Some specified chips in traditional Manchester-Ⅱencoding/decoding designs are used to guarantee strictly the stability of the input wave,otherwise the capacity of anti-interference and resilience are degraded serious...Some specified chips in traditional Manchester-Ⅱencoding/decoding designs are used to guarantee strictly the stability of the input wave,otherwise the capacity of anti-interference and resilience are degraded seriously.In this paper,a new Manchester-Ⅱencoding/ decoding system is used for nuclear logging by a 7 000 m armoring cable.A thorough hardware wave tracking decoding algorithm is proposed and realized in a FPGA hardware chip.An on-site measurements show that this transmission system can decode correctly in real time,with a bit error rate of better than 10^(-10).展开更多
Long non-coding RNAs(lncRNAs) play a key role in craniocerebral disease, although their expression profiles in human traumatic brain injury are still unclear. In this regard, in this study, we examined brain injury ti...Long non-coding RNAs(lncRNAs) play a key role in craniocerebral disease, although their expression profiles in human traumatic brain injury are still unclear. In this regard, in this study, we examined brain injury tissue from three patients of the 101 st Hospital of the People's Liberation Army, China(specifically, a 36-year-old male, a 52-year-old female, and a 49-year-old female), who were diagnosed with traumatic brain injury and underwent brain contusion removal surgery. Tissue surrounding the brain contusion in the three patients was used as control tissue to observe expression characteristics of lncRNAs and mRNAs in human traumatic brain injury tissue. Volcano plot filtering identified 99 lncRNAs and 63 mRNAs differentially expressed in frontotemporal tissue of the two groups(P < 0.05, fold change > 1.2). Microarray analysis showed that 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. Meanwhile, 59 mRNAs were up-regulated and 4 mRNAs were down-regulated. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analyses revealed 27 signaling pathways associated with target genes and, in particular, legionellosis and influenza A signaling pathways. Subsequently, a lncRNA-gene network was generated, which showed an absolute correlation coefficient value > 0.99 for 12 lncRNA-mRNA pairs. Finally, quantitative real-time polymerase chain reaction confirmed different expression of the five most up-regulated mRNAs within the two groups, which was consistent with the microarray results. In summary, our results show that expression profiles of mRNAs and lncRNAs are significantly different between human traumatic brain injury tissue and surrounding tissue, providing novel insight regarding lncRNAs' involvement in human traumatic brain injury. All participants provided informed consent. This research was registered in the Chinese Clinical Trial Registry(registration number: ChiCTR-TCC-13004002) and the protocol version number is 1.0.展开更多
课程学习是研究生教育的重要组成部分。由于药品是特殊的商品,受各地法律严格监管,因此,药政法规和行业指导原则应该成为药学教育,特别是研究生教育不可缺少的内容。笔者以新加坡国立大学(National University of Singapore,NUS)研究生...课程学习是研究生教育的重要组成部分。由于药品是特殊的商品,受各地法律严格监管,因此,药政法规和行业指导原则应该成为药学教育,特别是研究生教育不可缺少的内容。笔者以新加坡国立大学(National University of Singapore,NUS)研究生学位课程PR5211 Pharmaceutical Analysis IV(PR5211药物分析IV)为例,讨论如何以药政部门颁行的生物分析方法验证的行业指导原则(Guidance for Industry:Bioanalytical Method Validation)为基础,设计体内药物分析的研究生学位课程。此课程以行业指导原则为纲,在真实世界的具体个案中教授药物分析知识,在实景中考查分析技能的应用,特别强调培养学生的终身学习能力,在实践中取得了良好的效果,这样的教育模式值得坚持,并在药学其他研究生课程中推广。展开更多
文章主要探讨5G通信技术在电力自动化系统中的应用,特别是在实时监控与控制方面。概述了智能电网的核心技术,并强调集成先进信息与通信技术的重要性;对比分析了5G和现有长期演进(Long Term Evolution,LTE)技术在智能电网监控与控制中的...文章主要探讨5G通信技术在电力自动化系统中的应用,特别是在实时监控与控制方面。概述了智能电网的核心技术,并强调集成先进信息与通信技术的重要性;对比分析了5G和现有长期演进(Long Term Evolution,LTE)技术在智能电网监控与控制中的应用,特别是在实时性能和故障管理方面的差异;通过仿真实验和案例分析,展示了5G在电力自动化系统中的应用潜力,尤其在提高故障检测和处理速度方面具有显著优势。此外,还研究了基于5G通信技术的配电网实时监控与控制方法,如智能电网的监控和控制管理架构,并对比了基于LTE的集中式网络管理和基于5G的分布式网络管理2种场景。展开更多
基金Supported by the China National High Technology Research and Development Program(863 Plans) funding for this project(No,2006AA09A102-02)
文摘Some specified chips in traditional Manchester-Ⅱencoding/decoding designs are used to guarantee strictly the stability of the input wave,otherwise the capacity of anti-interference and resilience are degraded seriously.In this paper,a new Manchester-Ⅱencoding/ decoding system is used for nuclear logging by a 7 000 m armoring cable.A thorough hardware wave tracking decoding algorithm is proposed and realized in a FPGA hardware chip.An on-site measurements show that this transmission system can decode correctly in real time,with a bit error rate of better than 10^(-10).
基金supported by the National Natural Science Foundation of China,No.81571939(to KX),81601719(to JZ)and 81772134(to KX)Key Research and Development Program of Hunan Province of China,No.2018SK2091(to KX)+1 种基金Wu Jie-Ping Medical Foundation of the Minister of Health of China,No.320.6750.14118(to KX)Teacher Research Foundation of Central South University of China,No.2014JSJJ026(to KX)
文摘Long non-coding RNAs(lncRNAs) play a key role in craniocerebral disease, although their expression profiles in human traumatic brain injury are still unclear. In this regard, in this study, we examined brain injury tissue from three patients of the 101 st Hospital of the People's Liberation Army, China(specifically, a 36-year-old male, a 52-year-old female, and a 49-year-old female), who were diagnosed with traumatic brain injury and underwent brain contusion removal surgery. Tissue surrounding the brain contusion in the three patients was used as control tissue to observe expression characteristics of lncRNAs and mRNAs in human traumatic brain injury tissue. Volcano plot filtering identified 99 lncRNAs and 63 mRNAs differentially expressed in frontotemporal tissue of the two groups(P < 0.05, fold change > 1.2). Microarray analysis showed that 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. Meanwhile, 59 mRNAs were up-regulated and 4 mRNAs were down-regulated. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analyses revealed 27 signaling pathways associated with target genes and, in particular, legionellosis and influenza A signaling pathways. Subsequently, a lncRNA-gene network was generated, which showed an absolute correlation coefficient value > 0.99 for 12 lncRNA-mRNA pairs. Finally, quantitative real-time polymerase chain reaction confirmed different expression of the five most up-regulated mRNAs within the two groups, which was consistent with the microarray results. In summary, our results show that expression profiles of mRNAs and lncRNAs are significantly different between human traumatic brain injury tissue and surrounding tissue, providing novel insight regarding lncRNAs' involvement in human traumatic brain injury. All participants provided informed consent. This research was registered in the Chinese Clinical Trial Registry(registration number: ChiCTR-TCC-13004002) and the protocol version number is 1.0.
文摘课程学习是研究生教育的重要组成部分。由于药品是特殊的商品,受各地法律严格监管,因此,药政法规和行业指导原则应该成为药学教育,特别是研究生教育不可缺少的内容。笔者以新加坡国立大学(National University of Singapore,NUS)研究生学位课程PR5211 Pharmaceutical Analysis IV(PR5211药物分析IV)为例,讨论如何以药政部门颁行的生物分析方法验证的行业指导原则(Guidance for Industry:Bioanalytical Method Validation)为基础,设计体内药物分析的研究生学位课程。此课程以行业指导原则为纲,在真实世界的具体个案中教授药物分析知识,在实景中考查分析技能的应用,特别强调培养学生的终身学习能力,在实践中取得了良好的效果,这样的教育模式值得坚持,并在药学其他研究生课程中推广。
文摘文章主要探讨5G通信技术在电力自动化系统中的应用,特别是在实时监控与控制方面。概述了智能电网的核心技术,并强调集成先进信息与通信技术的重要性;对比分析了5G和现有长期演进(Long Term Evolution,LTE)技术在智能电网监控与控制中的应用,特别是在实时性能和故障管理方面的差异;通过仿真实验和案例分析,展示了5G在电力自动化系统中的应用潜力,尤其在提高故障检测和处理速度方面具有显著优势。此外,还研究了基于5G通信技术的配电网实时监控与控制方法,如智能电网的监控和控制管理架构,并对比了基于LTE的集中式网络管理和基于5G的分布式网络管理2种场景。
