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INTERFACE BEHAVIOR AND DECAY RATES OF COMPRESSIBLE NAVIER-STOKES SYSTEM WITH DENSITY-DEPENDENT VISCOSITY AND A VACUUM
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作者 郭真华 张学耀 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期247-274,共28页
In this paper,we study the one-dimensional motion of viscous gas near a vacuum,with the gas connecting to a vacuum state with a jump in density.The interface behavior,the pointwise decay rates of the density function ... In this paper,we study the one-dimensional motion of viscous gas near a vacuum,with the gas connecting to a vacuum state with a jump in density.The interface behavior,the pointwise decay rates of the density function and the expanding rates of the interface are obtained with the viscosity coefficientμ(ρ)=ρ^(α)for any 0<α<1;this includes the timeweighted boundedness from below and above.The smoothness of the solution is discussed.Moreover,we construct a class of self-similar classical solutions which exhibit some interesting properties,such as optimal estimates.The present paper extends the results in[Luo T,Xin Z P,Yang T.SIAM J Math Anal,2000,31(6):1175-1191]to the jump boundary conditions case with density-dependent viscosity. 展开更多
关键词 decay rates INTERFACE Navier-Stokes equations VACUUM
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Genetic and Agronomic Parameter Estimates of Growth, Yield and Related Traits of Maize (Zea mays L.) under Different Rates of Nitrogen Fertilization
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作者 Prince Emmanuel Norman Lansana Kamara +6 位作者 Aloysius Beah Kelvin Sahr Gborie Francess Sia Saquee Sheku Alfred Kanu Fayia Augustine Kassoh Yvonne Sylvia Gloria Ethel Norman Abdul Salaam Kargbo 《American Journal of Plant Sciences》 CAS 2024年第4期274-291,共18页
This study evaluated the genetic and agronomic parameter estimates of maize under different nitrogen rates. The trial was established at the Njala Agricultural Research Centre experimental site during 2021 and 2022 in... This study evaluated the genetic and agronomic parameter estimates of maize under different nitrogen rates. The trial was established at the Njala Agricultural Research Centre experimental site during 2021 and 2022 in a split block design with three maize varieties (IWCD2, 2009EVDT, and DMR-ESR-Yellow) and seven nitrogen (0, 30, 60, 90, 120, 150 and 180 kg∙N∙ha<sup>−</sup><sup>1</sup>) rates. Findings showed that cob diameter and anthesis silking time (ASI) had intermediate heritability, ASI had high genetic advance, ASI and grain yield had high genotypic coefficient of variation (GCV), while traits with high phenotypic coefficient of variation (PCV) were plant height, ASI, grain yield, number of kernel per cob, number of kernel rows, ear length, and ear height. The PCV values were higher than GCV, indicating the influence of the environment in the studied traits. Nitrogen rates and variety significantly (p < 0.05) influenced grain yield production. Mean grain yields and economic parameter estimates increased with increasing nitrogen rates, with the 30 and 180 kg∙N∙ha<sup>−</sup><sup>1</sup> plots exhibiting the lowest and highest grain yields of 1238 kg∙ha<sup>−</sup><sup>1</sup> and 2098 kg∙ha<sup>−</sup><sup>1</sup>, respectively. Variety and nitrogen effects on partial factor productivity (PFP<sub>N</sub>), agronomic efficiency (AEN), net returns (NR), value cost ratio (VCR) and marginal return (MR) indicated that these parameters were significantly affected (p < 0.05) by these factors. The highest PFP<sub>N</sub> (41.3 kg grain kg<sup>−</sup><sup>1</sup>∙N) and AEN (29.4 kg grain kg<sup>−</sup><sup>1</sup>∙N) were obtained in the 30 kg∙N∙ha<sup>−</sup><sup>1</sup> plots, while the highest VCR (2.8) and MR (SLL 1.8 SLL<sup>−</sup><sup>1</sup> spent on N) were obtained in the 180 kg∙N∙ha<sup>−</sup><sup>1</sup>. The significant influence of variety and nitrogen on traits suggests that increasing yields and maximizing profits require use of appropriate nitrogen fertilization and improved farming practices that could be exploited for increased productivity of maize. 展开更多
关键词 Nitrogen rates Genetic and Agronomic Estimates Introduced Genotypes Grain Yield Zea mays
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Dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates
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作者 Yuncheng Liu Ke Xu +4 位作者 Xuhao Fan Xinger Wang Xuan Yu Wei Xiong Hui Gao 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第1期36-46,共11页
Interactive holography offers unmatched levels of immersion and user engagement in the field of future display.Despite of the substantial progress has been made in dynamic meta-holography,the realization of real-time,... Interactive holography offers unmatched levels of immersion and user engagement in the field of future display.Despite of the substantial progress has been made in dynamic meta-holography,the realization of real-time,highly smooth interactive holography remains a significant challenge due to the computational and display frame rate limitations.In this study,we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates.To our knowledge,this is the first reported practical dynamic interactive metasurface holographic system.We spa-tially divided the metasurface device into multiple distinct channels,each projecting a reconstructed sub-pattern.The switching states of these channels were mapped to bitwise operations on a set of bit values,which avoids complex holo-gram computations,enabling an ultra-high computational frame rate.Our approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational platform.According to this methodology,we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay,color display,and on-the-fly hologram creation.Our technology presents an inspiration for advanced dynamic meta-holography,which is promising for a broad range of applications including advanced human-computer interaction,real-time 3D visualization,and next-generation virtual and augmented reality systems. 展开更多
关键词 interactive display meta-holography bitwise operation ultra-high frame rate
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Spalling characteristics of high-temperature treated granitic rock at different strain rates
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作者 L.F.Fan Q.H.Yang X.L.Du 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1280-1288,共9页
The dynamic spalling characteristics of rock are important for stability analysis in rock engineering.This paper presented an experimental investigation on the dynamic spalling characteristics of granite with differen... The dynamic spalling characteristics of rock are important for stability analysis in rock engineering.This paper presented an experimental investigation on the dynamic spalling characteristics of granite with different temperatures and strain rates.A series of dynamic spalling tests with different impact velocities were conducted on thermally treated granite at different temperatures.The dynamic spalling strengths of granite with different temperatures and strain rates were determined.A model was proposed to correlate the dynamic spalling strength of granite,high temperature and strain rate.The results show that the spalling strength of granite decreases with increasing temperature.Moreover,the spalling strength of granite with a higher strain rate is larger than that with a lower strain rate.The proposed model can describe the relationship among dynamic spalling strength of granite,high temperature and strain rate. 展开更多
关键词 Dynamic spalling characteristics High temperature Strain rate Dynamic loading GRANITE
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Success of susceptibility-guided eradication of Helicobacter pylori in a region with high secondary clarithromycin and levofloxacin resistance rates
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作者 Yan-Meng Wang Mo-Ye Chen +4 位作者 Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han Yi-Ling Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第2期184-195,共12页
BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of Helicobacter pylori(H.pylori)is increasing in severity,and successful eradication is essential.Presently,the eradication success rate has greatly dec... BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of Helicobacter pylori(H.pylori)is increasing in severity,and successful eradication is essential.Presently,the eradication success rate has greatly declined,leaving a large number of patients with previous treatment histories.AIM To investigate secondary resistance rates,explore risk factors for antibiotic resistance,and assess the efficacy of susceptibility-guided therapy.METHODS We recruited 154 subjects positive for Urea Breath Test who attended The First Affiliated Hospital of China Medical University between July 2022 and April 2023.Participants underwent a string test after an overnight fast.The gastric juice was obtained and transferred to vials containing storage solution.Subsequently,DNA extraction and the specific DNA amplification were performed using quantitative polymerase chain reaction(qPCR).Demographic information was also analyzed as part of the study.Based on these results,the participants were administered susceptibility-guided treatment.Efficacy was compared with that of the empiric treatment group.RESULTS A total of 132 individuals tested positive for the H.pylori ureA gene by qPCR technique.CLA resistance rate reached a high level of 82.6%(n=109),LFX resistance rate was 69.7%(n=92)and dual resistance was 62.1%(n=82).Gastric symptoms[odds ratio(OR)=2.782;95%confidence interval(95%CI):1.076-7.194;P=0.035]and rural residence(OR=5.152;95%CI:1.407-18.861;P=0.013)were independent risk factors for secondary resistance to CLA and LFX,respectively.A total of 102 and 100 individuals received susceptibility-guided therapies and empiric treatment,respectively.The antibiotic susceptibility-guided treatment and empiric treatment groups achieved successful eradication rates of 75.5%(77/102)and 59.0%(59/411)by the intention-to-treat(ITT)analysis and 90.6%(77/85)and 70.2%(59/84)by the per-protocol(PP)analysis,respectively.The eradication rates of these two treatment strategies were significantly different in both ITT(P=0.001)and PP(P=0.012)analyses.CONCLUSION H.pylori presented high secondary resistance rates to CLA and LFX.For patients with previous treatment failures,treatments should be guided by antibiotic susceptibility tests or regional antibiotic resistance profile. 展开更多
关键词 Helicobacter pylori Antibiotic resistance CLARITHROMYCIN LEVOFLOXACIN String-test Susceptibility-guided therapy Eradication rate
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Gas Exchange Rates of Texas Persimmon (Diospyros texana) in Central Texas Woodlands
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作者 Matthew B. Grunstra Oscar W. Van Auken 《American Journal of Plant Sciences》 CAS 2024年第5期329-348,共20页
Diospyros texana (Texas persimmon) is a secondary species in most Juniperus ashei/Quercus fusiformis woodlands in central Texas. It has high density, but plants are mostly in the community understory. Light response c... Diospyros texana (Texas persimmon) is a secondary species in most Juniperus ashei/Quercus fusiformis woodlands in central Texas. It has high density, but plants are mostly in the community understory. Light response curves at ambient and elevated levels of CO<sub>2</sub> and temperature were measured for D. texana. The A<sub>net</sub> (photosynthetic rate) increased significantly as both light level and CO<sub>2</sub> levels increased but not temperature. The A<sub>max</sub> (maximum photosynthetic rate) of D. texana in full sun at elevated levels of CO<sub>2</sub> was increased for all treatments. Stomatal conductance increased with levels of CO<sub>2</sub> but only if the interaction was removed from the model. Intercellular levels of CO<sub>2</sub> increased with both temperature and CO<sub>2</sub> treatments as did water use efficiency (WUE). Furthermore, light saturation (L<sub>sat</sub>) increased with CO<sub>2</sub> treatments and light compensation (L<sub>cp</sub>) increased with temperature. The dark respiration (R<sub>d</sub>) increased with both temperature and CO<sub>2</sub> treatments. Markov population models suggested D. texana populations would remain ecologically similar in the future. However, sub-canopy light levels and herbivory should be considered when examining population projections. For example, Juniperus ashei juveniles are not recruited into any canopy unless there are high light levels. Herbivory reduces the success of Quercus juveniles from reaching the canopy. These factors do not seem to be a problem for D. texana juveniles which would allow them to reach the canopy without need of a high light gap and are not prevented by herbivory. Thus, Juniperus/Quercus woodlands will change in the future to woodlands with D. texana a more common species. 展开更多
关键词 Replacement Dynamics Ecological Succession CO2 Concentrations Temperature Levels Photosynthetic rates Drought Tolerance HERBIVORY Species Replacement ENCROACHMENT Juniper
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Rates, predictors, and causes of readmission after transcatheter aortic valve replacement in patients with chronic kidney disease
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作者 Taha Teaima Gianfranco Bittar Carlini +5 位作者 Rohan A Gajjar Imran Aziz Sami J Shoura Abdul-Rahim Shilbayeh Naim Battikh Tareq Alyousef 《World Journal of Cardiology》 2024年第7期402-411,共10页
BACKGROUND Transcatheter aortic valve replacement(TAVR)is a revolutionary procedure for severe aortic stenosis.The coexistence of chronic kidney disease(CKD)and TAVR introduces a challenge that significantly impacts p... BACKGROUND Transcatheter aortic valve replacement(TAVR)is a revolutionary procedure for severe aortic stenosis.The coexistence of chronic kidney disease(CKD)and TAVR introduces a challenge that significantly impacts patient outcomes.AIM To define readmission rates,predictors,and causes after TAVR procedure in CKD stage 1-4 patients.METHODS We used the national readmission database 2018 and 2020 to look into readmission rates,causes and predictors after TAVR procedure in patients with CKD stage 1-4.RESULTS Out of 24758 who underwent TAVR and had CKD,7892(32.4%)patients were readmitted within 90 days,and had higher adjusted odds of being females(adjusted odds ratio:1.17,95%CI:1.02-1.31,P=0.02)with longer length of hospital stay>6 days,and more comorbidities including but not limited to diabetes mellitus,anemia,and congestive heart failure(CHF).CONCLUSION Most common causes of readmission included CHF(18.0%),sepsis,and complete atrioventricular block.Controlling readmission predictors with very close followup is warranted to prevent such high rate of readmission. 展开更多
关键词 Chronic kidney disease Transcatheter aortic valve replacement READMISSION PREDICTORS rates
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High-rate metal-free MXene microsupercapacitors on paper substrates
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作者 Han Xue Po‐Han Huang +11 位作者 Lee‐Lun Lai Yingchun Su Axel Strömberg Gaolong Cao Yuzhu Fan Sergiy Khartsev Mats Göthelid Yan‐Ting Sun Jonas Weissenrieder Kristinn BGylfason Frank Niklaus Jiantong Li 《Carbon Energy》 SCIE EI CAS CSCD 2024年第5期94-104,共11页
MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).Despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(... MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).Despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(>1000 mV s^(−1))on-paper MSCs,mainly due to the reduced electrical conductance of MXene films deposited on paper.Herein,ultrahigh-rate metal-free on-paper MSCs based on heterogeneous MXene/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)-stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser scribing.With a footprint area of only 20 mm^(2),the on-paper MSCs exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles)at a high scan rate of 1000 mV s^(−1),outperforming most of the present on-paper MSCs.Furthermore,the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal-free on-paper MSC arrays,which can also be simultaneously charged/discharged at 1000 mV s^(−1),showing scalable capacitive performance.The heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on-paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics. 展开更多
关键词 direct ink writing femtosecond laser scribing MXene on-paper microsupercapacitors PEDOT:PSS ultrahigh rate capability
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Comparison of the precision of glacier flow rates derived from offset-tracking using Sentinel-2 and Landsat-8/9 imagery
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作者 YANG Zhibin CHEN Zhuoqi +3 位作者 LI Gang MAO Yanting FENG Xiaoman CHENG Xiao 《Advances in Polar Science》 CSCD 2024年第2期238-251,共14页
Offset-tracking is an essential method for deriving glacier flow rates using optical imagery.Sentinel-2(S2)and Landsat-8/9(L8/9)are popular optical satellites or constellations for polar studies,offering high spatial ... Offset-tracking is an essential method for deriving glacier flow rates using optical imagery.Sentinel-2(S2)and Landsat-8/9(L8/9)are popular optical satellites or constellations for polar studies,offering high spatial resolution with relatively short revisit time,wide swath width,and free accessibility.To evaluate and compare the precision of offset-tracking results yielded with these two kinds of data,in this study S2 and L8/9 imagery observed in Petermann Glacier in Greenland,Karakoram in High-Mountains Asia,and Amery Ice Shelf in the Antarctic are analyzed.Outliers and various systematic error sources in the offset-tracking results including orbital and strip errors were analyzed and eliminated at the pre-process stage.Precision at the off-glacier(bare rock)region was evaluated by presuming that no deformation occurred;then for both glacierized and the off-glacier regions,precision of velocity time series was evaluated based on error propagation theory.The least squares method based on connected components was used to solve flow rates time series based on multi-pair images offset-tracking.The results indicated that S2 achieved slightly higher precision than L8/9 in terms of both single-pair derived displacements and least square solved daily flow rates time series.Generally,the RMSE of daily velocity is 26%lower for S2 than L8/9.Moreover,S2 provided higher temporal resolution for monitoring glacier flow rates. 展开更多
关键词 Sentinel-2 LANDSAT glacier flow rates offset-tracking PRECISION
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The effects of deformation parameters and cooling rates on the aging behavior of AZ80+0.4%Ce
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作者 Yongbiao Yang Jinxuan Guo +6 位作者 Cuiying Wang Ting Yan Zhang Wenxuan Jiang Zhimin Zhang Qiang Wang Guojun Li Jun Wang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第2期639-658,共20页
The extruded AZ80+0.4%Ce magnesium alloy was twisted in the temperature range of 300-380℃by using a Gleeble 3500 thermal simulation test machine with a torsion unit.The deformed cylindrical specimens were cooled at a... The extruded AZ80+0.4%Ce magnesium alloy was twisted in the temperature range of 300-380℃by using a Gleeble 3500 thermal simulation test machine with a torsion unit.The deformed cylindrical specimens were cooled at a cooling rate of 10℃/s or 0.1℃/s,respectively,and aged at 170℃.The microstructure analysis results showed that the grain size decreased with increasing specimen radial position from center(SRPC),and that the strong initial basal texture of the extruded magnesium alloy was weakened.Both continuous and discontinuous dynamic recrystallization mechanisms were involved in contributing to the grain refinement for all specimens investigated.And a novel extension twinning induced dynamic recrystallization mechanism was proposed for specimen deformed at 300℃.For the specimens deformed at 300℃and 340℃followed by a slow cooling rate(0.1℃/s),precipitates of various shapes(β-Mg_(17)Al_(12)),with the dominant precipitates being on the grains boundaries,appeared on the surface section.For specimen deformed at 380℃,lamellar precipitates(LPS)in the interiors of the grains were predominant.After aging,the LPS still dominated for specimens twisted at 380℃;however,the LPS gradually decreased with decreasing deformation temperatures from 380℃to 300℃.Dynamically precipitatedβ,especially those decorating the grain boundaries,changed the competition pictures for the LPS and precipitates of other shapes after aging.Interestingly,LPS dominated the areas for the center section of the specimens after aging regardless of deformation temperatures.Low temperature deformation with high SRPC followed by rapid cooling rate increased the micro hardness of the alloy after aging due to refined grain,reduced precipitates size,decreased lamellar spacing as well as strain hardening. 展开更多
关键词 AZ80+0.4%Ce magnesium alloy Hot torsion Deformation parameters Cooling rate Aging Micro hardness
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The variation in basal channels and basal melt rates of Pine Island Ice Shelf
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作者 Mingliang Liu Zemin Wang +2 位作者 Baojun Zhang Xiangyu Song Jiachun An 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第1期22-34,共13页
In recent years,there has been a significant acceleration in the thinning,calving and retreat of the Pine Island Ice Shelf(PIIS).The basal channels,results of enhanced basal melting,have the potential to significantly... In recent years,there has been a significant acceleration in the thinning,calving and retreat of the Pine Island Ice Shelf(PIIS).The basal channels,results of enhanced basal melting,have the potential to significantly impact the stability of the PIIS.In this study,we used a variety of remote sensing data,including Landsat,REMA DEM,ICESat-1 and ICESat-2 satellite altimetry observations,and Ice Bridge airborne measurements,to study the spatiotemporal changes in the basal channels from 2003 to 2020 and basal melt rate from 2010 to 2017 of the PIIS under the Eulerian framework.We found that the basal channels are highly developed in the PIIS,with a total length exceeding 450 km.Most of the basal channels are ocean-sourced or groundingline-sourced basal channels,caused by the rapid melting under the ice shelf or near the groundingline.A raised seabed prevented warm water intrusion into the eastern branch of the PIIS,resulting in a lower basal melt rate in that area.In contrast,a deepsea trough facilitates warm seawater into the mainstream and the western branch of the PIIS,resulting in a higher basal melt rate in the main-stream,and the surface elevation changes above the basal channels of the mainstream and western branch are more significant.The El Ni?o event in 2015–2016 possibly slowed down the basal melting of the PIIS by modulating wind field,surface sea temperature and depth seawater temperature.Ocean and atmospheric changes were driven by El Ni?o,which can further explain and confirm the changes in the basal melting of the PIIS. 展开更多
关键词 Pine Island Ice Shelf basal channel basal melt rate digital elevation models(DEMs) satellite altimetry
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Erosion Rates in Dam Catchments in Jordan—Effects of Topography, Geology, and Urbanizations
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作者 Elias Salameh Hakam Al-Alami Ibraheem Hamdan 《Open Journal of Soil Science》 2024年第5期319-331,共13页
Erosion as a natural process produces soils, which are very important natural resources for the fest land plant- and animal kingdoms. Loss of the soil cover reduces agricultural production, biodiversity, and the role ... Erosion as a natural process produces soils, which are very important natural resources for the fest land plant- and animal kingdoms. Loss of the soil cover reduces agricultural production, biodiversity, and the role of soil as a filter for infiltrating water to replenish the groundwater. It also threatens the food supplies. The knowledge of erosion rates of rocks and terrains is important for developing proactive measures to protect soils from erosion and loss. In this study, erosion rates of catchment areas were calculated based on dams’ catchment extensions and the sediment loads transported by flood flows into dams’ lakes. The study results show that the chemically, via floodwater, transported quantities of materials are negligible compared to the solid materials transported by the water. It calculates erosion rates ranging from 0.013 to 0.212 mm/yr (13 - 212 m/10<sup>6</sup> yr) for the different catchment areas. Erosion rates in Jordan are, generally, higher than those calculated for the different parts of the world ranging from 2.5 to 60 m/10<sup>6</sup> yr. This fact can be explained by the very steep topography, calcareous rock cover of the catchment areas and the barren rock exposures. 展开更多
关键词 Erosion rates JORDAN DAMS Sediment Load
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Comparative analysis of breast and lung cancer survival rates and clinical trial enrollments among rural and urban patients in Georgia
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作者 TATIANA KURILO REBECCA D.PENTZ 《Oncology Research》 SCIE 2024年第9期1401-1406,共6页
Objectives:Rural patients have poor cancer outcomes and clinical trial(CT)enrollment compared to urban patients due to attitudinal,awareness,and healthcare access differential.Knowledge of cancer survival disparities ... Objectives:Rural patients have poor cancer outcomes and clinical trial(CT)enrollment compared to urban patients due to attitudinal,awareness,and healthcare access differential.Knowledge of cancer survival disparities and CT enrollment is important for designing interventions and innovative approaches to address the stated barriers.The study explores the potential disparities in cancer survival rates and clinical trial enrollments in rural and urban breast and lung cancer patients.Our hypotheses are that for both cancer types,urban cancer patients will have longer 5-year survival rates and higher enrollment rates in clinical trials than those in rural counties.Methods:We compared breast and lung cancer patients’survival rates and enrollment ratios in clinical trials between rural(RUCC 4-9)and urban counties in Georgia at a Comprehensive Cancer Center(CCC).To assess these differences,we carried out a series of independent samples t-tests and Chi-Square tests.Results:The outcomes indicate comparable 5-year survival rates across rural and urban counties for breast and lung cancer patients,failing to substantiate our hypothesis.While clinical trial enrollment rates demonstrated a significant difference between breast and lung cancer patients at CCC,no significant variation was observed based on rural or urban classification.Conclusion:These findings underscore the need for further research into the representation of rural patients with diverse cancer types at CCC and other cancer centers.Further,the findings have considerable implications for the initiation of positive social change to improve CT participation and reduce cancer survival disparities. 展开更多
关键词 CANCER Cancer survival rates Clinical trial enrollment Rural patients Health disparities Barriers to clinical trial participation Geographic disparities
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Envita’s Precision Cancer Care: 35-Fold Improvement in Response Rates
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作者 Sheba Goklany John C. Oertle III +19 位作者 Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart Christopher Aussems Jon Moma Shannon Miller Zach Poteet Conner Coffin Courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino Prato 《Journal of Cancer Therapy》 2024年第4期99-120,共22页
New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individua... New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer. 展开更多
关键词 Envita Medical Centers Late-stage Cancer Overall Response rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) Precision Care
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Minimum 10-year follow-up outcomes of arthroscopic Bankart’s repair with metallic anchors:Reliable results with low redislocation rates
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作者 Prateek Kumar Gupta Vishesh Khanna +1 位作者 Nikunj Agrawal Pratyaksh Gupta 《World Journal of Methodology》 2024年第2期88-96,共9页
BACKGROUND With stiff competition from alternative albeit more expensive counterparts,it has become important to establish the applicability of metallic anchors for shoulder instability in the modern era.This can be a... BACKGROUND With stiff competition from alternative albeit more expensive counterparts,it has become important to establish the applicability of metallic anchors for shoulder instability in the modern era.This can be accomplished,in part,by analysing long-term outcomes.AIM To analyse minimum 10-year outcomes from 30 patients following arthroscopic anterior stabilisation using metallic anchors.METHODS Prospectively collected data from arthroscopic Bankart repairs performed using metal anchors during 2007P-2010 were retrospectively analysed in this singlesurgeon study.Comprehensive data collection included historical and clinical findings,dislocation details,operative specifics,and follow-up radiological and clinical findings including shoulder scores.The primary outcomes were patientreported scores(Constant,American Shoulder and Elbow Surgeons[ASES],and Rowe scores)and pain and instability on a visual analogue scale(VAS).RESULTS A 3% recurrence rate of dislocation was noted at the final follow-up.Total constant scores at 10 years postoperatively measured between 76 and 100(mean 89)were significantly better than preoperative scores(mean 62.7).Congruous improvements were also noted in the Rowe and ASES scores and VAS at the 10-year review.CONCLUSION Reliable long-term outcomes with metallic anchors in surgery for shoulder instability can be expected.Our results provide additional evidence of their continued,cost-effective presence in the modern scenario. 展开更多
关键词 Long-term outcomes Arthroscopic Bankart repair Metallic anchors Low failure rates
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Impact of Different Rates of Nitrogen Supplementation on Soil PhysicochemicalProperties and Microbial Diversity in Goji Berry
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作者 Xiaojie Liang Wei An +4 位作者 Yuekun Li Yajun Wang Xiaoya Qin Yanhong Cui Shuchai Su 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第3期467-486,共20页
Goji berry(Lycium barbarum L.)is substantially dependent on nitrogen fertilizer application,which can signifi-cantly enhance fruit yield and Goji berry industrial development in Ningxia,China.This study aimed to analyz... Goji berry(Lycium barbarum L.)is substantially dependent on nitrogen fertilizer application,which can signifi-cantly enhance fruit yield and Goji berry industrial development in Ningxia,China.This study aimed to analyze the functions of differential nitrogen application rates including low(N1),medium(N2),and high(N3)levels in soil microbial community structure(bacterial and fungal)at 2 diverse soil depths(0-20,20-40 cm)through high-throughput sequencing technology by targeting 16S RNA gene and ITS1&ITS2 regions.All the observed physicochemical parameters exhibited significant improvement(p<0.05)with increased levels of nitrogen and the highest values for most parameters were observed at N2.However,pH decreased(p<0.05)gradually.The alpha and beta diversity analyses for bacterial and fungal communities’metagenome displayed more similarities than differences among all groups.The top bacterial and fungal phyla and genera suggested no obvious(p>0.05)differences among three group treatments(N1,N2,and N3).Furthermore,the functional enrichment analysis demonstrated significant(p<0.05)enrichment of quorum sensing,cysteine and methionine metabolism,and transcriptional machinery for bacterial communities,while various saprotrophic functional roles for fungal communities.Conclusively,moderately reducing the use of N-supplemented fertilizers is conducive to increasing soil nitrogen utilization rate,which can contribute to sustainable agriculture practices through improved soil quality,and microbial community structure and functions. 展开更多
关键词 Goji berry production Ningxia China differential nitrogen supplementation rates 16S RNA gene and IT1&IT2 region sequencing soil physicochemical properties
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Grain yield and nitrogen use efficiency of an ultrashort-duration variety grown under different nitrogen and seeding rates in direct-seeded and double-season rice in Central China 被引量:1
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作者 WANG Xin-yu YANG Guo-dong +4 位作者 XU Le XIANG Hong-shun YANG Chen WANG Fei PENG Shao-bing 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第4期1009-1020,共12页
Nitrogen(N) and seeding rates are important factors affecting grain yield and N use efficiency(NUE) in directseeded rice. However, these factors have not been adequately investigated on direct-seeded and double-season... Nitrogen(N) and seeding rates are important factors affecting grain yield and N use efficiency(NUE) in directseeded rice. However, these factors have not been adequately investigated on direct-seeded and double-season rice(DDR) in Central China. The objective of this study was to evaluate the effects of various N and seeding rates on the grain yield and NUE of an ultrashort-duration variety grown under DDR. Field experiments were conducted in 2018 in Wuxue County and 2019 in Qichun County, Hubei Province, China with four N rates and three seeding rates.The results showed that the grain yield of the ultrashort-duration variety ranged from 6.32 to 8.23 t ha–1with a total growth duration of 85 to 97 days across all treatments with N application. Grain yield was increased significantly by N application in most cases, but seeding rate had an inconsistent effect on grain yield. Furthermore, the response of grain yield to the N rates was much higher than the response to seeding rates. The moderate N rates of 100–150 and 70–120 kg N ha–1in the early and late seasons, respectively, could fully express the yield potential of the ultrashort-duration variety grown under DDR. Remarkably higher N responses and agronomic NUE levels were achieved in the early-season rice compared with the late-season rice due to the difference in indigenous soil N supply capacity(INS) between the two seasons. Seasonal differences in INS and N response should be considered when crop management practices are optimized for achieving high grain yield and NUE in ultrashort-duration variety grown under DDR. 展开更多
关键词 direct-seeded and double-season rice grain yield nitrogen rate nitrogen use efficiency seeding rate
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Anomaly detection on displacement rates and deformation pattern features using tree-based algorithm in Japan and Indonesia 被引量:1
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作者 Adi Wibowo Satriawan Rasyid Purnama +3 位作者 Cecep Pratama Leni Sophia Heliani David P.Sahara Sidik Tri Wibowo 《Geodesy and Geodynamics》 CSCD 2023年第2期150-162,共13页
Research on strain anomalies and large earthquakes based on temporal and spatial crustal activities has been rapidly growing due to data availability, especially in Japan and Indonesia. However, many research works us... Research on strain anomalies and large earthquakes based on temporal and spatial crustal activities has been rapidly growing due to data availability, especially in Japan and Indonesia. However, many research works used local-scale case studies that focused on a specific earthquake characteristic using knowledgedriven techniques, such as crustal deformation analysis. In this study, a data-driven-based analysis is used to detect anomalies using displacement rates and deformation pattern features extracted from daily global navigation satellite system(GNSS) data using a machine learning algorithm. The GNSS data with188 and 1181 continuously operating reference stations from Indonesia and Japan, respectively, are used to identify the anomaly of recent major earthquakes in the last two decades. Feature displacement rates and deformation patterns are processed in several window times with 2560 experiment scenarios to produce the best detection using tree-based algorithms. Tree-based algorithms with a single estimator(decision tree), ensemble bagging(bagging, random forest and Extra Trees), and ensemble boosting(AdaBoost, gradient boosting, LGBM, and XGB) are applied in the study. The experiment test using realtime scenario GNSSdailydatareveals high F1-scores and accuracy for anomaly detection using slope windowing 365 and 730 days of 91-day displacement rates and then 7-day deformation pattern features in tree-based algorithms. The results show the potential for medium-term anomaly detection using GNSS data without the need for multiple vulnerability assessments. 展开更多
关键词 ANOMALY GNSS Displacement rates Deformation pattern Tree-based algorithm
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Experimental research on influence mechanism of loading rates on rock pressure stimulated currents 被引量:1
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作者 Min Li Zhijun Lin +5 位作者 Shiliang Shi Deming Wang Yi Lu He Li Qing Ye Xiaonan Zhang 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第2期243-250,共8页
The study of pressure stimulated current(PSC)changes of rocks is significant to monitor dynamic disasters in mines and rock masses.The existing studies focus on change laws and mechanism of currents generated under th... The study of pressure stimulated current(PSC)changes of rocks is significant to monitor dynamic disasters in mines and rock masses.The existing studies focus on change laws and mechanism of currents generated under the loading of rocks.An electrical and mechanics test system was established in this paper to explore the impacts of loading rates on PSCs.The results indicated that PSC curves of different rocks had different change laws under low/high loading rates.When the loading rate was relatively low,PSC curves firstly changed gently and then increased exponentially.Under high loading rates,PSC curves experienced the rapid increase stage,gentle increase stage and sudden change stage.The compressive strength could greatly affect the peak PSC in case of rock failure.The loading rate was a key factor in average PSC.Under low loading rates,the variations of PSCs conformed to the damage charge model of fracture mechanics,while they did not at the fracture moment.Under high loading rates,the PSCs at low stress didn’t fit the model due to the stress impact effects.The experimental results could provide theoretical basis for the influence of loading rates on PSCs. 展开更多
关键词 Pressure stimulated current Loading rate Influence mechanism Peak current
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Undrained vane shear strength of sand-foam mixtures subjected to different shear rates 被引量:2
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作者 Jiazheng Zhong Shuying Wang Tongming Qu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第6期1591-1602,共12页
The shear strength of sand-foam mixtures plays a crucial role in ensuring successful earth pressure balance(EPB)shield tunneling.Since the sand-foam mixtures are constantly sheared by the cutterhead and the screw conv... The shear strength of sand-foam mixtures plays a crucial role in ensuring successful earth pressure balance(EPB)shield tunneling.Since the sand-foam mixtures are constantly sheared by the cutterhead and the screw conveyor with varied rotation speeds during tunneling,it is non-trivial to investigate the effect of shear rates on the undrained shear strength of sand-foam mixtures under chamber pressures to extend the understanding on the tunneling process.This study conducted a series of pressurized vane shear tests to investigate the role of shear rates on the peak and residual strengths of sand-foam mixtures at different pore states.Different from the shear-rate characteristics of natural sands or clay,the results showed that the peak strength of sand-foam mixtures under high vertical total stress(σ_(v)≥200 kPa)and low foam injection ratio(FIR30%)decreased with the increase in shear rate.Otherwise,the peak strength was not measurably affected by shear rates.The sand-foam mixtures in the residual state resembled low-viscous fluid with yield stress and the residual strength increased slightly with shear rates.In addition,the peak and residual strengths were approximately linear with vertical effective stress regardless of the total stress and FIR.The peak effective internal friction angle remained almost invariant in a low shear rate(γ′<0.25 s1)but decreased when the shear rate continued increasing.The residual effective internal friction angle was lower than the peak counterpart and insensitive to shear rates.This study unveiled the role of shear rates in the undrained shear strength of sand-foam mixtures with various FIRs and vertical total stresses.The findings can extend the understanding of the rate-dependent shear characteristics of conditioned soils and guide the decision-making of soil conditioning schemes in the EPB shield tunneling practice. 展开更多
关键词 Sand-foam mixture Shear rate Peak and residual strengths Effective stress Effective internal friction angle
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