A total synthesis of(3S, 6S)- (+)-3,7-dimethyl-3-acetoxy-6-hydroxy-octa-1,7-diene via the rearrangement of chiral 2,3-epoxy alcohol, with the system of Ph3P, pyridine, I-2 and H2O, is described.
An effcient formal synthesis of（＋）-tashiromine was achieved by employing an intermolecular asymmetric Mannich-type reaction as the key step.Concurrently,a novel approach toward the total synthesis of（＋）-stemoami...An effcient formal synthesis of（＋）-tashiromine was achieved by employing an intermolecular asymmetric Mannich-type reaction as the key step.Concurrently,a novel approach toward the total synthesis of（＋）-stemoamide through dyotropic rearrangement of 3,4-cis-b-lactone was also explored.展开更多
文摘A total synthesis of(3S, 6S)- (+)-3,7-dimethyl-3-acetoxy-6-hydroxy-octa-1,7-diene via the rearrangement of chiral 2,3-epoxy alcohol, with the system of Ph3P, pyridine, I-2 and H2O, is described.
基金the financial supports from Beijing Natural Science Foundation (No. 2132037)NSFC (Nos. 21102081, 21272133)+1 种基金New Teachers’ Fund for Doctor Stations Ministry of Education (No. 20110002120011)Scientifc Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education (No. 20121027968)
文摘An effcient formal synthesis of（＋）-tashiromine was achieved by employing an intermolecular asymmetric Mannich-type reaction as the key step.Concurrently,a novel approach toward the total synthesis of（＋）-stemoamide through dyotropic rearrangement of 3,4-cis-b-lactone was also explored.
