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EFFECT OF ELECTROACUPUNCTURE ON RED BLOOD CELL IMMUNE AND T-CELL SUBGROUP IN THE RAT
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作者 高巍 黄裕新 +2 位作者 陈洪 孙大勇 张洪新 《World Journal of Acupuncture-Moxibustion》 2000年第3期29-32,共4页
In the present study, the effect of electroacupuncture (EA) on immune system was observed in the rat by using micro- whole blood direct immunofluorescence staining assay to detect changes of the peripheral blood T lym... In the present study, the effect of electroacupuncture (EA) on immune system was observed in the rat by using micro- whole blood direct immunofluorescence staining assay to detect changes of the peripheral blood T lymphocyte subgroup and employing red blood cell (RBC) C 3b receptor- yeast rosette test and red blood cell-IC rosette test to analyze erythrocytic immune function. Results showed that after EA of “Zusanli" (ST 36), CD+ 4, RBC-C 3bRR and RBC-ICR in the peripheral blood of the normal rats increased significantly while CD+ 8 had no any considerable changes and a positive correlation between CD+ 4 and RBC-C 3bRR was found. In immunosuppression model rats, the values of CD+ 4 and RBC-C 3bRR were obviously lower than those of the normal control group while CD+ 8 had no any striking changes; but after EA treatment, there were no evident differences between EA group and normal control group in the above-mentioned indexes. There were also no any significant differences between non-acupoint group and normal control group in those indexes. Results suggest that EA of “Zusanli" (ST 36) can raise T cell immune function and RBC adhesion function in both normal rats and immunosuppression model rats, both of which present a positive correlation. 展开更多
关键词 EA “Zusanli' (ST 36) red blood cell immune T lymphocyte subgroup Flowing cytometer
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The Popularization and Application of Cold Storage Red Blood Cells or Whole Blood at -80 ℃ of the Rh(D) Negative Patients in Surgical Operation 被引量:3
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作者 YU Zhongqing(余忠清) +7 位作者 HU Lihua(胡丽华) Han Min(韩敏) RAO Shenzong(饶神宗) LUO Chengwei(罗成伟) 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2002年第2期155-157,共3页
Summary: The efficiency of cold storage red blood cells (CSRBC) or whole blood at -80 ℃ used in 27 Rh(D) negative patients during surgical operation was reported. The Rh(D) negative patients received the transfusion... Summary: The efficiency of cold storage red blood cells (CSRBC) or whole blood at -80 ℃ used in 27 Rh(D) negative patients during surgical operation was reported. The Rh(D) negative patients received the transfusion of CSRBC or whole blood stored at -80 ℃ for 180 to 360 days. The changes in the indexes, such as blood TB, DB, K +, Na +, BUN, Cr, urine protein (URPO), UOB, Hb, HCT, serum total protein, relative to hemolytic reaction and blood volume before and after transfusion were observed. The results showed that after transfusion of CSRBC or whole blood 27 cases were negative for urine protein and UOB, and the levels of BUN and Cr were normal (P>0.05). Blood TB, DB, Hb, and HCT were increased, while pH, blood K + and blood Na + was normal with the difference being not significant before and after operation (P>0.05). Plasma protein was decreased, but there was no significant difference before and after operation (P>0.05). It was suggested that CSRBC or whole blood at -80 ℃ could be safely infused to the Rh(D) negative patients without side effects during the surgical operation. 展开更多
关键词 Rh(D) negative patient -80 cold storage red blood cells surgical operation hemolytic reaction
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Isolation of Fetal Nucleated Red Blood Cells from Maternal Blood 被引量:1
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作者 邹丽 叶晓静 +1 位作者 徐可树 朱剑文 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2000年第2期169-171,共3页
To find a simple, effective method of isolating fetal cells from maternal peripheral blood for prenatal diagnosis, 45 women were studied with their gestation being 6-14 weeks and age 21- 30 years. The fetal cells wer... To find a simple, effective method of isolating fetal cells from maternal peripheral blood for prenatal diagnosis, 45 women were studied with their gestation being 6-14 weeks and age 21- 30 years. The fetal cells were isolated from maternal blood by using discontinuous density gradient centrifugation. Some of the isolated cells were made smear and counted under the microscope; others were used for predicting fetal sex by PCR amplification of Y chromosome specific DYZ1 gene. The major cells in the upper separation interface were lymphocytes and monocytes, with occasionally seen nucleated red blood cells (NRBC); while those in the middle separation interface were neutrocytes, with NRBC scattering. The ratio of NRBC/nucleated cells was 1. 98±0. 28× 10-5. There was no significant difference between the first and second trimester (P>0. 05). The amount of isolated fetal cells was sufficient for prenatal genetic diagnosis. Male pregnancy was correctly predicted in 10 out of 13 cases. It is concluded that the method of discontinuous density gradient centrifugation was of considerable importance in the development of non-invasive prenatal genetic diagnosis. 展开更多
关键词 maternal peripheral blood nucleated red blood cell sex identification polymerase chain reaction
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Comparison of the conventional tube and erythrocyte-magnetized technology in titration of red blood cell alloantibodies 被引量:1
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作者 Xue-Hua He Hong Yan +7 位作者 Chun-Yan Wang Xue-Yun Duan Jia-Jia Qiao Xiao-Jun Guo Hong-Bin Zhao Dong Ren Jian-She Li Qiang Zhang 《World Journal of Biological Chemistry》 2023年第3期62-71,共10页
BACKGROUND Erythrocyte alloantibodies are mainly produced after immune stimulation,such as blood transfusion,pregnancy,and transplantation,and are the leading causes of severe hemolytic transfusion reactions and diffi... BACKGROUND Erythrocyte alloantibodies are mainly produced after immune stimulation,such as blood transfusion,pregnancy,and transplantation,and are the leading causes of severe hemolytic transfusion reactions and difficulty in blood grouping and matching.Therefore,antibody screening is critical to prevent and improve red cell alloantibodies.Routine tube assay is the primary detection method of antibody screening.Recently,erythrocyte-magnetized technology(EMT)has been increasingly used in clinical practice.This study intends to probe the application and efficacy of the conventional tube and EMT in red blood cell alloantibody titration to provide a reference for clinical blood transfusion.AIM To investigate the application value of conventional tube and EMT in red blood cell alloantibody titration and enhance the safety of blood transfusion practice.METHODS A total of 1298 blood samples were harvested from blood donors at the Department of Blood Transfusion of our hospital from March 2021 to December 2022.A 5 mL blood sample was collected in tubing,which was then cut,and the whole blood was put into a test tube for centrifugation to separate the serum.Different red blood cell blood group antibody titers were simultaneously detected using the tube polybrene test,tube antiglobulin test(AGT),and EMT screening irregular antibody methods to determine the best test method.RESULTS Simultaneous detection was performed through the tube polybrene test,tube AGT and EMT screening irregular antibodies.It was discovered that the EMT screening irregular antibody method could detect all immunoglobulin G(IgG)and immunoglobulin M(IgM)irregular antibodies,and the results of manual tube AGT were satisfactory,but the operation time was lengthy,and the equipment had a large footprint.The EMT screening irregular antibody assay was also conducted to determine its activity against type O Rh(D)red blood cells,and the outcomes were satisfactory.Furthermore,compared to the conventional tube method,the EMT screening irregular antibody method was more cost-effective and had significantly higher detection efficiency.CONCLUSION With a higher detection rate,the EMT screening irregular antibody method can detect both IgG and IgM irregular antibodies faster and more effectively than the conventional tube method. 展开更多
关键词 Erythrocyte-magnetized technology Conventional tube red blood cell alloantibodies Transfusion reactions Application
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THE INFLUENCE OF MEDICINAL CAKE-SEPARATED MOXIBUSTION UPON RED BLOOD CELL IMMUNITY AND FREE RADICAL IN THE AGED
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作者 赵粹英 丁菊英 +3 位作者 吴恒举 居贤水 黎飒 张英英 《World Journal of Acupuncture-Moxibustion》 1996年第4期40-44,共5页
Eighty-six senile persons,aged 60 years old or over,were treated by medicinalcake-separated moxibustion and the influence of moxibustion upon red blood cell immunity func-tion and free radical was observed.We have ado... Eighty-six senile persons,aged 60 years old or over,were treated by medicinalcake-separated moxibustion and the influence of moxibustion upon red blood cell immunity func-tion and free radical was observed.We have adopted the principle of tonifying the kidney andstrengthening the spleen,promoting blood flow and removing blood stasis.The tonic points suchas Dazhui(GV 14),Shenshu(BL 23),Guanyuan(CV 4),Shenque(CV 8)and Zhsanli(ST36)were chosen.Besides,it was supplemented with the principle of nourishing blood,tonifyingspleen and replenishing essence,using medicinal cake moxibustion.The moxibustion was givenonce every other day,three moxa-cone on each point,and twenty-four times as a therapeuticcourse.The total moxibustion amount is 264 moxa-cone.Before and after the treatment,wemeasured the red blood cell immunity function(RBC-C<sub>3</sub>b,RBC-IC,RFER,RFIR),the SOD ac-tivity of RBC,and the contents of serum LPo. Results show that in senile person,the RBC-C<sub>3</sub>b rosette formation falls while the 展开更多
关键词 MEDICINAL cake-separated MOXIBUSTION red blood cell IMMUNITY SOD Free RADICAL
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INFLUENCE OF ELECTROACUPUNCTURE ON HYPERTENSION VASCULAR DEMENTIA AND ITS RED CELL IMMUNE FUNCTION IN THE RAT
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作者 莫飞智 李坚强 +2 位作者 雷立屏 赖新生 刘颂豪 《World Journal of Acupuncture-Moxibustion》 2000年第2期32-36,共5页
Objective: To probe into the effect of electroacupuncture (EA)on vascular dementia and red cell immune function in the rat. Methods: 30 SD rats were made into renal hypertension rats(RHR) by clamping the kidney arteri... Objective: To probe into the effect of electroacupuncture (EA)on vascular dementia and red cell immune function in the rat. Methods: 30 SD rats were made into renal hypertension rats(RHR) by clamping the kidney arteries with silver clip. 42 days later, their bilateral common carotid arteries were blocked repeatedly to cause cerebral ischemia. The Hypertension vascular dementia model was then set up. Then they were randomly divided into VD model group, EA groupand medication group (Dihydroergotoxine, DHET), with 10 cases in each group. The therapeutic course was 28 days. The ability of learning and memory was using an obs erved by water maze, and the function of red blood cell immune was detected after treatment. Results: the latecy of the EA group and medication group was shorter than that of model group (P<0.05, P<0.005), and that of EA group was shorter than medication group (P<0.05, P<0.005). EA and medication could increase the RBCC 3b receptor flower circle rate and reduce the RBCIC flower circle rate significantly(P<0.05, P< 0.01). Conclusion: The results indicated that EA therapy could raise the ability of learning and memory and improve the function of red cell immune in VD rats, while the therapeutic effect of EAis better than DHET. 展开更多
关键词 Vascular Dementia Electroacupuncture Water maze red blood cell immune function Rat
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Expression of Toll-like Receptor 9 in Peripheral Blood Mononuclear Cells from Patients with Different Hepatitis B and C Viral Loads 被引量:10
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作者 周健 黄元成 +3 位作者 田德英 许东 陈淼 吴会玲 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2009年第3期313-317,共5页
The aim of the present study was to investigate the expression of toll-like receptors (TLR) 9 in peripheral blood mononuclear cells (PBMC) of patients with chronic hepatitis B and C with different virus copies. Th... The aim of the present study was to investigate the expression of toll-like receptors (TLR) 9 in peripheral blood mononuclear cells (PBMC) of patients with chronic hepatitis B and C with different virus copies. The study group included 90 patients (60 with chronic hepatitis B, and 30 with chronic hepatitis C), and 20 healthy people served as control group. The protein and mRNA levels of TLR9 were detected by using flow cytometry and real-time PCR. The serum viral copies of HBV and HCV were measured in all patients, and the correlation between HBV-DNA copies or HCV-RNA copies and the TLR9 expression was analyzed. Our results demonstrated that HBV or HCV infection led to a decreased expression of TLR9 mRNA and protein compared to the control group (P〈0.05). The TLR9 protein and mRNA levels were negatively correlated with serum viral copies of HBV and HCV (r=-0.632, r=-0.909, P〈0.01). It was concluded that TLR9 mRNA and protein are down-regulated in PBMC of HBV-infected or HCV-infected patients, and they are negatively correlated with serum viral copies and play an important role in detecting viral replication of HBV and HCV. 展开更多
关键词 peripheral blood mononuclear cells innate immunity toll-like receptor 9
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EFFECT OF SELENIUM ON IMMUNE FUNCTION OF ERYTHROCYTE IN KASHIN-BECK DISEASE
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作者 戴晓霞 熊咏民 +1 位作者 楚雍烈 王治伦 《Journal of Pharmaceutical Analysis》 SCIE CAS 2006年第1期40-43,64,共5页
Objective To investigate the relationship between erythrocyte immune function and selenium (Se) level. Methods Forty-nine Kashin-Beck patients in endemic area aged 13-16 years were divided into two groups and were ora... Objective To investigate the relationship between erythrocyte immune function and selenium (Se) level. Methods Forty-nine Kashin-Beck patients in endemic area aged 13-16 years were divided into two groups and were orally given either selenized yeast or sodium selenite to provide 200 μ g selenium per day for 12 weeks. Erythrocyte selenium level, glutathione peroxidase activity, the rosette formation rates of red blood cells complement receptor typeⅠ(CR1), the immune function of red blood cells, and circulating immune complexes(CIC) were determined. Results After supplementing with selenium for 12 weeks, erythrocyte selenium level, glutathione peroxidase activity, the rosette formation rates of red blood cells CR1 were significantly increased. But the difference in rosette formation rates of IC and CIC content was not significant between before and after Se supplementation. Conclusion The increase of the immune function of the erythrocyte by selenium-supplement may be one of the effective mechanisms for the prevention of Kashin-Beck disease. 展开更多
关键词 Kashin-Beck disease SELENIUM red blood cell immune function
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Immune evasion by Plasmodium falciparum parasites: converting a host protection mechanism for the parasite′s benefit
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作者 Bismarck Dinko Gabriele Pradel 《Advances in Infectious Diseases》 2016年第2期82-95,共15页
Immune evasion is a strategy used by pathogenic microbes to evade the host immune system in order to ensure successful propagation. Immune evasion is particularly important for the blood stages of Plasmodium falciparu... Immune evasion is a strategy used by pathogenic microbes to evade the host immune system in order to ensure successful propagation. Immune evasion is particularly important for the blood stages of Plasmodium falciparum, the causative agent of the deadly disease malaria tropica. Because Plasmodium blood stage parasites require human erythrocytes for replication, their ability to evade attack by the human immune system is essential for parasite survival. In order to escape immunity-induced killing, the intraerythrocytic parasites have evolved a variety of evasion mechanisms, including expansion of plasmodial surface proteins, organ-specific sequestration of the infected red blood cells and acquisition of immune-regulatory proteins by the parasite. This review aims to highlight recent advances in the molecular understanding of the immune evasion strategies by P. falciparum, including antigenic variation, surface protein polymorphisms and invasion ligand diversification. The review will further discuss new findings on the regulatory mechanisms applied by P. falciparum to avoid lysis by the human complement as well as killing by immune factors of the mosquito vector. 展开更多
关键词 MALARIA Plasmodium falciparum immune Evasion Infected red blood cell MEROZOITE Antibody COMPLEMENT Factor H
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红细胞分布宽度、系统免疫炎症指数与重性抑郁障碍的相关性研究
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作者 金曼 梁浩 +5 位作者 张石盼 张雪茹 井朋 杨越 王春阳 吕佩源 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2024年第7期409-414,共6页
目的探讨外周血红细胞分布宽度(red blood cell distribution width,RDW)、系统免疫炎症指数(systemic immune-inflammation index,SⅡ)与重性抑郁障碍(major depressive disorder,MDD)的相关性。方法回顾性分析2020-2022年于我院临床... 目的探讨外周血红细胞分布宽度(red blood cell distribution width,RDW)、系统免疫炎症指数(systemic immune-inflammation index,SⅡ)与重性抑郁障碍(major depressive disorder,MDD)的相关性。方法回顾性分析2020-2022年于我院临床心理科住院的176例MDD患者和常规体检的209例非MDD对照者的临床资料。从血液分析结果中,得到RDW、SⅡ、红细胞分布宽度与血小板计数比值(RDW to platelet ratio,RPR)。绘制受试者操作特征(receiver operator characteristic,ROC)曲线以确定RDW区分患者与对照的最佳临界值及曲线下面积(area under the curve,AUC)。结果MDD组患者的RDW[中位数及四分位数:13.20(12.70,13.98)vs.12.80(12.40,13.35)]、SⅡ水平[中位数及四分位数:510.87(350.95,878.12)vs.405.33(313.74,539.92)]高于非MDD组对照者,差异有统计学意义(P<0.05),两组间RPR差异无统计学意义(P>0.05)。多因素logistic回归分析结果显示,调整混杂因素后,RDW与MDD呈正关联(OR=3.086,95%CI:1.926~4.944)。ROC曲线结果显示,RDW区分MDD与非MDD的最佳临界值为12.85,AUC为0.647(95%CI:0.592~0.702;P<0.001)。结论高RDW可能是MDD发生的危险因素,是对MDD诊断有价值的重要参数。 展开更多
关键词 红细胞分布宽度 重性抑郁障碍 系统免疫炎症指数 红细胞分布宽度与血小板计数比值 炎症反应 相关性研究 危险因素
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红细胞在感染免疫中的作用研究进展
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作者 肖玲 田力 《中国输血杂志》 CAS 2024年第6期710-715,共6页
红细胞作为血液中数量最多的细胞,逐渐被发现不仅有运送氧气和二氧化碳的功能,还以多种途径参与机体免疫调节。近期有多项研究发现红细胞可通过TLR9在正常生理和感染状态下参与免疫调节,确定红细胞可通过表面的糖蛋白介导参与机体免疫应... 红细胞作为血液中数量最多的细胞,逐渐被发现不仅有运送氧气和二氧化碳的功能,还以多种途径参与机体免疫调节。近期有多项研究发现红细胞可通过TLR9在正常生理和感染状态下参与免疫调节,确定红细胞可通过表面的糖蛋白介导参与机体免疫应答,证实红细胞通过表面补体受体和结合细胞因子参与感染性疾病的进展和免疫调节。我们将总结红细胞通过以上几种分子在感染免疫应答中作用的研究进展,以增加对红细胞在感染免疫中作用的全面认识和理解。 展开更多
关键词 红细胞 感染免疫
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健脾生血方治疗小儿缺铁性贫血的疗效及对铁代谢的影响
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作者 颜鹏飞 田舒扬 张歌寻 《反射疗法与康复医学》 2024年第19期38-41,共4页
目的 探讨健脾生血方在治疗小儿缺铁性贫血中的应用价值。方法 选取安徽中医药大学附属太和县中医院2022年10月—2024年4月收治的80例缺铁性贫血患儿为研究对象,按照随机数字表法将其分为对照组和观察组,各40例。对照组给予患儿右旋糖... 目的 探讨健脾生血方在治疗小儿缺铁性贫血中的应用价值。方法 选取安徽中医药大学附属太和县中医院2022年10月—2024年4月收治的80例缺铁性贫血患儿为研究对象,按照随机数字表法将其分为对照组和观察组,各40例。对照组给予患儿右旋糖酐铁口服溶液治疗,观察组在对照组基础上加用健脾生血方治疗,两组均治疗3个疗程。对比两组的临床疗效、铁代谢指标、血红蛋白、红细胞计数及不良反应发生情况。结果 观察组治疗总有效率为97.50%,高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,观察组血清铁水平为(15.78±3.55)μmol/L,血清铁蛋白水平为(75.42±6.83)μg/L,血红蛋白水平为(131.53±6.73)g/L,红细胞计数为(5.45±0.53)×1012/L,均高于对照组的(11.47±2.93)μmol/L、(60.33±7.21)μg/L、(118.72±5.43)g/L、(4.15±0.72)×1012/L,组间差异有统计学意义(P<0.05);观察组总铁结合力水平为(63.53±2.14)μmol/L,低于对照组的(70.46±1.08)μmol/L,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论 健脾生血方治疗小儿缺铁性贫血效果显著,可改善患儿铁代谢指标,提升血红蛋白水平及红细胞计数,且不会增加不良反应。 展开更多
关键词 小儿缺铁性贫血 健脾生血方 铁代谢 血红蛋白 红细胞计数 不良反应
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气血瘀滞型非小细胞肺癌患者“瘀毒”病机临床特征及补肺化瘀汤辅助治疗干预机制 被引量:4
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作者 王芳 杨兴嫕 +1 位作者 孙琮 王士汉 《广州中医药大学学报》 CAS 2024年第1期68-77,共10页
【目的】探讨气血瘀滞型非小细胞肺癌(non-small cell lung cancer,NSCLC)患者“瘀毒”病机的临床特征以及补肺化瘀汤辅助治疗的干预机制。【方法】选取六安市中医院呼吸内科2021年1月至2022年9月收治的78例气血瘀滞型NSCLC患者作为NSCL... 【目的】探讨气血瘀滞型非小细胞肺癌(non-small cell lung cancer,NSCLC)患者“瘀毒”病机的临床特征以及补肺化瘀汤辅助治疗的干预机制。【方法】选取六安市中医院呼吸内科2021年1月至2022年9月收治的78例气血瘀滞型NSCLC患者作为NSCLC组,另选取71例同期健康体检志愿者为健康对照组,观察NSCLC组“瘀毒”病机的临床特征,比较2组凝血功能指标的差异。根据治疗方式的不同将NSCLC组患者分为补肺化瘀组40例和常规治疗组38例,常规治疗组采用常规化疗方案治疗,补肺化瘀组在常规治疗组的基础上加用补肺化瘀汤治疗,以3周为1个疗程,共治疗2个疗程。观察2组患者治疗前后中医证候积分、生活质量Karnofsky功能状态(KPS)评分、凝血功能、免疫功能、血清一氧化氮(NO)、血管内皮生长因子(VEGF)水平的变化情况,比较2组患者的临床疗效和治疗期间不良反应发生情况。【结果】(1)临床特征方面,NSCLC组患者临床分期为Ⅲ、Ⅳ期,病理类型为鳞癌、腺癌,KPS评分低于70分患者比例较高,中医证候积分较高,提示NSCLC患者病情较为严重;与健康对照组相比,NSCLC组患者的凝血酶原时间(PT)、凝血酶时间(TT)明显缩短,纤维蛋白原(FIB)、D-二聚体(D-D)水平明显升高,差异均有统计学意义(P<0.01)。(2)疗效方面,治疗6周后,补肺化瘀组的总有效率和总稳定率分别为32.50%(13/40)、85.00%(34/40),明显优于常规治疗组的13.16%(5/38)、60.53%(23/38),差异均有统计学意义(P<0.05)。(3)证候积分方面,治疗3周后,补肺化瘀组的各项中医证候积分(包括神疲乏力、胸闷气短、胸部刺痛、脉络瘀血等)和常规治疗组的神疲乏力、胸闷气短积分均较治疗前改善(P<0.05);治疗6周后,2组NSCLC患者的各项中医证候积分均较治疗前和治疗3周后改善(P<0.05);组间比较,除治疗3周后的胸闷气短外,补肺化瘀组在治疗3周和6周后对各项中医证候积分的改善作用均明显优于常规治疗组(P<0.05或P<0.01)。(4)凝血功能方面,治疗6周后,补肺化瘀组的PT、TT、FIB、D-D水平均较治疗前明显改善(P<0.05),而常规治疗组仅FIB、D-D水平较治疗前改善(P<0.05);组间比较,补肺化瘀组对PT、FIB、D-D水平的改善作用均明显优于常规治疗组(P<0.05)。(5)血清NO、VEGF水平方面,治疗6周后,2组患者的血清NO、VEGF水平均较治疗前明显降低(P<0.05),且补肺化瘀组的降低作用均明显优于常规治疗组(P<0.01)。(6)免疫功能方面,治疗6周后,补肺化瘀组的T细胞亚群CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)比值较治疗前升高(P<0.05)、CD8^(+)水平较治疗前降低(P<0.05),而常规治疗组的CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)比值较治疗前降低(P<0.05)、CD8^(+)水平较治疗前升高(P<0.05);组间比较,补肺化瘀组对CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)比值的升高作用及对CD8^(+)水平的降低作用均明显优于常规治疗组(P<0.01)。(7)生活质量方面,治疗6周后,2组患者的KPS评分均较治疗前明显升高(P<0.05),且补肺化瘀组的升高作用明显优于常规治疗组(P<0.01)。(8)不良反应方面,治疗过程中,2组患者的胃肠道反应、脱发的发生率比较,差异无统计学意义(P>0.05),而补肺化瘀组的肝肾功能损伤、骨髓抑制、口腔黏膜毒性的不良反应发生率均明显低于常规治疗组(P<0.05或P<0.01),表明补肺化瘀汤可一定程度上降低化疗所引起的不良反应。【结论】气血瘀滞型NSCLC患者普遍病情进展程度深,血液凝滞性高,契合中医“瘀毒”病机;针对“瘀毒”病机使用补肺化瘀汤治疗可明显改善患者中医证候积分和凝血功能,下调血清NO、VEGF水平,改善患者免疫功能,可提高患者临床疗效及生活质量,减少化疗所带来的不良反应,具有较高的安全性。 展开更多
关键词 非小细胞肺癌 气血瘀滞 “瘀毒”病机 补肺化瘀汤 凝血功能 免疫功能 生活质量 不良反应
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全身免疫炎症指数和红细胞分布宽度在儿童过敏性紫癜合并肾损害中的变化及意义
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作者 裘艺莎 吴锴 +1 位作者 胡剑 孙兴珍 《中国妇幼健康研究》 2024年第11期13-19,共7页
目的探讨全身免疫炎症指数(SII)和红细胞分布宽度(RDW)在预测儿童过敏性紫癜(HSP)合并肾损害中的临床价值。方法选取2018年6月至2022年12月在南京医科大学附属淮安第一医院住院治疗的191例HSP患儿为研究对象,其中77例为肾损害组,114例... 目的探讨全身免疫炎症指数(SII)和红细胞分布宽度(RDW)在预测儿童过敏性紫癜(HSP)合并肾损害中的临床价值。方法选取2018年6月至2022年12月在南京医科大学附属淮安第一医院住院治疗的191例HSP患儿为研究对象,其中77例为肾损害组,114例为无肾损害组。分析两组患儿的一般资料和实验室检查结果,通过多因素Logistic回归分析HSP合并肾损害的危险因素;以Spearman相关性分析SII和RDW与24小时尿蛋白定量(24h-UPRO)之间的相关性;利用受试者工作特征(ROC)曲线评估SII和RDW对HSP合并肾损害的预测价值。结果两组患儿的年龄(t=-2.449)、白细胞计数(t=-3.057)、血红蛋白(t=-2.304)、红细胞压积(t=-2.630)、RDW(t=-8.617)、中性粒细胞计数(t=-2.788)、中性粒细胞/淋巴细胞比值(Z=-2.887)、SII(Z=-3.325)比较差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,RDW(OR=1.861,95%CI:1.526~2.270,P<0.001)、SII(OR=1.003,95%CI:1.001~1.005,P=0.008)均是HSP患儿发生肾损害的独立危险因素。RDW、SII水平与24h-UPRO水平均呈正相关(r值分别为0.256、0.429,P<0.05)。ROC曲线评估显示,RDW预测HSP患儿合并肾损害的曲线下面积(AUC)为0.817(95%CI:0.757~0.877,P<0.001),最佳截断值为38.85fL,灵敏度和特异度分别为80.52%和70.18%;SII预测HSP患儿合并肾损害的AUC为0.642(95%CI:0.562~0.721,P=0.001),最佳截断值为401.67×10^(9)/L,灵敏度和特异度分别为81.82%和43.86%;二者联合预测HSP患儿合并肾损害的AUC为0.845(95%CI:0.790~0.900,P<0.001),灵敏度和特异度分别为87.01%和71.93%。结论SII和RDW对预测HSP患儿合并肾损害有一定的临床应用价值。 展开更多
关键词 全身免疫炎症指数 红细胞分布宽度 过敏性紫癜 肾损害 儿童
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红细胞免疫相关表面抗原及其功能
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作者 齐畅 孟祥红 《临床输血与检验》 CAS 2024年第6期855-859,共5页
近年来,对红细胞免疫物质的研究结果表明,红细胞不仅是运氧的主要载体,同时也作为固有免疫细胞发挥多种免疫和调节功能。红细胞可通过增强免疫黏附、促进吞噬作用、调节补体活性、清除循环免疫复合物等机制执行免疫调控功能,其表面的免... 近年来,对红细胞免疫物质的研究结果表明,红细胞不仅是运氧的主要载体,同时也作为固有免疫细胞发挥多种免疫和调节功能。红细胞可通过增强免疫黏附、促进吞噬作用、调节补体活性、清除循环免疫复合物等机制执行免疫调控功能,其表面的免疫物质如TOLL受体9、补体受体1、CD58等可作为桥梁参与维持机体免疫平衡。探索具有免疫特性的红细胞及其细胞因子在机体发育和疾病发生发展中的作用具有重要临床意义。 展开更多
关键词 红细胞 免疫 细胞因子
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鱼类早期红细胞发育与抗逆性状形成的研究进展
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作者 陈慧可 沈铮 +1 位作者 刘思遥 刘静霞 《水生生物学报》 CAS CSCD 北大核心 2024年第12期2133-2148,共16页
随着水产领域的设施化和高密度集约化养殖的发展,培育具有适应集约化养殖模式的耐低氧(抗非生物逆境)、抗病(抗生物逆境)、低应激等性状的鱼类新品种是解决水产养殖产业问题的关键。造血系统是维持鱼类正常生命活动最重要的系统之一,其... 随着水产领域的设施化和高密度集约化养殖的发展,培育具有适应集约化养殖模式的耐低氧(抗非生物逆境)、抗病(抗生物逆境)、低应激等性状的鱼类新品种是解决水产养殖产业问题的关键。造血系统是维持鱼类正常生命活动最重要的系统之一,其中,红细胞参与鱼类氧气、营养物质运输和免疫防御应答等功能,在鱼类抗病和耐低氧过程中发挥重要调控作用。红细胞发育及其功能调控的分子元件是鱼类抗病抗逆性状形成的重要遗传基础。文章以鱼类红细胞发育为切入点,关注调控红细胞发育、成熟、功能的经典信号和分子,并从氧气运输和免疫防御应答两方面详细阐述了鱼类红细胞的生理功能,同时,关注鱼类在逆境胁迫下的红细胞发育及其功能调控的适应性机制。文章探讨了鱼类红细胞发育及其抗逆性状形成的遗传基础研究,鱼类逆境胁迫下的红细胞生成及其生理响应,为水产养殖动物抗逆新种质创制提供理论依据。 展开更多
关键词 造血系统 红细胞发育 红细胞免疫 耐低氧 抗病 环境胁迫 抗逆育种
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洗涤红细胞在反复输注红细胞患者输血治疗中的应用效果
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作者 宋庆华 《中国现代药物应用》 2024年第12期93-96,共4页
目的研究洗涤红细胞在反复输注红细胞患者输血治疗中的应用价值。方法138例需反复输注红细胞治疗的患者为研究对象,以随机数字表法分为对照组与观察组,各69例。对照组采用去白细胞悬浮红细胞输注,观察组采用洗涤红细胞输注。对比两组的... 目的研究洗涤红细胞在反复输注红细胞患者输血治疗中的应用价值。方法138例需反复输注红细胞治疗的患者为研究对象,以随机数字表法分为对照组与观察组,各69例。对照组采用去白细胞悬浮红细胞输注,观察组采用洗涤红细胞输注。对比两组的输血不良反应发生率、实验室指标[血红蛋白(Hb)、红细胞计数(RBC)、网织红细胞比例(Rtc)、血小板计数(PLT)、白细胞计数(WBC)]及治疗效果。结果观察组患者的总有效率97.10%高于对照组的85.51%,差异显著(χ^(2)=5.841,P=0.016<0.05)。两组患者输血后的Hb、RBC均较输血前明显提高,Rtc较输血前明显降低,且观察组输血后的Hb(78.95±5.48)g/L、RBC(3.12±0.43)×10^(12)/L均高于对照组的(71.34±5.23)g/L、(2.75±0.39)×10^(12)/L,Rtc(18.54±1.23)%明显低于对照组的(23.43±1.58)%(P<0.05);观察组输血后的PLT和WBC比较差异均不显著(P>0.05)。观察组输血不良反应发生率为5.80%,对照组为8.70%,两组输血不良反应发生率比较差异不显著(χ^(2)=0.431,P=0.511>0.05)。结论洗涤红细胞在反复输注红细胞治疗的患者中应用效果肯定,能快速缓解患者的贫血症状,且安全性高,值得在临床进行推广。 展开更多
关键词 反复输注红细胞 洗涤红细胞 去白细胞 不良反应
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SII、RAR与AECOPD患者病情严重程度及并发呼吸衰竭的关系
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作者 屠昌明 田园 +2 位作者 汪鹏程 任鹏 赵寅生 《天津医药》 CAS 2024年第12期1317-1321,共5页
目的探究全身免疫炎症指数(SII)、红细胞分布宽度(RDW)与白蛋白(ALB)比值(RAR)与慢性阻塞性肺疾病急性加重期(AECOPD)患者病情严重程度及呼吸衰竭的关系。方法110例AECOPD患者依病情分为重症组37例和非重症组73例,依据是否并发呼吸衰竭... 目的探究全身免疫炎症指数(SII)、红细胞分布宽度(RDW)与白蛋白(ALB)比值(RAR)与慢性阻塞性肺疾病急性加重期(AECOPD)患者病情严重程度及呼吸衰竭的关系。方法110例AECOPD患者依病情分为重症组37例和非重症组73例,依据是否并发呼吸衰竭分为呼吸衰竭组26例和无呼吸衰竭组84例。对比各组血小板计数(PLT)、中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、RDW、ALB、SII、RAR水平,重症、并发呼吸衰竭的影响因素分析应用多因素Logistic回归,绘制受试者工作特征(ROC)曲线分析指标对患者发生重症或并发呼吸衰竭的预测价值。结果与非重症组比较,重症组NEU、SII、RDW、RAR水平增加,PLT、LYM水平降低(P<0.05);与无呼吸衰竭组比较,呼吸衰竭组NEU、SII、RDW、RAR水平增加,LYM、ALB水平降低(P<0.05);多因素Logistic回归分析示,SII、RAR水平高是AECOPD患者病情重症或并发呼吸衰竭的独立危险因素;ROC曲线分析示,SII联合RAR预测AECOPD患者病情重症及并发呼吸衰竭的ROC曲线下面积(AUC)分别为0.882(0.806~0.935)、0.908(0.837~0.954),均高于SII、RAR单独预测(P<0.05)。结论AECOPD患者SII、RAR联合检测可有效评估AECOPD患者病情及呼吸衰竭发生风险。 展开更多
关键词 肺疾病 慢性阻塞性 急性肺损伤 呼吸功能不全 全身免疫炎症指数 红细胞分布宽度与白蛋白比值
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丁苯酞胶囊联合依达拉奉在自发性蛛网膜下腔出血术后CVS中的效果
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作者 张伟杰 张培峰 《中国卫生标准管理》 2024年第2期157-160,共4页
目的探讨丁苯酞胶囊联合依达拉奉在自发性蛛网膜下腔出血术后脑血管痉挛(cerebral vasospasm,CVS)中的应用价值,分析其对脑脊液红细胞和神经功能的影响。方法回顾性分析2020年2月—2022年2月广东省中山大学附属汕头医院/汕头市中心医院... 目的探讨丁苯酞胶囊联合依达拉奉在自发性蛛网膜下腔出血术后脑血管痉挛(cerebral vasospasm,CVS)中的应用价值,分析其对脑脊液红细胞和神经功能的影响。方法回顾性分析2020年2月—2022年2月广东省中山大学附属汕头医院/汕头市中心医院收治的80例蛛网膜下腔出血术后CVS患者,按用药方式分为2组。在综合治疗基础上,对照组(n=40)用依达拉奉治疗,研究组(n=40)联合丁苯酞胶囊治疗。比较2组脑脊液红细胞数值、神经功能及不良反应。结果治疗后7、14 d,2组脑脊液红细胞计数均逐渐降低,其中研究组治疗后7、14 d脑脊液红细胞计数分别为(32.52±3.54)×10^(12)/L、(5.52±1.58)×10^(12)/L,低于对照组的(40.20±8.21)×10^(12)/L、(10.25±1.65)×10^(12)/L,差异有统计学意义(P<0.05);治疗后7、14 d,2组美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分均逐渐降低,且研究组更低;Barthel指数均逐渐升高,且研究组更高,差异有统计学意义(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论丁苯酞胶囊联合依达拉奉治疗自发性蛛网膜下腔出血术后CVS对微循环和脑组织灌注有改善作用,利于神经功能恢复,不增加不良反应。 展开更多
关键词 蛛网膜下腔出血 脑血管痉挛 丁苯酞 依达拉奉 神经功能 不良反应 红细胞数值
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RDW联合凝血七项对异位妊娠输血治疗不良反应的意义
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作者 文翠翠 《实用妇科内分泌电子杂志》 2024年第8期80-82,共3页
目的分析红细胞分布宽度(RDW)联合凝血七项对异位妊娠输血治疗不良反应的意义。方法选取85例异位妊娠输血治疗患者,根据患者有无发生不良反应将其分为对照组(45例,未发生不良反应)和研究组(40例,发生不良反应)。对比两组治疗前后RDW联... 目的分析红细胞分布宽度(RDW)联合凝血七项对异位妊娠输血治疗不良反应的意义。方法选取85例异位妊娠输血治疗患者,根据患者有无发生不良反应将其分为对照组(45例,未发生不良反应)和研究组(40例,发生不良反应)。对比两组治疗前后RDW联合凝血指标[凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D)、抗凝血酶Ⅲ(ATⅢ)与纤维蛋白降解产物(FDP)]水平。结果两组输血前RDW、PT、APTT、TT、FIB、D-D、ATⅢ、FDP水平比较,差异无统计学意义(P>0.05),输血后RDW、PT、APTT、TT、FIB、D-D、ATⅢ、FDP水平比较,差异具有统计学意义(P<0.05)。结论RDW联合凝血七项应用于异位妊娠输血治疗患者中,能够有效评估输血后的相关不良反应情况,具有重要的临床价值。 展开更多
关键词 红细胞分布宽度 凝血七项 异位妊娠输血 不良反应
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