Objective:To explore the clinical characteristics of Elemene Injection in the treatment of patients with esophageal cancer.Methods:A total of 310 patients diagnosed with esophageal cancer from the Hoptital Information...Objective:To explore the clinical characteristics of Elemene Injection in the treatment of patients with esophageal cancer.Methods:A total of 310 patients diagnosed with esophageal cancer from the Hoptital Information System(HIS)of 21 hospitals across the country were selected in the study,and these patients all had been treated with Elemene Injection.In this study,the clinical general medication record information,diagnosis scheme information,general treatment information and combined medications information were analyzed by frequency statistics and association rules.Results:Elemene Injection was used most in patients aged 46-65(177 cases,57.10%);male patients were more than female.Among the main diagnoses of the most seasons and solar terms in hospitalization,the top three diagnoses were esophageal malignant tumor,malignant tumor,and hypertension.In terms of combination medication,the combination of western medicine blood substitutes and perfusion fluids,general nutritional drugs,vitamins,antibacterial drugs,and immune-promoting drugs were the main ones;the combination of traditional Chinese medicine was mainly anti-tumor drugs(48.71%).In addition,among the combination medications,the highest frequency of Elemene Injection combined with western medicine and traditional Chinese medicine were Xiaoaiping Injection(消癌平注射液)and ascorbic acid.Conclusion:The main susceptible people of esophageal cancer was middle-aged around 46-65,and there were more male patients than female;through the first diagnosis of western medicine,it can be found that in addition to patients suffering from esophageal cancer or other cancers,patients with high blood pressure,heart disease,and diabetes could use Elemene Injection.Therefore,when receiving such patients,attention should be paid to checking whether the patient had such diseases.At the same time,when using Elemene Injection,it's necessary to pay attention to certain combined medications to avoid adverse reactions.展开更多
目的基于真实世界研究探讨全国名中医庞国明教授纯中医缓解2型糖尿病(T2DM)临床特征,为临床实践提供借鉴和参考。方法采集2020年1月—2022年10月开封市中医院庞国明教授工作室就诊的符合T2DM诊断,并采用纯中医“三辨诊疗模式”“序贯三...目的基于真实世界研究探讨全国名中医庞国明教授纯中医缓解2型糖尿病(T2DM)临床特征,为临床实践提供借鉴和参考。方法采集2020年1月—2022年10月开封市中医院庞国明教授工作室就诊的符合T2DM诊断,并采用纯中医“三辨诊疗模式”“序贯三法”治疗方案且达到缓解标准的T2DM患者共计30例。采集患者的人口学资料、中医证型及纯中医治疗前、治疗达标停药时、缓解时患者的体质量指数、血生化检验指标,计算纯中医治疗时长,使用稳态模型评估法评估胰岛素抵抗指数和胰岛β细胞功能指数。分析患者的临床特征、中医证型分布,比较纯中医治疗前与治疗达标停药时、缓解时各项指标的差异。结果患者平均年龄(50.77±9.77)岁;平均病程中位数22(10.5,39.0)个月;平均体质量指数中位数27.75(25.87,28.80)kg/m^(2),中医证型分布情况:痰浊中阻证频率最高,其次气阴两虚证。与治疗前比较,患者停药时空腹血糖(FPG)、餐后1 h血糖(1 h PG)、2 h PG、3 h PG、空腹胰高血糖素(FGC)、1 h GC、2 h GC、3 h GC、糖化血红蛋白(HbA1c)、果糖胺(FMN)、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)、总胆固醇(TC)水平明显下降,差异有统计学意义(P<0.05),1 h C肽(CP)、胰岛β细胞功能指数(HOMA-β)水平较前升高,差异有统计学意义(P<0.05),与治疗前比较,缓解时FPG、1 h PG、2 h PG、1 h GC、2 h GC、HbA1c、BMI、3 h PG、FGC、3 h GC、TC、HOMA-IR水平明显下降,差异有统计学意义(P<0.05),HOMA-β、1 h CP、高密度脂蛋白胆固醇(HDL-C)水平较前升高,差异有统计学意义(P<0.05)。结论纯中医缓解T2DM患者以糖尿病病程<5年,超重或肥胖为主,纯中医治疗时长多集中在3~12个月,中医证型以痰浊中阻证为主。纯中医可能通过降低体质量,改善胰岛素抵抗,改善胰岛β细胞功能,降低胰高血糖素等途径实现缓解T2DM。展开更多
基金Science and technology innovation project of China Academy of Chinese Medical Sciences(ci2021a00702)[approval:National key R&D plan"demonstration study on evidence-based evaluation and effect mechanism of ten large varieties of Chinese patent medicines and classic famous prescriptions in the treatment of major diseases after listing"(2018yfc1707400)]。
文摘Objective:To explore the clinical characteristics of Elemene Injection in the treatment of patients with esophageal cancer.Methods:A total of 310 patients diagnosed with esophageal cancer from the Hoptital Information System(HIS)of 21 hospitals across the country were selected in the study,and these patients all had been treated with Elemene Injection.In this study,the clinical general medication record information,diagnosis scheme information,general treatment information and combined medications information were analyzed by frequency statistics and association rules.Results:Elemene Injection was used most in patients aged 46-65(177 cases,57.10%);male patients were more than female.Among the main diagnoses of the most seasons and solar terms in hospitalization,the top three diagnoses were esophageal malignant tumor,malignant tumor,and hypertension.In terms of combination medication,the combination of western medicine blood substitutes and perfusion fluids,general nutritional drugs,vitamins,antibacterial drugs,and immune-promoting drugs were the main ones;the combination of traditional Chinese medicine was mainly anti-tumor drugs(48.71%).In addition,among the combination medications,the highest frequency of Elemene Injection combined with western medicine and traditional Chinese medicine were Xiaoaiping Injection(消癌平注射液)and ascorbic acid.Conclusion:The main susceptible people of esophageal cancer was middle-aged around 46-65,and there were more male patients than female;through the first diagnosis of western medicine,it can be found that in addition to patients suffering from esophageal cancer or other cancers,patients with high blood pressure,heart disease,and diabetes could use Elemene Injection.Therefore,when receiving such patients,attention should be paid to checking whether the patient had such diseases.At the same time,when using Elemene Injection,it's necessary to pay attention to certain combined medications to avoid adverse reactions.
文摘目的基于真实世界研究探讨全国名中医庞国明教授纯中医缓解2型糖尿病(T2DM)临床特征,为临床实践提供借鉴和参考。方法采集2020年1月—2022年10月开封市中医院庞国明教授工作室就诊的符合T2DM诊断,并采用纯中医“三辨诊疗模式”“序贯三法”治疗方案且达到缓解标准的T2DM患者共计30例。采集患者的人口学资料、中医证型及纯中医治疗前、治疗达标停药时、缓解时患者的体质量指数、血生化检验指标,计算纯中医治疗时长,使用稳态模型评估法评估胰岛素抵抗指数和胰岛β细胞功能指数。分析患者的临床特征、中医证型分布,比较纯中医治疗前与治疗达标停药时、缓解时各项指标的差异。结果患者平均年龄(50.77±9.77)岁;平均病程中位数22(10.5,39.0)个月;平均体质量指数中位数27.75(25.87,28.80)kg/m^(2),中医证型分布情况:痰浊中阻证频率最高,其次气阴两虚证。与治疗前比较,患者停药时空腹血糖(FPG)、餐后1 h血糖(1 h PG)、2 h PG、3 h PG、空腹胰高血糖素(FGC)、1 h GC、2 h GC、3 h GC、糖化血红蛋白(HbA1c)、果糖胺(FMN)、胰岛素抵抗指数(HOMA-IR)、体质量指数(BMI)、总胆固醇(TC)水平明显下降,差异有统计学意义(P<0.05),1 h C肽(CP)、胰岛β细胞功能指数(HOMA-β)水平较前升高,差异有统计学意义(P<0.05),与治疗前比较,缓解时FPG、1 h PG、2 h PG、1 h GC、2 h GC、HbA1c、BMI、3 h PG、FGC、3 h GC、TC、HOMA-IR水平明显下降,差异有统计学意义(P<0.05),HOMA-β、1 h CP、高密度脂蛋白胆固醇(HDL-C)水平较前升高,差异有统计学意义(P<0.05)。结论纯中医缓解T2DM患者以糖尿病病程<5年,超重或肥胖为主,纯中医治疗时长多集中在3~12个月,中医证型以痰浊中阻证为主。纯中医可能通过降低体质量,改善胰岛素抵抗,改善胰岛β细胞功能,降低胰高血糖素等途径实现缓解T2DM。
