Effect of dietary with Zhibai dihuang pills and gonadotropinreleasing-hormone-analogue on girls with precocious and rapidly progressive puberty

BACKGROUND At present,the clinical mechanisms underlying precocious puberty remain unclear,making effective intervention for children experiencing this condition and rapidly progressive puberty essential.AIM To explore the effects of Zhibai dihuang pills and gonadotropin-releasing hormone analogue(GnRHa)on growth and ovarian function in girls with precocious puberty.METHODS The clinical data of 84 adolescent girls with precocious puberty and rapidly progressive puberty from February 2017 to August 2023 were retrospectively analyzed.Girls were divided into a control group and an observation group,with 42 cases in each group.The control group received diet intervention combined with GnRHa treatment,while the observation group received diet intervention combined with Zhibai dihuang pills+GnRHa treatment.Outcomes such as clinical efficacy,growth indicators,ovarian function,and adverse reactions were compared between the two groups.RESULTS The observation group showed superior clinical efficacy compared to the control group(P<0.05).Prior to the intervention,no significant differences were found in growth or ovarian function between the groups(P>0.05).Post-intervention,the observation group exhibited significantly lower rates in growth,height,and bone age,along with reduced levels of progesterone,testosterone,estradiol,prolactin,luteinizing hormone,and follicle-stimulating hormone compared to the control group(P<0.05).The incidence of adverse reactions was similar across both groups(P>0.05).CONCLUSION Combining Zhibai dihuang pills with GnRHa and dietary intervention effectively improves growth,enhances ovarian function,and minimizes adverse reactions in adolescent girls with precocious and rapidly progressive puberty.

Microstructure and Properties of Cu-Cr-Zr Alloy after Rapidly Solidified Aging and Solid Solution Aging

The structure and properties of Cu-Cr-Zr alloy were studied after rapidly solidified aging and solid solution aging.At the early stage of aging （500℃ for 15 rain）, the hardness and the conductivity of the alloy rapidly solidified are 143 HV and 72% IACS, respectively. Under the same aging condition, the hardness and electrical conductivity of the alloy solid solution treated can reach 86 HV and 47% IACS, respectively. The microstructure was analyzed, and the grain size after rapid solidification is much smaller than that after solid solution treatment. By rapidly solidified aging the fine precipitates distribute inside the grains and along the grain boundary, while by solid solution aging there are large Cr particles along the grain boundary.

Microstructure and thermal stability behavior of a rapidly solidified Al-Ti-Fe-Cr alloy

A rapidly solidified Al-2.5Ti-2.5Fe-2.5Cr (mass fraction in percent) alloywas prepared by melt spinning. As-quenched and as-annealed microstructures were studied by X-raydiffractometry (XRD), transmission electron microscopy (TEM), high-resolution transmission electronmicroscopy (HREM) and energy dispersive spectrum (EDS) analysis. The microhardness of the alloy atdifferent annealing temperatures was measured. The results obtained indicate that the microhardnessof the rapidly solidified Al-2.5Ti-2.5Fe-2.5Cr alloy does not vary with different annealingtemperatures. The as-quenched microstructure of the alloy includes two kinds of dispersed primaryphases: Al_3Ti and Al_(13)(Cr, Fe)_2. After annealing at 400 deg C for 10 h, the stable phaseAl_(13)Fe_4 appears in the microstructure.

Effect of heat treatment on the microstructure and micromechanical properties of the rapidly solidified Mg61.7Zn34Gd4.3 alloy containing icosahedral phase

In this paper, the microstructure evolution of the rapidly solidified (RS) Mg61.7Zn34Gd4.3 (at%, atomic ratio) alloy at high temperatures was investigated. The hardness and elastic modulus of the main precipitated phases were also analyzed and compared with those of the α-Mg matrix on the basis of nanoindentation tests. The results show that the RS alloy consists of either a petal-like icosahedral quasicrystal (IQC) phase (~20 μm) and block-shaped H1 phase (~15 μm) or IQC particles with an average grain size of ~107 nm as well as a small proportion of amorphous phase, which mainly depends on the holding time at the liquid temperature and the thickness of the ribbons. The IQC phase gradually transforms at 400?C to a short-rod-shaped μ-phase (Mg28.6Zn63.8Gd7.7) with a hexagonal structure. The hardness of the IQC phase is higher than that of H1 phase, and both phases exhibit a higher hardness than the α-Mg matrix and the μ-phase. The elasticity of the H1 phase is superior to that of the α-Mg matrix. The IQC phase possesses a higher elastic modulus than H1 phase. The easily formed H1 phase exhibits the poorest plastic deformation capacity among these phases but a higher elastic modulus than the α-Mg matrix.

Effects of Additional Elements on Microstructure and Precipitation Behaviour in Rapidly Solidified Al-Ti Base Alloys

Rapidly solidified Al-Ti base alloys were prepared by melt spinning at the cooling rate about 107 K/s. The melt-spun ribbons were used to observe the dricrostructures after heat treatment.In the supersaturated Al-Tl-Si alloy, age hardening occurred after 1 h anneal in the temperature range of 4000~500℃, which seems to be attributed to the precipitation of metastable Ll2- (Al,Si)3Ti phase. However. the microhardness was relatively low because of the low v/o and the insufflcient stability of precipitates. Thus. Cr was added to Al-Ti-Si alloys in order to stabilize the microstructures and to increase the v/o of precipitate5. As a result. the alIoys containing Cr were evaluated to possess the improved properties at the service temperature.

Rugate filters prepared by rapidly alternating deposition

A methodology for the fabrication of composite （Nb205）l-x（SiO2）~ thin-film rugate filters by using pulsed direct current magnetron sputtering is presented. The two materials are mixed using rapidly alternating deposition technol- ogy. The optical properties of the composite films varying with the composition of the material are studied in detail, Refractive indices between 1.50 and 2.14 can be realized in our coating system. Two designed rugate filters with a re- flection band at the wavelength of 532 nm are fabricated using an automatic deposition process. The microstructure of the rugate filter is investigated by using scanning electron microscopy. The calculated and the measured transmittance spectra axe in good agreement with each other, The causes of the slight differences between them are also analysed.

Positron Annihilation Study on the Microstructural Stability in Rapidly Solidified Al_(92.3)Fe_(4.3)V_(0.7)Si_(1.7)Mm_(1.0) Alloy

Rapidly solidified Al92.3Fe4.3V0.7Si1.7Mm1.0 alloy has been studied by positron lifetime spectroscopy and the variations on the intedecial defects with the annealing temperature were revealed by an analysis of the lifetime results. The intedece characteristics derived from the positron-lifetime results could be used to give a satisfactory interpretation of the dependence of mechanical properties on the annealing temperature

Distinct protein kinase C isozymes mediates inhibitory effects of different G-protein coupled receptors on cardiac rapidly activating delayed rectifier K ~ current

Aim Evidence has shown that stimulation of alA-adrenorecetors receptor （alA-AR） or angiotensin II type 1 receptor （AT1R） acutely down-regulates the rapid component of the delayed rectifier K ＋ current （IKr） via protein kinase C （PKC）. This study was designed to investigate which PKC isozymes mediate down-regulations of IKr by alA-AR and AT1R. Method The whole-cell patch-clamp technique was used to record IKr in native cardio- myocytes and in human embryonic kidney （HEK） 293 cells co-transfected with human ether-a-go-go related gene （hERG） encoding α-subunit of IKr and human alA-AR or AT1R gene. Result In isolated guinea-pig ventricular cardiomyocytes the inhibitory action of Ang II on IKr was little affected by Go6976 （selectively inhibiting PKCα, β and γ） and Go6983 （selectively inhibiting PKCα, β, γ , δ, and ζ）, but was significantly antagonized by an inter- nal dialysis with PKCe-selective inhibitory peptide εV1 -2. In contrast, the inhibitory action of alA-AR agonist A61603 on IKr was remarkably attenuated by Go6976 or Go6983, but not affected by peptide εV1 -2. Moreover, specific PKC-selective inhibitory peptide antagonized the effect of A61603. The results suggested that PKCe and PKCα isoform respectively mediated the inhibitory effect of AT1R and a1A-AR. In heterologous expression system, both PKCα and e-selective activator peptides down regulated hERG current with different manner. PKCα activator peptide shifted the activation curve of the channel to the right, but PKCe-selective activator peptide did not. Simi- larly, A61603 shifted the activation curve to the right, whereas Ang Ⅱ had no effect. In addition, both A61603 and PKCα activator peptide showed inhibitory action on bERG A PKC current （an bERG mutant in which 17 of the 18 ROSITE-predicted PKC acceptor serines/threonines were changed to alanine） with a similar potency to wild type bERG current. But, both Ang Ⅱ and PKCe-selective activator peptide exhibited no effects on bERG △ PKC cur- rent. The results indicated that PKCα and PKCe isoforms down-regulated bERG current through different mecha- nism. Conclusion PKCα and PKCe isoform respectively mediates the inhibition on IKr by stimulation of AT1R and alA-AR via different molecular mechanism.

Microstructure Evolution and Tensile Properties of Pure Ti Subjected to Rapidly Heating and Quenching

The pure α-Ti samples were heated at an extremely high rate （～10^6 K/s） to the temperature of β phase zone followed by a rapidly quenching in an electro-pulsing treatment. After the treatment, micrometer-thick lamellar substructures were generated within the original equiaxed α-Ti coarse grains. Misorientations across adjacent lamellae are of a few degrees. The ultrafine lamellar substructures originated from a non-equilibrium α-β-α’ phase transformation during rapidly heating-quenching process with a short exposure time at high temperatures. Tensile strength was increased by about 100 MPa due to the formation of the ultrafine lamellar substructure while the same tensile plasticity （elongation-to-failure） was maintained relative to the original sample. The strengthening effect could be attributed to the effective blockage of dislocation motions by a high density of sub-boundaries.

Investigation on Rapidly Solidified T15 High Speed Steel Powder and Its Bulk Microcrystalline Material

Authors produced rapidly solidified T15 high speed steel powders by high pressure(5~ 6MPa) N_a atomization and liquid N_2 cooling,observed and analyzed the morphology and structure of the powders;at the same time,prepared bulk microcrystalline T15 high speed steel materials by hot extruding or HIPing and hot rolling of the powders,observed and measured the microstructure and performance of the bulk materials.It was shown that rapid solidification may change the solidification characteristics and structure of T15 high speed steel powder and improve the qualities and properties of T15 high speed steel materials.

AVERAGING PRINCIPLE FOR QUASI-GEOSTROPHIC MOTIONUNDER RAPIDLY OSCILLATING FORCING

A class of large scale geophysical fluid flows are modelled by the quasi-geostrophic equation. An averaging principle for quasi-geostrophic motion under rapidly oscil-lating ( non-autonomous) forcing was obtained, both on finite but large time intervals and on the entire time axis. This includes comparison estimate, stability estimate, and convergence result between quasi-geostrophic motions and its averaged motions. Furthermore, the existence of almost periodic quasi-geostrophic motions and attractor convergence were also investigated.

Characterizations of Skeletal Iron Catalysts Prepared from Rapidly and Naturally Quenched Fe-Al Alloys

Surface morphology, physical-chemical properties of skeletal iron catalysts prepared by leaching of the rapidly quenched(RQ) and naturally quenched(NQ) Fe-Al alloys with an aqueous solution of NaOH were characterized by using a series of techniques including XRD, BET, XPS, SEM, H_2 and CO-TPD. It was found that the RQ skeletal iron catalyst exhibits a smaller particle size, larger specific surface area and pore volume than the NQ one. The H_2 and CO-TPD experiments showed that the RQ skeletal iron exhibits stronger affinity for H_2 and milder affinity for CO compared with the NQ one. But the NQ skeletal catalyst shows a better thermal stability than the RQ catalyst.

Structural Characteristics of Rapidly Quenched Al-Si Alloys

The structure of rapldly quenched Al-Si alloys (1 and 4 wt-%Si) was systematically studied by optical and transmission electron microscopy (TEM ) as welI as X-ray djffractjon (XRD). ExperimentaIresults show that rapid solidification refines the grain size. extends the solid solubility of Si in Al and Introduces a high density ot defects which exist in the forms of vacancies, dislocations and dislocation loops. etc.. The decomposition process of the alloys was fol lowed by using differential scanning calorimeter (DSC) and the activation energy for precipitation of Si was obtained through Kissinger analysis. The precipitation behaviour of Supersaturated Si in both samples was further examined by TEM. It was found that Si mainly precipitated inside the grains in Al-1 wt-%Si alloy. while in Al-4 wt-%Si alloy. nearly all the Si precipitates distributed along the grain boundaries. This may be due to the structure difference between the alloys in as-quenched state

"Triple-positive" renal limited vasculitis presenting with rapidly progressive glomerulonephritis: A case report

Rationale:Coexistence of anti-glomerular basement membrane(anti-GBM)disease with anti-neutrophil cytoplasmic antibody(ANCA)in a case of glomerulonephritis is often identified as a"double-positive"disease.Interestingly,the majority of"double positive"ANCA is myeloperoxidase(MPO)-ANCA and some of the MPO-ANCA positive cases showed intrarenal arteritis,suggesting an ANCA-associated kidney lesion.Proteinase 3-ANCA positive diseases are also rarely reported.Patients positive for all three antibodies,i.e.,triple-positive patients,are extremely rare.Patient's Concern:A 53 year-old female presented with anasarca and oliguria of 2 months'duration.Diagnosis:Pauci-immune type renal limited crescentic glomerulonephritis positive for MPO-ANCA,proteinase 3-ANCA,and anti-GBM antibody(triple-positive).Interventions:Intravenous high dose cyclophosphamide,oral azathioprine,intravenous methylprednisolone,and plasma exchange as per British Health Professionals in Rheumatology Guidelines.Outcomes:After one-month follow-up,anasarca and proteinuria were lessened,serum creatinine was normalized,titers of MPO-ANCA levels were decreased,and anti-GBM antibody levels were normalized.Lessons:Triple-positive renal limited vasculitis is rare and response to combined immunosuppressive therapy and plasma exchange can contribute to successful remission.

Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance

Some biological uses of polyethylene glycol（PEG）：The use of PEG as a membrane fusogen was first reported in 1976with the creation of cell hybrids,formed by suspending two cell lines in a 50%w/w solution of PEG in water.

A two-order and two-scale computation method for nonselfadjoint elliptic problems with rapidly oscillatory coefficients

The purpose of this paper is to solve nonselfadjoint elliptic problems with rapidly oscillatory coefficients. A two-order and two-scale approximate solution expression for nonselfadjoint elliptic problems is considered, and the error estimation of the twoorder and two-scale approximate solution is derived. The numerical result shows that the presented approximation solution is effective.

THE CLINICAL AND PATHOLOGICAL FEATURES ANDTREATMENT OF RAPIDLY PROGRESSIVEGLOMERULONEPHRITIS

Objectivs For better understanding the incidence, clinical and pathological features of rapidlyprogressive glomerulonephritis and improving the level of diagnosis and treatent. Methods Records Of 19 biopsyproved RPGN were reviewed. Results Nephrotic syndrome and acute renal failure were common. The incidenceof this disease is about 2% of all renal biopsies of the same period. Conclusion 1. Renal biopsy should beperformed as soon as possible if RPGN is suspected. 2. The detection of antineutrophil cytoplasmic autoantibody isvery important. 3. The indication of pulse therapy should be strictly justified according to the pathologicalfindings. 4. Dialysis and plasma exchange should be given to ARF patients in the early stage.

QUASICRYSTALLINE AND CRYSTALLINE PHASES IN RAPIDLY SOLIDIFIED Al33Cu10Fe24Ti33 ALLOY POWDERS

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China's Health Tourism Grows Rapidly

Health tourism is one of the fastest-growing industries in the world. The health industry has become a compound industry that plays an important role in creating jobs, stimulating consumption, and building connections between China and the world when it comes to environmentally sustainable industires.In recent years, the Chinese government has approved the construction of two health tourism industry demonstration zones in Bo’ao and Beidaihe,and also approved several health tourism demonstration bases created by 13institutions;one of which is Tianjin Health Industry Park.