Development characteristics and failure modes of reactivated ancient landslides in the Sichuan–Tibet transportation corridor,China

The risk of reactivated ancient landslides in the Sichuan–Tibet transportation corridor in China is significantly increasing,primarily driven by the intensification of engineering activities and the increased frequency of extreme weather events.This escalation has resulted in a considerable number of fatalities and extensive damage to critical engineering infrastructure.However,the factors contributing to the reactivation and modes of destruction of ancient landslides remain unknown.Therefore,it is imperative to systematically analyze the developmental characteristics and failure modes of reactivated ancient landslides to effectively mitigate disaster risks.Based on a combination of data collection,remote sensing interpretation,and field investigations,we delineated the developmental attributes of typical ancient landslides within the study area.These attributes encompass morphological and topographic aspects,material composition,and spatial structure of ancient landslides.Subsequently,we identified the key triggers for the reactivation of ancient landslides,including water infiltration,reservoir hydrodynamics,slope erosion,and excavation,by analyzing representative cases in the study area.Reactivation of ancient landslides is sometimes the result of the cumulative effects of multiple predisposing factors.Furthermore,our investigations revealed that the reactivation of these ancient landslides primarily led to local failures.However,over extended periods of dynamic action,the entire zone may experience gradual creep.We categorized the reactivation modes of ancient landslides into three distinct types based on the reactivation sequences:progressive retreat,backward thrusting,and forward pulling–backward thrusting.This study is of great significance for us to identify ancient landslides,deepen our understanding of the failure modes and risks of reactivated ancient landslides on the eastern margin of the Tibetan Plateau,and formulate effective disaster prevention and mitigation measures.

Study on energy release characteristics of reactive material casings under explosive loading

Reactive Materials(RMs),a new material with structural and energy release characteristics under shockinduced chemical reactions,are promising in extensive applications in national defense and military fields.They can increase the lethality of warheads due to their dual functionality.This paper focuses on the energy release characteristics of RM casings prepared by alloy melting and casting process under explosive loading.Explosion experiments of RM and conventional 2A12 aluminum alloy casings were conducted in free field to capture the explosive fireballs,temperature distribution,peak overpressure of the air shock wave and the fracture morphology of fragments of reactive material(RM)warhead casings by using high-speed camera,infrared thermal imager temperature and peak overpressure testing and scanning electron microscope.Results showed that an increase of both the fireball temperature and air shock wave were observed in all RM casings compared to conventional 2A12 aluminum ally casings.The RM casings can improve the peak overpressure of the air shock wave under explosion loading,though the results are different with different charge ratios.According to the energy release characteristics of the RM,increasing the thickness of RM casings will increase the peak overpressure of the near-field air shock wave,while reducing the thickness will increase the peak overpressure of the far-field air shock wave.

Mechanical performances and microstructural characteristics of reactive MgO-carbonated silt subjected to freezing-thawing cycles

The characteristics of reactive magnesia(MgO)-carbonated silt in respect to long-term stability have not been well understood in severely cold climate despite the usage of reactive MgO in enhancing the engineering performances.Under the binder content of 15%and initial water content of 25%,MgO-admixed silt specimens were carbonized for 3 h and 6 h and then subjected to different numbers of freezingthawing(F-T)cycles.After different F-T cycles,the physico-mechanical properties of MgO-carbonated silt were analyzed in comparison with Portland cement(PC)-stabilized silt through physical and unconfined compression tests.Besides,a series of micro tests on MgO-carbonated specimens was performed including X-ray diffraction(XRD),scanning electron microscopy(SEM)and mercury intrusion porosimetry(MIP)tests.The results demonstrate that both mass change ratio and moisture content of carbonated/stabilized silt decrease,and these values of MgO-carbonated silt are significantly lower while the density is higher compared to PC-stabilized silt.The strengths and moduli of MgO-carbonated silt are still two times higher than those of PC-stabilized specimens and the strength change ratio of keeps above0.8 after F-T cycles.There is no visible transformation between nesquehonite and dypingite/hydromagnesite,although the XRD peaks of nesquehonite decrease and the bonding and filling effects weaken slightly.After 6 and 10 F-T cycles,the pore-size characteristics changed from a unimodal distribution to a three-peak and bimodal distribution,respectively.The total,macro and large pore volumes increase obviously while the medium and small pore volumes decrease except for intra-aggregate pore.The findings show better F-T durability of MgO-carbonated silt,which would be helpful for facilitating the application of MgO carbonation in the soil treatment.

Reactive Power Reserve Improvement Using Power Systems Inherent Structural Characteristics

This paper considers the use of the inherent structural characteristics of power system networks for improving the reactive power reserve margins for both topologically weak and strong networks. The inherent structural characteristics of the network are derived from the Schur complement of the partitioned Y-admittance matrix using circuit theory representations. Results show that topologically strong networks, operating close to the upper voltage limit could be made to increase their loadability margin by locating reactive power compensators close to generator sources, whereas topologically weak (ill conditioned) networks could be made to operate within the feasible operating limits by locating reactive power compensators on buses farther from generator sources.

Characteristics and chemical reactivity of biogenic volatile organic compounds from dominant forest species in the Jing-Jin-Ji area,China

Background:Biogenic volatile organic compounds(BVOCs)play an essential role in tropospheric atmospheric chemical reactions.There are few studies conducted on BVOCs emission of dominant forest species in the Jing-Jin-Ji area of China.Based on the field survey,forest resources data and the measured standard emission factors,the Guenther model developed in 1993(G93)was applied in this paper to estimate the emission of BVOCs from several dominant forest species(Platycladus orientalis,Quercus variabilis,Betula platyphylla,Populus tomentosa,Pinus tabuliformis,Robinia pseudoacacia,Ulmus pumila,Salix babylonica and Larix gmelinii)in the Jing-Jin-Ji area in 2017.Then the spatiotemporal emission characteristics and atmospheric chemical reactivity of these species were extensively evaluated.Results:The results showed that the total annual BVOCs emission was estimated to be 70.8 Gg C·year^(−1),consisting 40.5%(28.7 Gg C·year^(−1))of isoprene,36.0%(25.5 Gg C·year^(−1))of monoterpenes and 23.4%(16.6 Gg C·year^(−1))of other VOCs.The emissions from Platycladus orientalis,Quercus variabilis,Populus tomentosa and Pinus tabulaeformis contributed 56.1%,41.2%,36.0% and 31.1%,respectively.The total BVOCs emission from the Jing-Jin-Ji area accounted for 61.9% and 1.8%in summer and winter,respectively.Up to 28.8% of emission was detected from Chengde followed by Beijing with 24.9%,that mainly distributed in the Taihang Mountains and the Yanshan Mountains.Additionally,the Robinia pseudoacacia,Populus tomentosa,Quercus variabilis,and Pinus tabulaeformis contributed mainly to BVOCs reaction activity.Conclusions:The BVOCs emission peaked in summer(June,July,and August)and bottomed out in winter(December,January,and February).Chengde contributed the most,followed by Beijing.Platycladus orientalis,Quercus variabilis,Populus tomentosa,Pinus tabulaeformis and Robinia pseudoacacia represent the primary contributors to BVOCs emission and atmospheric reactivity,hence the planting of these species should be reduced.

Combustion characteristics of unburned pulverized coal and its reaction kinetics with CO2

The combustion characteristics of two kinds of unburned pulverized coal (UPC) made from bituminous coal and anthracite were investigated by thermogravimetric analysis under air. The reaction kinetics mechanisms between UPC and CO2 in an isothermal experiment in the temperature range 1000–1100°C were investigated. The combustion performance of unburned pulverized coal made from bituminous coal (BUPC) was better than that of unburned pulverized coal made from anthracite (AUPC). The combustion characteristic indexes (S) of BUPC and AUPC are 0.47 × 10^-6 and 0.34 × 10^-6 %2·min^-2·°C^-3, respectively, and the combustion reaction apparent activation energies are 91.94 and 102.63 kJ·mol^-1, respectively. The reaction mechanism of BUPC with CO2 is random nucleation and growth, and the apparent activation energy is 96.24 kJ·mol^-1. By contrast, the reaction mechanism of AUPC with CO2 follows the shrinkage spherical function model and the apparent activation energy is 133.55 kJ·mol^-1.

Generation of reactive species in atmospheric pressure dielectric barrier discharge with liquid water

Atmospheric pressure helium/water dielectric barrier discharge（DBD） plasma is used to investigate the generation of reactive species in a gas–liquid interface and in a liquid. The emission intensity of the reactive species is measured by optical emission spectroscopy（OES）with different discharge powers at the gas–liquid interface. Spectrophotometry is used to analyze the reactive species induced by the plasma in the liquid. The concentration of OH radicals reaches 2.2 μm after 3 min of discharge treatment. In addition, the concentration of primary longlived reactive species such as H;O;, NO;and O;are measured based on plasma treatment time.After 5 min of discharge treatment, the concentration of H;O;, NO;, and O;increased from 0 mg?·?L;to 96 mg?·?L;, 19.5 mg?·?L;, and 3.5 mg?·?L;, respectively. The water treated by plasma still contained a considerable concentration of reactive species after 6 h of storage. The results will contribute to optimizing the DBD plasma system for biological decontamination.

Investigation of optimum discharge characteristics and chemical activity of AC driven air plasma jet and its anticancer effect

In this study,we investigated the effects of the quartz tube diameter,air flow rate,and applied voltage on the characteristics of an air plasma jet to obtain the optimized discharge characteristics.The physicochemical properties and concentration of reactive oxygen and nitrogen species(RONS)in plasma-activated medium(PAM)were characterized to explore their chemical activity.Furthermore,we investigated the inactivation effect of air plasma jet on tumour cells and their corresponding inactivation mechanism.The results show that the tube diameter plays an important role in sustaining the voltage of the air plasma jet,and the gas flow rate affects the jet length and discharge intensity.Additionally,the air plasma jet discharge displays two modes,namely,ozone and nitrogen oxide modes at high and low gas flow rates,respectively.Increasing the voltage increases the concentration of reactive species and the length of discharge.By evaluating the viability of A549 cells under different parameters,the optimal treatment conditions were determined to be a quartz tube diameter of 4 mm,gas flow rate of 0.5 SLM,and voltage of 18 k V.Furthermore,an air plasma jet under the optimized conditions effectively enhanced the chemical activity in PAM and produced more aqueous RONS.The air plasma jet induced significant cytotoxicity in A549 cancer cells after plasma treatment.H_(2)O_(2) and NO_(2) are regarded as key factors in promoting cell inactivation.The present study demonstrates the potential use of tumour cell therapy by atmospheric air PAM,which aids a better understanding of plasma liquid chemistry.

儿童侵袭性流感嗜血杆菌感染的临床特征及血清学分型

目的分析儿童侵袭性流感嗜血杆菌(Hin)感染的临床特征及血清分型特点。方法回顾性分析2015—2021年山西省儿童医院收治的34例侵袭性Hin感染患儿的病例资料。根据临床诊断分为脑膜炎感染组和非脑膜炎感染组。分析患儿的一般资料、症状、体征、实验室血清学指标、Hin血清分型特点及两组间炎症因子水平的差异。结果34例患儿中男22例,女12例,男女比例为1.83∶1,≤36个月患儿占82.35%。脑膜炎感染组患儿降钙素原(PCT)为[23.71(4.10,77.80)]ng/mL、C反应蛋白(CRP)为[200.00(164.55,200.00)]mg/L,均高于非脑膜炎组[分别为1.08(0.49,6.00)ng/mL、69.46(48.09,125.63)mg/L],差异均具有统计学意义(均P<0.05)。血小板计数(PLT)非脑膜炎组[(312.56±186.81)×10^(9)/L]高于脑膜炎组[(183.28±165.67)×10^(9)/L],差异有统计学意义(P<0.05)。白细胞计数(WBC)和中性粒细胞百分比(NEUT)两组间比较,差异无统计学意义(均P>0.05)。分离的Hin菌株中,b型流感嗜血杆菌(Hib)27株,e型2株,f型2株,3株不可分型,未发现a、c、d血清型菌株。脑膜炎感染组与非脑膜炎感染组患儿可分型Hin菌株分布比较,差异无统计学意义(χ^(2)=0.25,P>0.05)。可分型Hin菌株在男、女患儿中的构成比(67.74%VS 32.26%)比较,差异无统计学意义(χ^(2)=1.42,P>0.05)。结论侵袭性Hin感染病例以3岁以内儿童居多,分离株以b型占优势,感染患儿CRP、PCT明显升高,PLT明显低于非感染患儿,对临床诊断有一定应用价值,可结合临床及其他检验项目为侵袭性感染疾病的早期分类诊断及抗感染治疗提供有效支持。

电力电子变压器参与配电网调压调频的应用研究

为提升配电网的稳定性,该文提出利用配电网电力电子变压器对配电网的电压和频率进行调节。通过电力电子变压器输入级进行配电网无功功率调节,利用母线电压下垂特性提出无功调节方法,并引入无功电流反馈以提高配电网电压质量和稳定性;同时,通过电力电子变压器输出级控制负载电压以调节配网有功功率,作为一次调频储备负载,从而在频率暂态期间减小频率偏差。通过对基于配电网电力电子变压器的调压调频控制方法进行实验验证,所提控制策略能改善配电网电压和频率质量,有效提升配电网的稳定性。

考虑系统稳定边界的同步调相机励磁与升压变参数联合优化

现有提升调相机动态无功特性的参数优化方法侧重于电磁参数的优化,这给生产企业带来较高的工艺要求和较大的成本压力。针对该问题提出考虑系统稳定约束的调相机励磁系统及升压变参数联合优化方法,分析其对电磁参数优化的可替代性。首先,推导了基于Park模型下调相机的无功频域特性,与6阶实用模型下的无功频域特性对比,基于调相机的Park模型可提升调相机动态无功特性的分析精度。然后,提出根据调相机并网系统的稳定边界确定参数的优化区间,采用频域灵敏度方法确定重点参数,并基于人工鱼群算法进行参数优化。最后,通过仿真结果表明,励磁系统与升压变参数的联合优化,可获得与仅优化电磁参数时相近的调相机动态无功性能,验证了电磁参数优化的可替代性,从而降低调相机的制造成本,扩大同步调相机的应用场合和范围。

失活石灰石自活化增强循环捕集CO_(2)特性

钙循环工艺是一种低成本高效率捕集CO_(2)技术,运行过程需不断补充新鲜吸收剂并排出失活吸收剂,实现失活钙基吸收剂原位资源化利用具有重要意义。为研究颗粒状石灰石失活后自活化特性,运用双固定床反应器制备了失活石灰石,分析了自活化后石灰石碳酸化转化率随循环次数的变化规律,采用XRD、SEM、N_(2)吸附等分析测试手段探究了自活化提高失活石灰石循环捕集CO_(2)性能机理。结果表明,失活石灰石置于环境中可吸收空气中水分生成Ca(OH)_(2),吸水率φ达100%后,继续吸水生成氢氧化钙水合物,极限吸水率为130%。不同程度自活化后的石灰石循环捕集CO_(2)性能均有不同程度提高,随吸水率变化呈线性升高趋势。与分析纯CaCO3相比,失活石灰石对吸水率变化更敏感,随吸水率升高其循环捕集CO_(2)性能提高更快。吸水率为130%时,自活化后石灰石循环捕集CO_(2)性能甚至优于新鲜石灰石。微观结构分析结果显示:新鲜石灰石因高温烧结而失活过程中,CaO晶粒尺寸由41.9 nm长大至72.2 nm,孔隙结构发生坍塌阻塞,比孔容和比表面积显著降低。经过自活化,煅烧后的石灰石中CaO晶粒尺寸降低,原本密实的表面重新生成孔隙结构;吸水率为130%时,晶粒尺寸降至35.1 nm,比孔容和比表面积分别恢复至新鲜石灰石的70.5%和107.6%,特别是10~100 nm孔隙得以再生,因此失活石灰石循环捕集CO_(2)性能恢复。虽然自活化过程会加剧失活石灰石颗粒磨损速率,但吸水率100%的自活化石灰石磨损导致直径每小时减小量仅为颗粒直径的0.55%。综上所述,自活化后的失活石灰石完全可替代新鲜石灰石,作为补充钙基吸收剂用于钙循环捕集CO_(2)。

长沙夏季大气非甲烷碳氢污染特征及来源解析

非甲烷碳氢(NMHCs)是臭氧等二次污染重要前体物.选择长沙市2个城市站(W和S点)于2017年夏季采集了大气NMHCs样品.结果显示,观测期间长沙市NMHCs平均体积浓度为(8.67±3.62)×10^(-9)(W)和(12.30±6.01)×10^(-9)(S).烷烃是最主要组分,贡献了64.7%(W)和60.5%(S);其次是芳香烃,占比21.6%(W)和24.4%(S).浓度组成及比值日变化特征表明W点NMHCs浓度上午高于下午,主要受机动车排放影响;S点则是早晚高中午低,可能与中午光化学反应强、早高峰机动车排放大等有关.芳香烃是最重要的活性化合物,贡献了53.9%—56.0%的臭氧生成潜势;异戊二烯和烯烃对等效丙烯浓度的贡献也较大(合计>40%).长沙市夏季大气NMHCs来源主要有汽油车尾气(25.0%)、工业过程与溶剂使用(20.2%)、生物质燃烧与天然气使用(19.8%)、汽油挥发(17.2%)、柴油车尾气(12.3%)和植物排放(5.5%).不同站点来源存在差异:W点受汽油车尾气影响最大(30.2%),其次是生物质燃烧与天然气使用(22.6%);而S点主要受工业过程与溶剂使用(23.9%)和汽油车尾气影响(20.2%).

活性弹丸超高速撞击蜂窝夹芯板双层结构的损伤特性

为了研究蜂窝夹芯板双层结构在活性弹超高速撞击下的损伤特性,制备了PTFE(polytetrafluoroethylene)/Al/Cu柱形活性弹丸,利用二级轻气炮对蜂窝夹芯板双层结构靶开展超高速撞击实验,采用超高速摄像机记录了活性弹撞击蜂窝板的碎片云演化过程,分析了蜂窝板的穿孔特性和结构内部各组件的损伤特征;数值模拟了撞击过程,分析了活性弹丸的超高速侵爆效应,获得了碎片云的膨胀运动规律,揭示了活性弹丸冲击-爆轰耦合效应对靶板的损伤机理。结果表明:活性弹丸在蜂窝板上形成较小的入射孔和较大的出射孔,出射孔直径随着撞击速度的提高而增大;蜂窝夹芯板入射孔、出射孔和蜂窝芯穿孔直径随着活性弹体质量的增加而增大,入射孔直径不受蜂窝板厚度和蜂窝芯胞格直径的影响,出射孔和蜂窝芯穿孔直径随着蜂窝板厚度的增大先增大后减小,随着蜂窝芯胞格直径的增大而增大;活性弹产生具有较高膨胀速度的高温碎片云,其膨胀速度随着撞击速度的提高而提高。活性弹的冲击-爆轰耦合效应增大了结构内部组件的毁伤面积。在2~6 km/s速度范围内,活性弹在蜂窝板上形成的出射孔直径约为铝合金弹的1.3~1.8倍,碎片云的膨胀速度是铝合金弹的1.8~3.2倍。相较于铝合金弹丸,活性弹丸增大了蜂窝夹芯板双层结构内部和后板的毁伤面积,提高了毁伤效能。

双馈风机定子侧串阻抗的阻值优化

当电网受到大扰动导致电压骤降时,双馈风机需配合硬件改造措施以实现机组的低电压穿越。针对双馈风机采用定子侧串联阻抗的低电压穿越策略中存在的阻值整定问题,首先推导了双馈风机的转子暂态电流和开路电动势表达式,再以故障期间换流器的运行限制分析其有功无功耦合特性,最后结合上述分析提出了一种基于无功最优定子侧串阻抗的阻值优化方法。通过转子暂态电流约束和转子开路电动势约束确定阻抗选取范围,以暂态期间最大无功出力为目标,优选串联的阻抗值。仿真结果表明,所提方法优选出的阻抗值不仅能够有效抑制双馈风机所受到的暂态冲击,还能保证机组在故障期间提供无功功率,为电网电压提供支撑,提升机组故障运行能力。

The state-of-the-art of atmospheric pressure plasma for transdermal drug delivery

Plasma-enhanced transdermal drug delivery(TDD) presents advantages over traditional methods,including painless application, minimal skin damage, and rapid recovery of permeability. To harness its clinical potential, factors related to plasma’s unique properties, such as reactive species and electric fields, must be carefully considered.This review provides a concise summary of conventional TDD methods and subsequently offers a comprehensive examination of the current state-of-the-art in plasma-enhanced TDD. This includes an analysis of the impact of plasma on HaCaT human keratinocyte cells, ex vivo/in vivo studies, and clinical research on plasma-assisted TDD. Moreover, the review explores the effects of plasma on skin physical characteristics such as microhole formation, transepidermal water loss(TEWL), molecular structure of the stratum corneum(SC), and skin resistance. Additionally, it discusses the involvement of various reactive agents in plasma-enhanced TDD, encompassing electric fields,charged particles, UV/VUV radiation, heat, and reactive species. Lastly, the review briefly addresses the temporal behavior of the skin after plasma treatment, safety considerations, and potential risks associated with plasma-enhanced TDD.

爆炸载荷下拼接陶瓷板膨胀破碎行为及飞散特性研究

为探究不同形状及尺寸的拼接陶瓷板在爆炸载荷下的膨胀破碎行为及飞散特性,对不同类型陶瓷平板药室的爆轰驱动过程进行了仿真,研究了陶瓷破片的粒径分布规律及陶瓷板不同位置处的破片速度和飞散角变化规律。结果表明:不同类型拼接陶瓷平板的膨胀破碎过程大致相同。拼接陶瓷片数目对陶瓷平板形成的破片数目及质量分布有较大影响,大部分破片对软目标杀伤能力小;陶瓷破片均满足Rosin-Rammler分布且拼接陶瓷片尺寸及形状影响破片的平均特征尺寸系数λ和幂指数系数k。不同类型陶瓷板水平轴向和垂直轴向破片速度变化趋势差异较大,而边缘横向及边缘纵向破片速度变化趋势相同;陶瓷平板不同位置处的破片飞散角均在-1.75~1.75°内变化,因此其杀伤区域有限。

基于线芯-护层过渡电阻无功特性的交叉互联电缆故障测距

高压电缆常见的接地方式是交叉互联接地,而交叉互联接地电缆故障时的测距相比单端接地或两端直接接地的电缆情况更为复杂,为此提出了基于线芯-护层过渡电阻无功特性的交叉互联电缆故障测距方法。首先,采集护层故障前后环流,构建不同电缆区段特征电流,判断故障发生区段;其次,考虑电缆金属护层对线芯的耦合作用和线路电容影响,建立交叉互联电缆的故障稳态等效阻抗模型,利用电缆首末两端线芯和护层的电压、电流推算电缆故障发生时不同区段沿线电压、电流,并基于同一位置电压相量对电缆参数进行修正;然后,利用故障点过渡电阻消耗无功功率为零的功率特性建立以故障距离为未知数的测距方程,采用二分法或弦截法等方法迭代计算求解得到故障点;最后,基于PSCAD/EMTDC仿真软件搭建了电缆故障模型,分析了故障距离、故障类型、过渡电阻、故障初相角等因素对故障测距方法的影响。结果表明,该方法的测距误差为0.4%左右,具有较高的准确性和有效性,对交叉互联接地电缆进行故障测距有一定的参考意义。

基于瘦煤煤质特性的炼焦配煤方案优化试验研究

在炼焦配煤中合理利用瘦煤并提升其占比,可实现焦化企业降本增效和保护优质炼焦煤资源。为探究焦化厂配煤方案中瘦煤比例添加及方案优化调整对焦炭质量的影响,选取贫瘦煤(MC)和瘦煤(LC1和LC2)及采用工业分析、岩相分析等了解单种煤的基本煤质特性,利用红外光谱、热重分析确定煤样的结构特征和挥发分释放行为,并基于瘦煤的煤质特性,采用40 kg焦炉试验对不同瘦煤比例的配合煤进行焦炭质量评价,探究焦炭质量差异原因。结果表明:基于基础配煤方案,将LC1和LC2的占比增加至35%时,焦炭反应性(CRI)降低,反应后强度(CSR)升高,焦炭质量依然优于基础方案所制备的焦炭质量;在基础方案中,MC能对LC1和LC2进行替换,且替换后的CRI降低及CSR升高,焦炭光学组织中的细粒和中粒镶嵌结构增加,焦炭质量未发生劣化;MC占比增加至11%时,CRI升高以及CSR降低,焦炭质量发生明显劣化。基于瘦煤的煤质特性,配煤中的瘦煤比例可达到较高的配比,为后续工业配煤方案中利用高阶煤提供理论依据。

平均血小板体积/淋巴细胞比值与克罗恩病患者内镜评分、疾病活动度的关系

目的 探讨平均血小板体积/淋巴细胞比值(MPVLR)与克罗恩病患者内镜评分、疾病活动度的关系。方法 回顾性选取2020年10月—2022年10月收治的126例克罗恩病作为研究对象,根据入院时简化克罗恩病活动指数将患者分入活动组(n=49)和缓解组(n=77),同时对患者进行克罗恩病国内标准内镜评分分级。另选取同期体检的100例健康志愿者作为对照组。统计所有对象临床资料及入院时MPVLR。采用多因素Logistic回归分析克罗恩病患者疾病活动度的影响因素,采用受试者工作特征曲线下面积(AUC)分析MPVLR对克罗恩病患者疾病活动度的预测价值。结果 与内镜评分轻度患者比较,重度和中度患者MPVLR水平升高,且重度患者高于中度患者(P<0.05)。与对照组比较,活动组和缓解组MPVLR水平升高,且活动组高于缓解组(P<0.05)。平均血小板体积、淋巴细胞预测克罗恩病患者疾病活动度的AUC分别为0.740、0.851,MPVLR预测的AUC为0.915。活动组肛周病变、C反应蛋白>3 mg/L比例高于缓解组,而红细胞压积与平均红细胞体积低于缓解组(P<0.01)。肛周病变、C反应蛋白、MPVLR是影响克罗恩病患者疾病活动度的独立危险因素(P<0.01)。结论 高水平MPVLR能够影响克罗恩病患者的内镜评分分级和疾病活动度,检测MPVLR可能有助于确定克罗恩病的活动期,为临床诊疗提供依据。