A new supercritical fluid(SCF)technique was developed for the preparation of microspheres for pulmonary drug delivery(PDD).This technique,based on the anti-solvent process,has incorporated advanced engineering design ...A new supercritical fluid(SCF)technique was developed for the preparation of microspheres for pulmonary drug delivery(PDD).This technique,based on the anti-solvent process,has incorporated advanced engineering design features to enable improved control of the particle formation process.Human recombinant insulin(HRI)was used as a model compound to evaluate the efficiency of this SCF process.An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water,leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.展开更多
基金Dongbao Pharmaceuticals Co.Ltd for generously offering HRI(API)China National Academy of Nanotechnology and Engineering for the analytical support of this project.
文摘A new supercritical fluid(SCF)technique was developed for the preparation of microspheres for pulmonary drug delivery(PDD).This technique,based on the anti-solvent process,has incorporated advanced engineering design features to enable improved control of the particle formation process.Human recombinant insulin(HRI)was used as a model compound to evaluate the efficiency of this SCF process.An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water,leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.
