on a finite fault for rapid reporting of seismic intensity. We use envelope attenuation relationships which were presented by Huo et al. （Acta Seismol Sin 16：519-525, 1994）. An important base of this work is the fault finiteness theory. We propose a new model to simulate high-frequency motions from earthquakes with large rupture dimension. The envelope of high-frequency ground motion from a large earthquake can be expressed as a rootmean-squared combination of envelope functions from smaller earthquakes. We use simulated envelopes of ground acceleration to estimate the direction and alongstrike length of a rupture. Using the Wenchuan and Jiji （Chi-Chi） earthquake dataset, we parameterize the fault geometry with an epicenter, a fault strike, and along-strike rupture lengths. So this methodology seems quite appropriate for the rapid reporting systems of seismic intensity.
基金supported by Program for Innovative Research Team in the University (Grant No. IRT0658)National Natural Science Foundation of China (Grant No. 90914006)
文摘Late-stage is defined here as the period when Neotectonism occurred since 5.1 Ma. Most petroliferous basins in China lie in the areas where Neotectonism occurred intensively. In recent years, Chinese petroleum geologists have paid much attention to late-stage petroleum accumulation. The PL19-3 giant oilfield is situated where faulting activities occurred violently during Neotectonism. To understand the mechanism of lat-stage rapid accumulation, we discussed the most important aspects responsible for the formation of the giant oilfield, including oil generation, active oil-source rock occurrence, fault activity and fault conduits, late-stage rapid oil injection as well as the distinguishing indicators. This study shows that: (1) sufficient oil was supplied to the PL19-3 field since 5.1 Ma because the PL19-3 structure was surrounded by four sags in which three intervals of high-quality source rocks remained active during Neotectonism; (2) densely distributed faults and high porosity/permeability sandstone carrier beds comprised the effective conduit system for oil migration and injection; (3) oil migrated along the faults and charged the PL19-3 structure rapidly by means of seismic pumping which was triggered by frequent earthquakes during Neotetonism. It is documented that elevated reservoir temperature, abnormal geothermal gradients and abnormally high homogenization temperatures of the fluid inclusions are the indicators for late-stage rapid oil accumulation.
基金supported by the National Nature Science Foundation of China(grant nos.21871266,21731006,and 21403241)the Strategic Priority Research Program of the Chinese Academy of Sciences(grant no.XDB20000000)+1 种基金Key Research Program of Frontier Science CAS(grant no.QYZDY-SSW-SLH025)Youth Innovation Promotion Association CAS.
文摘The crystalline sponge method is a pragmatic and promising strategy for molecular structure determination.However,the dominant metal-organic framework crystal sponge platforms always face poor chemical stability,especially solvent instability,hampering their application in a vaster domain.Herein,we report an ultrastable π-π stacked porous organic molecular framework which exhibits permanent porosity,high thermal stability,and good chemical resistance.It can efficiently implement an approach to molecular structure determination via a single-crystal-to-single-crystal transformation.This is the first example utilizing π-π stacked porous organic molecular framework as“crystalline sponge”to determine a wide variety of guests,ranging from hydrophilic to hydrophobic,and from aliphatic to aromatic,which complements the crystalline sponges based on the famous metal-organic frameworks.More importantly,it can achieve rapid structure determination of small molecules within 3 h.
文摘This paper presents an investigation on depo- sition of Inconel-625 using laser rapid manufacturing （LRM） and plasma transferred arc （PTA） deposition in individual and tandem mode. LRM has advantages in terms of dimensional accuracy, improved mechanical properties, finer process control, reduced heat input and lower thermal distortion, while PTA scores more in terms of lower initial investment, lower running cost and higher deposition rate. To quantify the clubbed advantages and limitations of both processes, these were studied individually and in tandem. A number of samples were deposited at different process parameters like power, scan speed, powder feed rate. They were subjected to tensile test, adhesion-cohesion test, impact test and micro hardness measurement. The results of individual tests showed the comparable mechanical prop- erties with i20% variation. The mixed dendritic-cellular and dendritic-columnar microstructures were respectively observed for LRM and PTA deposits with a distinct inter- face for the case of tandem deposition. The interface strength of tandem deposits was evaluated employing adhesion-cohesion test, and it was found to be （325 i 35） MPa. The study confirmed the viability of LRM and PTA deposition in tandem for hybrid manufacturing.
